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Whole-body phase plane analysis for standard maximum vertical jump assessment

Gait & Posture 2021年 90卷 203-204页

作者： Rodrigues, C. Correia, M. Abrantes, J. Rodrigues, B. Nadal, J. INESC TEC - Institute for Systems and Computer Engineering- Technology and Science C-BER - Centre for Biomedical Engineering Research Porto Portugal University of Porto Faculty of Engineering Porto Portugal Lusófona University CICANT Centre for Research in Applied Communication Culture and New Technologies - MovLab Laboratory of Technologies for Interactions and Interfaces Lisbon Portugal Federal University of Pernambuco Department of Electronic and Systems Recife Brazil Federal University of Rio de Janeiro Biomedical Engineering Program Rio de Janeiro Brazil

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Microspheres for 3D bioprinting: a review of fabrication methods and applications

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Frontiers in bioengineering and biotechnology 2025年 13卷 1551199页

作者： Dmitri Karaman Kira Williams Jolene Phelps Fynn La Boucan Gretchen Lewandowski Kerrin O'Grady Bosco Yu Stephanie M Willerth Department of Mechanical Engineering University of Victoria Victoria BC Canada. Division of Medical Sciences University of Victoria Victoria BC Canada. Axolotl Biosciences Victoria BC Canada. Biomedical Engineering Program Department of Mechanical Engineering University of Victoria Victoria BC Canada. Biology Program Department of Science University of Victoria Victoria BC Canada. Department of Biomedical and Chemical Engineering Syracuse University Syracuse NY United States. BioInspired Syracuse Institute for Material and Living Systems Syracuse University Syracuse NY United States. School of Biomedical Engineering Faculty of Applied Science and Faculty of Medicine University of British Columbia Vancouver BC Canada.

Bioprinting incorporates printable biomaterials into 3D printing to create intricate tissues that maintain a defined 3D structure while supporting the survival and function of relevant cell types. A major challenge in 3D bioprinting is tuning material properties to ensure compatibility with different types of cells, while accurately mimicking the physiological microenvironment. Developing novel bioinks tailored to specific applications can help address this challenge by combining various materials and additives to tune the bioink formulation. Microspheres - small spherical particles - can incorporate drugs or growth factors to enable their controlled release, encapsulate cells to provide protection during printing, and provide structural reinforcement to tune mechanical properties and enable complex architectures. The particles range in size from 1 to 1000 μm and can be tuned to meet desired functions by optimizing their mode of production and the materials used for fabrication. This review presents an overview of microsphere production methods and considerations for optimizing the production process. It then summarizes how microspheres have been used to date in bioprinting applications. Finally, the existing challenges associated with the creation and use of microspheres are discussed along with avenues for future research.

关键词： biomaterials bioprinting drug encapsulation electrospray emulsification microfluidics microspheres

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Biological evaluation of PCL-AgNPs biocomposites as guided tissue regeneration membranes

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AIP Conference Proceedings 2023年第1期2720卷

作者： Prihartini Widiyanti Mohammad Bagus Lazuardi Biomedical Engineering Program Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia Institute of Tropical Disease Universitas Airlangga Surabaya 60115 Indonesia

More than half of the world’s population still experiences dental and mouth disease which causes disruption to the quality of human life. The number of untreated dental and oral diseases increased by 40% from 1990 to 2015 which reached 3.5 billion people and periodontal disease in severe conditions reached 573 million. One of the cases of periodontal abnormalities is the Guided tissue regeneration (GTR) method. In this study the formation of GTR membranes derived from biocomposite PCL-AgNPs using the electrospinning method. The results obtained through FTIR characterization, degradation, antibacterial, and cytotoxicity that the addition of AgNPs did not show changes in functional groups. All biocomposite GTR membrane PCL-AgNPs samples showed that AgNPs only physically bonded to PCL. Degradation characterization shows that the addition of AgNPs causes the rate of degradation to increase with increasing number of AgNPs. The addition of AgNPs also shows the ability of membranes to inhibit bacteria and viability decreases with increasing number of AgNPs.

