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Spatio-temporal assessment of whole-body center of mass coordination on standard maximum vertical jump

Gait & Posture 2022年 97卷 S208-S209页

作者： Rodrigues, C. Correia, M. Abrantes, J. Rodrigues, B. Nadal, J. Faculty of Engineering- University of Porto Biomedical Engineering Program Porto Portugal INESC TEC - Institute for Systems and Computer Engineering- Technology and Science C-BER - Centre for Biomedical Engineering Research Porto Portugal University of Porto Faculty of Engineering Porto Portugal Lusófona University- CICANT - Centre for Research in Applied Communication- Culture and New Technologies MovLab Laboratory of Technologies for Interactions and Interfaces Lisbon Portugal Federal University of Pernambuco Department of Electronic and Systems Recife Brazil Federal University of Rio de Janeiro Biomedical Engineering Program Rio de Janeiro Brazil

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Protocol for behavioral and neural recording in macaques during a novelty detection task

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STAR Protocols 2024年第3期5卷 103252页

作者： Du, Xinyu Song, Peirun Gong, Yumei Zhai, Yuying Xu, Haoxuan Ye, Hangting Bao, Xuehui Huang, Qianyue Tu, Zhiyi Chen, Pei Zhao, Xuan Pérez-González, David Malmierca, Manuel S. Yu, Xiongjie Department of Anesthesia Women's Hospital Zhejiang University School of Medicine Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's Hospital Zhejiang University School of Medicine Department of Anesthesiology Shanghai Tenth People's Hospital Tongji University School of Medicine Hangzhou Extremely Weak Magnetic Field Major Science and Technology Infrastructure Research Institute Interdisciplinary Institute of Neuroscience and Technology College of Biomedical Engineering and Instrument Science Zhejiang University Cognitive and Auditory Neuroscience Laboratory (Lab 1) Institute of Neuroscience of Castilla y León (INCYL) University of Salamanca Institute for Biomedical Research of Salamanca (IBSAL) Department of Basic Psychology Psychobiology and Methodology of Behavioral Sciences Faculty of Psychology University of Salamanca Department of Cell Biology and Pathology Faculty of Medicine University of Salamanca

The neural mechanisms of novelty detection, especially in relation to behavior, are currently poorly understood. Here, we present a protocol for recording neuronal activity in macaque auditory cortex during novelty detection tasks. We describe steps for behavioral training, surgical headpost implantation, MRI-based electrode targeting, and electrophysiological recording. These steps allow direct assessment of the correlation between novelty detection behavior and neuronal activity. For complete details on the use and execution of this protocol, please refer to Gong et al.¹ © 2024 The Authors

关键词： Behavior Cognitive Neuroscience Neuroscience

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A Study of Eye Lens Radiation Dose Reduction During Head CT Scan Examination

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Journal of Medical Imaging and Radiation Sciences 2022年第4期53卷 S25-S25页

作者： Nur Istiqomah, Anisa Dewi, Sofie Nornalita Mufida, Widya Radiology Study Program Faculty of Health Sciences Universitas ‘Aisyiyah Yogyakarta Sleman DI Yogyakarta 55292 Indonesia Biomedical Engineering Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Depok West Java 16424 Indonesia Diagnostic Imaging Program Master of Applied Science Health Polytechnic of Semarang Semarang City Central Java 50268 Indonesia

BackgroundHead CT is the most frequently performed examination in every hospital in Indonesia. Considering of the large radiation dose of head CT produces and eye which is one of the most sensitive organs, radioprotection is should be done for every patient of head CT. The aim of this study is to determine the radiation dose of eye lens during head CT compared to the dose limit value determined by ICRP No. 87 of 2000 and provides recommendations for examination protocols that prioritize radiation protection in order to reducing eye lens radiation dose. MethodsRadiation dose measurement of eye lens were performed on 10 patient samples using two different scanograms for every 5 patients. The first five patients had a scanogram parallel to the Orbitomeatal line (OML) and the other 5 patients had a scanogram parallel to the Supraorbitomeatal line (SOML). Radiation dose measurement is done by placing the Thermoluminescent Dosimeter 100-chip on one of the patient's eyelid surfaces. The results of the radiation dose measurements are presented and compared with the standard dose CT scan according to ICRP No. 87 2000. ResultsThe research showed that the procedure using scanogram parallel to OML get eye lens radiation dose 53.889 mGy, 50.729 mGy, 60.407 mGy, 70.952 mGy, 70.952 mGy and the other procedure which is using scanogram parallel to SOML get eye lens radiation dose 7.265 mGy, 6.944 mGy, 8.747 mGy, 6.411 mGy, 6.944 mGy. ConclusionThe procedure using scanogram parallel to the OML produces a higher dose of eye lens and it exceeds the standard head CT eye lens dose according to ICRP No. 87 of 2000. While the another procedure using scanogram parallel to SOML produces a lower radiation dose. Head CT is advised to use a scanogram parallel to SOML to reduce the eye lens radiation dose.

