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四川生理科学杂志 2024年第7期46卷 1615-1615页

作者： Rayane da Cruz Albino Faculty of Pharmacy Federal University of Rio de Janeiro Rio de Janeiro RJ Brazil. Department of Host-Microbe Interactions St. Jude Children’s Research Hospital Memphis TN USA. School of the Environment The University of Queensland Whiterock QLD Australia. KU Leuven Ghent Belgium. Laboratory for Computational Social Systems Indraprastha Institute of Information Technology Delhi New Delhi India. University Medical College Shantou Guangdong China. Department of Ecoscience Aarhus Universitet Aarhus Denmark. Institute of Environment and Sustainable Development Banaras Hindu University Varanasi Uttar Pradesh India. Department of Medical Parasitology Faculty of Medicine and Health Sciences Sana’a University Sana’a Yemen and Tropical Disease Research Center Faculty of Medicine and Health Sciences University of Science and Technology Sana’a Yemen. Department of Medicine University of Montreal Montreal QC Canada. Electricity Infrastructure and Buildings Division Pacific Northwest National Laboratory Portland OR USA. Department of Biological Sciences University of New Brunswick Saint John Saint John NB Canada. Department of Biomedical Engineering The University of Melbourne Melbourne VIC Australia. Vagelos Molecular Life Sciences Program University of Pennsylvania Philadelphia PA USA. Doctoral Program in Neurobiology and Behavior Columbia University New York NY USA. Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York NY USA. Department of Engineering University of Cambridge Cambridge Cambridgeshire UK. Department of Geography Liverpool John Moores University Liverpool UK. Department of Biology Stanford University Stanford CA USA. Department of Psychology University of Nicosia Nicosia Cyprus. Department of Global Ecology Carnegie Institution for Science Stanford CA USA. Research and Support Division Stellenbosch University Cape Town South Africa.

We gave young scientists this prompt:Describe one change to scientific policy or culture that would substantially decrease incidents of scientific misconduct or other unethical behavior.

关键词： behavior. prompt culture

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人工智能赋能癌症免疫治疗——创新探索与未来机遇（英文）

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engineering 2025年第1期 12-16页

作者： Wei Xiang Lu Yu Xiaoyuan Chen Marco J.Herold Australian Centre for Artificial Intelligence in Medical Innovation La Trobe University School of Computing Engineering and Mathematical Sciences La Trobe University Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore Department of Chemical and Biomolecular Engineering College of Design and Engineering National University of Singapore Department of Biomedical Engineering College of Design and Engineering National University of Singapore Department of Pharmacy and Pharmaceutical Sciences Faculty of Science National University of Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Theranostics Center of Excellence(TCE) Yong Loo Lin School of Medicine National University of Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research(A*STAR) Olivia Newton-John Cancer Research Institute School of Cancer Medicine La Trobe University The Walter and Eliza Hall Institute of Medical Research Department of Medical Biology University of Melbourne

1. Introduction Cancer continues to be a major cause of global mortality rates, with conventional treatments such as chemotherapy and radiotherapy exhibiting inconsistent efficacy, high costs, and considerable side effects. Over the past decade, a promising alternative has emerged: cancer immunotherapy, which leverages the body's immune system to identify and eradicate cancer cells [1].

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The effectivity of Indonesian propolis from Tetragonula biroi bee as an antifungal agent for Candida sp. and Cryptococcus neoformans

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AIP Conference Proceedings 2021年第1期2344卷 040013页

作者： Robiatul Adawiyah Alifa Husnia AlHaq Davita Kristabel Mandala Muhammad Sahlan Diah Kartika Pratami Siti Farida Department of Parasitology Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia Study Program of Clinical Parasitology Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Depok 16424 West Java Indonesia Undergraduate programm Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia Department of Chemical Engineering Faculty of Engineering Universitas Indonesia Depok 16424 West Java Indonesia Lab of Pharmacognosy and Phytochemistry Faculty of Pharmacy Pancasila University Jakarta 12640 Indonesia Department of Pharmacy Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia

In recent years, there has been an increase in the incidence of fungal infections accompanied by a decrease in susceptibility to fluconazole as one of the drug choices for fungal infections. So that it needs to be considered the existence of an alternative drug that is effective and also expected to have a minimal side effect, one of which is Propolis. This research was done to determine the effectivity of Indonesian Propolis from Tetragonula biroi bee on the growth of Candida sp. and Cryptococcus neoformans. An experimental study to test the susceptibility of Propolis using disc diffusion technique performed on six types of fungi, e.g. Candida albicans, Candida glabrata, Candida parapsilosis, Candida krusei, Candida tropicalis, dan Cryptococcus neoformans. The samples tested were Indonesian propolis emulsion from Tetragonula biroi bee with a concentration of 10 mg/ml, 50 mg/ml, and 70 mg/ml. The sample selection based on the result of “Exploration of Antifungal Potential of Indonesian Propolis from Tetragonula biroi Bee“ from the faculty of engineering, University of Indonesia. Indonesian Propolis emulsion from Tetragonula biroi bee can inhibit the growth of Candida sp., especially Candida glabrata and Candida krusei, and also Cryptococcus neoformans with an optimum concentration of 10 mg/ml. The lower concentration than 10 mg/ml of Indonesian Propolis emulsion from Tetragonula biroi bee could be considered to provide more optimal results.

