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RCMNet: A deep learning model assists CAR-T therapy for leukemia

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arXiv 2022年

作者： Zhang, Ruitao Han, Xueying Gul, Ijaz Zhai, Shiyao Liu, Ying Zhang, Yongbing Dong, Yuhan Ma, Lan Yu, Dongmei Zhou, Jin Qin, Peiwu Institute of Biomedical and Health Engineering Tsinghua Shenzhen International Graduate School China Precision Medicine and Public Health Tsinghua-Berkeley Shenzhen Institute United States The First Affiliated Hospital of Harbin Medical University China Food Inspection & Quarantine Center Shenzhen Custom China Department of Computer Science Harbin Insitute of Technology Shenzhen China School of Mc chanical Electrical & Information Engineering Shandong University China

Acute leukemia is a type of blood cancer with a high mortality rate. Current therapeutic methods include bone marrow transplantation, supportive therapy, and chemotherapy. Although a satisfactory remission of the disease can be achieved, the risk of recurrence is still high. Therefore, novel treatments are demanding. Chimeric antigen receptor-T (CAR-T) therapy has emerged as a promising approach to treat and cure acute leukemia. To harness the therapeutic potential of CAR-T cell therapy for blood diseases, reliable cell morphological identification is crucial. Nevertheless, the identification of CAR-T cells is a big challenge posed by their phenotypic similarity with other blood cells. To address this substantial clinical challenge, herein we first construct a CAR-T dataset with 500 original microscopy images after staining. Following that, we create a novel integrated model called RCMNet (ResNet18 with CBAM and MHSA) that combines the convolutional neural network (CNN) and Transformer. The model shows 99.63% top-1 accuracy on the public dataset. Compared with previous reports, our model obtains satisfactory results for image classification. Although testing on the CAR-T cells dataset, a decent performance is observed, which is attributed to the limited size of the dataset. Transfer learning is adapted for RCMNet and a maximum of 83.36% accuracy has been achieved, which is higher than other SOTA models. The study evaluates the effectiveness of RCMNet on a big public dataset and translates it to a clinical dataset for diagnostic applications. Copyright © 2022, The Authors. All rights reserved.

关键词： T-cells

Progress in wearable electronics/photonics—Moving toward the era of artificial intelligence and internet of things

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InfoMat 2020年第6期2卷 1131-1162页

作者： Qiongfeng Shi Bowei Dong Tianyiyi He Zhongda Sun Jianxiong Zhu Zixuan Zhang Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore117576Singapore Center for Intelligent Sensors and MEMS National University of SingaporeSingapore117608Singapore Hybrid-Integrated Flexible(Stretchable)Electronic Systems Program National University of SingaporeSingapore117608Singapore NUS Suzhou Research Institute(NUSRI) Suzhou215123China NUS Graduate School for Integrative Science and Engineering National University of SingaporeSingapore117456Singapore

The past few years have witnessed the significant impacts of wearable electronics/photonics on various aspects of our daily life,for example,healthcare monitoring and treatment,ambient monitoring,soft robotics,prosthetics,flexible display,communication,human-machine interactions,and so *** to the development in recent years,the next-generation wearable electronics and photonics are advancing rapidly toward the era of artificial intelligence(AI)and internet of things(IoT),to achieve a higher level of comfort,convenience,connection,and ***,this review provides an opportune overview of the recent progress in wearable electronics,photonics,and systems,in terms of emerging materials,transducing mechanisms,structural configurations,applications,and their further integration with other ***,development of general wearable electronics and photonics is summarized for the applications of physical sensing,chemical sensing,humanmachine interaction,display,communication,and so *** self-sustainable wearable electronics/photonics and systems are discussed based on system integration with energy harvesting and storage ***,technology fusion of wearable systems and AI is reviewed,showing the emergence and rapid development of intelligent/smart *** the last section of this review,perspectives about the future development trends of the next-generation wearable electronics/photonics are provided,that is,toward multifunctional,self-sustainable,and intelligent wearable systems in the AI/IoT era.

