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Corrigendum to "ECM-based bioactive microencapsulation significantly improves islet function and graft performance" [Acta Biomaterialia. Volume 171, November 2023, Pages 249-260]

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Acta biomaterialia 2024年 173卷 526页

作者： Stasia Krishtul Michal Skitel Moshe Inna Kovrigina Limor Baruch Marcelle Machluf Faculty of Biotechnology & Food Engineering Technion - Israel Institute of Technology Haifa 3200003 Israel. Faculty of Biotechnology & Food Engineering Technion - Israel Institute of Technology Haifa 3200003 Israel The Interdisciplinary Program for Biotechnology Technion Haifa 32000 Israel. Faculty of Biotechnology & Food Engineering Technion - Israel Institute of Technology Haifa 3200003 Israel. Electronic address: machlufm@bfe.technion.ac.il.

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Design and Invention of Radiation Shielding Apparatus for Radiography in Neonatal Intensive Care Units

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Journal of Medical Imaging and Radiation Sciences 2024年第3期55卷 101652-101652页

作者： Cheewakul, Mr. Jongwat Ina, Mr Natee Sakjirapapong, Mr Seri Kulanuwach, Miss Wanaporn Petkhaek, Miss Wasana Kwanyuang, Dr. Atichart Udomsit, Miss Kananun Choosawat, Miss Papawee Phukrod, Miss Sasivimon Marshall, Dr Suphalak Khamruang Radiological Technology Program Department of Radiology Faculty of Medicine Prince of Songkla University Hat Yai Songkhla Thailand Neonatal Intensive Care unit Faculty of Medicine Prince of Songkla University Hat Yai Songkhla Thailand Department of Biomedical Sciences and Biomedical Engineering Hat Yai Songkhla Thailand

In this study, researchers created a radiation shielding apparatus for incubator warmers to reduce scatter radiation exposure during portable x-ray diagnostics in neonatal intensive care units (NICU). The covering, which is made of 0.6 mmPb lead sheet, is intended to envelop the incubator. Its efficacy was tested using a PMMA phantom positioned in the incubator's the center and subjected to x-rays from a portable x-ray. The scatter radiation levels were measured inside and outside the incubator, before and after the radiation shielding was applied, using a RaySafe X2 solo tool. The results showed a considerable reduction in scatter radiation, with drops ranging from 63.30 to 97.82%, and a significant attenuation of backscatter inside the incubator, with reductions ranging from 8.57 to 60.52%. It suggests that staff positioned at least 200 cm distant and 180 degrees from the exposure site may get reduced radiation exposures. Furthermore, using shielding on exposed and nearby incubators allows for safe operations at any distance while successfully reducing scatter radiation both inside and externally. Calculations of the yearly occupational effective dose using a typical NICU setting of 60 kVp and 2 mAs showed exposures less than 0.1 mSv/year. A satisfaction survey of thirty radiological technicians and NICU nurses revealed that the products received high acceptance, with an overall average satisfaction score of 4.59 out of 5. The equipment received an average rating of (4.87±0.43) for effectively reducing dispersed radiation. Respondents were less concerned about radiation risks (4.73±0.45) and more likely to start using the device with newborn incubators (4.67±0.48). Safety ratings averaged (4.77±0.43). Tensile tests on lead and vinyl sheets also indicated maximum forces of 3166.8 MPa and 652.1 MPa, demonstrating the longevity and efficacy of the lead sheet material applied in the shielding device.

