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4th International Conference on Photonics, Optics and Laser Technology, PHOTOPTICS 2016

作者： Jo, Songhyun Park, Kyoungsoo Choi, Sung Wook Lee, Seul Lee Jeong, Jun Hyeog Kim, Jihoon Lee, Yong Wook School of Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University 45 Yongso-ro Nam-gu Busan608-737 Korea Republic of School of Electrical Engineering Pukyong National University 45 Yongso-ro Nam-gu Busan608-737 Korea Republic of

ISBN: (纸本)9789897581748

The output states of polarization (SOP's) were investigated within the bandwidth of a filter channel (0.8 nm) for a variety of optical fiber comb filters based on polarization-diversity loop structure including a zerothorder comb filter, first-order Lyot-type and Solc-type comb filters, and a second-order Solc-type comb filter. The output SOP's (SOPout's) of the filters were calculated at a flat-top band operation mode of each filter for four different input SOP's (SOPin's) except for the zeroth-order filter. It was found that the SOPout of each filter had unique dependence on wavelength. Specifically, the SOPout's of first-order and second-order comb filters vary periodically with spectral periods of a channel bandwidth (0.8 nm) and its half (0.4 nm), respectively. If an output linear polarizer is located at the output port of each filter, the specific portion of transmission spectra can be passed or rejected, and the rejected band can be continuously tuned in a limited wavelength range by controlling the SOPin. Moreover, the SOPin can be figured out by analyzing the location of the spectral dip at the output transmission spectra obtained above by using the output polarizer. © Copyright 2016 by SCITEPRESS-Science and Technology Publications, Lda. All rights reserved.

关键词： Polarization-maintaining fiber

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Author Correction: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder

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Nature communications 2023年第1期14卷 6067页

作者： Aurélie de Thonel Johanna K Ahlskog Kevin Daupin Véronique Dubreuil Jérémy Berthelet Carole Chaput Geoffrey Pires Camille Leonetti Ryma Abane Lluís Cordón Barris Isabelle Leray Anna L Aalto Sarah Naceri Marine Cordonnier Carène Benasolo Matthieu Sanial Agathe Duchateau Anniina Vihervaara Mikael C Puustinen Federico Miozzo Patricia Fergelot Élise Lebigot Alain Verloes Pierre Gressens Didier Lacombe Jessica Gobbo Carmen Garrido Sandy D Westerheide Laurent David Michel Petitjean Olivier Taboureau Fernando Rodrigues-Lima Sandrine Passemard Délara Sabéran-Djoneidi Laurent Nguyen Madeline Lancaster Lea Sistonen Valérie Mezger Université de Paris CNRS Epigenetics and Cell Fate F-75013 Paris France. aurelie.dethonel@univ-paris-diderot.fr. Faculty of Science and Engineering Cell Biology Åbo Akademi University Turku Finland. Turku Bioscience Centre University of Turku and Åbo Akademi University Turku Finland. Université de Paris CNRS Epigenetics and Cell Fate F-75013 Paris France. Université de Paris CNRS Unité de Biologie Fonctionnelle et Adaptative Paris France. Ksilink Strasbourg France. Laboratory of Molecular Regulation of Neurogenesis GIGA-Stem Cells and GIGA-Neurosciences Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R) University of Liège CHU Sart Tilman Liège Belgium. Université de Nantes CHU Nantes Inserm CNRS SFR Santé Inserm UMS 016 CNRS UMS 3556 F-44000 Nantes France. INSERM UMR1231 Laboratoire d'Excellence LipSTIC Dijon France. University of Bourgogne Franche-Comté Dijon France. Département d'Oncologie médicale Centre Georges-François Leclerc Dijon France. CNRS UMR 7592 Institut Jacques Monod F-75205 Paris France. KTH Royal Institute of Technology Stockholm Sweden. Neuroscience Institute-CNR (IN-CNR) Milan Italy. Department of Medical Genetics University Hospital of Bordeaux Bordeaux France and INSERM U1211 University of Bordeaux Bordeaux France. Service de Biochimie-pharmaco-toxicologie Hôpital Bicêtre Hopitaux Universitaires Paris-Sud 94270 Le Kremlin Bicêtre Paris-Sud France. Université de Paris INSERM NeuroDiderot Robert-Debré Hospital F-75019 Paris France. Genetics Department AP-HP Robert-Debré University Hospital Paris France. Department of Cell Biology Microbiology and Molecular Biology College of Arts and Sciences University of South Florida Tampa FL USA. MRC Laboratory of Molecular Biology Cambridge Biomedical Campus Cambridge UK. Université de Paris CNRS Epigenetics and Cell Fate F-75013 Paris France. valerie.mezger@univ-paris-diderot.fr.

