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Eff-SAM: SAM-based Efficient Method for Brain Tumor Segmentation in Multimodal 3d MRI Scans

IEEE Access 2025年 13卷 90063-90087页

作者： Ahmad, Nisar Chen, Yao-Tien Ming Chi University of Technology International Ph.D. Program in Innovative Technology of Biomedical Engineering Medical Devices New Taipei City243303 Taiwan

Accurate brain tumor segmentation in MRI scans is crucial for effective diagnosis and treatment planning, as even minor segmentation errors can lead to significant clinical concerns. However, this task is challenged by the complex anatomy of the brain, variable tumor shapes, and low contrast between tumor sub-regions. Moreover, existing methods often lack generalizability across diverse segmentation tasks and imaging modalities. Large Vision Model (LVM) like the Segment Anything Model (SAM) represents a foundational advancement in tumor segmentation. While SAM has shown impressive performance on natural images, its effectiveness in medical imaging, especially brain tumor segmentation, is limited due to domain differences and indistinct boundaries in MRI scans. To address these challenges, we propose Eff-SAM, a 3d brain tumor segmentation framework that adapts SAM for medical applications through Parameter-Efficient Fine-Tuning (PEFT) technique. The framework incorporates PEFT with adapters into SAM’s encoder to fine-tune the model effectively and optimize its performance for medical imaging while maintaining computational efficiency. Additionally, a Cross-Sliced Attention (CSA) mechanism captures semantic relationships, improves tumor localization, and is introduced into the encoder. Robust data preprocessing further enhances the model’s generalization across datasets. Eff-SAM demonstrates state-of-the-art performance and outperforms benchmark methods on the BraTS 2020 and BraTS 2021 datasets. It achieves dice scores of 0.884 for Whole Tumor (WT), 0.853 for Tumor Core (TC), and 0.818 for Enhancing Tumor (ET) on the BraTS 2020 dataset, and 0.880 (WT), 0.861 (TC), and 0.821 (ET) on the BraTS 2021 dataset. This work highlights the potential of integrating vision models like SAM with lightweight, domain-specific modules to deliver accurate and efficient brain tumor segmentation offering a clinically valuable tool, especially in scenarios with limited data and complex tu

关键词： Semantic Segmentation

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High-Energy Lithium-Ion Capacitors Using the NiS2@MXene Electrode: Evidence of dual Faradaic Reactions driven by the Choice of Electrolytes

ACS Applied Engineering Materials

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ACS Applied engineering Materials 2025年第5期3卷 1277-1291页

作者： Keerthana dileep Pamangadan C. Sharafudeen Mani Govindasamy Pin-Yi Chen Perumal Elumalai Electrochemical Energy Storage Lab Department of Green Energy Technology Madanjeet School of Green Energy Technologies Pondicherry University Puducherry 605014 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 24301 Taiwan；Research Centre for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 24301 Taiwan；Department of Mechanical Engineering Ming Chi University of Technology New Taipei City 24301 Taiwan；Department of Mechanical Engineering Chang Gung University Taoyuan City 33302 Taiwan