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Inertial Stabilization of Upright Posture while walking

Inertial Stabilization of Upright Posture while walking

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International IEEE/EMBS Conference on Neural engineering, CNE

作者： José Quintanilla Moises Perez Rodolfo Balderas Alejandro González Antonio Cardenas Mauro Maya Davide Piovesan Faculty of Engineering Universidad Autónoma de San Luis Potosí San Luis Potosí Mexico CONACyT- Universidad Autónoma de San Luis Potosí San Luis Potosí Mexico Biomedical Engineering Program Gannon University Erie PA USA

The effect of inertial forces is well known in the field of dynamics and control. While such forces are often detrimental to the control of a mechanical system, specific cases can be found where self-excited oscillations will induce inertial, stabilizing effects. A classical example of this phenomenon is a Kapitza's pendulum, which stabilizes an inverted pendulum by means of a vertical oscillation of its base. With this in mind, the effect of inertial forces on the trunk during walking at a self-selected speed is analyzed in this work. These inertial effect are thought to be induced by the oscillation of the pelvis. Comparing a healthy to a parkinsonian gait shows that while the oscillation frequency and amplitude are very different in both cases, they provide similar inertial effects and can compensate for a marked reduction of equivalent hip stiffness.

关键词： Legged locomotion Dynamics Neural engineering Pelvis Mechanical systems Oscillators Hip

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Breathable Palladium Hydride Hydrogels Mediated 'Head and Tail' Co-Blocking HMGB1-RAGE Axis Strategy for Diabetic Foot Ulcer Treatment

SSRN

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SSRN 2025年

作者： Wang, Weidi Liu, Xueling Xiao, Jiali Zhang, Yunning Hao, Yu Hou, Ruidong You, Qing Song, Yilin Department of Pharmaceutical Sciences School of Pharmacy Shenyang Pharmaceutical University 103 Wenhua Road Shenyang110016 China Department of Pharmacy The Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Zhengzhou450008 China School of Food and Healthy Beijing Technology and Business University 11 Fucheng Road Haidian District Beijing100048 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine Faculty of Engineering National University of Singapore Singapore119074 Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore117597 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore117599 Singapore

Diabetes patients suffer from severe chronic consequences known as diabetic foot ulcers (DFUs), for which there are no particular therapy options. The inflammatory and oxidative microenvironments in DFUs stimulate the secretion of high mobility group box-1 (HMGB1), which binds with the receptor of advanced glycation endproducts (RAGE), causing inflammatory cascade reactions and immune microenvironment (IME) disorder, further exacerbating DFU damage. Strategies targeting the HMGB1-RAGE axis to end this vicious loop are still lacking. This study proposes a novel strategy based on "breathable hydrogels" to achieve HMGB1-RAGE axis "head and tail" co-blocking to regulate the IME for DFU treatments. Specifically, with palladium hydride (PdH) nanocubes as the functional structure, a hydrogel dressing was prepared from a double cross-linking network of biocompatible alginate and polyacrylamide and modified with trehalose as the network-repairing agent. Mechanistically, the obtained hydrogels can "inhale" the excess accumulated reactive oxygen species, inhibiting HMGB1 secretion, the "head" of the HMGB1-RAGE axis. Meanwhile, H2 "exhaled" from the hydrogels can suppress the expression of intracellular RAGE, thus blocking the HMGB1-RAGE axis and breaking the vicious cycle. The proposed "head and tail" co-blocking strategy based on "breathable hydrogels" offers a highly efficient, safe, and facile therapeutic protocol for DFUs. © 2025, The Authors. All rights reserved.

关键词： Crosslinking

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River pollution monitoring over an industrial catchment in urban ecosystem: Challenges and proposed geospatial framework

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Environmental Challenges 2022年 7卷

作者： Sekharan, Sheeba Samal, Dipak R. Phuleria, Harish C. Chandel, Munish K. Gedam, Shirish Kumar, Rakesh Sethi, Virendra Supate, Amar R. Karmakar, Subhankar Interdisciplinary Program in Climate Studies Indian Institute of Technology Bombay Mumbai India Environmental Science and Engineering Department Indian Institute of Technology Bombay Maharashtra Mumbai 400076 India Centre of Studies in Resources Engineering Indian Institute of Technology Bombay Mumbai India Centre for Urban Science and Engineering Indian Institute of Technology Bombay Mumbai India National Environmental Engineering Research Institute Nagpur India Faculty of Technology CEPT University Ahmedabad India Maharashtra Pollution Control Board Mumbai India