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Simulated CT scanner for educational purpose

Simulated CT scanner for educational purpose

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biomedical engineering International Conference (BMEiCON)

作者： Aniwat Juhong Chuchart Pintavirooj Biomedical Engineering Program Faculty of Engineering King Mongkut's Institute of Technology Ladkrabang Bangkok Thailand

ISBN: (纸本)9781509039418

Computed Tomography is a technique to reconstruct an image of trans-axial slab of the object from a series of x-ray radiographs taken at a prior-known angle. Sequences of x-ray radiographs are served as two-dimensional projection data for a 3D tomography. The most popular Feldkamp Algorithm which is based on Filtered Backprojection (FBP) approaches has shown to perform well for 3D reconstruction. Conventional x-ray computed tomography was implemented on a c-arm x-ray apparatus where the x-ray tube and detector is capable of rotating to capture radiograph at any specific angle. In this paper, we designed the simulated computed tomography that can be used for educational purpose. A number of digital cameras are attached on the rotating gantry to capture a series of image around the object. This mimics a conebeam projection for computed tomography. In order to design the embedded system, Raspberry Pi is used as the main microcontroller which acts as data acquisition system. All projection data are sent to cloud server which is later download to PC for further processing.

关键词： Three-dimensional displays Image reconstruction Computed tomography Cameras Shape X-ray imaging

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Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

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Scientific data 2021年第1期8卷 242页

作者： Julien Cohen-Adad Eva Alonso-Ortiz Mihael Abramovic Carina Arneitz Nicole Atcheson Laura Barlow Robert L Barry Markus Barth Marco Battiston Christian Büchel Matthew Budde Virginie Callot Anna J E Combes Benjamin De Leener Maxime Descoteaux Paulo Loureiro de Sousa Marek Dostál Julien Doyon Adam Dvorak Falk Eippert Karla R Epperson Kevin S Epperson Patrick Freund Jürgen Finsterbusch Alexandru Foias Michela Fratini Issei Fukunaga Claudia A M Gandini Wheeler-Kingshott Giancarlo Germani Guillaume Gilbert Federico Giove Charley Gros Francesco Grussu Akifumi Hagiwara Pierre-Gilles Henry Tomáš Horák Masaaki Hori James Joers Kouhei Kamiya Haleh Karbasforoushan Miloš Keřkovský Ali Khatibi Joo-Won Kim Nawal Kinany Hagen H Kitzler Shannon Kolind Yazhuo Kong Petr Kudlička Paul Kuntke Nyoman D Kurniawan Slawomir Kusmia René Labounek Maria Marcella Laganà Cornelia Laule Christine S Law Christophe Lenglet Tobias Leutritz Yaou Liu Sara Llufriu Sean Mackey Eloy Martinez-Heras Loan Mattera Igor Nestrasil Kristin P O'Grady Nico Papinutto Daniel Papp Deborah Pareto Todd B Parrish Anna Pichiecchio Ferran Prados Àlex Rovira Marc J Ruitenberg Rebecca S Samson Giovanni Savini Maryam Seif Alan C Seifert Alex K Smith Seth A Smith Zachary A Smith Elisabeth Solana Y Suzuki George Tackley Alexandra Tinnermann Jan Valošek Dimitri Van De Ville Marios C Yiannakas Kenneth A Weber Ii Nikolaus Weiskopf Richard G Wise Patrik O Wyss Junqian Xu NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. jcohen@polymtl.ca. Functional Neuroimaging Unit CRIUGM Université de Montréal Montreal QC Canada. jcohen@polymtl.ca. Mila - Quebec AI Institute Montreal QC Canada. jcohen@polymtl.ca. NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal QC Canada. Department of Radiology Swiss Paraplegic Centre Nottwil Switzerland. Centre for Advanced Imaging The University of Queensland Brisbane Australia. Department of Radiology University of British Columbia Vancouver BC Canada. Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Charlestown MA USA. Department of Radiology Harvard Medical School Boston MA USA. Harvard-Massachusetts Institute of Technology Health Sciences & Technology Cambridge MA USA. School of Information Technology and Electrical Engineering The University of Queensland Brisbane Australia. NMR Research Unit Queen Square MS Centre UCL Queen Square Institute of Neurology Faculty of Brain Sciences University College London London UK. Department of Systems Neuroscience University Medical Center Hamburg-Eppendorf Hamburg Germany. Department of Neurosurgery Medical College of Wisconsin Milwaukee WI USA. Aix-Marseille Univ CNRS CRMBM Marseille France. APHM Hopital Universitaire Timone CEMEREM Marseille France. Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center Nashville TN USA. Department of Computer and Software Engineering Polytechnique Montreal Montreal Canada. CHU Sainte-Justine Research Centre Montreal QC Canada. Centre de Recherche CHUS CIMS Sherbrooke Canada. Sherbrooke Connectivity Imaging Lab (SCIL) Computer Science department Université de Sherbrooke Sherbrooke Canada. Université de Strasbourg CNRS ICube Strasbourg France. UHB - University Hospital Brno and Masaryk University Department of Radiology and Nuclear

