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Toxicity assessment of SARS-CoV-2-derived peptides in combination with a mix of pollutants on zebrafish adults: A perspective study of behavioral, biometric, mutagenic, and biochemical toxicity

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The Science of the total environment 2023年第PT 2期858卷 159838页

作者： Ítalo Nascimento Freitas Amanda Vieira Dourado Amanda Pereira da Costa Araújo Sindoval Silva de Souza Thiarlen Marinho da Luz Abraão Tiago Batista Guimarães Alex Rodrigues Gomes Abu Reza Md Towfiqul Islam Md Mostafizur Rahman Andrés Hugo Arias Davoodbasha Mubarak Ali Chinnasamy Ragavendran Chinnaperumal Kamaraj Guilherme Malafaia Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil. Laboratory of Toxicology Applied to the Environment Goiano Federal Institute Urutaí GO Brazil. Post-Graduation Program in Environmental Sciences Federal University of Goiás Goiânia GO Brazil. Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil. Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil. Begum Rokeya University Department of Disaster Management Rangpur 5404 Bangladesh. Laboratory of Environmental Health and Ecotoxicology Department of Environmental Sciences Jahangirnagar University Dhaka 1342 Bangladesh. Instituto Argentino de Oceanografía (IADO) Universidad Nacional del Sur (UNS)-CONICET Florida 8000 Complejo CCT CONICET Bahía Blanca Edificio E1 B8000BFW Bahía Blanca Argentina. Petroleum and Chemical Engineering Faculty of Engineering Universiti Teknologi Brunei Bandar Seri Begawan BE1410 Brunei Darussalam. Department of Conservative Dentistry and Endodontics Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai India. Interdisciplinary Institute of Indian System of Medicine (IIISM) Directorate of Research and Virtual Education SRM Institute of Science and Technology (SRMIST) Kattankulathur 603203 Tamil Nadu India. Post-Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlândia Uberlândia MG Brazil Post-Graduation Program in Biotechnology and Biodiversity Federal University of Goiás Goiânia GO Brazil Post-Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutaí GO Brazil. Electronic address: guilhermeifgoiano@***.

The dispersion of SARS-CoV-2 in aquatic environments via the discharge of domestic and hospital sewage has been confirmed in different locations. Thus, we aimed to evaluate the possible impacts of zebrafish (Danio rerio) exposure to SARS-CoV-2 peptide fragments (PSPD-2001, 2002, and 2003) alone and combined with a mix of emerging pollutants. Our data did not reveal the induction of behavioral, biometric, or mutagenic changes. But we noticed an organ-dependent biochemical response. While nitric oxide and malondialdehyde production in the brain, gills, and muscle did not differ between groups, superoxide dismutase activity was reduced in the "PSPD", "Mix", and "Mix+PSPD" groups. An increase in catalase activity and a reduction in DPPH radical scavenging activity were observed in the brains of animals exposed to the treatments. However, the "Mix+PSPD" group had a higher IBRv2 value, with NO levels (brain), the reduction of acetylcholinesterase activity (muscles), and the DPPH radical scavenging activity (brain and muscles), the most discriminant factors for this group. The principal component analysis (PCA) and hierarchical clustering analysis indicated a clear separation of the "Mix+PSPD" group from the others. Thus, we conclude that exposure to viral fragments, associated with the mix of pollutants, induced more significant toxicity in zebrafish adults than in others.

关键词： Biomarkers COVID-19 Danio rerio Freshwater ecosystems Non-target organisms Novel coronavirus

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Quats stabilized gold nanospheres for efficient ligand exchange procedure

Results in Materials

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Results in Materials 2020年 5卷