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A biomimetic micropillar wound dressing with flavone and polyphenol control release in vitro and in vivo

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Journal of the Taiwan Institute of Chemical Engineers 2024年 160卷

作者： Cheng, Tien-Hsin Lin, Ruei-Hong Cheng, Yu-Shen Shih, Pin-Keng Show, Pau Loke Chen, Hsiao-Yi Nakmee, Pattarawadee Sumthong Chang, Jui-Jen Huang, Dong-Ming Wang, Hui-Min David Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Xingda Rd. South Dist. Taichung402 China Department of Neurological Institute Taichung Veterans General Hospital Taichung China Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung China Department of Surgery China Medical University Hospital Taichung Taiwan School of Medicine China Medical University Taichung Taiwan Department of Chemical Engineering Khalifa University Abu Dhabi United Arab Emirates Faculty of Science at Sriracha Kasetsart University Sriracha Campus 199 Moo 6 Sukhumvit Rd. Chonburi Sriracha20230 Thailand Department of Medical Research China Medical University Hospital China Medical University Taichung China Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County China Regenerative Medicine and Cell Therapy Research Center Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung China

Background: Wound healing is a complex and dynamic process involving the replacement of devitalized and missing cellular structures and tissue layers. Methods: This study involved developing a drug-loaded biomimetic micropillar wound dressing based upon inspiration from witnessing the adhesive ability in a gecko's footpad. The conformal adhesion was set up by applying a soft elastomer thin film on the developed wound dressing surfaces. The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. Results: The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. The results indicate that the developed biomimetic micropillar patches could release the loaded drugs and significantly increase cell viability and collagen content to 20 % ∼ 25 % in vitro and in vivo. Conclusion: In summation, the primary purpose of this study has been to design a novel encapsulated carrier (micropillar patch) for use in adjustable drug release, while combining with the biomimetic microstructure to reach wound healing through percutaneous absorption. © 2024 Taiwan Institute of Chemical Engineers

关键词： Chemical stability

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Dopaminergic and Serotoninergic Neurotoxicity of Lanthanide Phosphate (Tbpo4) in Developing Zebrafish

SSRN

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SSRN 2023年

作者： Chen, Siying Wang, Xiaohong Ye, Xiaolin Qin, Yingju Wang, Haiqing Liang, Zhenda Zhu, Lishan Zhou, Li Martyniuk, Christopher J. Yan, Bing Institute of Environ. Res. at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River Delta Ministry of Education Guangzhou University Guangzhou510006 China Center for Environmental and Human Toxicology Department of Physiological Sciences College of Veterinary Medicine UF Genetics Institute Interdisciplinary Program in Biomedical Sciences in Neuroscience University of Florida GainesvilleFL32611 United States School of Environmental Science and Engineering Shandong University Shandong Jinan250100 China

Rare earth elements (REEs) are exploited for global use in manufacturing. Such activities result in their release into the environment and the transformation into more stable phosphate deposition. The objective of this study was to evaluate molecular and behavioral changes of zebrafish exposed to the synthesized terbium phosphate (TbPO4) at concentrations of 10, 20, and 50 mg/L and to determine its potential for neurotoxicity. Metabolomic profiling and assessment of transcripts and proteins were conducted to uncover the molecular mechanisms underlying TbPO4 with emphasis on neurotransmitter systems. Exposure to 20 mg/L TbPO4 induced larval hyperactivity and perturbed the cholinergic system in zebrafish. Based on metabolomics, dopamine (DA), serotonin (5-HT), and many of their precursors and metabolites were decreased in abundance by TbPO4. In addition, the expression levels of transcripts related to the synthesis, transport, receptor binding, and metabolism of DA and 5-HT were analyzed at the mRNA and protein levels. Transcript and protein levels for tyrosine hydroxylase (TH), the rate-limiting enzyme for DA synthesis, were down-regulated in larval fish. Monoamine oxidase (MAO), an enzyme that catabolizes monoamines DA and 5-HT, also reduced mRNA abundance. We hypothesize that DA synthesis and monoamine metabolism are associated with behavioral alterations. In addition, a mechanism for the disruption of neurotransmitter systems by TbPO4 may be the apoptosis of neurons. This study elucidates putative mechanisms and exposure risks to wildlife and humans by characterizing phosphatic REE-induced neurotoxicity in developing zebrafish. © 2023, The Authors. All rights reserved.

