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Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimer＇s disease diagnosis

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Bio-Design and Manufacturing 2018年第3期1卷 182-194页

作者： Leming Sun Zhen Fan Tao Yues Jun Yin Jianzhong FU Mingjun Zhang Department of Biomedical Engineering College ofEngineering Ohio State University Columbus OH 43210USA School of Life Sciences Northwestern PolytechnicalUniversity Xi'an 710072 Shaanxi China Department of Polymeric Materials School of MaterialScience and Engineering Tongji UniversityShanghai 201804 China Institute for Advanced Study TongjiUniversity Shanghai 200092 China School of Mechatronic Engineering and Automation Shanghai University Shanghai 200444 China The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical Engineering ZhejiangUniversity Hangzhou 310028 China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang University Hangzhou 310028 China Dorothy M. Davis Heart & Lung Research Institute The OhioState University Wexner Medical Center Columbus OH43210 USA Interdisciplinary Biophysics Graduate Program Ohio StateUniversity Columbus OH 43210 USA

This paper proposes an additive nanomanufacturing approach to fabricate a personalized lab-on-a-chip fluorescent peptide nanoparticles （f-PNPs） array for simultaneous multi-biomarker detection that can be used in Alzheimer＇s disease （AD） diagnosis. We will discuss optimization techniques for the additive nanomanufacturing process in terms of reliability, yield and manufacturing efficiency. One contribution of this paper lies in utilization of additive nanomanufacturing techniques to fabricate a patient-specific customize-designed lab-on-a-chip device for personalized AD diagnosis, which remains a major challenge for biomedical engineering. Through the integrated bio-design and bio-manufacturing process, doctor＇s check- up and computer-aided customized design are integrated into the lab-on-a-chip array for patient-specific AD diagnosis. In addition, f-PNPs with targeting moieties for personalized AD biomarkers will be self-assembled onto the customized lab-on-a- chip through the additive nanomanufacturing process, which has not been done before. Another contribution of this research is the personalized lab-on-a-chip f-PNPs array for AD diagnosis utilizing limited human blood. Blood-based AD assessment has been described as ＂the holy grail＂ of early AD detection. This research created the computer-aided design, fabrication through additive nanomanufacturing, and validation of the f-PNPs array for AD diagnosis. This is a highly interdisciplinary research contributing to nanotechnology, biomaterials, and biomedical engineering for neurodegenerative disease. The conceptual work is preliminary with intent to introduce novel techniques to the application. Large-scale manufacturing based on the proposed framework requires extensive validation and optimization.

关键词： Nanomanufacturing Lab-on-a-chip Fluorescent peptide nanoparticle Alzheimer＇s disease Diagnosis

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Design and implementation of multichannel EMG for upper extremity myoelectric signal acquisition using IIR filter

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AIP Conference Proceedings 2020年第1期2314卷

作者： Akif Rahmatillah Amila Sofiah Prihartini Widiyanti 1Medical Instrumentation Laboratory Biomedical Engineering Study Program Faculty of Science & Technology Universitas Airlangga Surabaya Indonesia 2Institute of Tropical Disease (ITD) Universitas Airlangga Surabaya Indonesia

This study aimed at designing and implementing a multichannel EMG based on Infinite Impulse Response (IIR) filter and then compare its performance with the standard EMG devices. Hence, the design of this multichannel EMG system consists of two parts: hardware and software. The hardware comprises instrumentation amplifier and NI DAQ USB 6009 as data acquisition device, while the software is composed of myoelectric signal processing (e.g. filtering, rectifying, and smoothing) and interface signal on personal computer (PC) using LabVIEW programming. To test the device, two procedures were performed, there were instrumentation test and performance test of the EMG device. The instrumentation test resulted in the gain value of instrumentation amplifier at 12.794 times with linearity of 0.9998. Moreover, the response of implemented Butterworth IIR filter is compatible with the design at the cut off frequency of 30-400 Hz and 50 Hz. For the performance test, quantitative and qualitative data recorded from normal male subjects aged of 20-40 were compared. The result showed that EMG prototype work as well as EMG comparison with relative error percentage for each value parameter of maximum, minimum, and average amplitude signals at 14.05885 %, 14.82683 %, and 14.0411 % respectively. Furthermore, the features of recorded signal for similar simultaneous movements using EMG prototype also share identical features with the recorded signal using standard EMG.

