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Metal ratio and bimetal nanoarchitectonics of ammonia-based fluoride complex induced nickel hydroxide and manganese oxide composites as active materials of an energy storage device

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Journal of Energy Storage 2024年 80卷

作者： Hsu, Chuan-Chih Yu, You Zher Wu, Chung-Hsien Lee, Pin-Yan Chen, Hung-Ming Husain, Sadang Kongvarhodom, Chutima Hsiao, Yu-Cheng Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Nickel and manganese compounds are widely applied as efficient battery-type active materials for energy storage devices, due to high theoretical capacities and abundant redox states for generating redox reactions to store charges. Morphology plays significant roles on energy storage ability. Structure directing agent (SDA) is widely reported to have ability for modulating configurations of active materials and to achieve excellent surface properties. In this work, it is the first time to use NH4BF4 and NH4HF2 as structure directing agents for synthesizing nickel manganese compounds derived from ZIF67 as active materials of energy storage devices. Bimetallic compounds are composed of nickel hydroxide and manganese oxide, which presents the favorable two-dimensional flower-like structure with high surface area and abundant redox states. The largest specific capacitance (CF) of 1358.2 F/g corresponding to the capacity of 226.4 mAh/g are achieved for the bimetallic compound synthesized using the Ni to Mn precursor ratio of 1 to 1 (NiMn11). The energy storage device assembled using NiMn11 and reduced graphene oxide on Ni foams presents a maximum energy density of 11.45 Wh/kg at the power density of 0.35 kW/kg, and excellent long-term stability with the CF retention of 85.6% and Coulombic efficiency of 87.5% after 10,000 cycles. © 2023

关键词： Fluorine compounds

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Complexity Analysis based on Parietal Fuzzy Entropy to Facilitate ADHD Diagnosis in Young Children

Complexity Analysis based on Parietal Fuzzy Entropy to Facil...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： I-Wen Huang Yu-Ci Jheng I-Chun Chen Li-Wei Ko Institute of Biomedical Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan Institute of Electrical and Control Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan International Program in Interdisciplinary Neuroscience College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Physical Medicine and Rehabilitation Ton-Yen General Hospital Hsinchu Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Attention deficit hyperactivity disorder (ADHD) is the most common condition affecting the development of neurons in children. Therefore, early and accurate diagnosis of ADHD in young children is of paramount importance. In this study, the 8-channel wireless wearable EEG measurement device was employed to record EEG data from 30 children diagnosed with ADHD and 30 typical development (TD) young children aged 4-7 years. The data was collected both during rest and while the children performed a Kiddie Continuous Performance Test (K-CPT). We extract relative power spectral density (PSD) unaffected by factors like skull resistance and thickness. Additionally, a range of complex entropy values based on the time domain were extracted. These included sample entropy (SaEn), permutation entropy (PeEn), singular value decomposition entropy (SvdEn), and fuzzy entropy (FuEn). We compare the performance of k-Nearest Neighbors (kNN), Support Vector Machine (SVM), and XGBoost, and utilized the sequential forward selection (SFS) feature selection method in the wrapper approach. Through this process, the study identified the most effective EEG data segments and feature subsets. The findings indicated that using a combination of resting and K-CPT EEG data yielded greater discriminability. Notably, the study found that extracting beta power from the right occipital lobe along with fuzzy entropy from the parietal lobe resulted in optimal accuracy of 90% in distinguishing between children with ADHD and TD children. These outcomes highlight the potential of relative PSD and complexity metrics to support the clinical diagnosis of early ADHD. Furthermore, these metrics may contain unique neurobiomarkers that could be valuable for devising early intervention strategies.

关键词： Support vector machines Performance evaluation Pediatrics Accuracy Aging Feature extraction Entropy Electroencephalography Complexity theory Time-domain analysis

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An exploration of neural dynamics of motor imagery for people with amyotrophic lateral sclerosis

An exploration of neural dynamics of motor imagery for peopl...

