检索结果-内蒙古大学图书馆

Bioinks and bioprinting: A focused review

Bioprinting 2020年 18卷

作者： Mobaraki, Mohammadmahdi Ghaffari, Maryam Yazdanpanah, Abolfazl Luo, Yangyang Mills, D.K. Department of Biomedical Engineering Amirkabir University of Technology Tehran Iran Molecular Science and Nanotechnology Interdisciplinary Program Louisiana Tech University Ruston 71272 LA United States Center for Biomedical Engineering and School of Biological Sciences Louisiana Tech University Ruston 71272 LA United States

Bioprinting is a process based on additive manufacturing that uses biomaterials as the microenvironment for living cells. These materials often referred to as bioinks, are based on cytocompatible hydrogel precursors, which gel in a manner compatible with different bioprinting approaches. Hydrogels are highly hydrated three-dimensional (3D) networks of cross-linked hydrophilic polymer chains and have been widely explored for use as bioactive delivery agents, cell carriers, consumer products, tissue engineering scaffolds and for wound healing. Hydrogels can be tailored for different chemical, electrical, mechanical, and thermal properties and can even be made to conduct electricity. Recent trends in bioink development have focused on incorporating carbon-based nanomaterials, clay nanomaterials, ceramics, fibers, and growth factors to create hybrid and multi-composite hydrogels. The goal of this review paper is to examine the synergies resulting from the combination of these materials. This review will feature recent advances in this field, focusing on bioink developments and bioprinting applications, and the use of natural and synthetic additives that impart unique, novel, or critical functionalities. © 2020 Elsevier B.V.

关键词： Bioinks Bioprinting Organ replacement Regenerative medicine Tissue regeneration

来源：评论

学校读者我要写书评

暂无评论

Fractal complexity alternations in paroxysmal atrial fibrillation patients with and without recurrence after pulmonary vein isolation

引用

Annals of Noninvasive Electrocardiology 2023年第5期28卷 e13074-e13074页

作者： Liao, Ting-Wei Ernie Li, Cheng-Hung Lin, Yenn-Jiang Chang, Shih-Lin Hu, Yu-Feng Chung, Fa-Po Chao, Tze-Fan Liao, Jo-Nan Yang, Hui-Wen Lo, Men-Tzung Chen, Shih-Ann Lo, Li-Wei Faculty of Medicine School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan Institute of Clinical Medicine Cardiovascular Research Institute National Yang Ming Chiao Tung University Taipei Taiwan Cardiovascular Center Taichung Veterans General Hospital Taichung Taiwan Department of Biomedical Sciences and Engineering Institute of Translational and Interdisciplinary Medicine National Central University Taoyuan Taiwan Medical Biodynamics Program Division of Sleep and Circadian Disorders Brigham and Women's Hospital Boston MA United States National Chung Hsing University Taichung Taiwan

Background: Pulmonary vein isolation (PVI) is a cornerstone therapy for paroxysmal atrial fibrillation (PAF). The variations in nonlinear heart rate variability (HRV) between patients with and without recurrences remain unclear. We aimed to characterize the nonlinear HRV before and after PVI in patients with and without recurrence. Methods: Twenty-five drug-refractory PAF patients (56.0 ± 9.1 years old, 20 males) who received PVI were enrolled. Holter electrocardiography were performed before, 1–3, and 6–12 months after PVI. After 8.2 ± 2.5 months of follow-ups after PVI, patients were divided into two groups: the recurrence (n = 8) and non-recurrence (n = 17) groups. Linear and nonlinear HRV variables were analyzed, including the Poincaré Plot analysis and the Detrended Fluctuation Analysis (DFA). Results: The non-recurrence group, but not the recurrence group, had decreased high-frequency component (HF), the root mean square of successive RR interval differences (RMSSD), and the Poincaré Plot index SD1 1–3 months after PVI and increased DFA_slope2 6–12 months after PVI. The non-recurrence group's LF/HF ratio and DFA_slope1 decreased significantly 1–3 and 6–12 months after PVI, respectively, whereas there was no significant change in the recurrence group after PVI. Conclusions: Significantly reduced vagal tone 1–3 months after PVI, increased long-term fractal complexity 6–12 months after PVI, and decreased sympathetic tone as well as short-term fractal complexity 1–3 and 6–12 months after PVI led to a better AF-free survival after PVI. These findings suggest that neuromodulation and heart rate dynamics play crucial roles in AF recurrence following PVI. © 2023 The Authors. Annals of Noninvasive Electrocardiology published by Wiley Periodicals LLC.