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PID control design and implementation for laboratory scale infant incubator temperature using FOPDT model

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AIP Conference Proceedings 2020年第1期2314卷

作者： Akif Rahmatillah Inten Fauziah Hidayat Alfian Pramudita Putra Osmalina Nur Rahma Suhariningsih 1Medical Instrumentation Laboratory Biomedical Engineering Study Program Faculty of Science & Technology Universitas Airlangga Surabaya Indonesia 2Institute of Tropical Disease (ITD) Universitas Airlangga Surabaya Indonesia

Premature babies have difficulty for regulating their body temperature because weight deficiency. Infant incubator that equipped by temperature control system can support thermoregulation process in baby body. This paper explained design of temperature control system using Proportional-Integral-Derivative (PID) controller and its implementation to the laboratory scale infant incubator. The transfer function of infant incubator was obtained by step test method using First-Order and Dead Time (FOPDT) model where process gain K = 0.29, settling time Ts = 18s and dead time Td = 1. Ziegler-Nichols (ZN) and Direct Synthesis (DS) PID coefficients tuning method was used is this experiment and it resulted for ZN tunning method, proportional gain Kc = 20.14, integration time Ti = 0.2 and derivative time Td = 0.05 and DS tunning method proportional gain Kc = 5, integration time Ti = 18. PID controller was implemented to the Personal Computer (PC) with LabVIEW 2013 programing language, LabJack U3 HV data acquisition device and LM-35 temperature sensor. Set point of temperature that required was 350C with t and 250C initial temperature. The controller performance that resulted by this experiment were for ZN tunning method 38 minutes for settling time while DS tunning method resulted 12 minutes for setling time.

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Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor

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Angewandte Chemie 2021年第32期133卷

作者： Dr. Kuikun Yang Dr. Guocan Yu Zhiqing Yang Ludan Yue Dr. Xiangjun Zhang Chen Sun Jianwen Wei Dr. Lang Rao Prof. Xiaoyuan Chen Prof. Ruibing Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Science University of Macau Avenida da Universidade Taipa Macau China MoE Frontiers Science Center for Precision Oncology University of Macau Avenida da Universidade Taipa Macau China Key Lab of Organic Optoelectronics & Molecular Engineering Department of Chemistry Tsinghua University Beijing China Institute of Biomedical Health Technology and Engineering Shenzhen Bay Laboratory Shenzhen China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

The clinical application of chemodynamic therapy is impeded by the insufficient intracellular H 2 O 2 level in tumor tissues. Herein, we developed a supramolecular nanoparticle via a simple one-step supramolecular polymerization-induced self-assembly process using platinum (IV) complex-modified β-cyclodextrin-ferrocene conjugates as supramolecular monomers. The supramolecular nanoparticles could dissociate rapidly upon exposure to endogenous H 2 O 2 in the tumor and release hydroxyl radicals as well as platinum (IV) prodrugs in situ, which is reduced into cisplatin to significantly promote the generation of H 2 O 2 in the tumor tissue. Thus, the supramolecular nanomedicine overcomes the limitation of conventional chemodynamic therapy via the self-augmented cascade radical generation and drug release. In addition, dissociated supramolecular nanoparticles could be readily excreted from the body via renal clearance to effectively avoid systemic toxicity and ensure long term biocompatibility of the nanomedicine. This work may provide new insights on the design and development of novel supramolecular nanoassemblies for cascade chemo/chemodynamic therapy.

关键词： drug delivery self-amplified dissociation self-assembly supramolecular polymerization synergistic chemo/chemodynamic therapy

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Enhancing luteolin solubility through solid dispersion-based oral gels: A novel approach for periodontal disease treatment

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Journal of Drug Delivery Science and Technology 2025年 111卷

作者： Koromili, Maria Kapourani, Afroditi Chaclioutaki, Konstantina Christoudia, Nikoletta Pettas, Spyros Dafou, Dimitra Sklaviadis, Theodoros Andreadis, Dimitrios A. Papageorgiou, Spyros Assimopoulou, Andreana N. Xanthopoulos, Konstantinos Fatouros, Dimitrios N. Barmpalexis, Panagiotis Laboratory of Pharmaceutical Technology School of Pharmacy Faculty of Health Sciences Aristotle University of Thessaloniki Thessaloniki 54124 Greece Department of Genetics Development and Molecular Biology School of Biology Aristotle University of Thessaloniki Thessaloniki 541 24 Greece Laboratory of Pharmacology Department of Pharmacy School of Health Sciences Aristotle University of Thessaloniki Thessaloniki 541 24 Greece Department of Oral Medicine/Pathology School of Dentistry Aristotle University of Thessaloniki Thessaloniki Greece University of West Attica Department of Biomedical Sciences Research Laboratory of Chemistry Biochemistry and Cosmetic Science Athens Greece Laboratory of Organic Chemistry School of Chemical Engineering Aristotle University of Thessaloniki Thessaloniki 54124 Greece Natural Products Research Centre of Excellence-AUTH (NatPro-AUTH) Center for Interdisciplinary Research and Innovation (CIRI-AUTH) Thessaloniki 57001 Greece Institute of Applied Biosciences Centre for Research and Technology Thessaloniki Greece

