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Enhanced electrochemical detection of tartrazine in beverages and liquid soap via nickel phosph.de-adorned functionalized carbon nanofibers

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Journal of the Taiwan Institute of Chemical Engineers 2024年 157卷

作者： Gokulkumar, Kumar Huang, Song-Jeng Kogularasu, Sakthivel Aljuwayid, Ahmed M. Maheshwaran, Selvarasu Govindasamy, Mani Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei City106335 Taiwan Super micro mass research and technology center Cheng Shiu University Kaohsiung833301 Taiwan Center for Environmental Toxin and Emerging-Contaminant Research Cheng Shiu University Kaohsiung833301 Taiwan Department of Chemistry College of Science King Saud University P. O. Box 2455 Riyadh11451 Saudi Arabia Department of Aeronautics and Astronautics National Cheng Kung University Tainan701 Taiwan International Ph.D. Program In Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Tamil Nadu Chennai602105 India

Background: Tartrazine (TAT) is a widely used food colorant dye, offering an orange-yellow hue in various products such as foods, cosmetics, and pharmaceuticals. despite its popularity, TAT is banned in several countries due to its potential health risks, including respiratory issues, migraines, and skin allergies. Moreover, TAT is linked with adverse effects on human physiology, including mutagenicity, biliary cirrhosis, changes in liver and kidney functions, and neurodegeneration at varying doses. Consequently, the detection of this food additive is crucial for safeguarding human health and protecting aquatic organisms. Methods: In this study, a novel sensor was developed for the detection of TAT, utilizing a composite material made from nickel phosph.de decorated with functionalized carbon nanofiber (Ni2P@f-CNF). The Ni2P@f-CNF was synthesized and characterized through several techniques, including X-ray diffraction, X-ray photoelectron spectroscopy, field emission-scanning electron microscopy, and elemental mapping. The composite was then integrated with a glassy carbon electrode to create a sensor. The sensor's performance was evaluated in terms of detection limit, linear range, selectivity, sensitivity, reproducibility, repeatability, and long-term stability. Main Findings: The developed Ni2P@f-CNF composite sensor displayed a lower detection limit of 0.011 µM and a broad linear range from 0.01 to 1875 µM. Its selectivity and sensitivity were exceptional, primarily due to the catalytic activity of the Ni2P@f-CNF composite towards TAT. The sensor also demonstrated excellent reproducibility, repeatability, and notable long-term stability. Importantly, when applied in real-world scenarios, the sensor successfully detected TAT in soft drink and liquid soap samples, yielding high recovery rates between 97.45 % to 99.37 % and 98.26 % to 99.01 %, respectively, underscoring its potential applicability in practical settings. © 2024 Taiwan Institute of Chemical Engineer

关键词： Nickel compounds

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Bioactive phytol from Thymus vulgaris, a promising source of alternative medicine to combat blaKPC and blaOXA-48 genotypes of Klebsiella pneumoniae: A retrospective in vitro and in silico approach

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Microbial Pathogenesis 2025年 206卷

作者： Murugan, Shibasini Karuppiah, Vijay Pandi, Sangavi Govindasamy, Mani Thangavel, Kavitha Department of Microbiology Science Campus Alagappa University Tamil Nadu Karaikudi India Department of Microbiology Thiagarajar College (An Autonomous institution Affiliated to Madurai Kamaraj University) Tamil Nadu Madurai India Department of Bioinformatics Science Campus Alagappa University Tamil Nadu Karaikudi India Department of Microbiology Center for Bioinformatics Karpagam Academy of Higher Education Tamil Nadu Coimbatore 641 021 India International Ph.D Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Science and Technology New Taipei City 24303 Taiwan

Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant public health challenge due to its multidrug resistance and limited treatment options. This study investigates the antibacterial potential of Thymus vulgaris ethanolic extract and its bioactive compounds against multidrug-resistant K. pneumoniae strains harboring blaKPC and blaOXA-48 carbapenemase genes. The presence of these resistance genes was confirmed by multiplex PCR. The extract exhibited a dose-dependent inhibitory effect, with a maximum inhibition zone of 18 ± 1.5 mm at 100 μg. Chromatographic techniques, including thin-layer chromatography (TLC) and column chromatography, yielded six fractions, among which fraction F3 showed the strongest antibacterial activity. Gas chromatography–mass spectrometry (GC-MS) and ultra-performance liquid chromatography (UPLC) analyses identified phytol as the predominant bioactive constituent. Further evaluation of phytol revealed a minimum inhibitory concentration (MIC) of 125 μg/mL and a minimum bactericidal concentration (MBC) of 250 μg/mL against CRKP. Alamar Blue viability assays and bacterial culture confirmed phytol's bacteriostatic and bactericidal effects, independent of the ethanol solvent. These findings suggest that phytol inhibits bacterial growth, possibly through membrane-targeting mechanisms. Notably, this study is among the first to comprehensively assess phytol's efficacy against carbapenem-resistant K. pneumoniae strains carrying blaKPC and blaOXA-48 genes, integrating molecular characterization, chromatographic purification and antimicrobial activity. Overall, the results highlight phytol as a promising natural agent to combat multidrug-resistant bacterial infections and address the urgent global threat of antibiotic resistance. © 2025 Elsevier Ltd

关键词： Antibacterials Carbapenem-resistant enterobacteriacae Klebsiella pneumoniae Molecular docking phytol Thymus vulgaris

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Use of machine learning algorithms to determine the relationship between air pollution and cognitive impairment in Taiwan

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Ecotoxicology and environmental safety 2024年 284卷 116885页

作者： Cheng-Hong Yang Chih-Hsien Wu Kuei-Hau Luo Huang-Chih Chang Sz-Chiao Wu Hung-Yi Chuang Department of Information Management Tainan University of Technology Tainan 71002 Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung 80778 Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung 80708 Taiwan School of Dentistry Kaohsiung Medical University Kaohsiung 80708 Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan. Electronic address: chyang@nkust.edu.tw. Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung 80778 Taiwan. Electronic address: F108152123@nkust.edu.tw. Graduate Institute of Medicine College of Medicine Kaohsiung Medicine University Kaohsiung 80708 Taiwan. Electronic address: u107800007@kmu.edu.tw. Divisions of Pulmonary & Critical Care Medicine Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung 83341 Taiwan Ph.D Program in Environmental and Occupational Medicine and Research Center for Environmental Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Electronic address: kuan2101@yahoo.com.tw. Epidemiology in the Public Health Program College of Health Oregon State University Oregon 97331 USA. Electronic address: wusz550@***. Graduate Institute of Medicine College of Medicine Kaohsiung Medicine University Kaohsiung 80708 Taiwan Ph.D Program in Environmental and Occupational Medicine and Research Center for Environmental Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Public Health and Environmental Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan Department of Occupational and Environmental Medicine Kaohsiung Medicine University Hospital Kaohsiung Medicine University Kaohsiung 80708 Taiwan. Electronic address: ericch@kmu.edu.tw.

Air pollution has become a major global threat to human health. Urbanization and industrialization over the past few decades have increased the air pollution. Plausible connections have been made between air pollutants and dementia. This study used machine learning algorithms (k-nearest neighbors, random forest, gradient-boosted decision trees, eXtreme gradient boosting, and CatBoost) to investigate the association between cognitive impairment and air pollution. data from the Taiwan Biobank and 75 air-pollution-monitoring stations in Taiwan were analyzed to determine individual levels of exposure to air pollutants. The pollutants examined were particulate matter with a diameter of ≤ 2.5 μm (PM), nitrogen dioxide, nitric oxide, carbon monoxide, and ozone. The results revealed that the most strongly correlated with cognitive impairment were ozone, PM, and carbon monoxide levels with adjustment of educational level, age, and household income. The model based on these factors achieved accuracy as high as 0.97 for detecting cognitive impairment, indicating a positive association between air pollutions and cognitive impairment.

关键词： Air pollution Carbon monoxide Cognitive impairment dementia Ozone PM(2.5)

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Analysis of discharge and area of the debris flow based on geological structural and rainfall levels in the slopes of Mount Abang, Kintamani

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IOP Conference Series: Materials science and Engineering 2021年第2期1098卷

作者： I N Sinarta P I Wahyuni P Aryastana Department of Civil Engineering Universitas Warmadewa Jl. Terompong No.24 Denpasar Bali Indonesia International Ph.D. Program in Environmental Science and Technology (University System of Taiwan) National Central University Taiwan