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Nucleic Acid Amplification: Mie Scatter and Interfacial Tension Based Real-Time Quantification of Colloidal Emulsion Nucleic Acid Amplification (Adv. Biosys. 10/2017)

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Advanced Biosystems 2017年第10期1卷

作者： Ariana M. Nicolini Tyler D. Toth Samuel Y. Kim M. Alejandra Mandel David W. Galbraith Jeong-Yeol Yoon Biomedical Engineering Graduate Interdisciplinary Program and Department of Biomedical Engineering The University of Arizona Tucson AZ 85721 USA School of Plant Sciences The University of Arizona Tucson AZ 85721 USA

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Robot-arm control system using LEAP motion controller

Robot-arm control system using LEAP motion controller

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International Conference on biomedical engineering (BME-HUST)

作者： Y. Pititeeraphab P. Choitkunnan N. Thongpance K. Kullathum Ch. Pintavirooj Faculty of Biomedical Engineering Rangsit University Pathumthani Thailand Biomedical Engineering Program King Mongkut's Institute of Technology Ladkrabang Thailand

ISBN: (纸本)9781509011001

The objective of this research was to design and construction of the system for control robot arm using LEAP Motion Controller. This research has adapted the principle of LEAP Motion Controller and servo motor control. The designed and constructed the project was composed of 3 main parts: 1) detector part, 2) signal control and processing part using microcontroller ATMEL 328 on board (Arduino UNO R3) and 3) display part consists of a robotic arm with a handle two inches. The results of functional testing shown that the system can handle and control the movement of the robot arm to the objectives of the project.

关键词： High definition video Manipulators Reactive power Servomotors Motor drives

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2D Transition Metal Dichalcogenide: Unraveling High-Yield Phase-Transition Dynamics in Transition Metal Dichalcogenides on Metallic Substrates (Adv. Sci. 7/2019)

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Advanced Science 2019年第7期6卷 1970042-1970042页

作者： Xinmao Yin Chi Sin Tang Di Wu Weilong Kong Changjian Li Qixing Wang Liang Cao Ming Yang Yung-Huang Chang Dianyu Qi Fangping Ouyang Stephen J. Pennycook Yuan Ping Feng Mark B. H. Breese Shi Jie Wang Wenjing Zhang Andrivo Rusydi Andrew T. S. Wee Department of Physics Faculty of Science National University of Singapore Singapore 117542 Singapore Singapore Synchrotron Light Source (SSLS) National University of Singapore Singapore 117603 Singapore NUS Graduate School for Integrative Sciences and Engineering National University of Singapore Singapore 117456 Singapore International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Shenzhen University Shenzhen 518060 China Hunan Key Laboratory of Super-microstructure and Ultrafast Process School of Physics and Electronics Central South University No. 932 South Lushan Road Changsha Hunan Province 410083 China Department of Materials Science and Engineering National University of Singapore 9 Engineering Drive 1 Singapore 117575 Singapore Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory of the Chinese Academy of Sciences Hefei 230031 China Institute of Materials Research and Engineering A∗STAR (Agency for Science Technology and Research) 2 Fusionopolis Way Singapore 138634 Singapore Bachelor Program in Interdisciplinary Studies National Yunlin University of Science and Technology Yunlin 640 Taiwan