Luteolin (LUT) is a bioactive flavonoid with numerous pharmacological properties, such as antioxidant, antimicrobial, and anti-cancer activity. A prominent example of LUT's properties concerns its administration for the treatment of periodontal disease. However, its low water solubility poses a serious challenge regarding its formulation into an effective dosage form. To this end, the present study investigates the incorporation of LUT's solid dispersions (SDs) into oral gels, as a way to improve LUT solubility in saliva for the treatment of periodontitis. Initially, SDs of LUT were formulated at drug-to-polymer weight ratios of 1:9 and 1:12 using either polyethylene glycol 6000 (PEG) or poloxamer P188 (P188), employing both melting and solvent evaporation techniques. Subsequently, these drug-loaded SDs were integrated into oral gels designed for the local treatment of periodontal disease within the mouth. The SDs resulted in a remarkable solubility enhancement for LUT, showing up to a 16-fold increase compared to its pure crystalline form. Physicochemical characterization using differential scanning calorimetry (DSC) and powder X-ray diffractometry (pXRD), revealed that LUT was amorphously dispersed within the SDs, while ATR-FTIR spectroscopy indicated the presence of significant molecular interactions between the drug and the matrix/carriers. The gels containing the SDs of LUT displayed appropriate rheological properties for handling and storage, while the in vitro dissolution studies in simulated saliva revealed that the PEG SD-based oral gels were able to significantly enhance LUT's release. Moreover, cell viability studies, which examined two promising SDs (one with PEG and one with P188), revealed negligible cytotoxicity, suggesting that the prepared formulations exhibit favorable and non-toxic characteristics. In addition, in vitro assays demonstrated that the formulations retained LUT's anti-inflammatory effect. Finally, ex vivo permeation studies using porc

关键词： Luteolin Oral cavity Oral gel formulations Periodontitis Solid dispersions

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Radiation shielding properties of Nd0.6Sr0.4Mn1−yNiyO3 substitute with different concentrations of nickle

arXiv

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arXiv 2020年

作者： Hamad, M.Kh. Mhareb, M.H.A. Alajerami, Y.S. Sayyed, M.I. Saleh, Gameel Maswadeh, Y. Ziq, Kh.A. Physics Department King Fahd University of Petroleum and Minerals Dhahran31261 Saudi Arabia Department of Physics College of Science Imam Abdulrahman Bin Faisal University P.O. Box 1982 Dammam31441 Saudi Arabia Basic and Applied Scientific Research Center Imam Abdulrahman Bin Faisal University P.O. Box 1982 Dammam31441 Saudi Arabia Physics and Astronomy Science Faculty Ohio University United States Medical Imaging Department Applied Medical Sciences Faculty Al Azhar University-Gaza Department of Physics Faculty of Science University of Tabuk Tabuk Saudi Arabia Department of Biomedical Engineering College of Engineering Imam Abdulrahman Bin Faisal University P.O. Box 1982 Dammam Saudi Arabia Department of Physics and Science of Advanced Materials Program Central Michigan University Mt. PleasantMI48859 United States

In this work, we investigate the effect of Ni concentration on several shielding properties of Nd0.6Sr0.4Mn1−yNiyO3 (0.00≤y≤0.20) perovskite ceramic for possible use as radiation shielding materials. X-ray diffraction (XRD) analysis revealed that these ceramics have the orthorhombic structure with group space Pnma over a wide range of Ni-substitutions. Moreover, the analysis showed a nearly linear decrease in the lattice parameters and the unit cell volume (V) causing a gradual increase in the packing density with increasing Ni concentration. The shielding features for photons, neutrons, and protons of all ceramic samples were assessed. The mass attenuation coefficient (MAC) was computed at 0.1, 0.6, 1.25, 5 and 15 MeV by utilizing (MCNP) (version 5.0);the results were compared with the corresponding values obtained using Phy-X and XCOM program. The results obtained showed slight enhancement with increasing Ni contents. The substitution of Ni leads to progressive enhancement in effective removal cross-section of fast neutron (∑R) values. Whereas the values of Mass Stopping Power (MSP) and projected range for the protons showed a gradual reduction with increasing Ni concentration. These findings suggest that the current ceramic samples can be useful as radiation shielding materials. Copyright © 2020, The Authors. All rights reserved.