关键词： Head CT scan Radiation Dose Orbitomeatal line Supraorbitomeatal line TLD

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Caffeine, riboflavin and curcumin amended clays for PFAS binding

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Computers & Chemical engineering 2025年 201卷

作者： Xenophon Xenophontos Johnson O. Oladele Meichen Wang Kendall Lilly Laura Martinez Timothy D. Phillips Phanourios Tamamis Artie McFerrin Department of Chemical Engineering College of Engineering Texas A&M University College Station TX 77843 USA Department of Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station TX 77843 USA Interdisciplinary Faculty of Toxicology College of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station TX 77843 USA Department of Environmental Health Sciences University of Massachusetts Amherst Amherst MA 01003 USA Department of Materials Science and Engineering College of Engineering Texas A&M University College Station TX 77840 USA

Per- and polyfluoroalkyl substances (PFAS) are usually found in mixtures with other toxic compounds. Therefore, the study and design of broad acting sorbents, such as clays, is an attractive sorption solution. We previously demonstrated that clays amended with choline and carnitine could enhance PFAS sorption properties. Here, we used computations to screen from a pool of chemical compounds, which are either supplements or generally recognized as safe, and identified particular supplements that can be amended to clay and potentially improve its sorbing capacity for PFAS in acidic conditions. Simulations were initially used as a tool to identify promising amendments to the clay, while subsequently, simulations evaluated which selected amendments could potentially bind PFAS. Our results showed that caffeine-, riboflavin- and curcumin-amended clays can, in particular instances, enhance the binding of different PFAS compared to parent clays. Experiments investigated the sorption properties of the designed systems. Notably, caffeine-amended clay significantly enhanced GenX binding when compared to parent clay, with its binding capacity being increased from 0.15 mol/kg to 1.17 mol/kg. Caffeine-amended clay also enhanced binding for PFOS by 125%, compared to the parent clay, and for PFOA to a lesser extent. Additionally, riboflavin-amended clay enhanced binding for GenX, PFOA and PFOS by 120%, 23%, and 70%, respectively, compared to the parent clay. Our studies provide atomistic details into their mechanisms of action. Both the novel computational library of chemical compound-amended clays and the approach utilized, combining computations and experiments, could enhance the future design of novel amended clays for other toxins.

关键词： Montmorillonite clay Caffeine Curcumin Riboflavin PFAS Molecular dynamics simulations

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Transformative lactera-polypyrrole@carrageenan microparticles leveraging NIR for skin regeneration and stress relief

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International journal of biological macromolecules 2025年 316卷 144436页

作者： Sih-Chi Chuang Shih-An Yu Pei-Chia Hung Andrew E-Y Chuang Jia-Wei Liang Lekshmi Rethi Chih-Kuang Chen Hsu-Wei Fang Hieu Trung Nguyen Hsien-Tsung Lu Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Doctoral Program of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei 10608 Taiwan. Hsuan Chen Technology CO. LTD. New Taipei City 22055 Taiwan. Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei 11696 Taiwan. Hsuan Chen Technology CO. LTD. New Taipei City 22055 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan. International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan. Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital Taoyuan Taiwan. School of Medicine Chang Gung University Taoyuan Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan. Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Viet Nam. Department of Orthopedic Taipei Medical University Hospital Taipei City 11031 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Electronic address: lu7788@tmu.edu.tw.