Urban river pollution is considered a ‘necessary evil’ consequence of disproportionate developmental expansion in metropolises. Unprecedented expansion and anthropic activities amongst other reasons lead to choking of urban rivers with municipal and industrial sewage. Urban rivers are dying while awaiting rescue, despite the hard efforts by civic authorities, largely due to lack of coordination amongst river authorities and stakeholders, underlying conflicts spanning across all levels, balkanisation, pluralization, scarcity of reliable technical data, and financial constraints. Challenges faced by stakeholders in river pollution management as revealed in informational interviews are foregrounded. In an attempt to reduce some of the overwhelm faced by officials on ground, a geospatial framework is proposed which if functionally implemented can transparentize river water quality (WQ) monitoring, and facilitate pollution control. The pollution situation in a persistently polluted urban river near Mumbai city, India was explored and assessed in the middle of a restoration battle waged by environmental activists. Following secondary river water quality data acquisition, primary sample collection campaign and WQ testing, multivariate statistical data analysis was performed under data- and resource-constraint situation. Spatiotemporal monitoring and visualization of river water quality data holds great promise for effectively controlling anthropic river pollution. A subsequent geospatial analysis of the study area was performed using digital elevation model (DEM) based watershed delineation, land use land cover (LULC) classification, mapping of WQ monitoring locations, mapping of industrial clusters, integration of spatial data, and identifying polluter industries. This steered us to formulate and propose the geospatial framework and supplementary recommendations on how better to save this dying river. The framework displays near real-time information on river water qualit

关键词： GIS Industrial catchment Multivariate statistics River pollution Urban ecosystem Urban river

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Bacterial cellulose composite-collagen-glycerol as an innovation of artificial dura mater candidates for open head trauma case

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AIP Conference Proceedings 2024年第1期3047卷

作者： Prihartini Widiyanti Annisaa Wahyu Alifiany Adri Supardi Biomedical Engineering Program Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia Institute of Tropical Disease Universitas Airlangga Surabaya 60115 Indonesia Department of Physics Faculty of Science and Technology Universitas Airlangga Surabaya 60115 Indonesia

Head injury is one of the leading causes of death and disability in the productive age. According to the World Health Organization (WHO), 90% of the causes of head injuries in Indonesia are caused by traffic accidents. It causes tearing of the dura mater layer on the head and will be fatal if not treated immediately. The aim of this study is finding out the replacement composites of artificial head dura mater layers which are compatible. In this study, artificial dura mater derived from the bacterial cellulose Acetobacter xylinum which was synthesized on coconut water media. In this study, four variations of composition were used, namely bacterial cellulose (control), bacterial cellulose-glycerol, bacterial cellulose – collagen, and bacterial cellulose-collagen-glycerol. Characterization of the river group (FTIR), tensile strength, swelling and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay. Assay was conducted in this study. Characterization of functional groups shows the functional groups characteristic of bacterial cellulose, collagen, and glycerol. The results of the tensile strength characterization show that of the four variations in sample composition have average UTS ( Ultimate Tensile Strength) and Elongation values that are close to the standard value of artificial dura mater. The best results in the swelling test were obtained on the composition of the bacterial cellulose sample-Collagen-Glycerol with a swelling value of 28.30%. These results did not exceed the membrane swelling ratio limit of 70%. For the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay test, the percentage of living cells from each sample is above 50% which means that the material produced is not toxic when applied to the body. Bacterial Cellulose Composites-Collagen has the potential to be an artificial dura mater candidate based on the characterization of functional groups, tensile strength,

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Development of novel gene carrier using modified nano hydroxyapatite derived from equine bone for osteogenic differentiation of dental pulp stem cells

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Bioactive Materials 2021年第9期6卷 2742-2751页