作者： Muniba Naz, Gul Anjum, Muhammad Naeem Irfan, Muhammad Irfan, Masooma Arshad, Muhammad Bajwa, Sadia Z. Khan, Waheed S. Department of Physics Faculty of Science The Islamia University of Bahawalpur Baghdad-ul-Jadid Campus Bahawalpur 63100 Pakistan Interdisciplinary Research Centre in Biomedical Materials (IRCBM) COMSATS University Islamabad Lahore Campus Defence Road Off Raiwind Road Lahore Pakistan Department of Chemistry COMSATS University Islamabad Lahore Campus Defence. Road Off Raiwind Road Lahore Pakistan Nanosciences and Nanotechnology Department National Cener for Physics Quaid-i-Azam University Islamabad Pakistan National Institute for Biotechnology and Genetic Engineering (NIBGE) Faisalabad Pakistan

In present work, fine spherical shaped gold nanoparticles are prepared by using a new type of quaternary ammonium cationic surfactant (quats) i.e. didecyldimethylammonium chloride (DDAC) following one step room temperature method. Optical characterization and crystal symmetry has been observed through UV–Vis spectroscopy and XRD analysis, respectively. DDAC coated gold nanospheres (GNSs) are also analysed by using FTIR technique in order to observe binding of the ligand onto the surface of gold. Ligand weight loss has been determined by using TGA technique. Particle size has been examined by using TEM and DLS techniques both. Stability of DDAC coated gold nanoparticles are also examined by using Zeta-potential. A comparison of stabilities of different quats stabilized gold nanoparticles (GNPs) has also been discussed in the present work. Unlike usual CTAB and CTAC ligands, the low binding affinity of DDAC to the gold surface may be more efficient for ligand-exchange procedure. A sharp and fine peak of PL spectrum at around 600 nm has been noticed for these GNSs. These luminescent, monodispersed and fine spherical shaped GNPs of size less than 40 nm can be valuable in plasmonics and single molecular tracking for further characterizations. © 2020 The Author(s)

关键词： Didecyldimethylammonium chloride (DDAC) Gold nanospheres Ligand exchange Visible luminescence and single molecular tracking

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Coordinating the Mechanisms of Action of Ferroptosis and the Photothermal Effect for Cancer Theranostics

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Angewandte Chemie 2021年第13期134卷

作者： Fantian Zeng Dr. Longguang Tang Qianyu Zhang Changrong Shi Zicheng Huang Sureya Nijiati Prof. Xiaoyuan Chen Dr. Zijian Zhou State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 P. R. China International Institutes of Medicine The Fourth Affiliated Hospital of Zhejiang University School of Medicine Yiwu Zhejiang 322000 P. R. China Departments of Diagnostic Radiology and Surgery Clinical Imaging Research Centre Centre for Translational Medicine Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine Departments of Chemical and Biomolecular Engineering and Biomedical Engineering Faculty of Engineering National University of Singapore Singapore 117597 Singapore

Combination therapy based on different mechanisms of cell death has shown promise in tumor therapy. However, when different modalities are integrated, the maximum synergy of the therapeutic effects is often lacking in the design. Herein, we report a cancer theranostic nanomedicine formula developed by considering the mechanisms of action of ferroptosis and the photothermal effect in combination therapy. The croconaine molecule was encapsulated as both a photothermal converter and an iron-chelating agent with BSA, thus leading to biocompatible and stable Cro-Fe@BSA nanoparticles (NPs). The Cro-Fe@BSA NPs in the tumor milieu showed an activated photothermal effect leading to enhanced radical formation owing to the temperature-dependent Fenton reaction kinetics, while radical formation during ferroptosis in turn prevented the heat-induced formation of heat shock proteins and thus the self-protection mechanism of cancer cells in response to heat. The activatable photoacoustic and magnetic resonance imaging performance of the Cro-Fe@BSA NPs also enabled safe and reliable cancer theranostics.