Transition metal sulfides (TMSs) are emerging as promising supercapacitor electrodes due to their excellent pseudocapacitive properties and substantial theoretical charge density. The combination of TMS and layered MXene synergistically enhances the energy and power, making them ideal for advanced energy storage applications. Here, NiS2@MXene composites were successfully synthesized via a simple probe sonication, and their formation, morphology, and composition were scrutinized using materials characterization techniques. Electrochemical analyses of the NiS2@MXene electrode in the KOH electrolyte revealed the occurrence of a Faradaic reaction involving (Ni3+/Ni2+) redox. Consequently, lithium-ion capacitors (LICs) using the NiS2@MXene and reduced graphene oxide (rGO) as respective positive and negative electrodes in aqueous and different nonaqueous electrolytes were fabricated, and their performances were analyzed in the form of coin cells. It turned out that the aqueous LIC (NiS2@MXene|1 M LiClO4(aq.)|rGO) delivered a specific energy of 48.4 W h kg–1at a specific power of 800 W kg–1. Notably, the nonaqueous LIC (NiS2@MXene|1 M LiClO4(EC/dMC)|rGO) achieved an increased specific energy of 64 W h kg–1at a specific power of 1500 W kg–1and exhibited excellent capacity retention of 80% over 20,000 long cycles. Excitingly, the nonaqueous LIC (NiS2@MXene|1 M LiPF6(EC/dEC)|rGO) delivered a remarkable specific energy of 117.3 W h kg–1at a specific power of 2100 W kg–1and successfully powered a commercial LEd bulb and a stopwatch, showcasing the practicality of the electrode. The electrochemical measurements and the ex situ X-ray diffraction analyses confirmed the simultaneous occurrence of the conversion/reconversion and the intercalation/deintercalation reactions, facilitated on the electrode that led to such a high Li+charge storage performance. The conductive MXene matrix contributed to enhancing the charge transport by reducing the diffusion path and led to more active s

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Microwave dielectric and structural characteristics in Li2O-B2O3-SiO2 glass ceramics

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Ceramics international 2025年

作者： Qiu, Jun-Yan Tu, Chi-Shun Huang, Szu-Ting Li, Yongxiang Chen, Pin-Yi Chen, Cheng-Sao Montecillo, Rhys Feng, Kuei-Chih International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan Department of Physics Fu Jen Catholic University New Taipei City Taiwan Department of Mechanical Engineering Ming Chi University of Technology New Taipei City Taiwan School of Engineering RMIT University MelbourneVIC3000 Australia Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City Taiwan Department of Mechanical Engineering Hwa Hsia University of Technology New Taipei City Taiwan

Advancements in high-frequency communication devices have emphasized miniaturization and low energy consumption. This work focuses on developing microwave dielectric materials characterized by an ultra-low dielectric constant and low dielectric loss coefficient. In this study, B2O3 and Li2O were added into the SiO2 matrix to form the LBS glass-ceramics. The B2O3-added SiO2 shows a formation of α-cristobalite phase, and the Li2O additive in the B2O3-SiO2 glass-ceramics sintered at 900 °C reveal a primary quartz phase with a secondary phase Li2Si2O5, that partially transformed into Li2SiO3 in the specimen sintered at 950 °C. The LBS12 (x = 12 wt%) show stronger Raman peaks of Li2Si2O5 and Li2SiO3, indicating increase of highly-crystallized Si-O network. As the quartz phase diminishes, Li2Si2O5 and Li2SiO3 begin to develop in the glass-ceramic matrix. dense microstructures and well-formed crystalline grains were observed in the LBS glass-ceramics. The quality factors were primarily affected by grain size and density. The Li2Si2O5 additive in the LBS glass-ceramics can reduce dielectric permittivity (Εr) and increase Q × f, particularly at higher frequencies. A low Εr of 4.7–5, a high Q × f of 2600 GHz, and a hardness of 249 MHV were achieved in the LBS12 sintered at 900 °C. These LBS glass-ceramics exhibit potential for use in low-temperature co-fired ceramic (LTCC) applications in high-frequency communication devices. © 2025

关键词： Sintering

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Optical sensor for dissolved ammonia by embedding eosin Y in cellulose acetate and silicone rubber via the phase inversion method

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Microchemical Journal 2025年 213卷

作者： Putro, dimas Trio Sari, desy Purnama Chu, Cheng-Shane International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan Department of Mechanical Engineering Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan

This study presents the phase inversion method for fabricating a new optical sensing membrane designed for dissolved ammonia detection. Eosin Y was embedded into composite materials of cellulose acetate (CA) and silicone rubber to enhance optical performance and modify the membrane structure. Sensing performance was evaluated using luminescence quenching, which involved measuring changes in both intensity and wavelength. The fabricated membrane exhibited a microporous structure with pore diameters ranging from 1 to 10 µm, a quenching response (I₀/I₄₀₀) of 15.15, a response time (↓t₉₀) of 53 s, and effective detection at a concentration of 400 mM, a room temperature (20–25 °C), and ph 6.02, with sensing response slightly decreasing at elevated temperatures (up to 50 °C) and at ph 3.17 and 9.29. The nonlinear quenching response plot was converted into a linear form using the decibel (dB) formula, significantly improving linearity (R² = 0.9862). The membrane also exhibited excellent selectivity and the ability to detect in both gas and dissolved phases. Additionally, the sensing mechanism was investigated, revealing a combination of static and dynamic quenching, which led to an intensity decrease and a bathochromic shift of 16.56 nm. These findings highlight the potential of the developed optical sensor for rapid and highly selective ammonia monitoring in various environments. © 2025 Elsevier B.V.

关键词： Bathochromic shift dissolved ammonia detection Eosin Y Optical sensing membrane phase inversion method

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Achieving high surface bioactivity and adhesion in Ti-6Al-4V alloy via anodic oxidation and electrophoretic deposition

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Ceramics international 2025年

作者： Wu, Yu-Jie Wang, Chi-Yun Mana-ay, Haidee Tu, Chi-Shun Lai, Po-Liang Chen, Pin-Yi International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Bone and Joint Research Center Department of Orthopedic Surgery Chang Gung Memorial Hospital Taoyuan City33305 Taiwan Department of Mechanical Engineering Chang Gung University Taoyuan City33302 Taiwan Department of Physics Silliman University Dumaguete City6200 Philippines

This study combines 3d printing, anodic oxidation (AO), and electrophoretic deposition (Ed) technologies to develop Ti-6Al-4V alloy (abbreviated as Ti64) with high hydrophilicity, adhesion, and bioactivity. Titanium oxide nanotubes formed by AO treatment on the Ti64 surface exhibited reduced contact angles from 53 ° to 10 °. The adhesion of the calcium (Ca) layer through the integrated technology of the AO and Ed treatments (herein abbreviated as AEd) displays an optimal adhesive force of over 30 N on the Ti64 surface, which is attributed to the stable chemical bond due to the formation of OH− ions on the substrate after the AO treatment and the subsequent oxidation reaction of the Ca2+ ions to form a predominantly Ca(OH)2 layer after the Ed treatment. Moreover, the AEd treatment forms tiny needle-like structures that can effectively promote osteogenic differentiation. The expressions of the osteocyte marker genes (i.e., OCN, OPN, and dMP1) were improved after the AEd treatment, showing increased osteogenic differentiation into mature bone tissue. This work presents the AEd treatment as a valuable surface modification technique to boost the surface bioactivity of Ti64 for clinical orthopedic applications. © 2025

关键词： Anodic oxidation

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doping ratio between ZnO/MgO tunes antimicrobial, osteogenic, and anti-osteoclast activity of CaO-MgO-ZnO-SiO2 bioactive glass-ceramics

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Ceramics international 2025年