作者： Myung Chul Lee Hoon Seonwoo Kyoung Je Jang Shambhavi Pandey Jaewoon Lim Sangbae Park Jae Eun Kim Yun-Hoon Choung Pankaj Garg Jong Hoon Chung Department of Biosystems&Biomaterials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea Department of Biosystems Engineering Seoul National UniversitySeoul08826Republic of Korea Department of Industrial Machinery Engineering Sunchon National University315 Maegok-dongSunchon57922Republic of Korea Interdisciplinary Program in IT-Bio Convergence System Sunchon National UniversitySuncheon57922Republic of Korea Division of Agro-system Engineering Gyeongsang National University501 Jinju-daeroJinju52828Republic of Korea Institute of Agriculture&Life Science Gyeongsang National UniversityJinju52828Republic of Korea Research Institute for Agriculture and Life Sciences Seoul National UniversitySeoul08826Republic of Korea Department of Otolaryngology Ajou University School of MedicineSuwon16499Republic of Korea Ajou University Graduate School of Medicine Bk21 Plus Research Center for Biomedical SciencesSuwon16499Republic of Korea BK21 Global Smart Farm Educational Research Center Seoul National UniversitySeoul08826Republic of Korea

Hydroxyapatite(HA)is a representative substance that induces bone *** research team extracted nanohydroxyapatite(EH)from natural resources,especially equine bones,and developed it as a molecular biological ***(PEI)was used to coat the EH to develop a gene *** verify that PEI is well coated in the EH,we first observed the morphology and dispersity of PEI-coated EH(pEH)by electron *** pEH particles were well distributed,while only the EH particles were not distributed and ***,the existence of nitrogen elements of PEI on the surface of the pEH was confirmed by EDS,calcium concentration measurement and fourier transform infrared spectroscopy(FT-IR).Additionally,the pEH was confirmed to have a more positive charge than the 25 kD PEI by comparing the zeta *** a result of pGL3 transfection,pEH was better able to transport genes to cells than 25 kD *** verification as a gene carrier for pEH,we induced osteogenic differentiation of DPSCs by loading the BMP-2 gene in pEH(BMP-2/pEH)and delivering it to the *** a result,it was confirmed that osteogenic differentiation was promoted by showing that the expression of osteopontin(OPN),osteocalcin(OCN),and runt-related transcription factor 2(RUNX2)was significantly increased in the group treated with BMP-2/*** conclusion,we have not only developed a novel nonviral gene carrier that is better performing and less toxic than 25 kD PEI by modifying natural HA(the agricultural byproduct)but also proved that bone differentiation can be effectively promoted by delivering BMP-2 with pEH to stem cells.

关键词： Nanocomposites biomedical applications Hydroxyapatite Polyethyleneimine Gene carrier Osteogenic differentiation

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Plasma-Derived Nanoclusters for Site-Specific Multimodality Photo/Magnetic Thrombus Theranostics

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Advanced Healthcare Materials 2023年第28期12卷 e2301504页