关键词： Cancer theranostics Combination therapy Ferroptosis Nanotechnology Photothermal effect

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The Chemistry of Organic Contrast Agents in the NIR-II Window

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Angewandte Chemie 2021年第14期134卷

作者： Dr. Jing Mu Ming Xiao Dr. Yu Shi Xuewen Geng Dr. Hui Li Prof. Yuxin Yin Prof. Xiaoyuan Chen Institute of Precision Medicine Peking University Shenzhen Hospital Shenzhen 518036 China Department of Biology University of Rochester Rochester NY 14627 USA Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

Optical imaging, especially fluorescence and photoacoustic imaging, is a non-invasive imaging approach with high spatial and temporal resolution and high sensitivity, compared to positron emission tomography (PET) or magnetic resonance imaging (MRI). Due to the merits of imaging using the second near-infrared (NIR-II) window, like deeper penetration depth, high signal-to-noise ratio, high resolution, and low tissue damage, researchers have devoted great effort to developing contrast agents with NIR-II absorption or emission. In this Review, we summarize recently developed organic luminescent and photoacoustic materials, ranging from small molecules to conjugated polymers. Then, we systematically introduce engineering strategies and describe the imaging performance classified by the skeleton cores. Finally, we elucidate the challenges and prospects of these NIR-II organic dyes for potential clinical applications. We expect our summary can inspire researchers to expand the spectrum of NIR-II contrast agents for diverse bioapplications.

关键词： fluorescence imaging organic fluorophores photoacoustic imaging second near-infrared (NIR-II)

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Cover Picture: Addressing Environmental Challenges of Porphyrin Mixtures Obtained from Statistical Syntheses (Chemistry - Methods 3/2021)

Chemistry–Methods

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Chemistry–Methods 2021年第3期1卷

作者： Helen Hölzel Maximilian Muth Prof. Dr. Dominik Lungerich Prof. Dr. Norbert Jux Department of Chemistry and Pharmacy & Interdisciplinary Center for Molecular Materials (ICMM) Friedrich-Alexander-University Erlangen-Nuernberg Nikolaus-Fiebiger-Str. 10 91058 Erlangen Germany Center for Nanomedicine Institute for Basic Science (IBS) 50 Yonsei-ro Seodaemun-gu Seoul 03722 South Korea Graduate Program for Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 South Korea

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Community-developed checklists for publishing images and image analyses

arXiv

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arXiv 2023年

作者： Schmied, Christopher Nelson, Michael S. Avilov, Sergiy Bakker, Gert-Jan Bertocchi, Cristina Bischof, Johanna Boehm, Ulrike Brocher, Jan Carvalho, Mariana Chiritescu, Catalin Christopher, Jana Cimini, Beth A. Conde-Sousa, Eduardo Ebner, Michael Ecker, Rupert Eliceiri, Kevin Fernandez-Rodriguez, Julia Gaudreault, Nathalie Gelman, Laurent Grunwald, David Gu, Tingting Halidi, Nadia Hammer, Mathias Hartley, Matthew Held, Marie Jug, Florian Kapoor, Varun Koksoy, Ayse Aslihan Lacoste, Judith Le Dévédec, Sylvia Le Guyader, Sylvie Liu, Penghuan Martins, Gabriel G. Mathur, Aastha Miura, Kota Llopis, Paula Montero Nitschke, Roland North, Alison Parslow, Adam C. Payne-Dwyer, Alex Plantard, Laure Ali, Rizwan Schroth-Diez, Britta Schütz, Lucas Scott, Ryan T. Seitz, Arne Selchow, Olaf Sharma, Ved P. Spitaler, Martin Srinivasan, Sathya Strambio-De-Castillia, Caterina Taatjes, Douglas Tischer, Christian Jambor, HelenaKlara Fondazione Human Technopole Viale Rita Levi-Montalcini 1 Milano20157 Italy Department of Biomedical Engineering University of Wisconsin-Madison MadisonWI53706 United States Max Planck Institute of Immunobiology and Epigenetics Freiburg79108 Germany Medical BioSciences department Radboud University Medical Centre Nijmegen Netherlands Laboratory for Molecular mechanics of cell adhesions Pontificia Universidad Católica de Chile Santiago Chile Osaka University Graduate School of Engineering Science Japan Euro-BioImaging ERIC Bio-Hub Meyerhofstr. 1 Heidelberg69117 Germany Carl Zeiss AG Carl-Zeiss-Straße 22 Oberkochen73447 Germany BioVoxxel Scientific Image Processing and Analysis Eugen-Roth-Strasse 8 Ludwigshafen67071 Germany Nanophotonics and BioImaging Facility at INL International Iberian Nanotechnology Laboratory 4715-330 Portugal Phi Optics Inc. 1800 S. Oak St Ste 106 ChampaignIL61820 United States Biochemistry Center Heidelberg Heidelberg University Germany Imaging Platform Broad Institute CambridgeMA02142 United States i3S Instituto de Investigação e Inovação Em Saúde and INEB Instituto de Engenharia Biomédica Universidade do Porto Porto Portugal Translational Research Institute Queensland University of Technology 37 Kent Street WoolloongabbaQLD4102 Australia School of Biomedical Sciences Faculty of Health Queensland University of Technology BrisbaneQLD4059 Australia TissueGnostics GmbH Vienna1020 Austria Department of Medical Physics and Biomedical Engineering University of Wisconsin-Madison MadisonWI53706 United States Centre for Cellular Imaging Core Facility Sahlgrenska Academy University of Gothenburg Sweden Allen Institute for Cell Science SeattleWA United States Friedrich Miescher Institute for Biomedical Research Basel Switzerland RNA Therapeutics Institute University of Massachusetts Chan Medical School WorcesterMA01605 United States University of Oklahoma NormanOK United States Advanced Light Microscopy Unit Ce

Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However for scientists wishing to publish the obtained images and image analyses results, there are to date no unified guidelines. Consequently, microscopy images and image data in publications may be unclear or difficult to interpret. Here we present community-developed checklists for preparing light microscopy images and image analysis for publications. These checklists offer authors, readers, and publishers key recommendations for image formatting and annotation, color selection, data availability, and for reporting image analysis workflows. The goal of our guidelines is to increase the clarity and reproducibility of image figures and thereby heighten the quality and explanatory power of microscopy data is in publications. © 2023, CC BY-SA.

关键词： Image analysis

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Evaluation on requirements of nuclear medicine facility building

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AIP Conference Proceedings 2019年第1期2180卷

作者： Anita Nur Mayani Basari 1Biomedical Engineering Course Program Departement of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 2Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia

Nuclear medicine is one of medical fields that uses ionizing radiation sources for therapeutic and diagnostic imaging for cancer. The number of nuclear medicine services in Indonesia is 17 hospitals, which only 10 is active in conducting nuclear medicine services because it doesn’t meet the requirements. Regulations about the standards of nuclear medicine services Indonesia are regulated by KMK number 008/MENKES/SK/I/2009 but it have not yet been discussed the requirements in details for building design and layout design as reference. For this reason, the author did study about the requirements of a nuclear medical service facility referring to KMK number 008/MENKES/SK/I/2009 and the International Health Facility Guidelines to create layout design of nuclear medicine facility. This study is done by comparing national and international regulation for planning criteria and construct layout design of nuclear medicine facility as recommendation to accomplish the regulations in Ministry of Health decree, Republic of Indonesia number 008/MENKES/SK/I/2009 regarding nuclear medical requirements.

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0032 Timing of Daily Rhythm of Cardiac Autonomic Control Contributes to Weight Loss Resistance, Independent of Daily Energy Intake and Physical Activity Level

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Sleep 2020年第SUPPLEMENT_1期43卷 A13-A13页

作者： Yang, H Garaulet, M Li, P Bandin, C Lin, C Lo, M Hu, K Medical Biodynamcis Program Division of Sleep and Circadian Disorders Departments of Medicine and Neurology Brigham and Women’s Hospital Boston MA Department of Physiology University of Murcia Murcia SPAIN Institute of Translational and Interdisciplinary Medicine and Department of Biomedical Sciences and Engineering National Central University Taoyuan TAIWAN