关键词： Radiation shielding

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Short-Term Effects of a Therapeutic Diet on Biochemical Parameters in Hemodialysis Patients: A Randomized Crossover Trial

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Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2023年第6期33卷 731-739页

作者： Wan-Chuan Tsai Shih-Ping Hsu Yen-Ling Chiu Hon-Yen Wu Chia-Chin Luan Ju-Yeh Yang Mei-Fen Pai Cheng-Jui Lin Wan-Yu Lin Wen-Huei Sun Yu-Sen Peng Division of Nephrology Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan Center for General Education Lee-Ming Institute of Technology New Taipei City Taiwan. School of Life Science National Taiwan Normal University Taipei City Taiwan. Graduate Program in Biomedical Informatics Yuan Ze University Taoyuan City Taiwan. Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei City Taiwan Faculty of Medicine School of Medicine National Yang-Ming University Taipei City Taiwan. Dietary Department Far Eastern Memorial Hospital New Taipei City Taiwan. Division of Nephrology Department of Internal Medicine Far Eastern Memorial Hospital New Taipei City Taiwan. Division of Nephrology Department of Internal Medicine Mackay Memorial Hospital Taipei City Taiwan Department of Medicine Mackay Medical College Taipei City Taiwan Mackay Junior College of Medicine Nursing and Management Taipei City Taiwan. Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei City Taiwan. Dietary Department Far Eastern Memorial Hospital New Taipei City Taiwan. Electronic address: 830636231@mail.femh.org.tw. Department of Applied Cosmetology Lee-Ming Institute of Technology New Taipei City Taiwan Department of Electrical Engineering Yuan Ze University Taoyuan City Taiwan. Electronic address: taan70@***.

OBJECTIVE:Although unhealthy diets exacerbate nutritional and metabolic derangements in patients with end-stage kidney disease (ESKD), how therapeutic diets that possess a variety of different dietary strategies acutely modify diverse biochemical parameters related to cardiovascular disease remains underexplored. METHODS:Thirty-three adults with end-stage kidney disease undergoing thrice-weekly hemodialysis participated in a randomized crossover trial comparing a therapeutic diet with their usual diets for 7 days, separated by a 4-week washout period. The therapeutic diet was characterized by adequate calorie and protein amounts, natural food ingredients with a low phosphorus-to-protein ratio, higher portions of plant-based food, and high fiber content. The primary outcome measure was the mean difference in the change-from-baseline intact fibroblast growth factor 23 (FGF23) level between the 2 diets. The other outcomes of interest included changes in mineral parameters, uremic toxins, and high-sensitivity C-reactive protein (hs-CRP) levels. RESULTS:Compared with the usual diet, the therapeutic diet lowered intact FGF23 levels (P = .001), decreased serum phosphate levels (P < .001), reduced intact parathyroid hormone (PTH) levels (P = .003), lowered C-terminal FGF23 levels (P = .03), increased serum calcium levels (P = .01), and tended to lower total indoxyl sulfate levels (P = .07) but had no significant effect on hs-CRP levels. Among these changes, reduction in serum phosphate level achieved in 2 days, modifications of intact PTH and calcium levels in 5 days, and reductions in intact and C-terminal FGF23 levels in 7 days of therapeutic diet intervention. CONCLUSION:Within the 1-week intervention period, the dialysis-specific therapeutic diet rapidly reversed mineral abnormalities and tended to decrease total indoxyl sulfate levels in patients undergoing hemodialysis but had no effect on inflammation. Future studies to assess the long-term effects of such therapeuti

关键词： FGF23 dialysis inflammation therapeutic diet uremic toxin

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Development of a pressure sensor system for unobtrusive monitoring of abdominal muscle activities

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Journal of Medical engineering and Technology 2018年第3期42卷 163-174页

作者： Lee, Joonnyong Park, Jonghyun Lee, Kyu Jin Cho, Minkyung Kim, Keewon Kim, Hee Chan Chung, Sun Gun Interdisciplinary Program of Bioengineering Seoul National University Graduate School Seoul Korea Republic of Creta Co. Ltd. Seoul Korea Republic of Department of Rehabilitation Medicine Seoul National University Hospital Seoul Korea Republic of Institute of Medical and Biological Engineering Medical Research Center Department of Biomedical Engineering Seoul National University College of Medicine Seoul Korea Republic of Institute of Aging Seoul National University Seoul Korea Republic of Rheumatism Research Institute Medical Research Center Seoul National University Seoul Korea Republic of