关键词： Rare earth elements

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Applications and prospects of cryo-EM in drug discovery

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Military Medical Research 2023年第6期10卷 848-861页

作者： Kong-Fu Zhu Chuang Yuan Yong-Ming Du Kai-Lei Sun Xiao-Kang Zhang Horst Vogel Xu-Dong Jia Yuan-Zhu Gao Qin-Fen Zhang Da-Ping Wang Hua-Wei Zhang Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Structural Biology St.Jude Children’s Research HospitalMemphisTN 38105USA Center for Protein Science and Crystallography School of Life SciencesFaculty of ScienceChinese University of Hong KongHong Kong 999077China Interdisciplinary Center for Brain Information the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen 518055GuangdongChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055GuangdongChina State Key Lab for Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhou 510275China Cryo‑EM Facility Center Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Orthopedics Shenzhen Intelligent Orthopaedics and Biomedical Innovation PlatformGuangdong Provincial Research Center for Artifcial Intelligence and Digital Orthopedic TechnologyShenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityShenzhen 518000GuangdongChina Guangdong Provincial Key Laboratory of Advanced Biomaterials Southern University of Science and TechnologyShenzhen 518055GuangdongChina

Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time-and effort-consuming. Structural biology has been demonstrated as a powerful tool to accelerate drug development. Among different techniques, cryo-electron microscopy(cryo-EM) is emerging as the mainstream of structure determination of biomacromolecules in the past decade and has received increasing attention from the pharmaceutical industry. Although cryo-EM still has limitations in resolution, speed and throughput, a growing number of innovative drugs are being developed with the help of cryo-EM. Here, we aim to provide an overview of how cryo-EM techniques are applied to facilitate drug discovery. The development and typical workflow of cryo-EM technique will be briefly introduced, followed by its specific applications in structure-based drug design, fragment-based drug discovery, proteolysis targeting chimeras, antibody drug development and drug repurposing. Besides cryo-EM, drug discovery innovation usually involves other state-of-the-art techniques such as artificial intelligence(AI), which is increasingly active in diverse areas. The combination of cryo-EM and AI provides an opportunity to minimize limitations of cryo-EM such as automation, throughput and interpretation of mediumresolution maps, and tends to be the new direction of future development of cryo-EM. The rapid development of cryo-EM will make it as an indispensable part of modern drug discovery.

关键词： Cryo-electron microscopy(cryo-EM) Drug discovery Structure-based drug design Fragment-based drug discovery Proteolysis targeting chimeras Drug repurposing Artificial intelligence(AI)

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Laryngeal Hypersensitivity From the Perspective of Pain Science: An Integrative Review of Empirical Studies on Associated Factors and Processes

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Journal of Voice 2025年

作者： Saint-Jules, William Massé-Alarie, Hugo Li-Jessen, Nicole Y.K. Desjardins, Maude Faculty of Medicine Université Laval Quebec City QC Canada Faculty of Medicine and Health Sciences University of Sherbrooke Sherbrooke QC Canada Center for Interdisciplinary Research in Rehabilitation and Social Inclusion Quebec City QC Canada School of Rehabilitation Sciences Université Laval Quebec City QC Canada School of Communication Sciences and Disorders McGill University Montreal QC Canada Department of Biomedical Engineering McGill University Montreal QC Canada The Centre for Research on Brain Language and Music McGill University Montreal QC Canada Department of Otolaryngology - Head and Neck Surgery McGill University Montreal QC Canada Translational Research in Respiratory Diseases Program Research Institute of McGill University Health Center Montreal QC Canada

