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Frontispiece: Visible Light-Driven Molecular Switches and Motors: Recent Developments and Applications

Chemistry – A European Journal 2022年第18期28卷

作者： Dr. Hao Wang Dr. Hari Krishna Bisoyi Xinfang Zhang Dr. Fathy Hassan Prof. Quan Li Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State University Kent Ohio 44242 USA Department of Chemistry Faculty of Science Tanta University Tanta El-Gharbia 31527 Egypt Institute of Advanced Materials School of Chemistry and Chemical Engineering and Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research Southeast University Nanjing 211189 China

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Conceptual Design of Space Biosurgeon for Robotic Surgery and Aerospace Medicine

Conceptual Design of Space Biosurgeon for Robotic Surgery an...

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IEEE ANDESCON

作者： José Cornejo J. Paul Perales-Villarroel Raul Sebastian Jorge A. Cornejo-Aguilar Space Medicine & Biomechatronics Research Group-TMSP Biomedical Engineering Master’s Program–VIU Valencia Spain Cleveland Clinic Florida Florida U.S. George Washington University Hospital Washington DC U.S. VP-Surgical Engineering Society Faculty of Human Medicine URP Lima Peru

ISBN: (数字)9781728193656

ISBN: (纸本)9781728193663

The surgeon needs excellent manual dexterity and precision in order to optimize skills applied in hand-eye coordination and visual-spatial localization. On the other hand, during the surgical procedure the patient requires safety, minimally invasive incisions, shorter hospital stay and effective recovery. Therefore, a research study was conducted from 2016 to 2019 at Universitat Internacional Valenciana, in order to suggest the design of a futurist tele-operated Surgical Robotic System prototype, combining the efficiency of the robots used in microsurgery with the synchronized accuracy of the technology used in aerospace medicine, considered the first of its kind in Latin America. For applications on The Earth, the main objective of this project is to show an alternative to provide mechatronic support in advanced laparoscopic surgical procedures applied for General and Gastrointestinal Surgery. The proposed Medical Robotic Device called "Space Biosurgeon" has 4 robotic arms with 8 degrees of freedom (DOF) that allow performing semi-automated tasks controlled by the surgeon while a robotic axis slides vertically through anatomical planes of the patient. In the design process, the International Standard IEC 80601-2-77 was applied using SolidWorks for computer-aided design and Matlab for simulation, taking into account patient safety, quality and effectiveness for innovation in surgical incision approach and Single Port Surgery. In addition, a Clinical engineering analysis is developed, showing the interaction between the 4 important factors in the operating room, which are the physician/surgeon, the patient, the robot and the hospital environment. In conclusion, the application for Aerospace Medicine is the early detection of gastrointestinal diseases by coupling an ultrasound transducer. Furthermore, is planned to integrate sensors for vital signs monitoring, and the first small-scale prototype will be implemented in 2022.

关键词： Robots Surgery Manipulators Robot kinematics Instruments Space vehicles Robot sensing systems

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Initial Results on Primary Field Cancellation of Magnetic Induction Spectroscopy Technique for Fetal Acidosis Detection using COMSOL Multiphysics

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Journal of Physics: Conference Series 2021年第1期2071卷

作者： S F Abdul Halim M H Zakaria Z Zakaria A N Norali A Mohd Noor A A Ahmed J Pusppanathan M H Fazalul Rahiman S Z Mohd Muji R Abdul Rahim Biomedical Electronic Engineering Faculty of Electronic Engineering Technology Universiti Malaysia Perlis Arau Perlis 02600 Malaysia. Sport Innovation & Technology Centre (SiTC) Institute of Human Centered Engineering (iHumen) Universiti Teknologi Malaysia Skudai 81310 Johor Malaysia. Mechatronic Engineering Program Faculty of Electrical Engineering Technology Universiti Malaysia Perlis. Electronic Engineering Department Faculty of Electrical and Electronic Engineering Universiti Tun Hussein Onn. School of Electrical Engineering Faculty of Engineering Universiti Teknologi MalaysiaSkudai81310 Johor Malaysia.

Monitoring of fetal condition during labor could save hundred lives in a single year. During labor, fetus is at critical condition as acidosis may occur suddenly without any early symptoms. Invasive method such as Fetal Blood Sampling (FBS) has been used to detect the decline in pH level of fetus. However, fetal loss rate after FBS may range from 1.4% up to 25%. In this paper, magnetic field induction spectroscopy was implemented to determine fetal acidosis by using primary magnetic field cancellation technique. Magnetic Induction Spectroscopy (MIS) probe was design where transmitter coil (TX) is perpendicular to receiver coil (RX). The result shows that the secondary magnetic field produced have been successfully measured without any interruption from primary magnetic field. By using transmitter input 1A, it shows that voltage is inversely proportional to the blood pH due to the conductivity properties of blood.

