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作者： Sung Lee, Jae Chee, Youngjoon Kim, Boyeon Lee, Jong Min Park, Kwang Suk Kwark, Cheoleun Lee, Myung Chul Interdisciplinary Program in Medical and Biological Engineering Major Department of Biomedical Engineering Seoul National University Korea Republic of

Cross-modality coregistration of functional and anatomical images has rapidly grown as the aid for the interpretation of functional images. Various methods have been previously investigated so that the coregistered images can be easily interpreted and realistically visualized. We used the time/intensityweighted alternation method to display the coregistered images simultaneously. Stereotactic registration was done with two methods. We realized the automated method of alignment using the boundary of head scalp extracted from the sinogram of a PET emission scan and surface-matching algorithm in brain, and the semi-automated method using a paired point-matching algorithm in the chest and abdomen. For the simultaneous display of the stereotactically registered images, rapid switching of the screens were applied on which both images were written with independent color scales. Rapid alternate display of two images, that is synchronized using the monitor scanning process, could induce the fusion of images in the human visual perception system. Also, intensification of an interesting image is possible by weighting the displaying time or global intensities of images with the degree of interest. These techniques could be useful for the interpretation and visualization of the coregistered images. © 1997 The authors.

关键词： Display devices

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The ECG measurement in the bathtub using the insulated electrodes

The ECG measurement in the bathtub using the insulated elect...

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Conference Proceedings - 26th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2004

作者： Lim, Yong Kyu Kim, Ko Keun Park, Kwang Suk Med. and Biol. Engineering Major Interdisciplinary Program Seoul National University Department of Biomedical Engineering College of Medicine Seoul National University

The ECG recording in the bathtub was studied using insulated electrode. Prior studies of the ECG recording in the bathtub used conductive electrodes having some problems such as the possibility of the electric shock and sensitivity to contamination of the electrode surfaces. The insulated electrodes were made of copper plate coated with PET film. The electrodes were attached on bathtub at both sides of the chest High-input-impedance amplifier was designed to amplify ECG signal sensed by insulated electrodes of high impedance. The recorded signals in this study were noisier than those recorded with conventional conductive electrodes. But the R peaks in the recorded signals were large enough to be auto-detected. Further study will improve SNR by reducing of power line noise and common-mode noise.

关键词： Electrocardiography

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Bioimplant-on-a-Chip for Facile Investigation of Periodontal Ligament Formation on Biogenic Hydroxyapatite/Ti6Al4 V Implants

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ACS applied materials & interfaces 2025年第21期17卷 2025 May 13页

作者： Sangbae Park Jae Eun Kim Juo Lee Woochan Kim Woobin Choi Myung Chul Lee Jae Woon Lim Kyoung-Je Jang Hoon Seonwoo Jangho Kim Jong Hoon Chung Department of Biosystems Engineering Seoul National University Seoul 08826 Korea. Research Institute of Agriculture and Life Sciences Seoul National University Seoul 08826 Republic of Korea. Integrated Major in Global Smart Farm College of Agriculture and Life Sciences Seoul National University Seoul 08826 Republic of Korea. Department of Convergent Biosystems Engineering College of Life Science and Natural Resources Sunchon National University Suncheon 57922 Republic of Korea. Department of Convergence Biosystems Engineering Chonnam National University Gwangju 61186 Republic of Korea. Department of Rural and Biosystems Engineering Chonnam National University Gwangju 61186 Republic of Korea. Interdisciplinary Program in IT-Bio Convergence System Chonnam National University Gwangju 61186 Republic of Korea. Medicinal Materials Research Center Biomedical Research Division Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea. Department of Bio-Systems Engineering Institute of Smart Farm Gyeongsang National University Jinju 52828 Republic of Korea. Institute of Agriculture & Life Science Gyeongsang National University Jinju 52828 Republic of Korea. Interdisciplinary Program in IT-Bio Convergence System Sunchon National University Suncheon 57922 Republic of Korea. Institute of Nano-Stem Cells Therapeutics NANOBIOSYSTEM Co. Ltd Gwangju 61008 Republic of Korea. ELBIO Inc Seoul 08812 Republic of Korea.