作者： Hung, Guan-Yi Xia, Yun-Ze Chen, Pin-Yi Lai, Po-Liang Feng, Kuei-Chih Tu, Chi-Shun Cheng, I.-C. Wang, Chi-Yun International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Department of Mechanical Engineering Ming-Chi University of Technology New Taipei City24301 Taiwan Bone and Joint Research Center Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan City33305 Taiwan College of Medicine Chang Gung University Taoyuan City33305 Taiwan Department of Mechanical Engineering Chang Gung University Taoyuan City33305 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Limitations such as donor site morbidity hamper autologous bone grafts. On the other hand, allogeneic grafts, sourced from cadavers, pose risks of viral transmission and rejection. While hydroxyapatite is a prevalent synthetic graft material, antibiotic-laden fillers addressing infection face challenges with antibiotic-resistant pathogens, driving the emergence of nonantibiotic materials to combat persistent bone infections. Bioactive glass is a potential bone void filler superior to hydroxyapatite. Thus, to improve the antibacterial efficacy and bioactivity, we adjusted the doping ratio of the novel CaO-(1-x) MgO-(x) ZnO-SiO2 glass-ceramics (x = 0, 0.25, 0.50, 0.75, 1). Using XRd, we found a typical amorphous structure alongside polycrystalline diopside (CaMgSi2O6), hardystonite (Ca2ZnSi2O7), and petedunnite (CaZnSi2O6) formations. Raman spectroscopy revealed the silicate-glass matrix structure in all the Zn(100x) glass-ceramics and confirmed that the Zn ions replaced the Mg ions. Zn-doped glass-ceramics promoted apatite layer formation and had greater antibacterial efficacy against E. coli and S. aureus. Zn25 glass-ceramic were biocompatible with L929 and MC3T3-E1 cells. Furthermore, Zn25 glass-ceramic promoted bone cell mineralization and reduced osteoclast formation without affecting ALP activity. In vivo, the Zn25 glass-ceramic exhibited greater osteointegration ability than the HAP and Zn0 glass-ceramic. Taken together, the present study demonstrated that bioactive glass-ceramics with a doping ratio between ZnO and MgO (25:75) can enhance antibacterial and osteogenic activity while impeding osteoclastogenic activity. © 2025

关键词： Escherichia coli

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Electrochemical sensor based on ZnO@MWCNT/ glassy carbon electrode for the detection of warfarin (blood anticoagulant)

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Surfaces and Interfaces 2025年 67卷

作者： Manjunath, Kumbar Mudakappa Yemmi, Rajeshwari Swamy, B.E. Kumara Eldesoky, Gaber E. Govindasamy, Mani Division of Plant Breeding and Genetics Central Coffee Research Institute Karnataka Chikkamagaluru 577117 India Department of Industrial Chemistry Kuvempu University Karnataka Shivamogga India Department of Chemistry College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Department of Chemistry Korea University Seoul Seongbuk-gu South Korea

This study employed ZnO nanoparticles, multi-walled carbon nanotubes (MWCNTs), and a modified glassy carbon electrode (GCE) as a quick and sensitive method for detecting warfarin at biological ph levels. The ultrasonication technique was utilized in the synthesis of the ZnO@MWCNTs nanocomposite. The ZnO@MWCNTs were characterized using Transmission electron microscopy (TEM), Scanning electron microscopy (SEM), X-ray diffraction (XRd), spectroscopy, analytical techniques, and electrochemical impedance spectroscopy (EIS). Cyclic voltammetry (CV) as well as differential pulse voltammetry (dPV) techniques are employed in the presence of PBS buffer as an electrolyte. We observed unique oxidative peak currents an indication of the electrochemical mechanism of warfarin at low potentials for ZnO @MWCNTs/GCE. Moreover, we successfully attained effective electrochemical detection of warfarin utilizing the proposed sensor, which exhibited an excellent low limit of detection (LOd) of 0.0188 μM across a linear range of 0.02–2867.37 μM. The proposed sensor exhibits excellent storage stability, repeatability, and reproducibility, and has been effectively utilized for the quantification of warfarin in real samples, including blood serum and urine as obtained good recovery and RSd value. © 2025 Elsevier B.V.

关键词： differential pulse voltammetry Glassy carbon electrode Multiwalled carbon nanotubes Warfarin ZnO nanoparticles

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Enhanced deep Learning Model Performance in 3d Multimodal Brain Tumor Segmentation with Gabor Filter 10

Enhanced Deep Learning Model Performance in 3D Multimodal Br...