Surface electromyogram (sEMG) is often used by to objectively measure muscular activity during rehabilitation exercises. sEMG is accurate, but it is unsuitable for uses outside the clinic, and patients can benefit from an unobtrusive device which can be readily used to ubiquitously measure abdominal muscle activation. In this study, we present a pressure sensor system which can be latched onto a belt to measure abdominal muscle activation. sEMG and pressure sensor output were measured in 15 healthy young males during isometric trunk flexion exercise (public trials registration number, KCT0002351), and the results were highly correlated (median R > 0.939). As initial contact force can change the pressure sensor sensitivity, the experiment was performed at two different levels of belt tightness, but the correlations did not significantly improve after tightening the belt, suggesting that the system can be used to ubiquitously and unobtrusively monitor abdominal muscle activity with minimal discomfort. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Pressure sensors

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The complete mitogenome of Bagrid catfishChrysichthys nigrodigitatus(Siluriformes: Claroteidae)

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Mitochondrial DNA Part B 2018年第2期3卷 1239-1240页

作者： Nack-Keun Kim Fantong Zealous Gietbong Sapto Andriyono Ah Ran Kim Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Department of Marine Biology Pukyong National University Busan Republic of KoreaKOICA-PKNU International Graduate Program of Fisheries Science Graduate School of Global Fisheries Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Fisheries and Marine Faculty Universitas Airlangga C Campus Jl. Mulyorejo Surabaya East Java Indonesia Department of Marine Biology Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

We here report the complete mitochondrial genome ofChrysichthys nigrodigitatus, which is 16,514 bp in length. Mitogenome ofC. nigrodigitatusshowed the conserved 13 protein-coding genes, 22 tRNA genes, two rRNA genes, and two noncoding regions including the light-strand replication origin (OL) and a putative control region (CR). All tRNA genes were predicted to fold into the typical cloverleaf secondary structures with the typical base-pairing except for tRNA-Ser(AGC). Phylogenetic analysis with currently known complete mitogenome sequences in Siluriformes showed thatC. nigrodigitatusis most closely related toAuchenoglanis occidentalisforming a family Claroteidae cluster.

关键词： Chrysichthys nigrodigitatus mitochondrial genome catfish Cameroon Africa

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scTenifoldXct: A semi-supervised method for predicting cell-cell interactions and mapping cellular communication graphs

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Cell systems 2023年第4期14卷 302-311.e4页

作者： Yongjian Yang Guanxun Li Yan Zhong Qian Xu Yu-Te Lin Cristhian Roman-Vicharra Robert S Chapkin James J Cai Department of Electrical and Computer Engineering Texas A&M University College Station TX 77843 USA. Department of Statistics Texas A&M University College Station TX 77843 USA. Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of Statistics East China Normal University 3663 North Zhongshan Road Shanghai 200062 China. Department of Veterinary Integrative Biosciences Texas A&M University College Station TX 77843 USA. Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan. Department of Nutrition and the Program in Integrative Nutrition & Complex Diseases Texas A&M University College Station TX 77843 USA. Electronic address: r-chapkin@tamu.edu. Department of Electrical and Computer Engineering Texas A&M University College Station TX 77843 USA Department of Veterinary Integrative Biosciences Texas A&M University College Station TX 77843 USA Interdisciplinary Program of Genetics Texas A&M University College Station TX 77843 USA. Electronic address: jcai@tamu.edu.

We present scTenifoldXct, a semi-supervised computational tool for detecting ligand-receptor (LR)-mediated cell-cell interactions and mapping cellular communication graphs. Our method is based on manifold alignment, using LR pairs as inter-data correspondences to embed ligand and receptor genes expressed in interacting cells into a unified latent space. Neural networks are employed to minimize the distance between corresponding genes while preserving the structure of gene regression networks. We apply scTenifoldXct to real datasets for testing and demonstrate that our method detects interactions with high consistency compared with other methods. More importantly, scTenifoldXct uncovers weak but biologically relevant interactions overlooked by other methods. We also demonstrate how scTenifoldXct can be used to compare different samples, such as healthy vs. diseased and wild type vs. knockout, to identify differential interactions, thereby revealing functional implications associated with changes in cellular communication status.

关键词： cell-cell interaction cellular communication gene regression network machine learning manifold alignment neural networks scRNA-seq single-cell RNA sequencing

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