Highly osseointegrative dental implants surrounded by reconstructed periodontal tissues represent a promising strategy for functional tooth replacement, as they mimic the structural and physiological characteristics of natural teeth. However, there is currently a lack of in vitro platforms that can effectively evaluate the integration of engineered periodontal ligament (PDL) tissues with bioimplants. In this study, we developed a bioimplant-on-a-chip (BoC) platform designed to recapitulate the native PDL-cementum interface and assess the early stage biological performance of bioimplants in vitro. The BoC consists of a dental implant, a calcium phosphate cement (CPC) insert, a nanopatterned polydimethylsiloxane (PDMS) substrate, and PDL-like tissue derived from human dental pulp stem cells (DPSCs). To establish viable culture conditions within the platform, surface coatings and cell seeding densities were optimized to support the formation of PDL-like tissue. Nanogrooved substrates were incorporated to guide cellular alignment, which was assessed through orientation analysis. Collagen fiber organization and matrix deposition were further examined as indicators of ligamentous tissue maturation. Cementogenic activity was evaluated by immunofluorescent staining of cementum protein-1 (CEMP-1) in response to varying biogenic hydroxyapatite (bHA) contents in the bioimplants. The results demonstrated successful reproduction of a PDL-like tissue interface and material-dependent differences in CEMP-1 expression. This platform provides a modular and reproducible tool for the comparative evaluation of bioimplants in a physiologically relevant setting and may be useful in advancing regenerative strategies in dental implantology.

关键词： bioimplant-on-a-chip bioimplants in vitro model periodontal ligament tissue engineering

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Cell chip to monitor the influence of electric field on the human mesendhymal stem cells 11

Cell chip to monitor the influence of electric field on the ...

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11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

作者： Kwon, Gu-Han Lee, Kwang Ho Lee, Eun-Joong Lee, Sang-Hoon Department of Biomedical Engineering College of Medicine Korea University Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Korea Republic of

ISBN: (纸本)9780979806407

A new micro cell chip which can induce stem cells to differentiate into specific body cell types has been designed and fabricated for tissue engineering. This paper presents the fabrication and preliminary test results of a MEMS cell electric stimulator. It provides a new tool of cell electric stimulation, culture and analysis for stem cell research. This study provides the controlling proliferation as well as morphology of human mesenchymal stem cell on the microchip. DC 1V, 5V, 12V, AC 5V, 1 Hz, 1K Hz, 1M Hz were compared with electric stimulation for their impact on the expansion and morphology of mesenchymal stem cells (MSCs). It provides a new generation of cell culture, stimulation and analysis devices for stem cell research and tissue engineering. © 2007 CBMS.

关键词： Stem cells

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Artificial neural network-based estimation of the eyeball position using the magnetic contact lens sensing technique

Artificial neural network-based estimation of the eyeball po...

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2005 27th Annual International Conference of the engineering in Medicine and Biology Society, IEEE-EMBS 2005

作者： Lee, Seung Yup Kim, Keun Young Kim, Hee Chan Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)0780387406

We have created an artificial neural network based approach for measuring eye movement using a magnetic contact lens sensing technique. The sensor array is based on using four magnetoresistive sensors. A two-layer feed-forward artificial neural network was used and an artificial eyeball model was made for the test. The neural network is trained with sample data obtained from nine spots. After training, we compared the position calculated from the developed system with the real one. The result shows that there is a good linear relationship between them. This indicates the developed system is capable of recording the position of the eyeball with a high degree of accuracy. © 2005 IEEE.

关键词： Contact lenses

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Personal dialysis using a web-based, portable system - C-PAK (Carry-on Pulse Artificial Kidney)

Personal dialysis using a web-based, portable system - C-PAK...

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BIODEVICES 2008 - 1st International Conference on biomedical Electronics and Devices

作者： Lee, Jung Chan Kim, Wook Eun Lim, Ki Moo Kim, Jeong Chul Min, Byoung Goo Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Biomedical Engineering Seoul National University Seoul Korea Republic of

ISBN: (纸本)9789898111173

While the number of patients suffering from acute and chronic renal failure has been steadily increasing every year, the mortality rate is not improving. For the purpose of improvement on the quality of life and mortality of renal disease patients, we employ the hemofiltration principle to treat the end-stage renal disease patients. Hemofiltration equipment can be installed without additional plumbing and electrical power construction;operated only with several pre-packaged fluid bags without a huge water treatment facility. This paper describes the development of portable renal treatment equipment based on hemofiltration treatment, Carry-on Pulse Artificial Kidney (C-PAK), and reports the results of animal test using the equipment. The web-based remote monitor/control system for C-PAK is introduced also. We expect that our portable hemofiltration device for chronic renal failure patient would be an alternative for conventional hemodialysis machine and a solution to home renal treatment.