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Seizure pathways and seizure durations can vary independently within individual patients with focal epilepsy

arXiv

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arXiv 2021年

作者： Schroeder, Gabrielle M. Chowdhury, Fahmida A. Cook, Mark J. Diehl, Beate Duncan, John S. Karoly, Philippa J. Taylor, Peter N. Wang, Yujiang CNNP Lab Interdisciplinary Computing and Complex BioSystems Group School of Computing Newcastle University Newcastle upon Tyne United Kingdom Faculty of Medical Sciences Newcastle University Newcastle upon Tyne United Kingdom UCL Queen Square Institute of Neurology Queen Square London United Kingdom Graeme Clark Institute St Vincent's Hospital University of Melbourne MelbourneVIC Australia Department of Biomedical Engineering University of Melbourne MelbourneVIC Australia

A seizure's electrographic dynamics are characterised by its spatiotemporal evolution, also termed dynamical "pathway", and the time it takes to complete that pathway, which results in the seizure's duration. Both seizure pathways and durations can vary within the same patient, producing seizures with different dynamics, severity, and clinical implications. However, it is unclear whether seizures following the same pathway will have the same duration or if these features can vary independently. We compared within-subject variability in these seizure features using 1) epilepsy monitoring unit intracranial EEG (iEEG) recordings of 31 patients (mean 6.7 days, 16.5 seizures/subject), 2) NeuroVista chronic iEEG recordings of 10 patients (mean 521.2 days, 252.6 seizures/subject), and 3) chronic iEEG recordings of 3 dogs with focal-onset seizures (mean 324.4 days, 62.3 seizures/subject). While the strength of the relationship between seizure pathways and durations was highly subject-specific, in most subjects, changes in seizure pathways were only weakly to moderately associated with differences in seizure durations. The relationship between seizure pathways and durations was weakened by seizures that 1) had a common pathway, but different durations ("elastic pathways"), or 2) had similar durations, but followed different pathways ("duplicate durations"). Even in subjects with distinct populations of short and long seizures, seizure durations were not a reliable indicator of different seizure pathways. These findings suggest that seizure pathways and durations are modulated by different processes. Uncovering such modulators may reveal novel therapeutic targets for reducing seizure duration and severity. Copyright © 2021, The Authors. All rights reserved.

关键词： Neurology

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Citric acid-polyurethane-chitosan-based innovative biocomposites as candidates of antibacterial dialyzer membrane

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Journal of International Dental and Medical Research 2018年第2期11卷 718-722页

作者： Santoso, Evlyn Anggraini Widiyanti, Prihartini Nabilla, Fathania Rahayu, Novita Putri Rahmania, Adita Wardani Department of Biomedical Engineering Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia Biomedical Study Program Faculty of Science and Technology Universitas Airlangga Surabaya Indonesia

Hemodialysis treatment is a replacement therapy renal function. Hemodialysis therapy with reuse system causes a risk of bacterial infection. In addition, routine vascular access by hemodialysis patients also factors of bacterial contamination which can increase the comorbidity and mortality rates of patients. This research aims to obtain biocompatibility and antibacterial properties by adding concentration chitosan in three variations. The functional group test showed the presence of a bond between PU-CA-PES-CS at a certain wavelength. SEM test proved that the pores produced on dialyzer membrane are still within the size range for the hemodialysis application at 0.001-0.1 μm. Hemolysis test results showed that the percentage of hemolysis in Sample A, Sample B, Sample C, and Sample D were 4.18%, 3.34%, 2.30% and 1.67% respectively. The percentage of hemolysis at less 5% is safe for contact with blood. Antibacterial test results revealed that PES-PU-CA membrane samples coated with chitosan variation are antibacterial. It can be seen from the formation of clear zone around the sample disc with diameter of 6,946-11,086 mm. PES-PU-CA dialyzer membrane coated with chitosan is a safe composite and potentially applicable as an antibacterial dialyzer membrane based on functional group test, antibacterial test, hemolysis assay, SEM, and cytotoxicity test. © 2018 University of Dicle.