Geological structural and rainfall intensity causes the parameters of soil shear strength to decline, especially in the surface layer of soil in volcanic rocks that have not experienced weathering. Study of geological structures and rainfall intensity against the hazard of a landslide was destroyed on the slopes of Mount Abang in the Abang Batudinding Village. Soil investigations using the Geoelectric method and sampling at 6 boreholes. Geological analysis on interpretation of slope outcrops, average rainfall analysis of the Thiessen Polygon method and analysis of design flood discharge using the NHSU method. Analysis results show the morphology of the slopes of Mount Abang with a slope of more than 40% and lithology of weathered volcanic rocks consisting of volcanic breccias, and tuffs breccias in conditions rather mild to moderate weathering, if have average effective rainfall for 10-50 years at 238 mm/day. The results also show that the peak discharge of debris flow was 98.639 m3/sec with the volume of debris flow 50072.85 m3 and the width of the range was 49.5 m. This debris flow volume indicated that residents around the river with a range of 49.5 m are at risk of debris flow sediment with a thickness of 1-1.5 m.

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data on lung and intestinal microbiome after air pollution exposure in ageing rats

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data in brief 2023年 47卷 109004页

作者： Vincent Laiman Yu-Chun Lo Hsin-Chang Chen Tzu-Hsuen Yuan Ta-Chih Hsiao Jen-Kun Chen Ching-Wen Chang Ting-Chun Lin Ssu-Ju Li You-Yin Chen didik Setyo Heriyanto Kian Fan Chung Kai-Jen Chuang Kin-Fai Ho Jer-Hwa Chang Hsiao-Chi Chuang International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Anatomical Pathology Faculty of Medicine Public Health and Nursing Universitas Gadjah Mada - Dr. Sardjito Hospital Yogyakarta Indonesia. Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Chemistry College of Science Tunghai University Taichung Taiwan. Department of Health and Welfare College of City Management University of Taipei Taipei Taiwan. Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan. Institute of Biomedical Engineering & Nanomedicine National Health Research Institutes Miaoli Taiwan. Industrial Ph.D. Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Taipei Taiwan. Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei Taiwan. National Heart and Lung Institute Imperial College London London UK. School of Public Health College of Public Health Taipei Medical University Taipei Taiwan. Department of Public Health School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. School of Public Health and Primary Care the Chinese University of Hong Kong Hong Kong. School of Respiratory Therapy College of Medicine Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan. Division of Pulmonary Medicine Departments of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan. Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan. Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan.

Air pollution has been linked to respiratory diseases, and urban air pollution can be attributed to a number of emission sources. The emitted particles and gases are the primary components of air pollution that enter the lungs during respiration. Particulate matter with an aerodynamic diameter of ≤ 2.5 µm (PM) can deposit deep into the respiratory tract via inhalation and has been proposed as a causative agent for adverse respiratory health. In addition, the lung contains a diverse microbial community (microbiome) that maintains normal homeostasis and is significantly altered in a variety of pulmonary disorders. Air pollution, specifically PM, has previously been shown to significantly alter the composition of the lower airway microbiome, which has been linked to decreased lung function in chronic obstructive pulmonary disease (COPd) patients. Surprisingly, the intestinal microbiome has also been implicated in the modulation of pulmonary inflammatory diseases. Therefore, dysbiosis of the lung and intestinal microbiomes pose significant negative effects on human health. This dataset describes the microbial community profiles of the lungs and intestines of ageing rats exposed to ambient unconcentrated traffic-related air pollution for three months. The whole-body exposure system was equipped with and without high efficiency particulate air (HEPA) filtration (gaseous vs. PM pollution). The data can provide valuable information on lung and intestinal microbiome changes, including that which was only found after traffic-related air pollution exposure.

关键词： Air pollution Intestinal microbiome Lung microbiome PM2.5

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Construction status and prospects of the Hyper-Kamiokande project

Construction status and prospects of the Hyper-Kamiokande pr...

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37th international Cosmic Ray Conference, ICRC 2021