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A Serotonergic Axon-Cilium Synapse Drives Nuclear Signaling to Maintain Chromatin Accessibility

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 1091-1091页

作者： Sheu, Shu-Hsien Upadhyayula, Srigokul Dupuy, Vincent Pang, Song Deng, Fei Wan, Jinxia Walpita, Deepika Pasolli, H Amalia Houser, Justin Sanchez-Martinez, Silvia Brauchi, Sebastian E. Banala, Sambashiva Freeman, Melanie Xu, C Shan Kirchhausen, Tom Hess, Harald F. Lavis, Luke Li, Yulong Chaumont-Dubel, Séverine Clapham, David E. Janelia Research Campus Ashburn VA United States Harvard Medical School Boston MA United States Boston Children's Hospital Department of Pathology Boston MA United States HHMI Boston Children's Hospital Department of Cardiology Boston MA United States Advanced Bioimaging Center University of California at Berkeley Berkeley CA United States Department of Molecular and Cell Biology University of California at Berkeley Berkeley CA United States Institut de Génomique Fonctionnelle Université de Montpellier CNRS INSERM Montpellier France School of Life Sciences Peking University Beijing China Current address: The Rockefeller University New York NY USA Program in Cellular and Molecular Medicine Boston Children's Hospital Boston MA United States Current address: Department of Biomedical Engineering University of Texas at Austin Austin TX United States Current address: The University of Wyoming Laramie WY United States Department of Physiology Faculty of Medicine Universidad Austral de Chile Valdivia Chile Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD) Valdivia Chile Department of Cell Biology Harvard Medical School Boston MA United States Department of Pediatrics Harvard Medical School Boston MA United States

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Positive Feedback Mechanisms among Local Ca Releases, NCX, and I_CaL Ignite Pacemaker Action Potentials (vol 114, pg 1176, 2018)

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BIOPHYSICAL JOURNAL 2018年第8期114卷 2024-2024页

作者： Lyashkov, Alexey E. Behar, Joachim Lakatta, Edward G. Yaniv, Yael Maltsev, Victor A. Laboratory of Cardiovascular Science Biomedical Research Center Intramural Research Program National Institute on Aging NIH Baltimore Maryland Biomedical Engineering Faculty Technion-IIT Haifa Israel [∗]Corresponding author [∗∗]Corresponding author

Recent data suggest that cardiac pacemaker cell function is determined by numerous time-, voltage-, and Ca-dependent interactions of cell membrane electrogenic proteins (M-clock) and intracellular Ca cycling proteins (Ca-clock), forming a coupled-clock system. Many aspects of the coupled-clock system, however, remain underexplored. The key players of the system are Ca release channels (ryanodine receptors), generating local Ca releases (LCRs) from sarcoplasmic reticulum, electrogenic Na/Ca exchanger (NCX) current, and L-type Ca current (I_CaL). We combined numerical model simulations with experimental simultaneous recordings of action potentials (APs) and Ca to gain further insight into the complex interactions within the system. Our simulations revealed a positive feedback mechanism, dubbed AP ignition, which accelerates the diastolic depolarization (DD) to reach AP threshold. The ignition phase begins when LCRs begin to occur and the magnitude of inward NCX current begins to increase. The NCX current, together with funny current and T-type Ca current accelerates DD, bringing the membrane potential to I_CaL activation threshold. During the ignition phase, I_CaL-mediated Ca influx generates more LCRs via Ca-induced Ca release that further activates inward NCX current, creating a positive feedback. Simultaneous recordings of membrane potential and confocal Ca images support the model prediction of the positive feedback among LCRs and I_CaL, as diastolic LCRs begin to occur below and continue within the voltage range of I_CaL activation. The ignition phase onset (identified within the fine DD structure) begins when DD starts to notably accelerate (∼0.15 V/s) above the recording noise. Moreover, the timing of the ignition onset closely predicted the duration of each AP cycle in the basal state, in the presence of autonomic receptor stimulation, and in response to specific inhibition of either the M-clock or Ca-clock, th

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