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Methodological Properties of Transcutaneous Electrical Nerve Stimulation (TENS) Equipment Used for Analgesia in Humans: a Systematic Review

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SN Comprehensive Clinical Medicine 2021年第6期3卷 1363-1372页

作者： Guimarães, Igor Batista Volpini Lana, Mariana Ribeiro de Aquino, Mariana Rodrigues Carvalho Cavalheiro, Jessé Mendonça Alves, Davi Neiva Vimieiro, Claysson Bruno Santos Associação Mineira de Reabilitação Orthotics for Humans Laboratory (OhLab) Child Rehabilitation Center Belo Horizonte Brazil Graduate Program in Mechanical Engineering Bioengineering Laboratory Labbio Universidade Federal de Minas Gerais Belo Horizonte Brazil Faculty of Engineering and Architecture Biomedical Engineering Department Universidade FUMEC Belo Horizonte Brazil Graduate Program in Mechanical Engineering Pontifícia Universidade Católica de Minas Gerais Belo Horizonte Brazil

Pain is considered a public health problem due to its high economic cost, high prevalence, and great impact on the quality of life of patients and their families. Transcutaneous electrical nerve stimulation (TENS) has been shown to be a safe, inexpensive option with satisfactory results in improving pain control. However, the success of this therapy presents as key factors the parameters used, among them the intensity and duration of treatment. However, little is known about the validation of such equipment. To perform a systematic review of the equipment available for the application of electrostimulation as a therapeutic resource for analgesia, which had their methodological properties tested. A systematic literature search was conducted for all relevant scientific articles in the SCIELO, Medline/PubMed, PEDRo, and EBSCO databases. A total of 318 articles were found. Sixty-six were duplicate studies, 252 were selected by title, 72 by abstract, 5 by text full reading, and finally only 2 were included, since the others did not meet the pre-established inclusion criteria. The evidence gathered in this study shows that the performance evaluation of commercially available electrostimulation equipment may be a responsibility of the national regulatory agency. Our findings reinforce the importance of greater availability of information about the regulatory processes of these devices and the verification of the parameters of the regulated devices, so that the achievement of therapeutic goals is not compromised.

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A Reliable Method to Estimate the Bispectral Index Value Using a Single Frontal EEG Channel for Intra and Inter Subject Variability

A Reliable Method to Estimate the Bispectral Index Value Usi...

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IEEE International Workshop on Medical Measurement and Applications (MEMEA)

作者： Mohammad Shahbakhti Matin Beiramvand Roza Krycinska Erfan Nasiri Wei Chen Jordi Solé-Casals Michal Wierzchon Anna Broniec-Wójcik Piotr Augustyniak Vaidotas Marozas Biomedical Engineering Institute Kaunas University of Technology Kaunas Lithuania Faculty of Information Technology and Communication Tampere University Tempere Finland Doctoral School in Medical and Health Sciences Jagiellonian University Medical College Krakow Poland Department of Interdisciplinary Intensive Care Jagiellonian University Collegium Medicum Krakow Poland Faculty of Statistics Mathematics and Computer Allameh Tabataba’i University Tehran Iran Center for Intelligent Medical Electronics School of Information Science and Technology Fudan University Shanghai China Data and Signal Processing Research Group University of Vic-Central University of Catalonia Vic Spain Institute of Psychology Jagiellonian University Krakow Poland Department of Biocybernetics and Biomedical Engineering AGH University of Science and Technology Krakow Poland