关键词： atrial fibrillation detrended fluctuation analysis heart rate variability nonlinear heart rate variability Poincaré plot analysis

来源：评论

学校读者我要写书评

暂无评论

Complete mitochondrial genome of Staghorn damselfish,Amblyglyphidodon curacao(Perciformes, Pomacentridae)

引用

Mitochondrial DNA Part B 2019年第1期4卷 1101-1102页

作者： Hyun-Woo Kim Sinar Pagi Sektiana Md. Jobaidul Alam Sapto Andriyono Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaAquaculture Technology Study Program Sekolah Tinggi Perikanan Jakarta Indonesia Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Fisheries Ministry of Fisheries and Livestock Dhaka Bangladesh Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Fisheries and Marine Faculty Universitas Airlangga C Campus Jl. Mulyorejo Surabaya East Java Indonesia

The complete mitochondrial genome of the Staghorn damselfish,Amblyglyphidodon curacaowas determined by next-generation sequencing (NGS) platform. The circular mitochondrial genome ofA. curacao(16,612 bp) encoded the 13 protein-coding genes, 22 tRNA genes,2rRNA genes, and 2 non-coding regions (origin of light strand replication (OL) and the control region (D-Loop)). All the tRNAs have typical clover-leaf structures except for tRNA-Ser. Phylogenetic analysis based on the currently reported mitochondrial genomes in Pomacentridae showed thatA. curacaowas most closely related toAmphiprion frenatus. The complete mitogenome sequence ofA. curacaowould provide essential genetic information of Pomacentrinae related to them for their scientific management in the coral-reef ecosystem in Indonesian waters.

关键词： Next generation sequencing damselfish complete mitogenome coral-reef fish

来源：评论

学校读者我要写书评

暂无评论

A Model of Fluid-Structure and Biochemical Interactions for Applications to Subclinical Leaflet Thrombosis

arXiv

引用

arXiv 2022年

作者： Barrett, Aaron Brown, Jordan A. Smith, Margaret Anne Woodward, Andrew Vavalle, John P. Kheradvar, Arash Griffith, Boyce E. Fogelson, Aaron L. Department of Mathematics University of Utah Salt Lake CityUT United States Department of Mathematics University of North Carolina Chapel HillNC United States Advanced Medical Imaging Lab University of North Carolina Medical Center Chapel HillNC United States University of North Carolina School of Medicine Chapel HillNC United States Division of Cardiology Department of Medicine University of North Carolina Chapel HillNC United States Department of Biomedical Engineering University of California Irvine IrvineCA United States Department of Mathematics Applied Physical Sciences and Biomedical Engineering University of North Carolina Chapel HillNC United States Carolina Center for Interdisciplinary Applied Mathematics University of North Carolina Chapel HillNC United States Computational Medicine Program University of North Carolina Chapel HillNC United States McAllister Heart Institute University of North Carolina Chapel HillNC United States Department of Mathematics and Biomedical Engineering University of Utah Salt Lake CityUT United States

Subclinical leaflet thrombosis (SLT) is a potentially serious complication of aortic valve replacement with a bioprosthetic valve in which blood clots form on the replacement valve. SLT is associated with increased risk of transient ischemic attacks and strokes and can progress to clinical leaflet thrombosis. SLT following aortic valve replacement also may be related to subsequent structural valve deterioration, which can impair the durability of the valve replacement. Because of the difficulty in clinical imaging of SLT, models are needed to determine the mechanisms of SLT and could eventually predict which patients will develop SLT. To this end, we develop methods to simulate leaflet thrombosis that combine fluid-structure interaction and a simplified thrombosis model that allows for deposition along the moving leaflets. Additionally, this model can be adapted to model deposition or absorption along other moving boundaries. We present convergence results and quantify the model's ability to realize changes in valve opening and pressures. These new approaches are an important advancement in our tools for modeling thrombosis in which they incorporate both adhesion to the surface of the moving leaflets and feedback to the fluid-structure interaction. © 2022, CC BY-SA.

关键词： Deposition

来源：评论

学校读者我要写书评

暂无评论

Effect of Thai Silk Fibroin on Mechanical Properties of Bioactive Glass Silk Fibroin Hybrid Bone Scaffolds

引用

IOP Conference Series: Materials Science and engineering 2021年第1期1163卷

作者： Ayuth Vejpongsa Peerapat Thongnuek Biomaterial Engineering for Medical and Health Research Unit Faculty of Engineering Chulalongkorn University Pathum Wan 10330 Thailand Interdisciplinary Program of Biomedical Engineering Faculty of Engineering Chulalongkorn University Pathum Wan 10330 Thailand