作者： Itow, Yoshitaka Abe, K. Adrich, P. Aihara, H. Akutsu, R. Alekseev, I. Ali, A. Alj Hakim, Y.I. Ameli, F. Anthony, L.H.V. Araya, A. Asaoka, Y. Aushev, V. Ballester, F. Bandac, I. Barbi, M. Barr, G. Batkiewicz-Kwasniak, M. Bellato, M. Berardi, V. Bernard, L. Bernardini, E. Berns, L. Bhadra, S. Bian, J. Blanchet, A. Blondel, A. Boiano, A. Bolognesi, S. Bonavera, L. Booth, N. Bordoni, S. Borjabad, S. Boschi, T. Bose, d. Boyd, S.B. Bozza, C. Bravar, A. Bronner, C. Brown, L. Bubak, A. Buchowicz, A. Buizza Avanzini, M. Cafagna, F.S. Calabria, N.F. Calvo-Mozota, J.M. Cao, S. Carroll, A. Catanesi, M.G. Cebriàn, S. Chakraborty, S. Choi, J.H. Choubey, S. Cicerchia, M. Coleman, J. Collazuol, G. Cuen-Rochin, S. danilov, M. díaz López, G. de la Fuente, E. de Perio, P. de Rosa, G. dealtry, T. densham, C.J. dergacheva, A. deshmukh, N. devi, M.M. di Lodovico, F. di Meo, P. di Palma, I. doyle, T.A. drakopoulou, E. drapier, O. dumarchez, J. Eklund, L. El Hedri, S. Ellis, J. Emery, S. Esmaili, A. Esteve, R. Fedotov, S. Feng, J. Fernandez, P. Fernández-Martinez, E. Ferrario, P. Ferrazzi, B. Finch, A. Finley, C. Fiorillo, G. Fitton, M. Friend, M. Fujii, Y. Fujisawa, C. Fukuda, Y. Galinski, G. Gao, J. Garde, C. Garfagnini, A. Garode, S. Gialanella, L. Giganti, C. Gomez-Cadenas, J.J. Gonin, M. González-Nuevo, J. Gorin, A. Gornea, R. Gousy-Leblanc, V. Gramegna, F. Grassi, M. Grella, G. Guigue, M. Hadley, d.R. Harada, M. Hartz, M. Hassani, S. Hastings, N.C. Hayato, Y. Hernando-Morata, J.A. Herrero, V. Hiraide, K. Holin, A. Hoshina, K. Hultqvist, K. Iacob, F. Ichikawa, A.K. Idrissi Ibnsalih, W. Ieki, K. Ikeda, M. Ioannisian, A. Ishida, T. Ishidoshiro, K. Ishino, H. Ishitsuka, M. Israel, H.T. Ito, H. Itow, Y. Izumi, N. Izumiyama, S. Jakkapu, M. Jamieson, B. Jang, J.S. Jo, H.S. Jonsson, P. Joo, K.K. Kajita, T. Kakuno, H. Kameda, J. Kaneshima, R. Kano, Y. Karlen, d. Kataoka, Y. Kato, A. Katori, T. Kazarian, N. Khabibullin, M. Institute for Space-Earth Environmental Research Kobayashi-Maskawa Institute for the Origin of Particles and the Universe Nagoya University Aichi Nagoya Japan University of Tokyo Institute for Cosmic Ray Research Kamioka Observatory Kamioka Japan University of Tokyo Institutes for Advanced Study Kashiwa Japan University of Tokyo Next-generation Neutrino Science Organization Kamioka Japan National Centre for Nuclear Research Warsaw Poland University of Tokyo Department of Physics Tokyo Japan TRIUMF VancouverBC Canada P.N.Lebedev Physical Institute of the Russian Academy of Sciences Moscow Russia Kyoto University Department of Physics Kyoto Japan Imperial College London Department of Physics London United Kingdom INFN Sezione di Roma Università Sapienza Dipartimento di Fisica Roma Italy University of Tokyo Earthquake Research Institute Tokyo Japan Kyiv National University Department of Nuclear Physics Kyiv Ukraine Valencia Spain Laboratorio Subterráneo de Canfranc Estación Canfranc Spain University of Regina Department of Physics ReginaSK Canada Oxford University Department of Physics Oxford United Kingdom H. Niewodniczański Institute of Nuclear Physics PAN Cracow Poland INFN Sezione di Padova Università di Padova Dipartimento di Fisica Padova Italy INFN Sezione di Bari Università e Politecnico di Bari Bari Italy Ecole Polytechnique IN2P3-CNRS Laboratoire Leprince-Ringuet Palaiseau France Tokyo Institute of Technology Department of Physics Tokyo Japan York University Department of Physics and Astronomy TorontoON Canada University of California Irvine Department of Physics and Astronomy IrvineCA United States Laboratoire de Physique Nucleaire et de Hautes Energie IN2P3 CNRS Sorbonne Universitè Paris France INFN Sezione di Napoli Napoli Italy IRFU CEA Universitè Paris-Saclay Gif-sur-Yvette France University of Oviedo Applied Mathematical Modeling Group Department of Physics Oviedo Spain University of Victoria Department of