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作者： Hosni, Sarah M. Deligani, R.J. Zisk, A. McLinden, J. Borgheai, S.B. Shahriari, Y. Department of Electrical Computer and Biomedical Engineering University of Rhode Island KingstonRI United States Interdisciplinary Neuroscience Program University of Rhode Island KingstonRI United States

Objective. Studies of the neuropathological effects of amyotrophic lateral sclerosis (ALS) on the underlying motor system have investigated abnormalities in the magnitude and timing of the event-related desynchronization (ERD) and synchronization (ERS) during motor execution (ME). However, the spatio-spectral-temporal dynamics of these sensorimotor oscillations during motor imagery (MI) have not been fully explored for these patients. This study explores the neural dynamics of sensorimotor oscillations for ALS patients during MI by quantifying ERD/ERS features in frequency, time, and space. Approach. Electroencephalogram (EEG) data were recorded from six patients with ALS and 11 age-matched healthy controls (HC) while performing a MI task. ERD/ERS features were extracted using wavelet-based time-frequency analysis and compared between the two groups to quantify the abnormal neural dynamics of ALS in terms of both time and frequency. Topographic correlation analysis was conducted to compare the localization of MI activity between groups and to identify subject-specific frequencies in the µ and β frequency bands. Main results. Overall, reduced and delayed ERD was observed for ALS patients, particularly during right-hand MI. ERD features were also correlated with ALS clinical scores, specifically disease duration, bulbar, and cognitive functions. Significance. The analyses in this study quantify abnormalities in the magnitude and timing of sensorimotor oscillations for ALS patients during MI tasks. Our findings reveal notable differences between MI and existing results on ME in ALS. The observed alterations are speculated to reflect disruptions in the underlying cortical networks involved in MI functions. Quantifying the neural dynamics of MI plays an important role in the study of EEG-based cortical markers for ALS. © 2019 IOP Publishing Ltd.

关键词： Electroencephalography

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Urban heat mitigation by green and blue infrastructure:Drivers,effectiveness,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.Debele Soheila Khalili Christos H.Halios Jeetendra Sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamaldeep Bhui Nerea Calvillo Shi-Jie Cao Frederic Coulon Jill L.Edmondson David Fletcher Edmilson Dias de Freitas Hai Guo Matthew C.Hort Madhusudan Katti Thomas Rodding Kjeldsen Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lidia Morawska Rajan Parajuli Christopher D.F.Rogers Runming Yao Fang Wang Jannis Wenk Laurence Jones Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Environment University of ReadingWhiteknightsReading RG66BUUK School Design and the Built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Psychiatry and Nuffield Department of Primary Care Health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdisciplinary Methodologies University of WarwickWarwickUK School of Architecture Southeast University2 SipailouNanjing 210096China Cranfield University School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Forestry and Environmental Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and Health Science and Engine

The combination of urbanization and global warming leads to urban overheating and compounds the frequency and intensity of extreme heat events due to climate ***,the risk of urban overheating can be mitigated by urban green-blue-grey infrastructure(GBGI),such as parks,wetlands,and engineered greening,which have the potential to effectively reduce summer air *** many reviews,the evidence bases on quantified GBGI cooling benefits remains partial and the practical recommendations for implementation are *** systematic literature review synthesizes the evidence base for heat mitigation and related co-benefits,identifies knowledge gaps,and proposes recommendations for their implementation to maximize their *** screening 27,486 papers,202 were reviewed,based on 51 GBGI types categorized under 10 main *** GBGI(green walls,parks,street trees)have been well researched for their urban cooling ***,several other GBGI have received negligible(zoological garden,golf course,estuary)or minimal(private garden,allotment)*** most efficient air cooling was observed in botanical gardens(5.0±3.5℃),wetlands(4.9±3.2℃),green walls(4.1±4.2℃),street trees(3.8±3.1℃),and vegetated balconies(3.8±2.7℃).Under changing climate conditions(2070–2100)with consideration of RCP8.5,there is a shift in climate subtypes,either within the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other climate zones(e.g.,Dfb[continental warm-summer humid]to BSk[dry,cold semi-arid]and Cwa[temperate]to Am[tropical]).These shifts may result in lower efficiency for the current GBGI in the *** the importance of multiple services,it is crucial to balance their functionality,cooling performance,and other related co-benefits when planning for the future *** global GBGI heat mitigation inventory can assist policymakers and urban planners in prioritizing effective interventions to reduce the risk of urban overheating,fi

