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Clinical "MUTATOME" Of Myelodysplastic Syndrome;Comparison To Primary Acute Myelogenous Leukemia

BLOOD 2013年第21期122卷 518-518页

作者： Makishima, Hideki LaFramboise, Thomas Przychodzen, Bartlomiej P. Yoshida, Kenichi Ruffalo, Matthew Gomez-Segui, Ines Husseinzadeh, Holleh D. Shiraishi, Yuichi Sanada, Masashi Nagata, Yasunobu Sato, Yusuke Sato-Otsubo, Aiko Chiba, Kenichi Tanaka, Hiroko Nakamaki, Tsuyoshi Hofmann, Wolf-Karsten Miyawaki, Shuichi Shih, Lee-Yung Chiba, Shigeru Miyano, Satoru Hosono, Naoko Polprasert, Chantana Thota, Swapna Dienes, Brittney Guinta, Kathryn M. Sauntharatajah, Yogen Sekeres, Mikkael A. Ogawa, Seishi Maciejewski, Jaroslaw P. Translational Hematology and Oncology Research Cleveland Clinic Taussig Cancer Institute Cleveland OH USA Department of Electrical Engineering and Computer Science Case Western Reserve University Cleveland OH USA Department of Pathology and Tumor biology Kyoto University Kyoto Japan Electrical Engineering and Computer Science Case Western Reserve University Cleveland OH USA Hematology Department University Hospital La Fe Valencia Spain Laboratory of DNA Information Analysis Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan Department of Pathology and Tumor Biology Graduate School of Medicine Kyoto University Kyoto Japan Cancer Genomics Project Graduate School of Medicine The University of Tokyo Tokyo Japan Laboratory of Sequence Data Analysis Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan Division of Hematology Department of Medicine Showa University School of Medicine Tokyo Japan Department of Hematology and Oncology University Hospital Mannheim Mannheim Germany Division of Hematology Department of Internal Medicine Tokyo Metropolitan Ohtsuka Hospital Tokyo Japan Chang Gung Memorial Hospital Taoyuan Taiwan Department of Hematology Faculty of Medicine University of Tsukuba Tsukuba Japan Translational Hematology Oncology Research Cleveland Clinic Taussig Cancer Institute Cleveland OH USA Department of Translational Hematology and Oncology Research Taussig Cancer Institute Cleveland Clinic Cleveland OH USA Translational Hematology and Oncology Research Taussig Cancer Institute Cleveland Clinic Cleveland OH USA Leukemia Program Department of Hematologic Oncology and Blood Disorders Taussig Cancer Institute Cleveland Clinic Cleveland OH USA

Chromosomal aberrations and somatic mutations constitute key elements of the pathogenesis of myelodysplastic syndromes (MDS), a clonal hematologic malignancy characterized by cytopenias, a dysplastic bone marrow and propensity to clonal evolution. Next generation sequencing (NGS) enables definition of somatic mutational patterns and clonal architecture as a discovery platform, and for clinical *** systematically applied NGS to 707 cases of MDS and MDS-related disorders. 205 cases (low-risk MDS: N=78, high-risk MDS: N=42, MDS/MPN: N=48 and sAML: N=37) were tested by whole exome sequencing (WES). For validation in an additional 502 patients (low-risk MDS: N=192, high-risk MDS: N=104, MDS/MPN: N=111 and sAML: N=95), targeted deep NGS was applied for 60 index genes which were most commonly affected in the cohort analyzed by WES. For NGS data analysis a statistical pipeline was developed to focus on: i) identification of the most relevant somatic mutations, and ii) minimization of false positive results. We studied serial samples from 21 exemplary informative patients. We also compared somatic mutational patterns to those seen in primary AML TCGA cohort (N=201). Given the size of the cohort, there was, for example, a 87% chance of seeing mutations at a frequency of 1% and a 98% of seeing those with a frequency of 2%. While focusing on the most common events, we observed 1117 somatic mutations in 199 genes. The 88 genes mutated mutated in >1% of cases with MDS carried 388 mutations in MDS+sAML (2.5/case), 128 in MDS/MPN (2.7/case) and 398 in pAML (2.0/case). The average number of mutations per case increased during progression (2.2 in lower-risk, 2.8 in higher-risk MDS, 3.4 in sAML). In MDS, the 30 most frequently affected genes were present at least once in 70% of patients. The 30 most frequently mutated genes in MDS/MPN were mutated in 82% of patients. Individual mutations were also sub-grouped according to their function. When we compared three MDS subcateg

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Hybrid clutter canceler with feedback guided predicative filtering on a heterogeneous parallel processing system

Hybrid clutter canceler with feedback guided predicative fil...