Objective: Monitoring the depth of anesthesia (DoA) plays an important role for administering the drug injection during a surgery, i.e., preventing undesired awareness and inordinate anesthetic depth. Although the bispectral index (BIS) monitor is the golden standard system for the DoA monitoring, it is still not affordable for the developing countries. Alternatively, a low-cost electroencephalogram (EEG) headband can be used. The objective of this paper is to present a new algorithm for estimating the BIS values using a single frontal EEG channel. Method: In the first step, the EEG signal is filtered for the elimination of artifacts and is split into its sub-bands. In the second step, several linear and nonlinear features are extracted from each sub-band and fed to a random forest regression model in order to estimate the BIS. The performance of the proposed algorithm is assessed using EEG data recorded from twenty-four subjects during the general anesthesia and is validated in terms of correlation coefficient (CC) and absolute error (AE) between the reference and estimated BIS values. Results: The proposed algorithm achieved the mean CC of 0.83 and AE of 6.5 for intra subject variability and mean CC of 0.87 and AE of 5.5 for inter subject variability. Significance: Given the similar results for both intra and inter subject variability, the proposed algorithm has the potential to be used in the real-world scenario.

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Pulmonary entrapping predicts occult diaphragmatic injury in blunt thoracic trauma with rib fractures

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Asian Journal of Surgery 2025年第5期48卷 2859-2865页

作者： Chang, Po-Chih Chen, Chao-Wen Liu, Yu-Wei Chou, Shah-Hwa Chang, Ting-Wei Li, Hsien-Pin Chiang, Hung-Hsing School of Medicine College of Medicine National Sun Yat-sen University Kaohsiung City Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Weight Management Center Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Department of Sports Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Ph. D. Program in Biomedical Engineering College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan Division of Trauma and Surgical Critical Care Department of Surgery Kaohsiung Medical University Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Division of Thoracic Surgery Department of Surgery Kaohsiung Medical University Ganshan Hospital/Kaohsiung Medical University Kaohsiung City Taiwan Ph.D. Program in Environmental and Occupational Medicine College of Medicine Kaohsiung Medical University Kaohsiung City Taiwan

Background: Blunt thoracic trauma (BTT) often leads to rib fractures (RFs), with an increasing trend in surgical stabilization of rib fractures (SSRF) combined with thoracoscopic exploration, revealing previously underestimated occult diaphragmatic injuries (ODIs) that can result in hernias if not promptly addressed. We present our experience managing ODIs following BTT with complex RFs in a tertiary hospital in Southern Taiwan. Methods: We conducted a retrospective study including patients undergoing SSRF for BTT with complex RFs from January 2018 to March 2024. We analyzed demographic data, trauma details, clinical presentations, intraoperative findings, radiological features, and attempted to identify predictive factors for ODIs using logistic regression analysis. We also reviewed previous case series on ODIs. Results: We identified 11 ODIs, primarily detected during thoracoscopic exploration performed concurrently with SSRF (n = 8) or excessive bloody pleural effusion (n = 3). One hundred and twenty-two patients underwent SSRFs for their complex RFs simultaneously. All these patients with incidental ODI findings during SSRF for complex RFs underwent successful diaphragm repair via thoracoscopy. Multivariate logistic regression analysis revealed a significant association between trapped lung and ODI occurrence in patients undergoing SSRF after BTT (odds ratio: 24.423;95 % confidence interval: 2.77–215.369;p = 0.004). Conclusions: Our findings emphasize the importance of considering pulmonary entrapment as a significant predictive factor for ODI after BTT with complex RFs. Routine thoracoscopy during SSRF is crucial for early detection and management of this rare condition. © 2025 Asian Surgical Association and Taiwan Society of Coloproctology

关键词： Blunt injury Diaphragm Fracture fixation Pulmonary entrapping Rib fractures Thoracoscopy

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biomedical data and AI

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Science China Life Sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

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Improving the Accuracy and Equity of Pulse Oximeters: Collaborative Recommendations

JACC: Advances

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JACC: Advances 2022年第4期1卷 100118-100118页

作者： Rathod, Megh Ross, Heather J. Franklin, Daniel Institute of Biomedical Engineering Faculty of Applied Science and Engineering University of Toronto Toronto ON Canada Translational Biology and Engineering Program Ted Rogers Center for Heart Research Toronto ON Canada Ted Rogers Center for Heart Research Peter Munk Cardiac Center University Health Network Toronto ON Canada Division of Cardiology Department of Medicine University of Toronto Toronto ON Canada

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Large Amplitude Harmonic Vibration under Pulse Doppler Measurement

Large Amplitude Harmonic Vibration under Pulse Doppler Measu...