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PO-438 Hyperthermia as neoadjuvant treatment for pancreatic tumours in murine models

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ESMO Open 2018年 3卷 A403-A403页

作者： Krzykawska-Serda, M. Ware, M.J. Lapin, N. Agha, M. Ho, J. Law, J. Newton, J. Nguyen, L. Curley, S. Corr, S. Faculty of Biochemistry- Biophysics and Biotechnology- Jagiellonian University Biophysics Krakow Poland Baylor Collage of Medicine Surgery Houston USA Baylor College of Medicine Interdepartmental program in Translational Biology and Molecular Medicine Houston USA Swansea University School of Medicine Swansea UK University of Houston Biomedical Engineering Houston USA Rice University Mechanical Engineering and Materials Science Houston USA

ABSTRACTIntroductionPancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. The hallmarks of this malignancy, such as it’s deprived vasculature, dense tumour stroma and hypoxic tumour microenvironment are some of the reasons for very poor chemotherapy and radiotherapy treatment efficacy. In these regards, a new combinatory treatment regimen was proposed: 1 non-invasive radiofrequency (RF) hyperthermia treatment to increase tumour perfusion, enhance cancer cell death and immune system stimulus; 2 chemotherapy regiment with Gemzar and Abraxane. Material and methodsOrthotropic and subcutaneous models of PDAC were induce by injection of PANC-1, AsPc-1 and Pan_O2 cancer cells into Balb/c nude or C57BL/6J mice. Tumour growth was monitored via ultrasound VEVO2100. Tumour perfusion after hyperthermia was monitored via intravital confocal microscopy and ultrasound microbubble contrast imaging. The tumour active vasculature was investigated using Doppler imaging. The chemotherapy with Gemzar and Abraxane was administered in combination with RF hyperthermia. A portable-RF system was used to produce local hyperthermia in the tumour tissue. The device is powered by 200 W and emits 13.56 MHz electric fields. The entire treatment scheme was repeated a total of 6 times at 72 hour time intervals (Q3D × 6 protocol) resulting in 16 days of treatment. The variety of histochemistry staining was performed post mortem to show the influence of treatment on the tumour vasculature and the degree of perfusion and necrosis. Results and discussionsWe showed that RF hyperthermia treatment as a neoadjuvant therapy can be promising for PDAC treatment. However, the effect is still unpredictable and depends on pre-existing tumour physiology before therapy. We established the most effective RF hyperthermia procedure to increase drug perfusion into tumour tissue (41°C for 20–30 min). We studied a variety of chemotherapy dosages to adjust clinical protocols into mouse mode

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National identity predicts public health support during a global pandemic (vol 13, 517, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-14页