Bioactive glass (70 mol% Si and 30% Ca; 70S30C) has been used as tissue engineering scaffolds in various research despite its brittleness due to its easy-to-replicate formula, extensive interconnected pores and natural bone bonding property of bioactive glass (BG). Thai silk fibroin (SF) is natural polymer with many desirable properties; biocompatibility, mechanical strength, biodegradability. Using BG-SF hybrid scaffolds could employ the positive effects of both bioactive glass and silk fibroin. Serving as bone scaffolds, BG-SF scaffolds must resist compression and other types of mechanical load depending on the application. This study fabricates scaffolds with various ratios of BG:SF (BG:SF; 90:10, 80:20 with 100:0 as control), and their stress-strain profiles were investigated. As expected, the scaffolds with highest BG content exhibited the curve resembling that of porous foam while the elastomeric stress-strain profile was becoming more evident when the SF content was increased. This study hence demonstrated fine-tuning mechanical properties of the BG using locally enriched SF.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Molecular characterization of the complete mitochondrial genome of morotoge shrimpPandalopsis japonica(Decapoda: Pandalidae)

引用

Mitochondrial DNA Part B 2019年第1期4卷 545-546页

作者： Tae-Ho Yoon Sapto Andriyono Hye-Eun Kang Nack-keun Kim Soo Rin Lee Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Fisheries and Marine Faculty Universitas Airlangga Surabaya East Java Indonesia Department of Marine Biology Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The complete mitochondrial genome of the morotoge shrimp,Pandalopsis japonicawas determined by the high-throughput sequencing technique. The mitogenome ofP. japonica(15,909 bp) encoded the 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes as well as the non-coding control region (D-Loop). The mitochondrial genome ofP. japonicashowed an identical gene arrangement in its mitochondrial genome to its relative Pandalid shrimps includingP. borealis and P. *** 13 compared mitogenomes within order Suborder Pleocyemata,P. japonicawas most closely related toP. hypsinotuswith 86% sequence identity clustering together with three other shrimps in family Pandalidae.

关键词： High-throughput sequencing Pandalidae mitochondrial genome shrimp East/Japan Sea

来源：评论

学校读者我要写书评

暂无评论

The complete mitochondrial genome of spearnose grenadier,Coelorinchus multispinulosus, Katayama, 1942 (Gadiformes: Macrouridae)

引用

Mitochondrial DNA Part B 2019年第1期4卷 1123-1124页

作者： Sapto Andriyono Ah-Ran Kim Md. Jobaidul Alam Hyun Park Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaFisheries and Marine Faculty Universitas Airlangga Surabaya Indonesia Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Korea Polar Research Institute Korea Ocean Research and Development Institute Incheon Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The complete mitochondrial genome ofCoelorinchus multispinulosuswas determined using the MiSeq platform. The mitogenome ofC. multispinulosus(15,937 bp) contained 13 protein-coding genes, 22 tRNAs, two ribosomal RNAs (12S and 16S), and a control region (D-Loop). The G + C content of its mitogenome was 44.69%, which was lower than A + T contents (55.31%). Unusual start codon (GTG) was identified in three protein-coding genes including COX1, ND2, and ND3. Incomplete stop codons (TA–/T–) were shown in six genes including COX1, COX2, COX3, ND3, ND4, and ATP6. Based on the phylogenetic tree with the currently reported mitogenomes in the family Macrouridae,C. multispinulosuswas most closely related toCoelorinchus kishinouyeiwith 85% nucleotide sequence identity.

关键词： Next-generation sequencing Coelorinchus multispinulosus mitochondrial genome deep-sea fish

来源：评论

学校读者我要写书评

暂无评论

The complete mitochondrial genome of black-spot snapper,Lutjanus fulviflamma(Perciformes: Lutjanidae)

引用

Mitochondrial DNA Part B 2019年第1期4卷 366-367页

作者： Sapto Andriyono Sinar Pagi Sektiana Jobaidul Alam Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Fisheries and Marine Faculty Universitas Airlangga C Campus Jl. Mulyorejo Surabaya East Java Surabaya Indonesia Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The complete mitochondrial genome sequence of Dory snapper,Lutjanus fulviflamma,was determined by high-throughput sequencing (HTS) technique. The circular mitogenome ofL. fulviflammawas 16,512bp in length encoding 37 genes (13 proteins, 22 tRNAs, 2 ribosomal RNAs) and 2 conserved noncoding elements; the control region (D-Loop) and the origin of light strand synthesis (OL). Among the protein-coding genes, unusual start codons were identified in ND2, COX1 and ND3 genes and incomplete stop codons were identified in seven genes. Phylogenetic analysis with the currently known mitogenomes in genus Lutjanus revealed thatL. fulviflammawas most closely related toLutjanus russelliiwith 91% sequence identity.