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2021 International Conference on biomedical engineering, ICoBE 2021

作者： Hermawan, N. Ishii, T. Yamakoshi, Y. Saijo, Y. Graduate School of Biomedical Engineering Tohoku University 6-6-12 Aramaki Aza Aoba Aoba-ku Miyagi Sendai980-8579 Japan Biomedical Engineering Department Institut Teknologi Sepuluh Nopember Gedung A B C dan AJ Kampus ITS Keputih Sukolilo Jawa Timur Surabaya60111 Indonesia Frontier Research Institute for Interdisciplinary Sciences Tohoku University 6-3 Aramaki Aza Aoba Aoba-ku Sendai980-8578 Japan Faculty of Science and Technology Gunma University 1-5-1 Tenjin-cho Gunma Kiryu-shi376-8515 Japan

A flow velocity or tissue motion can be measured by pulse Doppler method. However, when the method is applied to a sinusoid motion or harmonic vibration, the estimation result is deviated. In this paper, the generalized theory of pulse Doppler measurement to the sinusoid motion is explained and the relation between the estimation deviation and the real value is given. Furthermore, a special case of binary velocity estimation is expanded and simulated with different parameters. This simulation result suggested that different selection of parameters may fundamentally affect the output of pulse Doppler estimation. © 2021 Institute of Physics Publishing. All rights reserved.

关键词： Flow velocity

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Expert consensus on quality control of multimodal MRI data in multicenter cohort projects

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Chinese Journal of Radiology 2025年第5期59卷 487-496页

作者： Xia, Mingrui Li, Shuyu Huang, Ruiwang He, Hongjian Zhu, Litao Huang, Chuzhong Jiang, Hua Lei, Xu Li, Hai Liu, Hesheng Liu, Yong Lu, Qing Men, Weiwei Rao, Hengyi Shen, Dinggang Sui, Jing Tong, Qiqi Xiao, Yaqiong Yan, Chaogan Yin, Xuntao Zang, Yufeng Zhao, Li Zhao, Tengda Zuo, Xinian Peng, Yun Gong, Gaolang Gao, Jiahong He, Yong State Key Laboratory of Cognitive Neuroscience and Learning Beijing Key Laboratory of Brain Imaging and Connectomics IDG/McGovern Institute for Brain Research Beijing Normal University Beijing 100875 China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing 100875 China School of Psychology South China Normal University Guangzhou 510631 China School of Physics Zhejiang University Hangzhou 310027 China School of Psychology and Cognitive Science East China Normal University Shanghai 200062 China School of Biomedical Engineering ShanghaiTech University Shanghai 201210 China Faculty of Psychology Southwest University Chongqing 400715 China Center for MRI Research Academy for Advanced Interdisciplinary Studies IDG/McGovern Institute for Brain Research Peking University Beijing 100871 China Biomedical Pioneering Innovation Center (BIOPIC) Peking University Beijing 100871 China School of Artificial Intelligence Beijing University of Posts and Telecommunications Beijing 100876 China School of Biological Sciences & Medical Engineering Southeast University Nanjing 210000 China Center for MRI Research Academy for Advanced Interdisciplinary Studies Institute of Heavy Ion Physics School of Physics Peking University Beijing 100871 China School of Business and Management Shanghai International Studies University Shanghai 200083 China State Key Laboratory of Cognitive Neuroscience and Learning IDG/McGovern Institute for Brain Research Beijing Normal University Beijing 100875 China Zhejiang Lab Hangzhou 311121 China Shenzhen Institute of Neuroscience Shenzhen 518107 China Department of Psychology University of Chinese Academy of Sciences Beijing 100101 China Department of Radiology Guangzhou Women and Children′s Medical Center Guangzhou Medical University Guangzhou 510600 China Centre for Cognition and Brain Disorders The Affiliated Hospital of Hangzhou Normal University Hangzhou 310015 China Department of