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international Waveform Diversity and Design Conference, WDD 2012

作者： Brinkhus, Jeffrey M. Jezak, Joseph A. Berdanier, Charles Levitan, Steven P. Chiarulli, Donald M. Electical and Computer Engineering University of Pittsburgh United States Computer Engineering Graduate Program University of Pittsburgh United States Electrical Engineering Wright State University United States Computer Science Department University of Pittsburgh United States

ISBN: (纸本)9781509005987

In this paper we describe a novel clutter cancellation platform based on a two stage approach that combines a feedback guided predictive front-end hybrid clutter canceller with high performance back-end filtering and target detection. The front-end architecture is based on an FPGA implementation of a Kalman filter that predicts target locations in real time and removes the target signals from the incoming data prior to hybrid cancellation. The back-end is user configurable and exploits high performance GPU and multi-core parallel hardware to simultaneously compute multiple clutter suppression and target detection algorithms coupled to an intelligent selection strategy for selecting the most accurate result. These target locations are fed back to the FPGA Kalman filter periodically to update the target predictions. © 2012 IEEE.

关键词： Kalman filters

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Forces of Orthodontic Closed Coil Springs Measured using Fiber Bragg Gratings

Forces of Orthodontic Closed Coil Springs Measured using Fib...

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Latin America Optics and Photonics Conference, LAOP 2012

作者： Milczewski, Maura Scandelari Dinisio, Felipe Gonçalves Martelli, Cicero Borges, Paulo César Kalinowski, Hypolito José da Cunha, José Carlos Munhoz Federal University of Technology - Paraná Curitiba80230-901 Brazil Graduate Program on Electrical Engineering and Applied Computer Science Canada Department of Mechanical Engineering Brazilian Dentistry Association Paraná Brazil

The aim of this study is to compare forces generated by three different orthodontic closed coil springs supplied by three companies, optical fiber Bragg gratins are used to evaluate the force of closing of springs. &#... 详细信息

ISBN: (纸本)9781557529589

关键词： Fiber Bragg gratings

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Proceedings of the 8th Annual Conference on the science of Dissemination and Implementation : Washington, DC, USA. 14-15 December 2015

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Implementation science : IS 2016年第2期11 Suppl 2卷 100页