关键词： Antibacterial Chitosan Membrane dialyzer Polyethersulfone Polyurethane

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Improving the robustness of the immersed interface method through regularized velocity reconstruction

arXiv

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arXiv 2025年

作者： Sun, Qi Kolahdouz, Ebrahim M. Griffith, Boyce E. Department of Mathematics University of North Carolina Chapel HillNC United States Department of Biomedical Engineering University of North Carolina Chapel HillNC United States Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel HillNC United States Computational Medicine Program University of North Carolina School of Medicine Chapel HillNC United States McAllister Heart Institute University of North Carolina School of Medicine Chapel HillNC United States

Robust, broadly applicable fluid-structure interaction (FSI) algorithms remain a challenge for computational mechanics. Efforts in this area are driven by the need to enhance predictive accuracy and efficiency in FSI simulations, align with experimental observations, and unravel complex multiscale and multiphysics phenomena, while addressing challenges in developing more robust and efficient methodologies. In previous work, we introduced an immersed interface method (IIM) for discrete surfaces and an extension based on an immersed Lagrangia-Eulerian (ILE) coupling strategy for modeling FSI involving complex geometries. The ability of the method to sharply resolve stress discontinuities induced by singular immersed boundary forces in the presence of low-regularity geometrical representations makes it a compelling choice for three-dimensional modeling of complex geometries in diverse engineering applications. Although the IIM we previously introduced offers many desirable advantages, it also imposes a restrictive mesh factor ratio, requiring the surface mesh to be coarser than the fluid grid to ensure stability. This is because when the mesh factor ratio constraint is not satisfied, parts of the structure motion are not controlled by the discrete FSI system. This constraint can significantly increase computational costs, particularly in applications involving multiscale geometries with highly localized complexity or fine-scale features. To address this limitation, we devise a stabilization strategy for the velocity restriction operator inspired by Tikhonov regularization. This study demonstrates that using a stabilized velocity restriction operator in IIM enables a broader range of structure-to-fluid grid-size ratios without compromising accuracy or altering the flow dynamics. This advancement significantly broadens the applicability of the method to real-world FSI problems involving complex geometries and dynamic conditions, offering a robust and computationally effi

关键词： Mesh generation

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Corrigendum to “Multilayered nanocomposite membrane orchestrating targeted dual release strategies for enhanced guided bone regeneration” [Chem. Eng. J. 484 (2024) 149237]

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Chemical engineering Journal 2025年 517卷

作者： Zahra Assadi Parsa Rezvanian Zahra Gounani Fatemeh Ejeian Ali Zarrabi Elahe Masaeli Department of Animal Biotechnology Cell Science Research Center Royan Institute for Biotechnology ACECR Isfahan P.O. Box 81593-58686 Iran Department of Biotechnology Faculty of Advanced Sciences and Technologies University of Isfahan Isfahan 81746-73441 Iran Feinberg Cardiovascular and Renal Research Institute Northwestern University School of Medicine Chicago IL USA Drug Research Program Division of Pharmaceutical Biosciences Faculty of Pharmacy University of Helsinki Viikinkaari 5 E FI-00790 Helsinki Finland Department of Biomedical Engineering Faculty of Engineering and Natural Sciences Istinye University Sariyer 34396 Istanbul Türkiye Department of Research Analytics Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai 600 077 India

The authors regret that, during the proofing of the above-mentioned article, the incorrect reference library was used, inadvertently leading to changes in some references. As a result, several unrelated references were cited. With this official corrigendum, we aim to rectify these errors (and a few minor points that we recently detected) and sincerely apologize for any inconvenience caused. [Table presented] © 2025 Elsevier B.V.

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Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification

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Nature Communications 2024年第1期15卷 2187页

作者： Turner, Mackenzie E. Blum, Kevin M. Watanabe, Tatsuya Schwarz, Erica L. Nabavinia, Mahboubeh Leland, Joseph T. Villarreal, Delaney J. Schwartzman, William E. Chou, Ting-Heng Baker, Peter B. Matsumura, Goki Krishnamurthy, Rajesh Yates, Andrew R. Hor, Kan N. Humphrey, Jay D. Marsden, Alison L. Stacy, Mitchel R. Shinoka, Toshiharu Breuer, Christopher K. Center for Regenerative Medicine Research Institute at Nationwide Children’s Hospital Columbus OH United States Molecular Cellular and Developmental Biology Graduate Program The Ohio State University Columbus OH United States The Ohio State University College of Medicine Columbus OH United States Department of Biomedical Engineering Yale University New Haven CT United States Biomedical Sciences Graduate Program The Ohio State University College of Medicine Columbus OH United States Department of Exercise and Health Science National Taipei University of Nursing and Health Sciences Taipei City Taiwan Pathology Department at Nationwide Children’s Hospital and The Ohio State University Columbus OH United States Department of Medical Safety Management Tokyo Women’s Medical University Tokyo Japan Department of Radiology Nationwide Children’s Hospital and The Ohio State University Columbus OH United States Department of Pediatrics The Ohio State University College of Medicine Columbus OH United States The Heart Center Nationwide Children’s Hospital Columbus OH United States Departments of Pediatrics and Bioengineering Stanford University Stanford CA United States Department of Surgery The Ohio State University College of Medicine Columbus OH United States Interdisciplinary Biophysics Graduate Program The Ohio State University Columbus OH United States Department of Cardiothoracic Surgery Nationwide Children’s Hospital Columbus OH United States Department of Surgery Nationwide Children’s Hospital Columbus OH United States

Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures. Herein, we describe the natural history of calcification in the most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through a retrospective clinical study and an ovine model, we compare the degree of calcification between tissue-engineered vascular grafts and polytetrafluoroethylene grafts. Results indicate superior durability in tissue-engineered vascular grafts, displaying reduced late-term calcification in both clinical studies (p < 0.001) and animal models (p < 0.0001). Further assessments of graft compliance reveal that tissue-engineered vascular grafts maintain greater compliance (p < 0.0001) and distensibility (p < 0.001) than polytetrafluoroethylene grafts. These properties improve graft hemodynamic performance, as validated through computational fluid dynamics simulations. We demonstrate the promise of tissue engineered vascular grafts, remaining compliant and distensible while resisting long-term calcification, to enhance the long-term success of congenital heart surgeries. © The Author(s) 2024.

关键词： Translational research Cardiac device therapy Cardiovascular models

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An immersed interface method for incompressible flows and geometries with sharp features

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Journal of Computational Physics 2025年 537卷

作者： Michael J. Facci Ebrahim M. Kolahdouz Boyce E. Griffith Department of Mathematics University of North Carolina Chapel Hill NC USA Flatiron Institute Simons Foundation New York NY USA Department of Biomedical Engineering University of North Carolina Chapel Hill NC USA Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel Hill NC USA Computational Medicine Program University of North Carolina School of Medicine Chapel Hill NC USA McAllister Heart Institute University of North Carolina School of Medicine Chapel Hill NC USA

The immersed interface method (IIM) for models of fluid flow and fluid-structure interaction imposes jump conditions that capture stress discontinuities generated by forces that are concentrated along immersed boundaries. Most prior work using the IIM for fluid dynamics applications has focused on smooth interfaces, but boundaries with sharp features such as corners and edges can appear in practical analyses, particularly on engineered structures. The present study builds on our work to integrate finite element-type representations of interface geometries with the IIM. Initial realizations of this approach used a continuous Galerkin (CG) finite element discretization for the boundary, but as we show herein, these approaches generate large errors near sharp geometrical features. To overcome this difficulty, this study introduces an IIM approach using a discontinuous Galerkin (DG) representation of the jump conditions. Numerical examples explore the impacts of different interface representations on accuracy for both smooth and sharp boundaries, particularly flows interacting with fixed interface configurations. We demonstrate that using a DG approach provides accuracy that is comparable to the CG method for smooth cases. Further, we identify a time step size restriction for the CG representation that is directly related to the sharpness of the geometry. In contrast, time step size restrictions imposed by DG representations are demonstrated to be nearly insensitive to the presence of sharp features.

关键词： Discrete surface Finite element Fluid-structure interaction Immersed interface method Incompressible flow Jump condition Sharp geometry

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Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization (vol 22, pg 1538, 2021)

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NATURE IMMUNOLOGY 2022年第6期23卷 985-985页

作者： Mayer, Johannes U. Hilligan, Kerry L. Chandler, Jodie S. Eccles, David A. Old, Samuel I. Domingues, Rita G. Yang, Jianping Webb, Greta R. Munoz-Erazo, Luis Hyde, Evelyn J. Wakelin, Kirsty A. Tang, Shiau-Choot Chappell, Sally C. von Daake, Sventja Brombacher, Frank Mackay, Charles R. Sher, Alan Tussiwand, Roxane Connor, Lisa M. Gallego-Ortega, David Jankovic, Dragana Le Gros, Graham Hepworth, Matthew R. Lamiable, Olivier Ronchese, Franca Malaghan Institute of Medical Research Wellington New Zealand Immunobiology Section Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA Lydia Becker Institute of Immunology and Inflammation Manchester Collaborative Centre for Inflammation Research Faculty of Biology Medicine and Health University of Manchester Manchester Academic Health Science Centre Manchester UK International Centre for Genetic Engineering and Biotechnology (ICGEB) Cape Town component & Institute of Infectious Diseases and Molecular Medicine (IDM) Division of Immunology Health Science Faculty University of Cape Town Cape Town South Africa Infection and Immunity Program Monash Biomedicine Discovery Institute Monash University Melbourne VIC Australia Department of Biomedicine University of Basel Basel Switzerland Immune Regulation Unit National Institute of Dental and Craniofacial Research National Institutes of Health Bethesda MD USA The Kinghorn Cancer Centre Garvan Institute of Medical Research Darlinghurst NSW Australia Centre for Single-Cell Technology School of Biomedical Engineering Faculty of Engineering and IT University of Technology Sydney Ultimo NSW Australia Immunoparasitology Unit Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD USA

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