近年来，多模态MRI脑成像技术迅速发展，为无创揭示健康人脑的组织规律和脑工作原理提供了重要的技术手段。基于多中心MRI脑影像大数据的研究，显著增加了样本的多样性和代表性，提高了统计分析的稳健性，促进了研究方法和数据处理的标... 详细信息

近年来，多模态MRI脑成像技术迅速发展，为无创揭示健康人脑的组织规律和脑工作原理提供了重要的技术手段。基于多中心MRI脑影像大数据的研究，显著增加了样本的多样性和代表性，提高了统计分析的稳健性，促进了研究方法和数据处理的标准化，提升了研究的可重复性和可比性，已成为脑科学研究的重要发展趋势。然而，当前多中心多模态MRI脑影像研究在扫描设备、序列、参数等方面存在较大异质性，为脑影像数据的质量控制带来了巨大挑战。在科技部科技创新2030-“脑科学与类脑研究”重大项目“中国学龄儿童脑智发育队列研究”的支持下，来自国内多家从事MRI脑影像研究的权威机构和专家团队，充分总结了当前国内外多中心MRI脑影像大型脑科学研究项目数据质量控制的经验，并基于不同机型的多中心多模态MRI脑影像数据分析，共同制定了《多中心队列项目的多模态MRI脑影像数据质量控制专家共识》。该共识旨在规范和指导多模态MRI脑影像研究的数据质量控制，为多中心项目的高质量脑影像数据研究奠定基础。

关键词：磁共振成像脑多中心质量控制

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The effect of thermal pre-Treatment on cassava rhizome properties for utilizing as green fuel in gasification 5

The effect of thermal pre-Treatment on cassava rhizome prope...

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2020 5th International Conference on Sustainable and Renewable Energy engineering, ICSREE 2020

作者： Sirinwaranon, Punchaluck Atong, Duangduen Sricharoenchaikul, Viboon Interdisciplinary Program in Environmental Science Graduate School Chulalongkorn University Bangkok10330 Thailand National Science and Technology Development Agency [NSTDA Thailand Science Park Pathum Thani12120 Thailand Department of Environmental Engineering Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand

Cassava rhizome (CR) was torrefied to provide superior solid fuel quality for further gasification process. The torrefaction was carried out in the absence of oxygen at 220, 240, 260, and 280°C with a fixed residence time. Solid fuel after torrefaction has a higher calorific value from that of reduced volatile matters. The optimum energy yield of torrefied CR is 88.16% at 260°C. The heating value of 20.86 MJ/kg for a torrefied product can be achieved compared to 15.37 MJ/kg for untreated CR. The subsequent gasification of torrefied CR at temperature of 800°C yielded the highest gas product of 65 wt.%. The carbon and hydrogen conversions into CO and H2 were 14.28% and 29.95%, respectively. Synthesis gas (syngas) from the conversion maintained the H2/CO ratio of around 2-2.50, which is suitable for the Fischer-Tropsch process or can be used as the feedstock for petrochemical industry. © The Authors, published by EDP Sciences, 2020.