作者： Chambers, David Simpson, Lisa Hill-Briggs, Felicia Neta, Gila Vinson, Cynthia Beidas, Rinad Marcus, Steven Aarons, Gregory Hoagwood, Kimberly Schoenwald, Sonja Evans, Arthur Hurford, Matthew Rubin, Ronnie Hadley, Trevor Barg, Frances Walsh, Lucia Adams, Danielle Mandell, David Martin, Lindsey Mignogna, Joseph Mott, Juliette Hundt, Natalie Kauth, Michael Kunik, Mark Naik, Aanand Cully, Jeffrey McGuire, Alan White, Dominique Bartholomew, Tom McGrew, John Luther, Lauren Rollins, Angie Salyers, Michelle Cooper, Brittany Funaiole, Angie Richards, Julie Lee, Amy Lapham, Gwen Caldeiro, Ryan Lozano, Paula Gildred, Tory Achtmeyer, Carol Ludman, Evette Addis, Megan Marx, Larry Bradley, Katharine VanDeinse, Tonya Wilson, Amy Blank Stacey, Burgin Powell, Byron Bunger, Alicia Cuddeback, Gary Barnett, Miya Stadnick, Nicole Brookman-Frazee, Lauren Lau, Anna Dorsey, Shannon Pullmann, Michael Mitchell, Shannon Schwartz, Robert Kirk, Arethusa Dusek, Kristi Oros, Marla Hosler, Colleen Gryczynski, Jan Barbosa, Carolina Dunlap, Laura Lounsbury, David O’Grady, Kevin Brown, Barry Damschroder, Laura Waltz, Thomas Ritchie, Mona Atkins, David Imel, Zac E. Xiao, Bo Can, Doğan Georgiou, Panayiotis Narayanan, Shrikanth Berkel, Cady Gallo, Carlos Sandler, Irwin Brown, C. Hendricks Wolchik, Sharlene Mauricio, Anne Marie Mehrotra, Sanjay Chandurkar, Dharmendra Bora, Siddhartha Das, Arup Tripathi, Anand Saggurti, Niranjan Raj, Anita Hughes, Eric Jacobs, Brian Kirkendall, Eric Loeb, Danielle Trinkley, Katy Yang, Michael Sprowell, Andrew Nease, Donald Lyon, Aaron Lewis, Cara Boyd, Meredith Melvin, Abigail Nicodimos, Semret Liu, Freda Jungbluth, Nathanial Flynn, Allen Landis-Lewis, Zach Sales, Anne Baloh, Jure Ward, Marcia Zhu, Xi Bennett, Ian Unutzer, Jurgen Mao, Johnny Proctor, Enola Vredevoogd, Mindy Chan, Ya-Fen Williams, Nathaniel Green, Phillip Bernstein, Steven Rosner, June-Marie DeWitt, Michelle Tetrault, Jeanette Dziura, James Hsiao, Allen Sussman, Scott O’Connor, Patrick Toll, Benjamin Jones, Michael Gassaway, Julie Tobin, Jonathan Zatzic Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health Rockville USA AcademyHealth Washington USA Department of Medicine and Welch Center for Prevention Epidemiology and Clinical Research Johns Hopkins Medical Institutions Baltimore USA Psychiatry University of Pennsylvania Philadelphia USA Family Medicine and Community Health University of Pennsylvania Philadelphia USA School of Social Policy and Practice University of Pennsylvania Philadelphia USA Psychiatry UC San Diego La Jolla USA Child & Adolescent Psychiatry The Child Study Center at NYU Langone Medical Center New York NY New York USA Psychiatry and Behavioral Sciences MUSC Charleston USA DBHIDS City of Philadelphia Philadelphia USA CBH City of Philadelphia Philadelphia USA Psychiatry University of Pennsylvania Perelman School of Medicine Philadelphia USA Health Services Research & Development Department of Veterans Affairs & Baylor College of Medicine Houston USA Treatment Core Department of Veterans Affairs Waco USA National Center for PTSD Executive Division Department of Veterans Affairs White River Junction USA HSR&D HSR&D Center for Health Information and Communication Roudebush VA Medical Center Indianapolis USA Psychology Indiana University Purdue University Indianapolis Indianapolis USA Department of Psychiatric Rehabilitation and Counseling Rutgers University Newark USA Health Services Research & Development Richard L. Roudebush VAMC Indianapolis USA IUPUI Department of Psychology ACT Center of Indiana Indianapolis USA Human Development Washington State University Pullman USA Prevention Science Washington State University Pullman USA Group Health Research Institute Group Health Seattle USA Behavioral Health Services Group Health Seattle USA Preventive Care Group Health Seattle USA Health Services Research & Development Primary and Specialty Medical Care Service VA Puget Sound Seattle USA School of Social Work Un