Objective: Laryngeal hypersensitivity (LHS) is a state of heightened sensorimotor response to stimuli in the upper airway. Although its clinical picture is becoming progressively clearer with recent research progress, specificities about its associated factors and processes remain to be clarified. The aim of this integrative review was to synthesize published empirical data from human studies on LHS, focusing on related factors and pathophysiology. Study Design and Data Sources: Integrative review of the literature;Pubmed, EMBASE, and Web of Science. Methods: Keywords associated with the following three main concepts were used to query databases: (1) manifestations potentially associated with an irritable larynx (dysphonia, inducible laryngeal obstruction (ILO), chronic cough, and globus);(2) hypersensitivity;and (3) pathophysiology. Peer-reviewed studies in English providing empirical original research data on the pathophysiology of LHS were included, with no restriction based on study design. Results: In total, 54 papers met the inclusion criteria. Factors potentially associated with LHS were identified, namely (1) psychological and lifestyle factors, (2) upper airway inflammation and injuries from exogenous/endogenous irritants, infections, or mucosal atrophy, (3) sex hormones, (4) metabolic abnormalities, and (5) aberrant respiratory behavior. Given the parallels between pain-related mechanisms and suggested LHS mechanisms, processes identified as putatively contributing to LHS were categorized in light of the current pain literature. Findings suggest that LHS may stem from a peripheral tissue insult, a neuropathic insult, and/or maladaptive neuroplasticity. Gaps in the literature were identified, in part driven by an uneven repartition of research across the various alleged manifestations of LHS. In fact, a large majority of studies pertained to chronic cough, with very few addressing muscle tension dysphonia, ILO, and globus. Conclusion: Future research can fo

关键词： Hypersensitivity—Chronic cough—Dysphonia—Inducible laryngeal obstruction—Irritable larynx

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Importance of Wearable Health Monitoring Systems Using IoMT;Requirements, Advantages, Disadvantages and Challenges

Importance of Wearable Health Monitoring Systems Using IoMT;...

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International Symposium on Computational Intelligence and Informatics

作者： Fahime Khozeimeh Mohamad Roshanzamir Afshin Shoeibi Mohammad Tayarani Darbandy Roohallah Alizadehsani Hamid Alinejad-Rokny Davood Ahmadian Abbas Khosravi Saeid Nahavandi Institute for Intelligent Systems Research and Innovation (IISRI) Deakin University Victoria Australia Department of Computer Engineering Fasa University Fasa Iran Internship in Health Data Analytics Program AI-enabled Processes (AIP) Research Centre Macquarie University Sydney Australia School of Architecture Islamic Azad University Taft Taft Iran BioMedical Machine Learning Lab The Graduate School of Biomedical Engineering UNSW Sydney Sydney NSW Australia Faculty of Mathematics Statistics and Computer Sciences University of Tabriz Tabriz Iran

ISBN: (纸本)9798350398830

Providing better quality of service is one of the most important goals in medical/healthcare systems. The services provided should have features such as low latency, appropriate geographic distribution, and real-time interaction. Internet of Medical Things (IoMT) technology is one of the solutions to achieve high quality of services with these features. The wearable health monitoring systems which have become popular in the last decade are one of the foundations of achievement to these features. In this paper, the importance of wearable devices under IoMT technology is investigated. There are several reasons for using wearable devices under IoMT technology, such as reducing healthcare costs and long waiting times. Therefore, anyone working on wearable devices needs to have a general understanding of how they are designed and function. In fact, the integration of new devices to monitor and alert patients about their physical health is a promising option for improving health care systems around the world. Overcrowding in medical centers will be prevented by upgrading the facilities for the virtual presence of patients. It can also ensure real-time monitoring and reduce operating costs. In addition, it can accelerate treatment of patients and reduce the cost of investment and increase its coverage.

关键词： Costs Medical devices Wearable computers Quality of service Organizations Real-time systems Security

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The Development of Learning Materials for Preparing Virtual Patients for Magnetic Resonance Imaging Study Using Virtual Reality Technology for Students of Radiological Technology

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Journal of Medical Imaging and Radiation Sciences 2024年第3期55卷 101653-101653页

作者： Mr Jongwat Cheewakul Mr. Natee Ina Miss Adchara Wanai Miss Wanaporn Kulanuwach Miss Chitchaya Suwanraksa Asst. Prof. Dr Sitthichok Chaichulee Asst. Prof. Dr Suphalak Khamruang Marshall Miss Sasicha Trisuwan Miss Varissara Tangkitworakul Miss Ornpalin Petchit Radiological Technology Program Department of Radiology Faculty of Medicine Prince of Songkla University Hat Yai Songkhla Thailand Department of Radiology Faculty of Medicine Prince of Songkla University Hat Yai Songkhla Thailand Department of Biomedical Sciences and Biomedical Engineering Faculty of Medicine Prince of Songkla University Hat Yai Songkhla Thailand