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A Nodal Immersed Finite Element-Finite Difference Method

arXiv

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arXiv 2021年

作者： Wells, David R. Vadala-Roth, Ben Lee, Jae H. Griffith, Boyce E. Department of Mathematics University of North Carolina Chapel HillNC United States Westborough MA United States Department of Mechanical Engineering Institute for Computational Medicine Johns Hopkins University BaltimoreMD United States Department of Mathematics Applied Physical Sciences and Biomedical Engineering University of North Carolina Chapel HillNC United States Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel HillNC United States Computational Medicine Program University of North Carolina Chapel HillNC United States McAllister Heart Institute University of North Carolina Chapel HillNC United States Center for Drug Evaluation and Research U.S. Food and Drug Administration Silver SpringMD United States

The immersed finite element-finite difference (IFED) method is a computational approach to modeling interactions between a fluid and an immersed structure. The IFED method uses a finite element (FE) method to approximate the stresses, forces, and structural deformations on a structural mesh and a finite difference (FD) method to approximate the momentum and enforce the incompressibility of the entire fluid-structure system on a Cartesian grid. The fundamental approach used by this method follows the immersed boundary framework for modeling fluid-structure interaction (FSI), in which a force spreading operator prolongs structural forces to a Cartesian grid, and a velocity interpolation operator restricts a velocity field defined on that grid back onto the structural mesh. With an FE structural mechanics framework, force spreading first requires that the force itself be projected onto the finite element space. Similarly, velocity interpolation requires projecting velocity data onto the FE basis functions. Consequently, evaluating either coupling operator requires solving a matrix equation at every time step. Mass lumping, in which the projection matrices are replaced by diagonal approximations, has the potential to accelerate this method considerably. This paper provides both numerical and computational analyses of the effects of this replacement for evaluating the force projection and for the IFED coupling operators. Constructing the coupling operators also requires determining the locations on the structure mesh where the forces and velocities are sampled. Here we show that sampling the forces and velocities at the nodes of the structural mesh is equivalent to using lumped mass matrices in the IFED coupling operators. A key theoretical result of our analysis is that if both of these approaches are used together, the IFED method permits the use of lumped mass matrices derived from nodal quadrature rules for any standard interpolatory element. This is different from s

关键词： Fluid structure interaction

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Expanded Diameter of Coronary Metal Stent: Simulation and Experiment

Expanded Diameter of Coronary Metal Stent: Simulation and Ex...

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International Conference on Bioinformatics, Biotechnology, and biomedical engineering - Bioinformatics and biomedical engineering (BioMIC)

作者： Alva Edy Tontowi Ogy Satria Ramadhani Sukiman Nurul Aulia Dewi Nahar Taufiq Department of Mechanical and Industrial Engineering Universitas Gadjah Mada Yogyakarta Indonesia Department of Mechanical Universitas Khairun Ternate Indonesia Department of Mechanical and Industrial Engineering Faculty of Engineering Yogyakarta Indonesia Biomedical Engineering Biotechnology Program Study Universitas Gadjah Mada Yogyakarta Indonesia

The following topics are dealt with: biomedical materials; diseases; finite element analysis; medical image processing; medical disorders; medical signal processing; electroencephalography; cellular biophysics; biolog... 详细信息

ISBN: (数字)9781728147116

ISBN: (纸本)9781728147123

关键词： Stress Numerical models Simulation Hydraulic systems Steel Scanning electron microscopy

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Yogurt-inspired hybrid membrane vesicles for the prevention and treatment of Helicobacter pylori infection

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Cell Biomaterials 2025年第4期1卷