The Hyper-Kamiokande project is a 258-kton Water Cherenkov together with a 1.3-MW high-intensity neutrino beam from the Japan Proton Accelerator Research Complex (J-PARC). The inner detector with 186-kton fiducial volume is viewed by 20-inch photomultiplier tubes (PMTs) and multi-PMT modules, and thereby provides state-of-the-art of Cherenkov ring reconstruction with thresholds in the range of few MeVs. The project is expected to lead to precision neutrino oscillation studies, especially neutrino CP violation, nucleon decay searches, and low energy neutrino astronomy. In 2020, the project was officially approved and construction of the far detector was started at Kamioka. In 2021, the excavation of the access tunnel and initial mass production of the newly developed 20-inch PMTs was also started. In this paper, we present a basic overview of the project and the latest updates on the construction status of the project, which is expected to commence operation in 2027. © Copyright owned by the author(s).

关键词： photomultipliers

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CXCR7 activation evokes the anti-Pd-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity

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Cell death & disease 2024年第6期15卷 434页

作者： Chan-Chuan Liu Wen-Bin Yang Chia-Hung Chien Cheng-Lin Wu Jian-Ying Chuang Pin-Yuan Chen Jui-Mei Chu Siao Muk Cheng Li-Ying Qiu Yung-Chieh Chang daw-Yang Hwang Chih-Yuan Huang Jung-Shun Lee Kwang-Yu Chang National Institute of Cancer Research National Health Research Institutes Tainan Taiwan. Research Center for Neuroscience Taipei Medical University Taipei Taiwan. Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan. School of Medicine I-Shou University Kaohsiung Taiwan. Department of Pathology National Cheng Kung University Hospital College of Medicine National Cheng-Kung University Tainan Taiwan. International Master Program in Medical Neuroscience Taipei Medical University Taipei Taiwan. Department of Biomedical Science and Environmental Biology Kaohsiung Medical University Kaohsiung Taiwan. School of Medicine Chang Gung University Taoyuan Taiwan. Department of Neurosurgery Keelung Chang Gung Memorial Hospital Keelung Taiwan. TMU Research Center of Cancer Translational Medicine Taipei Cancer Center Taipei Medical University Hospital College of Medicine Taipei Medical University Taipei Taiwan. Division of Neurosurgery Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan. National Institute of Cancer Research National Health Research Institutes Tainan Taiwan. kwang2@nhri.edu.tw. Department of Oncology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan. kwang2@nhri.edu.tw. Center of Cell Therapy National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan. kwang2@nhri.edu.tw.

The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that disrupting the communication between tumors and macrophages would enhance the efficacy of immunotherapies. Transcriptomic analysis of recurrent glioblastoma specimens indicated an enhanced neuroinflammatory pathway, with CXCL12 emerging as the top-ranked gene in secretory molecules. Single-cell transcriptome profiling of naïve glioblastoma specimens revealed CXCL12 expression in tumor and myeloid clusters. An analysis of public glioblastoma datasets has confirmed the association of CXCL12 with disease and Pd-L1 expression. In vitro studies have demonstrated that exogenous CXCL12 induces pro-tumorigenic characteristics in macrophage-like cells and upregulated Pd-L1 expression through NF-κB signaling. We identified CXCR7, an atypical receptor for CXCL12 predominantly present in tumor cells, as a negative regulator of CXCL12 expression by interfering with extracellular signal-regulated kinase activation. CXCR7 knockdown in a glioblastoma mouse model resulted in worse survival outcomes, increased Pd-L1 expression in GAMs, and reduced Cd8 T-cell infiltration compared with the control group. Ex vivo T-cell experiments demonstrated enhanced cytotoxicity against tumor cells with a selective CXCR7 agonist, VUF11207, reversing GAM-induced immunosuppression in a glioblastoma cell-macrophage-T-cell co-culture system. Notably, VUF11207 prolonged survival and potentiated the anti-tumor effect of the anti-Pd-L1 antibody in glioblastoma-bearing mice. This effect was mitigated by an anti-Cd8β antibody, indicating the synergistic effect of VUF11207. In conclusion, CXCL12 conferred immunosuppression mediated by pro-tumorigenic and Pd-L1-expressing GAMs in glioblastoma. Targeted activation of glioblastoma-derived CXCR7 inhibits CXCL12, thereby eliciting anti-tumor immunity and enha

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Prospects for neutrino astrophysics with Hyper-Kamiokande