作者： Van Bavel, Jay J. Cichocka, Aleksandra Capraro, Valerio Sjastad, Hallgeir Nezlek, John B. Pavlovic, Tomislav Alfano, Mark Gelfand, Michele J. Azevedo, Flavio Birtel, Michele D. Cislak, Aleksandra Lockwood, Patricia L. Ross, Robert Malcolm Abts, Koen Agadullina, Elena Aruta, John Jamir Benzon Besharati, Sahba Nomvula Bor, Alexander Choma, Becky L. Crabtree, Charles David Cunningham, William A. De, Koustav Ejaz, Waqas Elbaek, Christian T. Findor, Andrej Flichtentrei, Daniel Franc, Renata Gjoneska, Biljana Gruber, June Gualda, Estrella Horiuchi, Yusaku Huynh, Toan Luu Duc Ibanez, Agustin Imran, Mostak Ahamed Israelashvili, Jacob Jasko, Katarzyna Kantorowicz, Jaroslaw Kantorowicz-Reznichenko, Elena Krouwel, Andre Laakasuo, Michael Lamm, Claus Leygue, Caroline Lin, Ming-Jen Mansoor, Mohammad Sabbir Marie, Antoine Mayiwar, Lewend Mazepus, Honorata McHugh, Cillian Minda, John Paul Mitkidis, Panagiotis Olsson, Andreas Otterbring, Tobias Packer, Dominic J. Perry, Anat Petersen, Michael Bang Puthillam, Arathy Riano-Moreno, Julian C. Rothmund, Tobias Santamaria-Garcia, Hernando Schmid, Petra C. Stoyanov, Drozdstoy Tewari, Shruti Todosijevic, Bojan Tsakiris, Manos Tung, Hans H. Umbres, Radu G. Vanags, Edmunds Vlasceanu, Madalina Vonasch, Andrew Yucel, Meltem Zhang, Yucheng Abad, Mohcine Adler, Eli Akrawi, Narin Mdarhri, Hamza Alaoui Amara, Hanane Amodio, David M. Antazo, Benedict G. Apps, Matthew Ay, F. Ceren Ba, Mouhamadou Hady Barbosa, Sergio Bastian, Brock Berg, Anton Bernal-Zarate, Maria P. Bernstein, Michael Bialek, Michal Bilancini, Ennio Bogatyreva, Natalia Boncinelli, Leonardo Booth, Jonathan E. Borau, Sylvie Buchel, Ondrej Cameron, C. Daryl Carvalho, Chrissie F. Celadin, Tatiana Cerami, Chiara Chalise, Hom Nath Cheng, Xiaojun Cian, Luca Cockcroft, Kate Conway, Jane Cordoba-Delgado, Mateo Andres Crespi, Chiara Crouzevialle, Marie Cutler, Jo Cypryanska, Marzena Dabrowska, Justyna Daniels, Michael A. Davis, Victoria H. Dayley, Pamala N. Delouvee, Sylvain Denkovski, Ognjan Dezecache, Guillaume Dhaliwal, Nathan A. Diato, Department of Psychology and Neural Science New York University New York NY USA Department of Psychology University of Amsterdam Amsterdam Netherlands School of Psychology University of Kent Canterbury England Department of Economics Middlesex University London London England Department of Strategy and Management Norwegian School of Economics Bergen Norway SWPS University of Social Sciences and Humanities Poznań Poland Department of Psychological Sciences College of William and Mary Williamsburg VA USA Institute of Social Sciences Ivo Pilar Zagreb Croatia Department of Philosophy Macquarie University Sydney NSW Australia Stanford Graduate School of Business Stanford University Stanford CA USA Institute of Communication Science Friedrich-Schiller University Jena Jena Germany School of Human Sciences Institute for Lifecourse Development University of Greenwich London England Department of Experimental Psychology University of Oxford Oxford England Center for Human Brain Health School of Psychology University of Birmingham Birmingham England Department of Psychology Macquarie University Sydney NSW Australia KU Leuven Leuven Belgium National Research University Higher School of Economics (HSE) Moscow Russia De La Salle University Manila Philippines Department of Psychology University of the Witwatersrand Johannesburg South Africa Department of Political Science Aarhus University Aarhus Denmark X University Toronto Canada Department of Government Dartmouth College Hanover NH USA Department of Psychology University of Toronto Toronto ON Canada Gatton College of Business and Economics University of Kentucky Lexington KY USA Department of Mass Communication National University of Science and Technology (NUST) Islamabad Pakistan Department of Management Aarhus University Aarhus Denmark Center for Advanced Hindsight Duke University Durham NC USA Faculty of Social and Economic Sciences Comenius University Bratislava Slovakia IntraMed B

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1,N= 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N= 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r= −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.

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Metabolic profile of biodiverse diets in a healthy European cohort

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The American journal of clinical nutrition 2025年

