The Generation Challenge programme (GCP) is a global crop research consortium directed toward crop improvement through the application of comparative biology and genetic resources characterization to plant breeding. A...
The Generation Challenge programme (GCP) is a global crop research consortium directed toward crop improvement through the application of comparative biology and genetic resources characterization to plant breeding. A key consortium research activity is the development of a GCP crop bioinformatics platform to support GCP research. This platform includes the following: (i) shared, public platform-independent domain models, ontology, and data formats to enable interoperability of data and analysis flows within the platform;(ii) web service and registry technologies to identify, share, and integrate information across diverse, globally dispersed data sources, as well as to access high-performance computational (HPC) facilities for computationally intensive, high-throughput analyses of project data;(iii) platform-specific middleware reference implementations of the domain model integrating a suite of public (largely open-access/-source) databases and software tools into a workbench to facilitate biodiversity analysis, comparative analysis of crop genomic data, and plant breeding decision making.
We demonstrate the use of information-theoretic tools for the task of identifying segments of biomolecules (DNA or RNA) that are statistically correlated. We develop a precise and reliable methodology, based on the no...
详细信息
ISBN:
(纸本)9781424413973;1424413974
We demonstrate the use of information-theoretic tools for the task of identifying segments of biomolecules (DNA or RNA) that are statistically correlated. We develop a precise and reliable methodology, based on the notion of mutual information, for finding and extracting statistical as well as structural ependencies. A simple threshold function is defined, and its use in quantifying the level of significance of dependencies between biological segments is explored. These tools are used in two specific applications. First, for the identification of correlations between different parts of the maize zmSRp32 gene. There, we find significant dependencies between the 5' untranslated region and its alternatively spliced exons. This observation may indicate the presence of as-yet unknown alternative splicing mechanisms or structural scaffolds. Second, using data from CODIS, we demonstrate that our approach is well suited for the problem of discovering short tandem repeats (STRs).
Aboard current ships, such as the DDG 51, engineering control and damage control activities are manpower intensive. It is anticipated that, for future combatants, the workload demand arising from operation of systems ...
详细信息
Aboard current ships, such as the DDG 51, engineering control and damage control activities are manpower intensive. It is anticipated that, for future combatants, the workload demand arising from operation of systems under conditions of normal steaming and during casualty response will need to be markedly reduced via automated monitoring, autonomous control, and other technology initiatives. Current DDG 51 class ships can be considered as a manpower baseline and under Condition III typical engineering control involves seven to eight watchstanders at manned stations in the Central Control Station, the engine rooms and other machinery spaces. In contrast to this manning level, initiatives such as DD 21 and the integrated engineering plant (IEP) envision a partnership between the operator and the automation system, with more and more of the operator's functions being shifted to the automation system as manning levels decrease. This paper describes some human systems integration studies of workload demand reduction and, consequently, manning reduction that can be achieved due to application of several advanced technology concepts. Advanced system concept studies in relation to workload demand are described and reviewed including. Piecemeal applications of diverse automation and remote control technology concepts to selected high driver tasks in current DDG 51 activities. Development of the reduced ship's crew by virtual presence system that will provide automated monitoring and display to operators of machinery health, compartment conditions, and personnel health. The IEP envisions the machinery control system as a provider of resources that are used by various consumers around the ship. Resource needs and consumer priorities are at all times dependent upon the ship's current mission and the availability of equipment pawnbrokers.
The objectives of Human Engineering (HE) are generally viewed as increasing human performance, reducing human error, enhancing personnel and equipment safety, and reducing training and related personnel costs. There a...
详细信息
The objectives of Human Engineering (HE) are generally viewed as increasing human performance, reducing human error, enhancing personnel and equipment safety, and reducing training and related personnel costs. There are other benefits that are thoroughly consistent with the direction of the Navy of the future, chief among these is reduction of required numbers of personnel to operate and maintain Navy ships. The Naval Research Advisory Committee (NRAC) report on Man-Machine Technology in the Navy estimated that one of the benefits from increased application of man-machine technology to Navy ship design is personnel reduction as well as improving system availability, effectiveness, and safety The objective of this paper is to discuss aspects of the human engineering design of ships and systems that affect manning requirements, and impact human-performance and safety The paper will also discuss how the application of human engineering leads to improved performance, and crew safety, and reduced workload, all of which influence manning levels. Finally, the paper presents a discussion of tools and case studies of good human engineering design practices which reduce manning.
作者：
SHEA, JGThe Author:holds bachelor and master of engineering degrees in mechanical engineering
a M.Eng. in engineering management and is currently fulfilling requirements for the M.S. and Ph.D. degrees in computer science at the University of Louisville. He is employed as program manager Phalanx Advanced Engineering Development at the Naval Ordnance Station Crane Div. NavSurfWarCen Louisville Ky. During his tenure with Phalanx Mr. Shea has contributed to system reliability improvement system performance upgrading and the development of the Phalanx HOL (RISC) Computer. Mr. Shea is a member of ASNE the Institute of Electrical and Electronics Engineers American Institute of Aeronautics and Astronautics Society for Computer Simulation International Test & Evaluation Association and the Military Operations Research Society.
Knowledge-based modeling and simulation bridges the gap between ''conventional'' artificial intelligence implementations (such as expert systems) and more traditional computer-aided design techniques. ...
Knowledge-based modeling and simulation bridges the gap between ''conventional'' artificial intelligence implementations (such as expert systems) and more traditional computer-aided design techniques. We are currently developing software, whose primary function is to capture a user-input design specification and produce a ''virtual'' rapid prototvpe in the form of executable rule-based code. This code can then be exercised either as an interactive part of a hardware-in-the-loop testbed simulator or as a component of an object-oriented ''behavioral'' simulation environment. While the Phalanx Testbed is the immediate beneficiary of this work, the techniques described have a wide range of application in the modeling of conceptual design and performance characteristics. This paper describes the system architecture and software tools that we are applying to generate virtual rapid prototypes for use in the Phalanx Testbed. Particular attention is paid to defining the intelligent knowledge-capture mechanisms and model generation methodologies that we are using to translate design knowledge and performance requirements into rule-based simulations. The object-oriented programming approach to the merging of ''new'' data with previouslv-captured and stored data is discussed, and the issues of verifying and validating prototypes generated using such partiallv ''reengineered'' models are examined. An application currently in use as an investigative prototype for testbed development, a simple position controller servomechanism used to control the azimuth angle of a target-tracking sensor, is used to illustrate the process.
暂无评论