Prospects for neutrino astrophysics with Hyper-Kamiokande

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37th international Cosmic Ray Conference, ICRC 2021

作者： Yano, Takatomi Abe, K. Adrich, P. Aihara, H. Akutsu, R. Alekseev, I. Ali, A. Alj Hakim, Y.I. Ameli, F. Anthony, L.H.V. Araya, A. Asaoka, Y. Aushev, V. Ballester, F. Bandac, I. Barbi, M. Barr, G. Batkiewicz-Kwasniak, M. Bellato, M. Berardi, V. Bernard, L. Bernardini, E. Berns, L. Bhadra, S. Bian, J. Blanchet, A. Blondel, A. Boiano, A. Bolognesi, S. Bonavera, L. Booth, N. Bordoni, S. Borjabad, S. Boschi, T. Bose, d. Boyd, S.B. Bozza, C. Bravar, A. Bronner, C. Brown, L. Bubak, A. Buchowicz, A. Buizza Avanzini, M. Cafagna, F.S. Calabria, N.F. Calvo-Mozota, J.M. Cao, S. Carroll, A. Catanesi, M.G. Cebriàn, S. Chakraborty, S. Choi, J.H. Choubey, S. Cicerchia, M. Coleman, J. Collazuol, G. Cuen-Rochin, S. danilov, M. díaz López, G. de la Fuente, E. de Perio, P. de Rosa, G. dealtry, T. densham, C.J. dergacheva, A. deshmukh, N. devi, M.M. di Lodovico, F. di Meo, P. di Palma, I. doyle, T.A. drakopoulou, E. drapier, O. dumarchez, J. Eklund, L. El Hedri, S. Ellis, J. Emery, S. Esmaili, A. Esteve, R. Fedotov, S. Feng, J. Fernandez, P. Fernández-Martinez, E. Ferrario, P. Ferrazzi, B. Finch, A. Finley, C. Fiorillo, G. Fitton, M. Friend, M. Fujii, Y. Fujisawa, C. Fukuda, Y. Galinski, G. Gao, J. Garde, C. Garfagnini, A. Garode, S. Gialanella, L. Giganti, C. Gomez-Cadenas, J.J. Gonin, M. González-Nuevo, J. Gorin, A. Gornea, R. Gousy-Leblanc, V. Gramegna, F. Grassi, M. Grella, G. Guigue, M. Hadley, d.R. Harada, M. Hartz, M. Hassani, S. Hastings, N.C. Hayato, Y. Hernando-Morata, J.A. Herrero, V. Hiraide, K. Holin, A. Hoshina, K. Hultqvist, K. Iacob, F. Ichikawa, A.K. Idrissi Ibnsalih, W. Ieki, K. Ikeda, M. Ioannisian, A. Ishida, T. Ishidoshiro, K. Ishino, H. Ishitsuka, M. Israel, H.T. Ito, H. Itow, Y. Izumi, N. Izumiyama, S. Jakkapu, M. Jamieson, B. Jang, J.S. Jo, H.S. Jonsson, P. Joo, K.K. Kajita, T. Kakuno, H. Kameda, J. Kaneshima, R. Kano, Y. Karlen, d. Kataoka, Y. Kato, A. Katori, T. Kazarian, N. Khabibullin, M. Kamioka Observatory ICRR The University of Tokyo Mozumi Kamioka Hida Gifu456 Japan University of Tokyo Institute for Cosmic Ray Research Kamioka Observatory Kamioka Japan University of Tokyo Institutes for Advanced Study Kashiwa Japan University of Tokyo Next-generation Neutrino Science Organization Kamioka Japan National Centre for Nuclear Research Warsaw Poland University of Tokyo Department of Physics Tokyo Japan TRIUMF VancouverBC Canada P.N.Lebedev Physical Institute of the Russian Academy of Sciences Moscow Russia Kyoto University Department of Physics Kyoto Japan Imperial College London Department of Physics London United Kingdom INFN Sezione di Roma Università Sapienza Dipartimento di Fisica Roma Italy University of Tokyo Earthquake Research Institute Tokyo Japan Kyiv National University Department of Nuclear Physics Kyiv Ukraine Valencia Spain Laboratorio Subterráneo de Canfranc Estación Canfranc Spain University of Regina Department of Physics ReginaSK Canada Oxford University Department of Physics Oxford United Kingdom H. Niewodniczański Institute of Nuclear Physics PAN Cracow Poland INFN Sezione di Padova Università di Padova Dipartimento di Fisica Padova Italy INFN Sezione di Bari Università e Politecnico di Bari Bari Italy Ecole Polytechnique IN2P3-CNRS Laboratoire Leprince-Ringuet Palaiseau France Tokyo Institute of Technology Department of Physics Tokyo Japan York University Department of Physics and Astronomy TorontoON Canada University of California Irvine Department of Physics and Astronomy IrvineCA United States Laboratoire de Physique Nucleaire et de Hautes Energie IN2P3 CNRS Sorbonne Universitè Paris France INFN Sezione di Napoli Napoli Italy IRFU CEA Universitè Paris-Saclay Gif-sur-Yvette France University of Oviedo Applied Mathematical Modeling Group Department of Physics Oviedo Spain University of Victoria Department of Physics and Astronomy VictoriaBC Canada University of Geneva Section