Focusing on evaluating learning outcomes prior to and subsequent to the study, this research endeavors to develop educational resources utilizing virtual reality (VR) technology that can be employed to prepare patients for MRI examinations. 28 second-year radiological technology students were selected for the study via purposive random sampling from the faculty of Medicine at Prince of Songkla *** educator created instructional materials that emulated the functional elements of an MRI scanner by utilizing virtual world technology. Accessible in the Metaverse via Oculus Rift S spectacles and the *** application, this entailed the production of a 360-degree video utilizing Adobe Premiere Pro to prepare for an MRI assessment. Consensus among experts placed a mean score of 0.95 on technology acceptability and innovation, suggesting that content validity was a critical determinant,with an average score of 4.67 ± 0.24, the assessment of the appropriateness of the learning media and content was found to be highly *** demonstrated a substantial enhancement in their academic achievements after employing the educational resources. The average score improved to 16.93 ± 1.86 from 10.57 ± 3.06 prior to the study. A mean score of 4.78 ± 0.16 for the MRI examination simulation and 4.46 ± 0.55 for learning media incorporating VR technology indicated that students were extremely satisfied with the VR-based learning materials. As a result, radiological technology students' comprehension of MRI examination preparation is ultimately improved by means of this educational platform. It encourages students to comprehend the material by simulating the actual MRI scan environment, which is advantageous for educating patients about the magnetic field during examinations. Practical restrictions regarding time, location, and instructional equipment are also taken into account by the platform utilized in the pre-MRI preparation of *** concerns abo

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Deep Learning-based Integrated System for Intraoperative Blood Loss Quantification in Surgical Sponges

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IEEE Journal of biomedical and Health Informatics 2024年 PP卷 PP页

作者： Nguyen, Dang Le, Minh Huu Nhat Huynh, Phat K. Le, Trung Q. Charles-Okezie, Chinyere Diaz, Michael J. Sabet, Cameron Dang, Hung The Nguyen, Tuan Nguyen, Hoan Tran, Minh Le, Nguyen Quoc Khanh Muncey, Aaron Taipei Medical University International Ph.D. Program in Medicine College of Medicine Taipei110 Taiwan University of South Florida Department of Medical Engineering TampaFL United States University of South Florida Department of Industrial and Management Systems Engineering TampaFL United States Georgetown University School of Medicine Department of Medicine WashingtonDC United States Faculty of Life Sciences & Medicine King's College London School of Biomedical Engineering & Imaging Sciences London United Kingdom Minerva University San FranciscoCA United States Fredericton Leo Hayes High School NB Canada Taipei Medical University Research Center for Artificial Intelligence in Medicine Taipei106 Taiwan Taipei Medical University Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei110 Taiwan Taipei Medical University Hospital Translational Imaging Research Center Taipei110 Taiwan Moffitt Cancer Center and Research Institute Department of Anesthesiology TampaFL United States

Accurate quantification of intraoperative blood loss is crucial for enhancing patient safety and the success rate of surgeries. Traditional estimation techniques, mainly reliant on visual assessments, are prone to significant inaccuracies due to their subjective nature. This study introduces MDCare, an innovative deep learning-integrated system designed to substantially improve the precision of blood loss quantification using surgical sponges. By integrating advanced hardware components, including a mass sensor and webcam, with sophisticated algorithms like ResNet-18 and YOLOv4, MDCare achieves classification accuracy up to 96.2% and sponge detection accuracies above 91% for both synthetic and real blood scenarios. The system processes images at 7.4 frames per second, aligning with the exigent pace of surgical environments, thereby supporting surgeons with real-time, accurate blood loss data essential for timely and informed decision-making. The contributions of the paper are: (1) Demonstrating the application of advanced machine learning models in a critical clinical setting, achieving significantly higher accuracy in blood loss estimation compared to traditional methods;(2) Validating the system's efficacy in real-time surgical environments, thereby enhancing the decision-making process and potentially reducing postoperative complications;(3) Setting a new standard in surgical care by integrating a complex system into real-world clinical workflows, showcasing its adaptability and potential for widespread adoption. Future work will focus on expanding the dataset and refining the algorithms to ensure the MDCare system's robustness and adaptability across surgical settings. The findings underscore the potential of MDCare to automate and refine critical aspects of surgery, marking a significant advancement in surgical care. © 2024 IEEE.

关键词： Digital storage

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