关键词： estuary walls extreme

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CATD: Unified Representation Learning for EEG-to-fMRI Cross-Modal Generation

arXiv

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arXiv 2024年

作者： Yao, Weiheng Lyu, Zhihan Mahmud, Mufti Zhong, Ning Lei, Baiying Wang, Shuqiang Southern University of Science and Technology Shenzhen518055 China Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen518055 China Department of Game Design Faculty of Arts Uppsala University Sweden Department of Information and Computer Science SDAIA-KFUPM Joint Research Center for AI Interdisciplinary Research Center for Biosystems and Machines King Fahd University of Petroleum and Minerals Dhahran Saudi Arabia The Faculty of Engineering Maebashi Institute of Technology Gunma Japan Chongqing University of Posts and Telecommunications Chongqing China School of Biomedical Engineering Shenzhen University Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Health Science Center Guangdong Shenzhen518000 China

Multi-modal neuroimaging analysis is crucial for a comprehensive understanding of brain function and pathology, as it allows for the integration of different imaging techniques, thus overcoming the limitations of individual modalities. However, the high costs and limited availability of certain modalities pose significant challenges. To address these issues, this paper proposes the Condition-Aligned Temporal Diffusion (CATD) framework for end-to-end cross-modal synthesis of neuroimaging, enabling the generation of functional magnetic resonance imaging (fMRI)-detected Blood Oxygen Level Dependent (BOLD) signals from more accessible Electroencephalography (EEG) signals. By constructing Conditionally Aligned Block (CAB), heterogeneous neuroimages are aligned into a latent space, achieving a unified representation that provides the foundation for cross-modal transformation in neuroimaging. The combination with the constructed Dynamic Time-Frequency Segmentation (DTFS) module also enables the use of EEG signals to improve the temporal resolution of BOLD signals, thus augmenting the capture of the dynamic details of the brain. Experimental validation demonstrates that the framework improves the accuracy of brain activity state prediction by 9.13% (reaching 69.8%), enhances the diagnostic accuracy of brain disorders by 4.10% (reaching 99.55%), effectively identifies abnormal brain regions, enhancing the temporal resolution of BOLD signals. The proposed framework establishes a new paradigm for cross-modal synthesis of neuroimaging by unifying heterogeneous neuroimaging data into a latent representation space, showing promise in medical applications such as improving Parkinson’s disease prediction and identifying abnormal brain regions. Copyright © 2024, The Authors. All rights reserved.

关键词： Electroencephalography

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Metrological control of electrolytic sensors for measuring angular deviations: Application in monitoring displacements of engineering structures 10

Metrological control of electrolytic sensors for measuring a...

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10th Brazilian Congress on Metrology, Metrologia 2019

作者： Leaño, E.G. Filho, P. Rocha Hernández, J.D. Frota, M.N. Civil Engineering Depart. Pontifical Catholic University of Rio de Janeiro RJ22451-900 Brazil Postgraduate Programme in Metrology Metrology for Quality and Innovation Pontifical Catholic University of Rio de Janeiro Rio de Janeiro22451-900 Brazil Research Group GIFOURIER. Faculty of Mechanical Electronic and Biomedical Engineering. Mechanical Engineering Program University Antonio Nariño Puerto Colombia Colombia

The work evaluates the metrological reliability of electrolytic sensors (electrolevels) used to determine angular deviations of elements of engineering structures. The motivation for the work resulted from its strategic application to control the stability of civil engineering structures, notably with application in geotechnics (e.g.: different types of dams of interest in engineering). The methodology used is based on the metrological consistency associated with the quality control process of a set of electrolevels submitted, simultaneously, to a careful calibration process, with traceability ensured to a standard angular deviation pattern. Mounted on a rigid bar, but pivoted at one of its ends to allow angular displacements, the output of each electrolevel is compared with the previously calibrated standard, for different controlled conditions of angular deviation imposed on the bar articulated to a center of rotation. The result of the analysis of typical calibration data for nine electrolevels allowed to show that the expression of the uncertainties associated with the calibration measurements performed constitutes an essential foundation to ensure the metrological reliability of the electrolevels, having allowed to validate a method of discard of electrolevels not meeting the allowable tolerance for a specific engineering application. Among the conclusions of the work, it was possible to qualify the statistical treatment of the levels of uncertainty as a sufficiently robust strategy to validate the electrolevels as a reliable instrument for angular displacement measurements, with a level of confidence appropriate to its application in civil engineering. © 2021 Institute of Physics Publishing. All rights reserved.