Hyper-Kamiokande is a multi-purpose next generation neutrino experiment. The detector is a two-layered cylindrical shape ultra-pure water tank, with its height of 64 m and diameter of 71 m. The inner detector will be surrounded by tens of thousands of twenty-inch photosensors and multi-PMT modules to detect water Cherenkov radiation due to the charged particles and provide our fiducial volume of 188 kt. This detection technique is established by Kamiokande and Super-Kamiokande. As the successor of these experiments, Hyper-K will be located deep underground, 600 m below Mt. Tochibora at Kamioka in Japan to reduce cosmic-ray backgrounds. Besides our physics program with accelerator neutrino, atmospheric neutrino and proton decay, neutrino astrophysics is an important research topic for Hyper-K. With its fruitful physics research programs, Hyper-K will play a critical role in the next neutrino physics frontier. It will also provide important information via astrophysical neutrino measurements, i.e., solar neutrino, supernova burst neutrinos and supernova relic neutrino. Here, we will discuss the physics potential of Hyper-K neutrino astrophysics. © Copyright owned by the author(s).

关键词： Water tanks

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BHEL Smart Wall Blowing System: New Product development in Manufacturing Industry

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Vikalpa 2021年第4期45卷 240 - 249页

作者： Abhishek Kumar R. dhanuskodi R. Kaliappan K. Nandakumar Abhishek Kumar teaches design philosophies at Anant National University Ahmedabad. He earned his Ph.D in Management from Pondicherry University. He is an Economics graduate from Calcutta University and MBA from BIM Trichy. He has published more than 20 articles in reputed international journals has authored two books written articles and columns for newspapers and is quoted on issues related to leadership and marketing by various media platforms. His research work comprises construction of brand personality scale for media aesthetics and phenomenological design. His recent publications are on philosophy of a photograph hermeneutic reality of product and on philosophy of intimate spaces. R. Dhanuskodi has nearly 40 years of R&D experience at BHEL India in technical areas applicable for thermal power plants. He is a life member of The Institution of Engineers (India) and The Combustion Institute. He has won two BHEL’s Excel awards under the best author category for technical papers. He has visited France Netherlands and Germany under Indo-Europe Clean Coal Development Program. He has guided 42 UG PG and PhD project works. He holds 11 patents 40 copyrights and 2 design registrations. He has presented papers in 20 conferences and published in 10 national and international journals. R. Kaliappan completed his bachelors in electrical and electronics engineering and Masters in Computer Science. He has 36 years of research experience in different fields of power generation and power plant subsystems such as heat transfer studies on boiler circulation efficiency improvements of boiler subsystems product improvements/ enhancements and setting up test facilities for research studies. He has published a number of technical papers on MHD power generation and heat transfer studies in various national and international journals. He has more than 25 patents and copyrights on products development related to power boilers. He has won BHEL’S gold medal for product development for Smart Wall Blowing system. K. Nandakumar

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Publisher Correction: Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020

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Eye (London, England) 2024年第11期38卷 2229-2231页