作者： Lujie Liu Yiming Guo Baikui Wang Yuanwei Pan Chenchen Zhao Zhiping Xiao Yu Liu Guocan Yu Xiaoyuan Chen Lang Rao Institute of Chemical Biology Shenzhen Bay Laboratory Shenzhen 518132 China Department of Diagnostic Radiology Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore College of Animal Science Zhejiang University Hangzhou 310058 China Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 China Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Theranostics Center of Excellence (TCE) Yong Loo Lin School of Medicine National University of Singapore Singapore 138667 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A∗STAR) Singapore 138673 Singapore Department of Chemical and Biomolecular Engineering College of Design and Engineering National University of Singapore Singapore 117575 Singapore Department of Biomedical Engineering College of Design and Engineering National University of Singapore Singapore 117575 Singapore Department of Pharmacy and Pharmaceutical Sciences Faculty of Science National University of Singapore Singapore 117544 Singapore

Helicobacter pylori ( H. pylori ) infection is a critical initiating factor in numerous gastrointestinal diseases. Here, we present yogurt-inspired hybrid membrane vesicles (hMVs) engineered by fusing bacterial outer membrane vesicles (OMVs) with modified milk fat globule membrane vesicles (MMVs) to prevent and treat H. pylori infection. The hMVs function as binding site competitors, reducing bacterial adhesion while regulating epithelial integrity and immune responses. This dual mechanism synergistically inhibits H. pylori infection and promotes gastric epithelial repair. In vitro , hMVs demonstrated remarkable efficacy in accelerating scratch-wound healing, enhancing lipid raft formation, increasing tight junction protein ZO-1 expression, and promoting macrophage phagocytosis of apoptotic epithelial cells. In mouse models for both H. pylori prevention and treatment, oral administration of hMVs effectively reduced H. pylori loads by 86% and 66%, respectively. Additionally, this treatment mitigated inflammatory factor secretion, decreased neutrophil recruitment, and preserved the abundance of beneficial probiotics in the stomach.

关键词： Helicobacter pylori infection drug delivery nanomedicine extracellular vesicles nanobiotechnology

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Author Correction: Predicting the efficiency of prime editing guide RNAs in human cells

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Nature biotechnology 2024年第3期42卷 529页

作者： Hui Kwon Kim Goosang Yu Jinman Park Seonwoo Min Sungtae Lee Sungroh Yoon Hyongbum Henry Kim Department of Pharmacology Yonsei University College of Medicine Seoul Republic of Korea. Brain Korea 21 Plus Project for Medical Sciences Yonsei University College of Medicine Seoul Republic of Korea. Center for Nanomedicine Institute for Basic Science (IBS) Seoul Republic of Korea. Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul Republic of Korea. Electrical and Computer Engineering Seoul National University Seoul Republic of Korea. Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea. Graduate School of Data Science Seoul National University Seoul Republic of Korea. Department of Pharmacology Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Brain Korea 21 Plus Project for Medical Sciences Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Center for Nanomedicine Institute for Basic Science (IBS) Seoul Republic of Korea. hkim1@yuhs.ac. Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul Republic of Korea. hkim1@yuhs.ac. Severance Biomedical Science Institute Yonsei University College of Medicine Seoul Republic of Korea. hkim1@yuhs.ac. Graduate Program of NanoScience and Technology Yonsei University Seoul Republic of Korea. hkim1@yuhs.ac.

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Adaptive governance in the water-energy-food-ecosystem nexus for sustainable community sanitation

World Development Sustainability

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World Development Sustainability 2025年 6卷

作者： Sofiyah, Evi Siti Sianipar, Imelda Masni Juniaty Rahman, Ari Caesarina, Naila Putri Suhardono, Sapta Suryawan, I Wayan Koko Lee, Chun-Hung Department of Environmental Engineering Faculty of Infrastructure Planning Universitas Pertamina Jalan Sinabung II Terusan Simprug Jakarta 12220 Indonesia Department of International Relations Faculty of Social Science and Political Science Universitas Kristen Indonesia Jakarta 13630 Indonesia Environmental Sciences Study Program Faculty of Mathematics and Natural Sciences Universitas Sebelas Maret Surakarta 57126 Indonesia Department of Natural Resources and Environmental Studies College of Environmental Studies and Oceanography National Dong Hwa University Hualien 97401 Taiwan Center for Environmental Solution (CVISION) Universitas Pertamina Jalan Sinabung II Terusan Simprug Jakarta 12220 Indonesia Center for Interdisciplinary Research on Ecology and Sustainability College of Environmental Studies and Oceanography National Dong Hwa University Hualien 97401 Taiwan

As the intensity of global environmental challenges increases, so does the need to understand and strengthen the resilience of interconnected systems. This research underscores the crucial role of adaptive governance in navigating the complexities of the Water-Energy-Food-Ecosystem nexus, particularly under the pressures of changing climatic conditions. The study conducts an in-depth analysis of adaptive capacities by identifying critical components such as assets, flexibility, organization, learning, and agency as fundamental elements of adaptive governance in sanitation practices. Data were collected through structured questionnaires and analyzed using binary probit and logit models to examine how these attributes influence community engagement in sanitation. Descriptive analysis was also used to summarize respondent characteristics and attribute distributions. © 2025 The Author(s)