关键词： Gasification

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Dual Fluorescence Emission by Irradiation of Single Optical Source for Fluorescein Sodium and 5-ALA Applications

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Journal of engineering and Science in Medical Diagnostics and Therapy 2022年第1期5卷 011002页

作者： Kwon, So Yoon Yoon, Ki-Cheol Kim, Kwang Gi Interdisciplinary Program in Bioengineering Graduate School Seoul National University Korea Republic of Gachon University Gil Medical Center 21 774 beon-gil Namdong-daero Namdong-gu Incheon21565 Korea Republic of Department of Biomedical Engineering College of Medicine Gachon University 38-13 Dokjom-ro 3 Namdong-gu Incheon21565 Korea Republic of Medical Devices R&D Center Gachon University Gil Medical Center 21 774 beon-gil Namdong-daero Namdong-gu Incheon21565 Korea Republic of Gachon University 38-13 3 Dokjom-ro Namdong-gu Incheon21565 Korea Republic of

Most brain surgeries aim to completely resection a tumor. However, the arrangement of blood vessels around brain tumors is often complex. Moreover, the tumors and blood vessels have similar colors, making it difficult to identify the boundaries between them with the naked eye. Fluorescent staining is a method used to distinguish the borders between brain tumors and blood vessels. The fluorescent contrast agents commonly used to observe tumors are 5-aminolevulinic acid and fluorescein sodium, which have different surgical sensitivities, depending on the type of tumor. In this article, a dual band bandpass filter with dual-wavelength emission for 5-aminolevulinic acid and fluorescein sodium is designed, and the dual-band bandpass filter capable of inducing simultaneous fluorescence emission of fluorescein sodium and 5-aminolevulinic acid was investigated experimentally to improve accuracy, speed, and energy efficiency in clinical settings. The possibility of dual fluorescence emission with a single irradiation is proposed. The efficiency of transmission and reflection (optical density) is 98% and 0.01%, respectively, and the bandwidth is 50% in the proposed filter. The proposed fluorescent dual-band filter has the advantage of saving energy, reducing auxiliary manpower and unit costs, and reducing operating room space requirements by producing two fluorescence diagnostic effects using a single equipment. © 2022 American Society of Mechanical Engineers (ASME). All rights reserved.

关键词： Tumors

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High-temperature strain-mediated oxidation of 2D MoS2

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Materials and Design 2023年 236卷

作者： Rouhan, Mehdi Hobley, Jonathan Lin, Kuang-I Hofmann, Mario Yao, Yu-Chi Chang, Yung-Huang Carpick, Robert William Schall, J. David Jeng, Yeau-Ren Department of Biomedical Engineering National Cheng Kung University 1 University Road Tainan City70101 Taiwan Core Facility Center National Cheng Kung University 1 University Road Tainan City70101 Taiwan Department of Physics National Taiwan University Taipei106 Taiwan Bachelor Program in Interdisciplinary Studies National Yunlin University of Science and Technology 123 University Road Yunlin64002 Taiwan Department of Mechanical Engineering and Applied Mechanics University of Pennsylvania 220 S. 33rd St. PhiladelphiaPA19104-6315 United States Department of Mechanical Engineering North Carolina Agricultural and Technical State University GreensboroNC27411 United States Tainan70101 Taiwan

MoS2 is 2D material applicable for electronics, photo-detectors, light-emitting diodes, and solar cells. Since these applications operate at elevated temperatures, determining and controlling the environmental stability of MoS2 is essential. This study uses Raman spectroscopic experiments at elevated temperatures to observe reversible and irreversible changes in 2D MoS2 films with varying thickness, morphology, and substrate to explore the limits of its thermal stability. Molecular dynamics simulations and in-situ X-ray diffraction confirm that thermal expansion causes the Raman reversible spectral shifts. Further analysis reveals irreversible spectral shifts associated with oxidation and strain effects caused by oxidation with two distinct modes. The former is due to the general homogenous thinning of layers from the top layer down through randomly spaced sulfur vacancies. The latter is due to inhomogeneous oxidation, which known to occur as localized pitting at grain boundaries, void formation from nucleation centers, or stress corrosion cracking starting from edges under strain. Segregation of doping and strain contributions confirms higher strain in the edges. Annealing increases the spread of the strain distribution. These results highlight the critical role of strain, resulting from thermal expansion coefficient mismatch between substrates and 2D MoS2 films, on their environmental stability. © 2023 The Authors

关键词： Raman spectroscopy

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