关键词： Diseases

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Microfluidic cell culture chip employing polymeric nanofiber membrane

Microfluidic cell culture chip employing polymeric nanofiber...

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10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

作者： Kim, Sung Rak Lee, Ki Hwa Lee, Kwang Ho Baek, Ju Yeoul Park, Yong Doo Sun, Kyung Lee, Sang Hoon Dept. of Biomedical Engineering Korea Univ. Korea Republic of Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Korea Republic of Korea Republic of

In this paper, we have developed cell chip employing polymeric nanofiber membrane which was used for the better diffusion of nutrition or other materials suchas growth factor and for the scaffold of cell culture, and we evaluated the function of this chip by culturing the human mesenchymal stem cells (hMSCs) which have large potential applications in the tissue engineering. © 2006 Society for Chemistry and Micro-Nano Systems.

关键词： Cell culture

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Perspective error compensation of pupillography using glint images

Perspective error compensation of pupillography using glint ...

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ETRA 2006 - Symposium on Eye Tracking Research and Applications

作者： Lee, Inbum Park, Kwangsuk Interdisciplinary Program of Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)1595933050

This paper suggests a new method to compensate perspective error in measuring real size of pupil of pupillography for pupil light response. To get real size of pupil, the distance between cornea and camera should be calculated. The glints on the eye of the image were used to estimate the distance. The suggested method was validated using telecentric lens. © 2006 ACM.

关键词： Image analysis

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The electrically non-contacting ECG measurement on the toilet seat using the capacitively-coupled insulated electrodes

The electrically non-contacting ECG measurement on the toile...

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Conference Proceedings - 26th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2004

作者： Kim, Ko Keun Lim, Yong Kyu Park, Kwang Suk Med. and Biol. Engineering Major Interdisciplinary Program Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

The studies of ECG measurement on the toilet seat have been performed specifically for the ubiquitous health care. Instead of the mainly used dry electrodes having several problems such as the electrical safety or the environmental stability, we used the capacitively-coupled insulated electrodes, which were composed of the Cu plate and the PTFE film for the measurement. The bio-signal sensed with the insulated electrodes was measured through the ultra-high input impedance system including OPA111 having the common mode impedance of 1014 Ω. As the result of measuring the signal, with the electrical ground on the neck or the hand, the R-peaks were detected very positively. However, without the electrical ground on the body, we could detect the heartbeat signal, a kind of the motion artifacts by the variation of the blood vessel volume. It seems that this heartbeat signal can be also used as the important parameter like the R-peaks for the HRV (heart rate variability) analysis. In addition, it is thought that, without the directly electrical ground, the R-peak detection will be possible by the improvement of the SNR with the active common canceling system.

关键词： Electrocardiography

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Development of an integrated home telemedicine system

Development of an integrated home telemedicine system

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IEEE EMBS Asian-Pacific Conference on biomedical engineering 2003, APBME 2003

作者： Chun, Honggu Kim, Ki-Jung Kangl, Jae Min Kim, Hee Chan Interdisciplinary Program in Medical and Biological Engineering Major Seoul National University Seoul Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Seoul Korea Republic of

ISBN: (纸本)0780379438

We developed an integrated home telemedicine system equipped with automatic diagnosis and consultation function for patients with chronic disease such as cardiac disease, respiratory disease, diabetes and hypertension. The system measures standard 12ch ECG, respiratory function, blood glucose level and noninvasive blood pressure (NIBP). The measured data were stored on the system and transmitted to the central server everyday through the internet. The system performed automatic diagnosis at every measurement and offered medical consultation to the patient If there was any abnormality in the diagnostic result, the system gave a real time alarm to the healthcare center for adequate teleconsultation or medical service. We have installed the developed system on an apartment for the performance evaluation and confirmed the possibility of the system as an effective tool for the telemedicine. © 2003 IEEE.

关键词： Electrocardiograms

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