A1 Introduction to the 8th Annual Conference on the science of Dissemination and Implementation: Optimizing Personal and Population Health David Chambers, Lisa Simpson D1 Discussion forum: Population health D&I research Felicia Hill-Briggs D2 Discussion forum: Global health D&I research Gila Neta, Cynthia Vinson D3 Discussion forum: Precision medicine and D&I research David Chambers S1 Predictors of community therapists’ use of therapy techniques in a large public mental health system Rinad Beidas, Steven Marcus, Gregory Aarons, Kimberly Hoagwood, Sonja Schoenwald, Arthur Evans, Matthew Hurford, Ronnie Rubin, Trevor Hadley, Frances Barg, Lucia Walsh, Danielle Adams, David Mandell S2 Implementing brief cognitive behavioral therapy (CBT) in primary care: Clinicians' experiences from the field Lindsey Martin, Joseph Mignogna, Juliette Mott, Natalie Hundt, Michael Kauth, Mark Kunik, Aanand Naik, Jeffrey Cully S3 Clinician competence: Natural variation, factors affecting, and effect on patient outcomes Alan McGuire, Dominique White, Tom Bartholomew, John McGrew, Lauren Luther, Angie Rollins, Michelle Salyers S4 Exploring the multifaceted nature of sustainability in community-based prevention: A mixed-method approach Brittany Cooper, Angie Funaiole S5 Theory informed behavioral health integration in primary care: Mixed methods evaluation of the implementation of routine depression and alcohol screening and assessment Julie Richards, Amy Lee, Gwen Lapham, Ryan Caldeiro, Paula Lozano, Tory Gildred, Carol Achtmeyer, Evette Ludman, Megan Addis, Larry Marx, Katharine Bradley S6 Enhancing the evidence for specialty mental health probation through a hybrid efficacy and implementation study Tonya VanDeinse, Amy Blank Wilson, Burgin Stacey, Byron Powell, Alicia Bunger, Gary Cuddeback S7 Personalizing evidence-based child mental health care within a fiscally mandated policy reform Miya Barnett, Nicole Stadnick, Lauren Brookman-Frazee, Anna Lau S8 Leveraging an existing

关键词： Veteran Affair Motivational Interview Qualitative Comparative Analysis Community That Care Supplemental Nutrition Assistance program

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Accelerated DSP functions on the CBE for the X-Midas Toolkit

Accelerated DSP functions on the CBE for the X-Midas Toolkit

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international Waveform Diversity and Design Conference, WDD 2012

作者： Jezak, Joseph A. Berdanier, Charles Levitan, Steven P. Chiarulli, Donald M. Computer Engineering Graduate Program University of Pittsburgh United States USAF AFRL/RYMDA Wright Patterson Air Force Base United States Department of Electrical and Computer Engineering University of Pittsburgh United States Department of Computer Science University of Pittsburgh United States

ISBN: (纸本)9781509005987

We characterize the impact of the Cell Broadband Engine architecture, on commonly used radar DSP algorithms. We use the capabilities of the CBE to accelerate several key computational kernels including Matrix Multiplication, Matrix Inversion, and the Finite Impulse Response (FIR) filter. These algorithms are implemented and benchmarked as library routines within the X-Midas Toolkit. We observe speedups as large as 1200x for complex matrix multiplication, but speedups of 40x to 60x are more typical. We find that system I/O overhead within the X-Midas toolkit severely limited the performance of the applications. © 2012 IEEE.

关键词： FIR filters

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Finding optimal random boolean networks for reservoir computing

Finding optimal random boolean networks for reservoir comput...

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13th international Conference on the Simulation and Synthesis of Living Systems: Artificial Life 13, ALIFE 2012

作者： Snyder, David Goudarzi, Alireza Teuscher, Christof Department of Computer Science Portland State University Portland OR 97201 United States Systems Science Graduate Program Portland State University Portland OR 97201 United States Department of Electrical and Computer Engineering Portland State University Portland OR 97201 United States

ISBN: (纸本)9780262310505

Reservoir Computing (RC) is a computational model in which a trained readout layer interprets the dynamics of a component called a reservoir that is excited by external input stimuli. The reservoir is often constructed using homogeneous neural networks in which a neuron's in-degree distributions as well as its functions are uniform. RC lends itself to computing with physical and biological systems. However, most such systems are not homogeneous. In this paper, we use Random Boolean Networks (RBN) to build the reservoir. We explore the computational capabilities of such a RC device using the temporal parity task and the temporal density classification. We study the sufficient dynamics of RBNs using kernel quality and generalization rank measures. We verify findings by Lizier et al. (2008) that the critical connectivity of RBNs optimizes the balance between the high memory capacity of RBNs with (K) 2. We show that in a RBN-based RC system, the optimal connectivity for the parity task, a processing intensive task, and the density classification task, a memory intensive task, agree with Lizier et al.'s theoretical results. Our findings may contribute to the development of optimal selfassembled nanoelectronic computer architectures and biologically-inspired computing paradigms. © 2012 Massachusetts Institute of Technology.

关键词： computer architecture

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Smart antenna using a combination of D3LS and NCLS algorithms

Smart antenna using a combination of D3LS and NCLS algorithm...