关键词： High-throughput sequencing Lutjanidae mitogenome snapper coral reef

来源：评论

学校读者我要写书评

暂无评论

Characterization of the complete mitochondrial genome ofBothrocara hollandi(Perciformes: Zoarcidae)

引用

Mitochondrial DNA Part B 2019年第1期4卷 523-524页

作者： Nack-Keun Kim Sapto Andriyono Jobaidul Alam Sung-Tae Kim Kyung Mi Jung Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaFisheries and Marine Faculty Universitas Airlangga Surabaya Indonesia Dokdo Fisheries Research Center National Institute of Fisheries Science Pohang Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The full mitogenome ofBothrocara hollandiwas determined by high-throughput sequencing (HTS) platform. The genome was 16,732 bp in length, which included 13 protein-coding genes, 22 tRNAs, two ribosomal RNAs (12S and 16S), and a control region (D-Loop). The overall composition of G + C in the mitogenome was 45.90%, which was lower than A + T contents (54.10%). Except for COX1 (GTG), the other twelve protein-coding genes begin with typical start codon, ATG. The incomplete stop codon (TA − or T–) was identified in five genes, including COXI, COXII, COXIII, ND3, and ND4. The phylogenetic analysis with the currently reported mitogenome sequences showed thatB. hollandiwas most closely related toLycodes tanakae, suggesting that additional mitogenome sequences in genusBothrocaraare required for its clear evolutional relationship.

关键词： High-throughput sequencing Bothrocara hollandi mitogenome phylogenetic eelpout

来源：评论

学校读者我要写书评

暂无评论

Machine Learning-Based Prediction of Pulmonary Thromboembolism to Reduce Unnecessary Computed Tomography Scans in Gastrointestinal Cancer Patients: A Retrospective Multicenter Study

SSRN

引用

SSRN 2023年

作者： Kim, Joo Seong Kwon, Doyun Kim, Kyungdo Lee, Sang Hyub Lee, Seung-Bo Kim, Kwangsoo Kim, Dongmin Lee, Min Woo Park, Namyoung Choi, Jin Ho Jang, Eun Sun Cho, In Rae Paik, Woo Hyun Lee, Jun Kyu Ryu, Ji Kon Kim, Yong-Tae Department of Internal Medicine Liver Research Institute Seoul National University Hospital Seoul National University College of Medicine Seoul Korea Republic of Department of Internal Medicine Dongguk University College of Medicine Dongguk University Ilsan Hospital Goyang-si Korea Republic of Interdisciplinary Program of Medical Informatics Seoul National University College of Medicine Seoul Korea Republic of Department of Biomedical Engineering Pratt School of Engineering Duke University DurhamNC27708 United States Transdisciplinary Department of Medicine & Advanced Technology Seoul National University Hospital Seoul Korea Republic of Department of Medicine Seoul National University College of Medicine Seoul Korea Republic of Department of Medical Informatics Keimyung University School of Medicine Daegu Korea Republic of Biomedical Research Institute Seoul National University Hospital Seoul Korea Republic of Department of Medicine Kyung Hee University Gangdong Hospital Seoul Korea Republic of Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Republic of Department of Internal Medicine Seoul National University Bundang Hospital Seongnam-si Korea Republic of

Background: Pulmonary thromboembolism (PTE) is one of the most important complications in cancer patients. Gastrointestinal cancers entail an increased risk of PTE. However, there were few research on predicting pulmonary embolism using machine learning (ML) in cancer patients. The purpose of this study was to develop an ML based prediction model for PTE in gastrointestinal cancer ***: We conducted a retrospective, multicenter study in which ML model was developed and subsequently internally and externally validated. We reviewed gastrointestinal cancer patients who had undergone computed tomographic pulmonary angiography (CTPA) from 2010 to 2020. Demographic and predictor variables including the Wells score and D-dimer were investigated. The ML model was based on the random forest model. The area under receiver operating curve (AUROC) was used to evaluate the performance of ML ***: 446 patients in hospital A and 139 patients in hospital B were analyzed in this study. The training set comprised 356 patients in hospital A. The ML model was validated both internally (90 patients) and externally (139 patients). AUROC was 0.736 in hospital A and 0.669 in hospital B. The number of patients classified as requiring CTPA was significantly reduced according to the prediction with ML (hospital A;100.0% vs 91.1%, P Conclusion: Prediction model based on ML might have advantages in reducing the number of CTPA compared to the conventional diagnostic strategy for PTE in patients with gastrointestinal cancer. © 2023, The Authors. All rights reserved.

关键词： Hospitals

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：