Effective wound healing remains a significant challenge in regenerative medicine, particularly in minimizing inflammation and promoting scarless recovery. This study introduces a bioengineered LAC-PPy@Car MF composite, designed to leverage near-infrared (NIR)-induced photothermal therapy alongside biotherapeutics to accelerate tissue regeneration. The composite integrates the photothermal properties of polypyrrole (PPy) with the anti-inflammatory and regenerative potential of Lactera (LAC) and Carrageenan (Car). Upon NIR activation, the composite generates localized mild-hyperthermia, reducing oxidative stress, enhancing Aryl Hydrocarbon Receptor (AhR) activity, and upregulating heat shock proteins (HSP). These effects synergistically create a bioactive environment conducive to cellular proliferation and tissue repair. Biochemical evaluations demonstrate that LAC-PPy@Car MF effectively reduces oxidative stress, stimulates fibroblast migration, and promotes the proliferation of skin cells. Immunofluorescence staining reveals significant activation of AhR and HSP in treated tissues, correlating with accelerated cellular proliferation and improved skin architecture. The NIR-triggered photothermal effect enhances the therapeutic potential of the composite, ensuring precise and minimally invasive treatment for burn injuries. These findings position phototherapeutic LAC-PPy@Car MF as a promising candidate for advanced wound healing applications. Its dual functionality, combining photothermal therapy with bioactive healing properties, offers a transformative approach to regenerative medicine, paving the way for improved clinical outcomes in wound care.

关键词： Tissue regeneration

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A consensus protocol for functional connectivity analysis in the rat brain (vol 26, pg 673, 2023)

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NATURE NEUROSCIENCE 2023年第6期26卷 1127-1128页

作者： Grandjean, Joanes Desrosiers-Gregoire, Gabriel Anckaerts, Cynthia Angeles-Valdez, Diego Ayad, Fadi Barriere, David A. Blockx, Ines Bortel, Aleksandra Broadwater, Margaret Cardoso, Beatriz M. Celestine, Marina Chavez-Negrete, Jorge E. Choi, Sangcheon Christiaen, Emma Clavijo, Perrin Colon-Perez, Luis Cramer, Samuel Daniele, Tolomeo Dempsey, Elaine Diao, Yujian Doelemeyer, Arno Dopfel, David Dvorakova, Lenka Falfan-Melgoza, Claudia Fernandes, Francisca F. Fowler, Caitlin F. Fuentes-Ibanez, Antonio Garin, Clement M. Gelderman, Eveline Golden, Carla E. M. Guo, Chao C. G. Henckens, Marloes J. A. G. Hennessy, Lauren A. Herman, Peter Hofwijks, Nita Horien, Corey Ionescu, Tudor M. Jones, Jolyon Kaesser, Johannes Kim, Eugene Lambers, Henriette Lazari, Alberto Lee, Sung-Ho Lillywhite, Amanda Liu, Yikang Liu, Yanyan Y. Lopez-Castro, Alejandra Lopez-Gil, Xavier Ma, Zilu MacNicol, Eilidh Madularu, Dan Mandino, Francesca Marciano, Sabina McAuslan, Matthew J. McCunn, Patrick McIntosh, Alison Meng, Xianzong Meyer-Baese, Lisa Missault, Stephan Moro, Federico Naessens, Daphne M. P. Nava-Gomez, Laura J. Nonaka, Hiroi Ortiz, Juan J. Paasonen, Jaakko Peeters, Lore M. Pereira, Mickael Perez, Pablo D. Pompilus, Marjory Prior, Malcolm Rakhmatullin, Rustam Reimann, Henning M. Reinwald, Jonathan Del Rio, Rodrigo Triana Rivera-Olvera, Alejandro Ruiz-Perez, Daniel Russo, Gabriele Rutten, Tobias J. Ryoke, Rie Sack, Markus Salvan, Piergiorgio Sanganahalli, Basavaraju G. Schroeter, Aileen Seewoo, Bhedita J. Selingue, Erwan Seuwen, Aline Shi, Bowen Sirmpilatze, Nikoloz Smith, Joanna A. B. Smith, Corrie Sobczak, Filip Stenroos, Petteri J. Straathof, Milou Strobelt, Sandra Sumiyoshi, Akira Takahashi, Kengo Torres-Garcia, Maria E. Tudela, Raul van den Berg, Monica van der Marel, Kajo van Hout, Aran T. B. Vertullo, Roberta Vidal, Benjamin Vrooman, Roel M. Wang, Victora X. Wank, Isabel Watson, David J. G. Yin, Ting Zhang, Yongzhi Zurbruegg, Stefan Achard, Sophie Alcauter, Sarael Auer, Dorothee P. Barbier, Emmanuel L. Baudewig, Juergen Beckmann, Chri Donders Institute for Brain Behaviour and Cognition Radboud University Nijmegen The Netherlands Department for Medical Imaging Radboud University Medical Center Nijmegen The Netherlands Cerebral Imaging Centre Douglas Mental Health University Institute Verdun QC Canada Integrated Program in Neuroscience McGill University Montreal QC Canada Bio-imaging Lab University of Antwerp Antwerp Belgium µNEURO Research Centre of Excellence University of Antwerp Antwerp Belgium Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Mexico Biological and Biomedical Engineering McGill University Montreal QC Canada McConnell Brain Imaging Centre McGill University Montreal QC Canada Montreal Neurological Institute McGill University Montreal QC Canada UMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction Physiologie de la reproduction et des comportements Centre de recherche INRAE de Nouzilly Tours France Department of Neurology and Neurosurgery McGill University Montreal QC Canada Center for Animal MRI University of North Carolina at Chapel Hill Chapel Hill NC USA Department of Neurology University of North Carolina at Chapel Hill Chapel Hill NC USA Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC USA Preclinical MRI Champalimaud Research Champalimaud Centre for the Unknown Lisbon Portugal Laboratoire des Maladies Neurodégénératives Molecular Imaging Research Center (MIRCen) Université Paris-Saclay Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA) CNRS Fontenay-aux-Roses France Departamento de Neurobiología Conductual y Cognitiva Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro México Translational Neuroimaging and Neural Control Group High-Field Magnetic Resonance Max Planck Institute for Biological Cybernetics Tuebingen Germany Graduate Training Centre of Neuroscience International Max

Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

关键词： Databases Neural circuits

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Development of a Model for Estimating Hourly Erythemal Ultraviolet Radiation Utilizing Satellite and Meteorological Data in Thailand

SSRN

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SSRN 2025年

作者： Choosri, Pranomkorn Pratummasoot, Noppamas Buntoung, Sumaman Department of Biomedical Engineering College of Health Sciences Christian University of Thailand Nakhon Pathom73000 Thailand Applied Physics Program Faculty of Science and Technology Valaya Alongkorn Rajabhat University under the Royal Patronage Pathum Thani 13180 Thailand Department of Physics Faculty of Science Silpakorn University Nakhon Pathom73000 Thailand

Erythemal ultraviolet irradiance continues to impact human skin and is increasing. The irradiance data is important to people for preventing danger and prediction, especially for research. Erythemal ultraviolet irradiance data is very scare. Therefore, the objective of this study is to develop a model for estimation hourly EUV irradiance utilizing satellite and meteorological data. Data collected between 2016 to 2021 has been divided into two parts: the first part (2016–2019) was utilized for model development, while the second part (2020–2021) was employed for validation. An interaction among atmospheric variables and EUV irradiance was analyzed. The model results in an exponential equation based on the solar zenith angle, cloud index, visibility, and ozone concentration. The model validation indicated strong performance, evidenced by a root mean square difference (RMSD) of 21.8% and a mean bias difference (MBD) of 3.57%. © 2025, The Authors. All rights reserved.

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Design of Electrical Impedance Tomography (EIT) for Medical Imaging Application

Design of Electrical Impedance Tomography (EIT) for Medical ...

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IEEE International Conference on Smart Instrumentation, Measurement and Applications (ICSIMA)

作者： Arbariyanto Mahmud Wicaksono Basari Biomedical Engineering Course Program Faculty of Engineering Universitas Indonesia

ISBN: (数字)9781728139524

ISBN: (纸本)9781728139531

The rise of imaging in medical field has boost the progress of new imaging method and modality that safer, cheaper, and faster. Electrical Impedance Tomography (EIT) is one of imaging modalities that provides safe medical imaging through non ionizing method. The downside of the EIT method is the complex algorithm needed to produce imaging result and low resolution. This study is aimed to provide a simple EIT imaging system that are easily used and developed. The proposed system designed in this study is a Matlab TM and Arduino based imaging system, which are then tested under several observation object scenario. The imaging results that are produced by the system are able to represent the varying observational objects structure. Impedance measurement method that is implemented in the proposed system is a two-point technique using 8 electrodes and 16 electrodes with a frequency of 50 kHz. The main observation object of this system is an acrylic cup filled with tap water that has a TDS (Total Dissolved Solids) of 300 ppm. The proposed EIT imaging system is considered as a simple construction that is able to recognize two different objects according to its different impedance values.