作者： Bernadette Chimera Emine Koc Cakmak Jessica Blanco-Lopez Jeroen Berden Carine Biessy Pekka Keski-Rahkonen Geneviève Nicolas Justine Berlivet Carl Lachat Bernard Srour Kris A Murray Paolo Vineis Mathilde Touvier Oliver Jk Robinson Giles Hanley-Cook Lorenzo Mangone Raul Zamora-Ros Rosario Tumino Jytte Halkjær Agnetha Rostgaard-Hansen Sara Grioni Maria-Jose Sánchez Chloé Marques Marcela Prada Marcela Guevara Carlotta Sacerdote Maria Santucci de Magistris Inarie Jacobs Sahar Yammine Nathalie Kliemann Monique Wm Verschuren Pauline Frenoy Verena Katzke Renée T Fortner Guri Skeie Sabina Rinaldi Pietro Ferrari Marc J Gunter Mélanie Deschasaux-Tanguy Inge Huybrechts International Agency for Research on Cancer (IARC/WHO) Nutrition and Metabolism Branch 25 avenue Tony Garnier LYON CEDEX 07 France. Electronic address: chimerab@iarc.who.int. Medical Research Council Centre for Environment and Health School of Public Health Imperial College London UK. International Agency for Research on Cancer (IARC/WHO) Nutrition and Metabolism Branch 25 avenue Tony Garnier LYON CEDEX 07 France. International Agency for Research on Cancer (IARC/WHO) Nutrition and Metabolism Branch 25 avenue Tony Garnier LYON CEDEX 07 France Department of Food Technology Safety and Health Faculty of Bioscience Engineering Ghent University Ghent Belgium. Université Sorbonne Paris Nord and Université Paris Cité INSERM INRAE CNAM Center for Research in Epidemiology and Statistics (CRESS) Nutritional Epidemiology Research Team (EREN) Bobigny France. Centre on Climate Change and Planetary Health MRC Unit The Gambia at London School of Hygiene and Tropical Medicine Atlantic Boulevard Fajara The Gambia. Unit of Nutrition and Cancer Cancer Epidemiology Research Program Catalan Institute of Oncology (ICO) Bellvitge Biomedical Research Institute (IDIBELL) 08908 Barcelona Spain. Hyblean Association for Epidemiology Research AIRE ONLUS Ragusa Italy. Danish Cancer Institute at the Danish Cancer Society Strandboulevarden 49 Copenhagen Denmark. Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Via Venezian 1 20133 Milan Italy. Escuela Andaluza de Salud Pública (EASP) Granada Spain Instituto de Investigación Biosanitaria ibs.GRANADA Granada Spain Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP) Madrid Spain. Paris-Saclay University UVSQ Inserm Gustave Roussy CESP Villejuif France. Department of Molecular Epidemiology German Institute of Human Nutrition. Instituto de Salud Pública y Laboral de Navarra Pamplona Spain Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CI

BACKGROUND:There is increasing evidence that diets characterized by food biodiversity could contribute to health outcomes. Greater dietary species diversity has been linked to reduced gastrointestinal cancer risk and all-cause mortality. However, mechanistic pathways supporting the association between food biodiversity and health are just beginning to be explored. AIM:To characterize the metabolic profile associated with food biodiversity of diets in a pan-European population. METHODS:Dietary species richness (DSR), or the absolute number of unique species in an individual's diet, was calculated for 7,983 cancer-free control participants within the European Prospective Investigation into Cancer and Nutrition cohort study. Usual dietary intakes in the preceding year were assessed at recruitment with country-specific dietary questionnaires. Metabolomic profiles from blood which included 128 circulating endogenous metabolites,32 polyphenol compounds, and 39 fatty acid isomers were used as biomarkers of potential mechanisms underlying nutrition and health associations. Lasso regression identified key metabolites in discovery and replication sets, and multivariable stepwise linear regression were used to quantify associations between DSR and metabolomic profiles. RESULTS:A total of 52 metabolites were selected using Lasso regression in the replication set, of which 70% were statistically significant in stepwise linear regression. Higher DSR was associated with lower levels of 4 amino acids (e.g., tyrosine, -0.0231, 95% CI: -0.0362, -0.0100, p = 0.0009) and 2 acylcarnitines (e.g., C14:2, -0.0834, 95% CI: -0.1084, -0.0583, p < 0.0001). Conversely, higher levels were observed for 7 amino acids (e.g., tryptophan, -0.0954, 95% CI: -0.1049, -0.0860, p < 0.0001) and 9 polyphenols (e.g., epicatechin, p = 0.0017). CONCLUSION:In this European middle-aged adult population, the circulating metabolic profiles of biodiverse diets are consistent with the metabolome linked with health-p

关键词： Metabolomics biodiversity food biodiversity species richness

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