作者： Liu, Chia-Hung Liu, Ming-Che Jheng, Pei-Ru Yu, Jiashing Fan, Yu-Jui Liang, Jia-Wei Hsiao, Yu-Cheng Chiang, Chih-Wei Bolouki, Nima Lee, Jyh-Wei Hsieh, Jang-Hsing Mansel, Bradley W Chen, Yan-Ting Nguyen, Hieu Trung Chuang, Er-Yuan Department of Urology School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center of Urology and Kidney Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Department of Urology Shuang Ho Hospital Taipei Medical University 291 Zhongzheng Road Zhonghe District New Taipei City23561 Taiwan Clinical Research Center Taipei Medical University Hospital Taipei11031 Taiwan School of Dental Technology College of Oral Medicine Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering Graduate Institute of Biomedical Optomechatronics School of Biomedical Engineering Research Center of Biomedical Device Innovation Entrepreneurship Education Center College of Interdisciplinary Studies Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering College of Engineering National Taiwan University Taipei106 Taiwan Department of Orthopedics Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan Department of Physical Electronics Faculty of Science Masaryk University Brno60177 Czech Republic Department of Materials Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City24301 Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City700000 Viet Nam Cell Physiology and Molecular Image Research Center Taipei Medical University Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Traditional thrombolytic therapeutics for vascular blockage are affected by their limited penetration into thrombi, associated off-target side effects, and low bioavailability, leading to insufficient thrombolytic efficacy. It is hypothesized that these limitations can be overcome by the precisely controlled and targeted delivery of thrombolytic therapeutics. A theranostic platform is developed that is biocompatible, fluorescent, magnetic, and well-characterized, with multiple targeting modes. This multimodal theranostic system can be remotely visualized and magnetically guided toward thrombi, noninvasively irradiated by near-infrared (NIR) phototherapies, and remotely activated by actuated magnets for additional mechanical therapy. Magnetic guidance can also improve the penetration of nanomedicines into thrombi. In a mouse model of thrombosis, the thrombosis residues are reduced by ≈80% and with no risk of side effects or of secondary embolization. This strategy not only enables the progression of thrombolysis but also accelerates the lysis rate, thereby facilitating its prospective use in time-critical thrombolytic treatment. © 2023 Wiley-VCH GmbH.

关键词： Diseases

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A simple approach for curcumin extraction from turmeric roots

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AIP Conference Proceedings 2022年第1期2537卷 040016页

作者： Siti Fauziyah Rahman Adella Josephin Ridha Alviny Syakirah Grace Priscilla Nadia Wulandari Nurul Intan Yudan Whulanza Biomedical Engineering Study Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia Department of Mechanical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia

Turmeric, particularly its most active ingredient, curcumin, has a long list of scientifically documented health advantages, including the ability to boost heart health and protect against a variety of diseases. Curcumin is one of the most important active components in turmeric, with a wide range of bioactivity and medicinal uses. Preparing samples from biological components is a time-consuming and difficult operation. This study aims to understand the process of extracting curcumin from turmeric and to analyze the appropriate solvent for curcumin extraction. The method used is Soxhlet extraction with acetone and ethanol as solvents. The analysis of curcumin content was carried out using a UV-Vis spectrophotometer. The results showed that the curcumin extracted with acetone solvent had a higher concentration than the extraction with ethanol. Therefore, extracting curcumin from turmeric using the Soxhlet method, acetone is a superior solvent than ethanol.

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Sweat sensing in wearable sensor: A review of the future non-invasive technology for real-time health monitoring system

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AIP Conference Proceedings 2022年第1期2537卷

作者： Elly Septia Yulianti Nurul Intan Siti Fauziyah Rahman Basari 1Biomedical Engineering Study Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 2Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia

Wearable sensors are devices used in the diagnostic process for real-time health monitoring systems. Types of sensors are generally based on physical sensors and chemical sensors. However, the types of wearable sensors that are largely commercialized are limited to physical sensors. Some diagnostic processes generally use the blood collecting method to determine a patient’s condition. However, this method can cause adverse effects such as infection, pain, and bruising for some patients. Chemical-based wearable sensors are capable of detecting metabolic conditions in the body and can be an alternative to the existing method. Based on an approach using alternative analytes, sweat is the most frequently used because it is highly accessible and proceeds good parameters compared to the blood. Several studies related to wearable sensors using sweat have been done to increase convenience during the sampling process. Electrochemical, biosensor, and hybrid with several sampling methods, including microfluidic system, absorbent material, superhydrophobic-super hydrophilic surface, and iontophoresis, can be used for wearable sensor analysis method. Over the past decade, the characteristics of wearable sensors (i.e., selectivity, sensitivity, stability, and response time), textile materials, and biofuel cell technology for self-powered sensor development have also increased. From these classifications, it can be concluded that the method which is highly feasible to be developed is electrochemical wearable sensors that combine microfluidic and iontophoresis systems. The system is also expected to have stretchable material and is equipped with an integrated biofuel cell system that has the potential to be developed in our upcoming research topic.

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