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10th international Conference on Applied System Innovation, ICASI 2024

作者： Ahmad, Nisar Chen, Yao-Tien International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan

ISBN: (纸本)9798350394924

medical image segmentation plays a crucial role in identifying and analyzing anatomical structures in medical images. This requires an accurate medical segmentation tool to delineate and quantitatively analyze the target regions, diagnose any abnormality, and assist in treatment planning. deep learning approaches have emerged as a promising solution for automating medical segmentation. However, challenges arise when dealing with the complex shapes and spatial variations of some target regions, especially in 3d MRI scans. To deal with such transformations, specific techniques are required to properly analyze and preprocess the dataset and perform image filtering to provide better features for improved prediction performance of deep learning architectures. This study focuses on improving brain tumor segmentation in multimodal 3d MRI images. We observed significant improvements in multimodal brain tumor segmentation results (accuracy, IoU, and mIoU) using an optimized 3d Gabor filter, which helps extract meaningful features. Multichannel input images were preprocessed to remove noise and select an appropriate resolution to reduce computational complexity. An improvement in mean Intersection over Union (mIoU) from 0.714 to 0.804 and accuracy from 0.982 to 0.991 were achieved, which shows a major improvement. This work contributes to the field of medical image segmentation by offering an improved and efficient approach for brain tumor analysis in 3d MRI scans, potentially aiding in diagnosis and treatment planning. © 2024 IEEE.

关键词： Magnetic resonance imaging

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Using electroencephalography signals to explore the influence of Zentangle on meditation and mindfulness 9

Using electroencephalography signals to explore the influenc...

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9th international Conference on Applied System Innovation, ICASI 2023

作者： Usman, Muhammad Lin, Chun-Ling Ming Chi University of Technology International Ph.D Program in Innovative Technology of Biomedical Engineering and Medical Devices New Taipei City Taiwan Ming Chi University of Technology Department of Electrical Engineering New Taipei City Taiwan

ISBN: (纸本)9798350398380

Fifteen novices completed a Zentangle task while their brain activity was measured with electroencephalography (EEG) and their concentration emotional state, stress, and anxiety levels were evaluated with questionnaires. The study found increased activity in theta, alpha, beta, and gamma ranges associated with relaxation, focus, and mental activity. Participants reported improved concentration, emotional state, and reduced stress and anxiety levels after completing the task, suggesting the potential of Zentangle to enhance cognitive and emotional well-being. © 2023 IEEE.

关键词： Electroencephalography

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developing a Respiratory Pressure Simulation Platform for a Portable Negative Pressure Filtering Chest drainage System 16

Developing a Respiratory Pressure Simulation Platform for a ...

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16th IEEE international Conference on Nano/Molecular Medicine and engineering, NANOMEd 2023

作者： Liao, Hao-Yen Chu, Cheng-Shane Wu, Yang-Shun Lin, Sheng-Chieh Lin, Chia-Tsai Hung, Kuo-Yung Ming Chi University of Technology Dept. of Intl. Ph.D Program in Innovative Technology of Biomedical Engineering and Medical Devices Taiwan Ming Chi University of Technology Department of Mechanical Engineering Taiwan Ming Chi University of Technology Research Center for Intelligent Medical Devices Taiwan

ISBN: (纸本)9798350343700

This study aims to reduce the risk of aerosol infection in patients and healthcare workers by establishing a portable negative pressure filtering chest drainage system (PNPFCdS) that filters aerosols and microparticles. By controlling the negative pressure precisely, the system can prevent aerosol transmission under different air leaks. By using a respiratory pressure simulation platform (RPSP), it has been demonstrated that the negative pressure filtering chest drainage system can achieve a minimum measured pressure error of 1.6% without simulated intrapleural pressure changes when the air leak flow rises to 800 ml/min. When the target pressure is -1.5 kPa under simulated intrapleural pressure changes with air leak of 500 ml/min, the measured pressure change rate ranges from -16.7 % to +22.7%. When the target pressure is -9 kPa, the measured pressure change rates ranges from -2% to +6.7%. According to ISO 10079-1, this study provides a model of a negative pressure filtering chest drainage system that is effective and safe. © 2023 IEEE.

关键词： Aerosols

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