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2012 9th international Conference on electrical engineering/Electronics, computer, Telecommunications and Information Technology, ECTI-CON 2012

作者： Nilsuwan, Phichet Boonpoonga, Akkarat Tagapanij, Jukkrit Sirisuk, Phaophak Electrical Engineering Graduate Program Faculty of Engineering Mahanakorn University of Technology Bangkok Thailand Department of Electrical and Computer Engineering Faculty of Engineering King Mongkut's University of Technology North Bangkok Bangkok Thailand Department of Telecommunication Engineering Mahanakorn University of Technology Bangkok Thailand International College King Mongkut's Institute of Technology Ladkrabang Bangkok Thailand

ISBN: (纸本)9781467320245

This paper presents a smart antenna system using a combination of nonconventional least square (NCLS) optimization and direct data domain least square (D3LS) for direction-of-arrival (DOA) estimation and beamforming, respectively. In the proposed system, NCLS optimization is utilized to estimate DOA of incoming signal first. The estimated DOA is then assisted for initial processing of D3LS in beamforming. The performance in term of estimated signal amplitude and estimated DOA of the proposed system is evaluated via simulations. © 2012 IEEE.

关键词： Direction of arrival

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Performance evaluation of D3LS and NCLS smart antenna in mobile communications

Performance evaluation of D3LS and NCLS smart antenna in mob...

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2012 17th international Symposium on Antennas and Propagation, ISAP 2012

作者： Boonpoonga, Akkarat Nilsuwan, Phichet Tagapanij, Jukkrit Sirisuk, Phaophak Department of Electrical and Computer Engineering Faculty of Engineering King Mongkut's University of Technology North Bangkok Bangkok Thailand Electrical Engineering Graduate Program Faculty of Engineering Mahanakorn University of Technology Bangkok Thailand Department of Telecommunication Engineering Mahanakorn University of Technology Bangkok Thailand International College King Mongkut's Institute of Technology Ladkrabang Bangkok Thailand

ISBN: (纸本)9784885522703

A smart antenna was proposed to improve wireless communication systems. The smart antenna may comprises direction-of-arrival (DOA) estimation and/or adaptive antenna. The DOA estimation technique is used to estimate direction of transmitted signals. An adaptive antenna has ability of suppressing undesired signals namely interference or jammers in specific directions while receive only the desired one. There are a number of methods proposed to conduct in such way, including multiple signal classification (MUSIC), least mean squares (LMS), sample matrix inversion (SMI), recursive least squares (RLS), and their derivative forms as seen in the literatures in [1]. These methods require a training sequence or known information for adaptation and/or DOA estimation. Although a constant modulus algorithm (CMA) was proposed without the need of training sequence, it has a slow convergence. © 2012 IEICE.

关键词： Multiple signal classification

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Configurable clutter models for radar simulation

Configurable clutter models for radar simulation

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international Waveform Diversity and Design Conference

作者： Joseph A. Jezak Guy Gadola Charles Berdanier Steven P. Levitan Donald M. Chiarulli Computer Engineering Graduate Program University of Pittsburgh Department of Electrical Engineering Wright State University Department of Electrical and Computer Engineering University of Pittsburgh Department of Computer Science University of Pittsburgh

In this paper we describe an extension to the MATLAB Phased Array Toolkit that adds a configurable clutter object to model clutter signals returned along a specified signal path. The clutter model is based on the Simkins Unified Clutter Model[1]. The current implementation supports sea clutter in any of five sea states with configurable polarization, grazing angle, and beam width. We describe the implementation and give examples of modeled clutter returns.

关键词： Clutter Object oriented modeling Mathematical model Reflectivity Radar Computational modeling Arrays

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Hybrid clutter canceler with feedback guided predicative filtering on a heterogeneous parallel processing system

Hybrid clutter canceler with feedback guided predicative fil...

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international Waveform Diversity and Design Conference

作者： Jeffrey M. Brinkhus Joseph A. Jezak Charles Berdanier Steven P. Levitan Donald M. Chiarulli Electical and Computer Engineering University of Pittsburgh Computer Engineering Graduate Program University of Pittsburgh Electrical Engineering Wright State University Computer Science Department University of Pittsburgh

关键词： Clutter Kalman filters Mathematical model Field programmable gate arrays Radar Clocks Algorithm design and analysis

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