关键词： Adaptive governance Community engagement Environmental sustainability Sanitation resilience Water-energy-food-ecosystem nexus

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Co-assembly of oligo-urethane nanoparticles with defined lipid additives to tailor RNA delivery into cells

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Acta Biomaterialia 2025年

作者： Suja Shrestha Elaine Yan Beining Yang Aled Blundell Allen C.T. Teng Ryan M. Marks Ronald Cohn Evgueni Ivakine Anthony O. Gramolini J. Paul Santerre Faculty of Dentistry University of Toronto Toronto Ontario M5G 1G6 Canada Translational Biology and Engineering Program and Ted Rogers Centre for Heart Research Toronto Ontario M5G 1M1 Canada Department of Physiology University of Toronto Toronto Ontario M5S 1A8 Canada Genetics & Genome Biology Program The Hospital for Sick Children Toronto Ontario M5G 0A4 Canada Department of Molecular & Medical Genetics and Paediatrics Faculty of Medicine University of Toronto Toronto Ontario M5S 1A8 Canada Division of Clinical and Metabolic Genetics The Hospital for Sick Children Toronto Ontario M5G 0A4 Canada Institute of Biomedical Engineering University of Toronto Toronto Ontario M5S 3G9 Canada

Developing safe and effective biomaterials to deliver RNA into cells has grown in importance over recent years and has enabled the clinical translation of several gene therapies. Self-assembled oligo-urethane nanoparticles (PNPs) have several advantageous properties, such as (1) mitigating immune cell response in vivo , (2) low cytotoxicity in a broad range of cells, and (3) capable of delivering oligonucleotides or proteins into cells. Here, we were interested in defining unique configurations of PNPs to assess their relative cytotoxicity to human cells, comparing them to a popular commercial lipid system MessengerMax, as some cationic lipids have been found to have associated toxicity, instigating the search for less toxic counterparts. This was then followed by demonstrating the ability of enhanced green fluorescent protein (EGFP) mRNA to be loaded onto the PNPs, and to establish methods to enable the efficient transgene expression in a number of cell types, including Caco-2 and C 2 C 12 cells which are known to be difficult-to-transfect cells. The addition of small amounts of PEGylated lipid to PNP significantly increased EGFP expression in HEK293T cells, Caco-2 cells and C 2 C 12 cells at an effective mRNA/PNPs ratio (wt/wt) of 1:40, while the addition of the ionizable cationic lipid, significantly increased EGFP expression in C 2 C 12 cells and differentiated C 2 C 12 cells (myofibers) at mRNA/PNPs ratio (wt/wt) of 1:125, while keeping PNPs mass constant to 62.5 μg and changing the mRNA mass. Our study demonstrated that lipid-assisted, PNP-mediated mRNA delivery achieved a high transfection efficiency in terminally differentiated myofibers, paving the way for potential innovative therapeutics against muscular dystrophies. Statement of significance There are reports of diverse delivery agents for RNA, but there is still unmet need for more versatile, and safe delivery vehicles. In this study we demonstrated that when compared to MessengerMax (a lipid-based mRNA

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Human-computer-interface for controlling the assistive technology device

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AIP Conference Proceedings 2020年第1期2314卷

作者： Osmalina Nur Rahma Maydiana Nurul Kurniawati Akif Rahmatillah Khusnul Ain 1Biomedical Engineering Study Program Department of Physics Faculty of Science and Technology Airlangga University Indonesia

Imagining a motion without doing the actual movement is known as Motor imaginary (MI). However, translating MI as an input for BCI that control the Assistive Technology (AT) device was a challenging method due to the extensive training required, poor user engagement, and visual feedback response delays. For a person who has difficulties to imagine without visual stimulation, more training should be conducted. Even with a visual stimulus, sometimes a person still finds it hard to distinguish between one movement and another. So, finding a suitable input to control an AT device that suitable for someone who has extremely limited movement is very challenging. In the other hand, EEG signal had been proven sufficient in detecting facial expression. Even though the EEG signal contains EMG facial artifact and considered as an unwanted signal for BCI, facial movement artifact could become a compensator signal for EEG based Human Computer Interface (HCI) system to improve efficiency. This study aims to develop HCI systems to distinguish three different movements (forward, backward, and stop) EEG signals that recorded from EEG EMOTIV Epoc based on different facial expression. This HCI system could bring benefit if it is implemented for AT device, such as rollator since the user could easily distinguish different movement without any visual stimuli required so could reduce an extensive training before usage and could improve the quality of life people with limited extremity movement.

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