关键词： Tomography Impedance Impedance measurement Electrodes Matlab biomedical imaging

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Controlled release of carbamazepine at Therapeutically relevant doses using photocrosslinkable polyanhydrides

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International journal of pharmaceutics 2025年 679卷 125728页

作者： Hamzeh Ghaempanah Kalin I Penev Armin Geraili Jorge G Burneo Kibret Mequanint School of Biomedical Engineering the University of Western Ontario London Ontario Canada. Department of Chemical and Biochemical Engineering the University of Western Ontario London Ontario Canada. Department of Chemical and Biochemical Engineering the University of Western Ontario London Ontario Canada Department of Pharmaceutical Sciences Leslie Dan Faculty of Pharmacy University of Toronto Toronto Ontario Canada. Epilepsy Program Department of Clinical Neurological Sciences the University of Western Ontario London Ontario Canada. School of Biomedical Engineering the University of Western Ontario London Ontario Canada Department of Chemical and Biochemical Engineering the University of Western Ontario London Ontario Canada. Electronic address: kmequani@uwo.ca.

Epilepsy, one of the most common neurological disorders, is primarily managed with oral antiseizure medications. While effective for many patients, the short half-lives of most anti-epilepsy drugs (AEDs) necessitate frequent dosing, leading to poor adherence and compromised seizure control. Controlled-release drug delivery systems offer a promising solution by maintaining consistent drug levels, reducing dosing frequency, and minimizing side effects. Among these systems, photocrosslinkable polyanhydrides are particularly promising due to their unique surface erosion properties across a wide pH range, making them ideal for oral drug delivery applications. These polymers are synthesized from cost-effective starting materials, have tunable structures, and are biocompatible, biodegradable, and nontoxic. This study explores the potential of photocrosslinkable polyanhydrides synthesized via thiol-ene 'click' chemistry for the controlled release of carbamazepine. Carbamazepine is an antiepileptic drug with poor water solubility and a narrow therapeutic range. Unlike other controlled-release systems, which faced challenges with high drug loading or compromised polymer integrity, here we demonstrate that photocrosslinkable polyanhydrides can achieve carbamazepine loadings of up to 30 wt% while preserving their surface erosion properties. Cylindrical tablets fabricated from these polymers exhibit tailored release profiles, achieving sustained drug release over 5 to 33 h by adjusting the monomer ratios. Additionally, delayed release systems are demonstrated, allowing controlled onset times ranging from 2 to 10 h by varying the monomer composition. This approach provides a practical and efficient system for high-dose controlled-release carbamazepine delivery, offering a versatile and effective platform for enhanced epilepsy treatment.

关键词： Carbamazepine Controlled release tablet Epilepsy Photocrosslinkable polyanhydrides Surface erosion Therapeutic dose drug loading

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Electron Tomography Finds Three-Dimensional Chromatin Packing Domain Structure in Single Cell Different from Topological Associated Domains

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Microscopy and Microanalysis 2024年第SUPPLEMENT_1期30卷

作者： Li, Wing Shun Carter, Lucas Almassalha, Luay Pujadas, Emily Carignano, Marcelo Bleher, Reiner dos Reis, Roberto Backman, Vadim Dravid, Vinayak Applied Physics Program Northwestern University Evanston IL USA Department of Biomedical Engineering Northwestern University Evanston IL USA IBIS Interdisciplinary Biological Sciences Graduate Program Northwestern University Evanston IL USA Department of Materials Sciences and Engineering Northwestern University Evanston IL USA Northwestern University Atomic and Nanoscale Characterization Experimental (NUANCE) Center Northwestern University Evanston IL USA International Institute of Nanotechnology Northwestern University Evanston IL USA

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