作者： Konrad Pesudovs Hugh R. Taylor Tabassom Sedighi Rupert R. A. Bourne Shahina Pardhan Van Charles Lansingh John H. Kempen Ian Tapply Arthur G. Fernandes Maria Vittoria Cicinelli Alessandro Arrigo Nicolas Leveziel Serge Resnikoff Seth Flaxman Mukkharram M. Bikbov Tasanee Braithwaite Alain Bron Ching-Yu Cheng Monte A. del Monte Joshua R. Ehrlich Leon B. Ellwein david Friedman João M. Furtado Gus Gazzard Ronnie George M. Elizabeth Hartnett Jost B. Jonas Rim Kahloun Moncef Khairallah Rohit C. Khanna Janet Leasher Julie-Anne Little Vinay Nangia Michal Nowak Tunde Peto Pradeep Ramulu Fotis Topouzis Mitiadis Tsilimbaris Ya Xing Wang Ningli Wang Paul Svitil Briant Theo Vos Katrin Burkart Kaleb Coberly Xiaochen dai Stephen S. Lim Tomislav Mestrovic Ali H. Mokdad Christopher J. L. Murray Jaimie d. Steinmetz Awoke Misganaw Yohannes Habtegiorgis Abate Mohammad Abdollahi Mozhan Abdollahi Ayele Mamo Abebe Olumide Abiodun Richard Gyan Aboagye Woldu Aberhe Abrha Hasan Abualruz Hiwa Abubaker Ali Eman Abu-Gharbieh Salahdein Aburuz Tadele Girum Girum Adal Mesafint Molla Adane Isaac Yeboah Addo Qorinah Estiningtyas Sakilah Adnani Muhammad Sohail Afzal Muhammad Umair Shahin Aghamiri Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Ali Ahmadi Siamak Sabour Ayman Ahmed Haroon Ahmed Ahmad Samir Alfaar Abid Ali Syed Shujait Shujait Ali Awais Altaf Hubert Amu Emmanuel Manu Sofia Androudi Rodrigo Anguita Abhishek Anil Rimple Jeet Kaur Muhammad Aaqib Shamim Saeid Anvari Anayochukwu Edward Anyasodor Francis Appiah Jalal Arabloo Haleh Ayatollahi Mosab Arafat damelash Areda Reza Arefnezhad Brhane Berhe Aregawi Akeza Awealom Asgedom Tahira Ashraf Seyyed Shamsadin Athari Bantalem Tilaye Tilaye Atinafu Birhan Tsegaw Taye Maha Moh’d Wahbi Atout Alok Atreya Ahmed Y. Azzam Hassan Babamohamadi Sara Bagherieh Yogesh Bahurupi Atif Amin Baig Shumaila Nargus Biswajit Banik Mainak Bardhan Saurav Basu Kavita Batra Nebiyou Simegnew Bayileyegn Fatemeh Bazvand Addisu Shunu Beyene Awoke Masrie Asrat derese devidas S. Bhagat Akshaya Srikanth Bhagavathula Pankaj Bh Medicine & Health University of New South Wales Sydney NSW Australia School of Optometry and Vision Science University of New South Wales Sydney NSW Australia School of Population and Global Health University of Melbourne Carlton VIC Australia Vision and Eye Research Institute Anglia Ruskin University Cambridge UK HelpMeSee Instituto Mexicano de Oftalmologia Santiago de Querétaro Mexico University of Miami Gables FL USA University of Utah Salt Lake City UT USA Chief Medical Office HelpMeSee New York NY USA Mexican Institute of Ophthalmology Queretaro Mexico Department of Ophthalmology Massachusetts Eye and Ear/Shepens Eye Research Institute/Harvard Medical School Boston MA USA Eye Unit MyungSung Christian Medical Center (MCM) Comprehensive Specialized Hospital and MyungSun Medical College Addis Ababa Ethiopia Department of Ophthalmology Addis Ababa University Addis Ababa Ethiopia Sight for Souls Bellevue WA USA Department of Ophthalmology Harvard University Boston MA USA Eye Unit MyungSung Medical College Addis Ababa Ethiopia Addenbrooke’s Hospital Cambridge UK Department of Ophthalmology Cambridge University Hospitals Cambridge UK Federal University of Sao Paolo Sao Paolo SP Brazil University of Calgary Calgary AB Canada Department of Ophthalmology and Visual Sciences Federal University of São Paulo Sao Paulo Brazil School of Medicine Vita-Salute San Raffaele University Milan Italy Department of Ophthalmology IRCCS San Raffaele Scientific Institute Milan Italy Department of Ophthalmology San Raffaele Scientific Institute Milano Italy IRCCS San Raffaele Scientific Institute Vita-Salute University Milan Italy Scientific Institute San Raffaele Hospital Vita-Salute University Milan Italy University of Poitiers Poitiers France CHU de Poitiers Poitiers France Ophthalmology Department CHU de Poitiers (Poitiers University Hospital) Poitiers France Unité 1084 National Institute of Health and Medical Research (INSERM) Poitiers France

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