关键词： Uncertainty analysis

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Genome-Wide Analysis of Detoxification Genes Conferring Diamide Insecticide Resistance in Spodoptera Exigua Identifies Cyp9a40

SSRN

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SSRN 2024年

作者： Kim, Juil Han, Changhee Rahman, Md-Mafizur Lueke, Bettina Nauen, Ralf Interdisciplinary Graduate Program in Smart Agriculture Kangwon National University Chuncheon24341 Korea Republic of Department Biotechnology and Genetic Engineering Faculty of Biological Science Islamic University Kushtia7003 Bangladesh Agriculture and Life Science Research Institute Kangwon National University Chuncheon24341 Korea Republic of Bayer AG Crop Science Division Monheim40789 Germany

For over a decade, diamide insecticides have been effective against lepidopteran pests like beet armyworm, Spodoptera exigua (Hübner, 1808). However, the evolution of resistance poses a challenge to their sustainable use. We identified an I4790M mutation in the S. exigua ryanodine receptor (RyR) gene, but its correlation with resistance varied across the field-collected Korean populations of S. exigua. RNA sequencing and differential gene expression analysis were performed to investigate other resistance mechanisms. Diamide-resistant and susceptible strains and F1 hybrids were compared by mapping RNA-seq reads to the S. exigua reference genome. CYP9A40 was identified as a critical gene in diamide resistance due to its high expression in the resistant strains. Synergist bioassays with piperonyl butoxide supported the role of P450s in diamide metabolic resistance in S. exigua. A strong positive correlation between CYP9A40 over-expression levels (up to 80-fold) and diamide LC50 values was obtained for field-collected populations uniformly showing a 100% frequency of the RyR I4790M target-site resistance allele. To validate the function of CYP9A40 in diamide detoxification, we recombinantly expressed the gene and tested its ability to bind and degrade chlorantraniliprole as a substrate. The results confirmed its catalytic role in diamide metabolism. CYP9A40 has been identified and validated to confer metabolic resistance in Korean S. exigua populations. It works alongside the RyR target-site I4790M mutation to enhance diamide resistance. These mechanisms offer insights for resistance monitoring and support insecticide resistance management programs to improve control strategies for S. exigua. © 2024, The Authors. All rights reserved.

关键词： RNA

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Mesenchymal stromal cell exosomes enhance dental pulp cell functions and promote pulp-dentin regeneration

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Biomaterials and Biosystems 2023年 11卷

作者： Shi, Jiajun Teo, Kristeen Ye Wen Zhang, Shipin Lai, Ruenn Chai Rosa, Vinicius Tong, Huei Jinn Duggal, Mandeep S. Lim, Sai Kiang Toh, Wei Seong Faculty of Dentistry National University of Singapore Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research Singapore Oral Care Health Innovations and Designs Singapore National University of Singapore Singapore College of Dental Medicine QU Health Qatar University Qatar Department of Orthopaedic Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore Department of Biomedical Engineering Faculty of Engineering National University of Singapore Singapore Tissue Engineering Program Life Sciences Institute National University of Singapore Singapore Integrative Sciences and Engineering Program NUS Graduate School National University of Singapore Singapore

Mesenchymal stromal/stem cell (MSC) therapies are currently being explored for dental pulp regeneration. As the therapeutic effects of MSCs in tissue repair are mediated mainly through the release of extracellular vesicles (EVs) including exosomes, we investigated here the cellular processes and molecular mechanisms modulated by MSC exosomes in dental pulp regeneration. Using dental pulp cell (DPC) cultures, we demonstrated that MSC exosomes could increase DPC migration, proliferation, and odontogenic differentiation. The enhancement of these cellular processes was mediated through exosomal CD73-mediated adenosine receptor activation of AKT and ERK signaling. Consistent with these observations, MSC exosomes increased the expression of dentin matrix proteins and promoted the formation of dentin-like tissue and bridge-like structures in a rat pulp defect model. These effects were comparable to that of mineral trioxide aggregate (MTA) treatment. MSC exosomes also yielded recellularized pulp-dentin tissues in the root canal of endodontically-treated human premolars, following subcutaneous implantation in the mouse dorsum. Together, our findings suggest that MSC exosomes could exert a multi-faceted effect on DPC functions including migration, proliferation and odontogenic differentiation to promote dental pulp regeneration. This study provides the basis for development of MSC exosomes as a cell-free MSC therapeutic alternative for pulp-dentin regeneration. © 2023

关键词： Dental pulp Exosomes Extracellular vesicles Mesenchymal stromal/stem cells Regeneration

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Facilitating light utilization and electron transfer of TiO2 nanotube arrays for catalyzing photoelectrochemical water reduction via acid etching and copper doping