关键词： artificial intelligence energy harvesting human-machine interface internet of things wearable electronics wearable photonics

Riemann-Encircling Exceptional Points for Efficient Asymmetric Polarization-Locked Devices

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Physical Review Letters 2022年第12期129卷 127401-127401页

作者： Aodong Li Weijin Chen Heng Wei Guowei Lu Andrea Alù Cheng-Wei Qiu Lin Chen Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 China Department of Electrical and Computer Engineering National University of Singapore Singapore 117583 Singapore State Key Laboratory for Mesoscopic Physics School of Physics Peking University Beijing 100871 China Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA Physics Program Graduate Center City University of New York New York New York 10016 USA

Dynamically encircling exceptional points (EPs) have unveiled intriguing chiral dynamics in photonics. However, the traditional approach based on an open manifold of Hamiltonian parameter space fails to explore trajectories that pass through an infinite boundary. Here, by mapping the full parameter space onto a closed manifold of the Riemann sphere, we introduce a framework to describe encircling-EP loops. We demonstrate that an encircling trajectory crossing the north vertex can realize near-unity asymmetric transmission. An efficient gain-free, broadband asymmetric polarization-locked device is realized by mapping the encircling path onto L-shaped silicon waveguides.

关键词： PT-symmetric quantum mechanics Photonics

Low Temperature Spin Seebeck Effect in Non-Magnetic Vanadium Dioxide

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arXiv 2023年

作者： Luo, Renjie Legvold, Tanner J. Chen, Liyang Navarro, Henry Basaran, Ali C. Hong, Deshun Liu, Changjiang Bhattacharya, Anand Schuller, Ivan K. Natelson, Douglas Department of Physics and Astronomy Rice University HoustonTX77005 United States Applied Physics Graduate Program Rice Quantum Institute Rice University HoustonTX77005 United States Department of Physics Center for Advanced Nanoscience University of California La Jolla San DiegoCA92093 United States Materials Science Division Argonne National Laboratory LemontIL60439 United States Department of Electrical and Computer Engineering Department of Materials Science and NanoEngineering Rice University HoustonTX77005 United States

The spin Seebeck effect (SSE) is sensitive to thermally driven magnetic excitations in magnetic insulators. Vanadium dioxide in its insulating low temperature phase is expected to lack magnetic degrees of freedom, as vanadium atoms are thought to form singlets upon dimerization of the vanadium chains. Instead, we find a paramagnetic SSE response in VO2 films that grows as the temperature decreases below 50 K. The field and temperature dependent SSE voltage is qualitatively consistent with a general model of paramagnetic SSE response and inconsistent with triplet spin transport. Quantitative estimates find a spin Seebeck coefficient comparable in magnitude to that observed in strongly magnetic materials. The microscopic nature of the magnetic excitations in VO2 requires further examination. Copyright © 2023, The Authors. All rights reserved.

关键词： Paramagnetism

Effects of Hydrogen on Endurance Characteristics in NAND Flash Memories

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ECS Advances 2022年第4期1卷 042001-042001页

作者： Chiu, Yung-Yueh Liu, Wen-Chien Chen, Yu-Jung Kumaria, Roshni Takeshita, Toshiaki Yano, Masaru Shirota, Riichiro Department of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu 300 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu 300 Taiwan EECS International Graduate Program National Yang Ming Chiao Tung University Hsinchu 300 Taiwan Winbond Electronics Corporation Kanagawa 222-0033 Japan

This study comprehensively investigates the effect of hydrogen content in forming gas annealing (FGA) on the endurance of NAND flash memories by statistically analyzing the transconductance (G_m,max) characteristics. The G_m,max degradation (ΔG_m,max) worsened with higher cycling temperature, delayed time period from erasing to programming (t_EP) operation, and higher word-line bias (V_A) during t_EP. Moreover, these effects become more pronounced as the hydrogen content in FGA increases. Using the measured G_m,max distributions and Monte -Carlo TCAD technology, the activation energy (E_A) of oxide damage creation can be extracted. The extracted E_A values were 50 meV and 160 meV for the diluted (4%) and pure (100%) hydrogen samples, respectively. This suggests that a higher hydrogen concentration results in more ionized hydrogen atoms remaining in the oxide layer. During t_EP, these hydrogen ions can drift near the Si/SiO₂ surface, where they may react to form trap states. E_A is revealed to have a linear relationship with respect to V_A, where the slope is independent of the hydrogen content in FGA. © 2022 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited.