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Materials Today Chemistry 2023年 34卷

作者： Hsu, Chuan-Chih Kubendhiran, Subbiramaniyan Lai, Jhih-Hong Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Hsiao, Yu-Cheng Wu, Yung-Fu Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 03 Ouagadougou Burkina Faso Gingen Technology Co. LTD Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Photoelectrochemical catalytic capability mainly relies on light absorption and charge transfer efficiency. TiO2 nanotube array (TNA) having suitable band edges and one-dimensional hollow structure is regarded as one of efficient photoelectrocatalysts toward water reduction. In this study, two strategies are firstly applied to modify TNA as the photocatalyst of water reduction. Ti foils are etched by acid to produce multiple light reflections planes for improving light absorption, and Cu is doped in TNA to enhance charge transfer efficiency. The optimal Cu-doped TNA electrode on the acid-etched Ti foil presents a much smaller overpotential of 91 mV at 10 mA/cm2 compared with that of the undoped TNA (524 mV). A smaller Tafel slope of 134 mV/dec is obtained for the optimal Cu-doped TNA electrode than that of the undoped TNA (167 mV/dec). After measuring the photoelectrochemical performance for 1000 cycles, overpotential and charge-transfer resistance of modified TNA are largely reduced owing to activation. Current retention of 96.7% is achieved after continuously illuminating for 10 h. Highly improved photoelectrochemical catalytic ability of TNA modified by acid etching and Cu doping provides new pages for material modifications on substrate and active material. © 2023 Elsevier Ltd

关键词： Light absorption

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Hypoglycemic activity of curcuma mangga val. Extract via modulation of GLUT4 and ppar-γ mrna expression in 3T3-L1 adipocytes

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Journal of Experimental Pharmacology 2020年 12卷 363-369页

作者： Pujimulyani, Dwiyati Yulianto, Wisnu Adi Setyowati, Astuti Arumwardana, Seila Kusuma, Hanna Sari Widya Sholihah, Ika Adhani Rizal, Rizal Widowati, Wahyu Maruf, Ali Faculty of Agroindustry University of Mercu Buana Yogyakarta Yogyakarta 55753 Indonesia Biomolecular and Biomedical Research Center Aretha Medika Utama Bandung 40163 Indonesia Biomedical Engineering Study Program Department of Electrical Engineering Faculty of Engineering University of Indonesia Jakarta 16424 Indonesia Medical Research Center Faculty of Medicine Maranatha Christian University Bandung 40164 Indonesia Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College Faculty of Medicine Chongqing University Chongqing 400030 China

Background: There would be over 600 million people living with diabetes by 2040 as predicted by the World Health Organization. Diabetes is characterized by raised blood sugar and insulin resistance. Insulin regulates the influx of glucose into the cell by upregulating the glucose transporter type 4 (GLUT4) expression on the plasma membrane. Besides, PPAR-γ also controls the metabolism of glucose in adipose tissues. Curcuma mangga Val., denoted as C. mangga, is a native Indonesian medicinal plant that has many beneficial effects, including an antidiabetic potential. Purpose: In this research, we aimed to disclose the hypoglycemic activity of ethanol extract of C. mangga (EECM) in 3T3-L1 fibroblasts-derived adipocyte cells in regulating glucose uptake as confirmed by the GLUT4 and PPAR-γ gene expression. Methods: The uptake of glucose was determined using radioactive glucose, while the gene expression of GLUT4, PPAR-γ, and β-actin was quantified using mRNA segregation and real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR). Results: We discovered that EECM interventions (200 and 50 μg/mL) increased glucose uptake in lipid-laden 3T3-L1 cells by 14.75 and 8.86 fold compared to the control noninsulin, respectively (p < 0.05). At the same doses, they also increased GLUT4 mRNA expression by 8.41 and 11.18 fold compared to the control non-insulin, respectively (p < 0.05). In contrast, EECM interventions (200 and 50 μg/mL) showed lower levels of PPAR-γ mRNA expression compared to the control metformin, indicating the anti-adipogenic potentials of EECM. Conclusion: EECM showed hypoglycemic activity in lipid-laden 3T3-L1 cells by improving glucose ingestion into the cells, which was mediated by increased GLUT4 expression and downregulated PPAR-γ expression. © 2020 Pujimulyani et al.

关键词： 3T3-L1 adipocytes Curcuma mangga Val Glucose uptake GLUT4 PPAR-γ

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