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Reducing system dimensionality with long-range collective dipole-dipole interactions

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arXiv 2023年

作者： Boddeti, Ashwin K. Wang, Yi Juarez, Xitlali G. Boltasseva, Alexandra Odom, Teri W. Shalaev, Vladimir Alaeian, Hadiseh Jacob, Zubin Elmore Family School of Electrical and Computer Engineering Purdue University West LafayetteIN47907 United States Birck Nanotechnology Center Purdue University West LafayetteIN47907 United States Graduate Program in Applied Physics Northwestern University EvanstonIL60208 United States Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States Department of Chemistry Northwestern University EvanstonIL60208 United States School of Physics and Astronomy Purdue University West LafayetteIN47907 United States

Dimensionality plays a crucial role in long-range dipole-dipole interactions (DDIs). We demonstrate that a resonant nanophotonic structure modifies the apparent dimensionality in an interacting ensemble of emitters, as revealed by population decay dynamics. Our measurements on a dense ensemble of interacting quantum emitters in a resonant nanophotonic structure with long-range DDIs reveal an effective dimensionality reduction to d¯ = 2.20(12), despite the emitters being distributed in 3D. This contrasts the homogeneous environment, where the apparent dimension is d¯ = 3.00. Our work presents a promising avenue to manipulate dimensionality in an ensemble of interacting emitters. © 2023, CC0.

关键词： Dipole moment

Unitary Excitation Transfer between Coupled Cavities Using Temporal Switching

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Physical Review Letters 2021年第1期127卷 013902-013902页

作者： Yarden Mazor Michele Cotrufo Andrea Alù Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 USA School of Electrical Engineering Tel-Aviv University Ramat-Aviv Tel-Aviv 69978 Israel Photonics Initiative Advanced Science Research Center City University of New York New York New York 10031 USA Physics Program Graduate Center of the City University of New York New York New York 10016 USA

Tailored time variations can enable efficient control over signal flows, giving rise to exotic wave phenomena. In this work, we demonstrate how abrupt temporal switching of the coupling between two cavities can tailor the energy flow between them beyond the limitations of static scenarios, enabling unitary excitation transfer. The proposed scheme is robust with respect to a wide range of nonidealities, with implications for classical and quantum phenomena, from computing to nanophotonic systems.

关键词： Metamaterials Coupled oscillators

Biomedical data and AI

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science China Life sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

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Competing epidemics on graphs-global convergence and coexistence

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arXiv 2021年

作者： Doshi, Vishwaraj Mallick, Shailaja Eun, Do Young Operations Research Graduate Program North Carolina State University RaleighNC United States Department of Computer Science North Carolina State University RaleighNC United States Department of Electrical and Computer Engineering North Carolina State University RaleighNC United States

The dynamics of the spread of contagions such as viruses, infectious diseases or even rumors/opinions over contact networks (graphs) have effectively been captured by the well known Susceptible-Infected-Susceptible (SIS) epidemic model in recent years. When it comes to competition between two such contagions spreading on overlaid graphs, their propagation is captured by so-called bi-virus epidemic models. Analysis of such dynamical systems involve the identification of equilibrium points and its convergence properties, which determine whether either of the viruses dies out, or both survive together. We demonstrate how the existing works are unsuccessful in characterizing a large subset of the model parameter space, including all parameters for which the competitiveness of the bi-virus system is significant enough to attain coexistence of the epidemics. In this paper, we fill in this void and obtain convergence results for the entirety of the model parameter space;giving precise conditions (necessary and sufficient) under which the system globally converges to a trichotomy of possible outcomes: a virus-free state, a single-virus state, and to a coexistence state-the first such result. Copyright © 2021, The Authors. All rights reserved.

关键词： Viruses