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Wireless, self‑powered phototrophic algaerobot‑infused nanotherapeutic hydrogels for enhanced diabetic wound healing

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Chemical engineering Journal 2025年 515卷

作者： Wei-Yung Huang Jiunn-Horng Kang Yan-Ting Chen Jia-Wei Liang Lan pham Hoai Hoang Hieu Trung Nguyen Andrew E.-Y. Chuang Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City 23561 Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei 110 Taiwan Department of Physical Medicine and Rehabilitation School of Medicine College of Medicine Taipei Medical University No.250 Wuxing Street Xinyi District Taipei 110 Taiwan Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital Taipei 110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei 110 Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Viet Nam Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei 11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei 11031 Taiwan

diabetic wounds present a significant clinical challenge due to impaired immunity, hypoxia, poor neovascularization, and chronic inflammation, often resulting in severe complications such as amputation. Conventional therapies, including hyperbaric oxygen, antioxidants, and electrical stimulation, face limitations in delivering sustained and safe oxygen, hydrogen, and electrical stimulation to the wound site. This study introduces a groundbreaking approach by integrating phototrophic algae robots (AR) into a methylcellulose (MC) hydrogel, combined with platelet-derived extracellular vesicles (pEVs) and conductive glycol chitosan-polypyrrole nanoparticles (GCS-PPy NPs), forming a multifunctional composite system (MC-pEV-AR-GCS-PPy NPs). This advanced composite addresses the limitations of traditional treatments by integrating continuous, self-powered hydrogen and oxygen generation, electrical stimulation, and hyperthermia, all triggered by light-activated, electromagnetically driven mechanisms. photosynthetic algae robots offer a sustainable solution for the generation of hydrogen and oxygen, effectively targeting the prevalent issues of hypoxia and the deficit frequently encountered in diabetic wounds. This innovative approach improves therapeutic outcomes through the integration of electrochemical processes and nanophototherapeutics, creating a multimodal platform. This platform not only promotes tissue regeneration and angiogenesis but also alleviates hypoxic conditions, modulates immune responses, and addresses key challenges associated with chronic wound healing. Incorporating pEVs amplifies the regenerative potential of the system, accelerating wound healing and promoting tissue regeneration. This self-powered platform not only reduces inflammation and suppresses M1 macrophage bioactivity but also regulates immune responses, creating an optimized healing environment. The MC-pEV-AR-GCS-PPy NPs composite represents a promising translational approach to diabetic wo

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Overcoming the Blood-Brain Tumor Barrier with docetaxel-Loaded Mesoporous Silica Nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma

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ACS Applied Materials and Interfaces 2024年第17期16卷 21722-21735页

作者： Hsu, Tsung-I Chen, Yi-Ping Zhang, Rong-Lin Chen, Zih-An Wu, Cheng-Hsun Chang, Wen-Chang Mou, Chung-Yuan Chan, Hardy Wai-Hong Wu, Si-Han Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei110 Taiwan International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Nano Targeting & Therapy Biopharma Inc. Taipei110 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei110 Taiwan Department of Chemistry National Taiwan University Taipei106 Taiwan

While temozolomide (TMZ) has been a cornerstone in the treatment of newly diagnosed glioblastoma (GBM), a significant challenge has been the emergence of resistance to TMZ, which compromises its clinical benefits. Additionally, the nonspecificity of TMZ can lead to detrimental side effects. Although TMZ is capable of penetrating the blood-brain barrier (BBB), our research addresses the need for targeted therapy to circumvent resistance mechanisms and reduce off-target effects. This study introduces the use of PEGylated mesoporous silica nanoparticles (MSN) with octyl group modifications (C8-MSN) as a nanocarrier system for the delivery of docetaxel (dTX), providing a novel approach for treating TMZ-resistant GBM. Our findings reveal that C8-MSN is biocompatible in vitro, and dTX@C8-MSN shows no hemolytic activity at therapeutic concentrations, maintaining efficacy against GBM cells. Crucially, in vivo imaging demonstrates preferential accumulation of C8-MSN within the tumor region, suggesting enhanced permeability across the blood-brain tumor barrier (BBTB). When administered to orthotopic glioma mouse models, dTX@C8-MSN notably prolongs survival by over 50%, significantly reduces tumor volume, and decreases side effects compared to free dTX, indicating a targeted and effective approach to treatment. The apoptotic pathways activated by dTX@C8-MSN, evidenced by the increased levels of cleaved caspase-3 and PARP, point to a potent therapeutic mechanism. Collectively, the results advocate dTX@C8-MSN as a promising candidate for targeted therapy in TMZ-resistant GBM, optimizing drug delivery and bioavailability to overcome current therapeutic limitations. © 2024 The Authors. Published by American Chemical Society.

关键词： Tumors

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Effect of mouth-opening levels on sound field gain in the ear canal 45

Effect of mouth-opening levels on sound field gain in the ea...

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45th international Congress and Exposition on Noise Control engineering: Towards a Quieter Future, INTER-NOISE 2016

作者： Xiao, Jimg-Hong Yu, Jen-Fang Lee, Kun-Che Chiu, Hsiu-Hui Graduate Institute of Medical Mechatronics Chang Gung University Taiwan Taiouan Interdisciplinary Otolaryngology Laboratory Chang Gung University Taiwan Ph.D. Program in Biomedical Engineering College of Engineering Chang Gung University Taiwan

The human ear canal can become deformed when the mouth opens and closes, changing the sound field in the external auditory canal. Thus, measuring the mandibular movement trajectory may provide a reference for identifying mouth-opening levels. The human ear canal can become deformed when the mouth opens and closes, changing the sound field in the external auditory canal. Thus, measuring the mandibular movement trajectory may provide a reference for identifying mouth-opening levels. The K7 system and a Frye Fonix 7000 sensor were used to perform several measurements of mouth-opening and -closing to obtain the mean maximal mouth opening level. The mandible was fixed at the 1/3, 2/3, and maximal mouth-opening levels. Subsequently, a 65-dB sweep tone, which is the sound pressure level of people talking at a normal level, was adopted as the sound stimulus to measure sound fields at 5, 10, 15, and 20 mm from the entrance of the external auditory canal. The stimulus frequencies of 200, 500, 1000, 2000, 4000, 6000, and 8000 Hz were noted. The differences in sound field gains at depths of 5, 10, 15, and 20 mm were analyzed for the various mouth-opening levels. The results show that except for the 1.70-dB decrease at a depth of 5 mm with an 8000-Hz stimulus frequency, the differences at the other depths and stimulus frequencies were within 1 dB. Thus, the mouth-opening levels will influence the gain in ear canal. © 2016, German Acoustical Society (dEGA). All rights reserved.

关键词： Acoustic fields

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Ethylene Glycol-Manipulated Syntheses of Calcium Carbonate Particles and dNA Capsules toward Efficient ATP-Responsive Cargo Release

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ACS Applied Bio Materials 2023年第8期6卷 3351-3360页

作者： Lin, Yu-Hsuan Singuru, Murali Mohana Rao Marpaung, david Septian Sumanto Liao, Wei-Ching Chuang, Min-Chieh Department of Chemistry Tunghai University Taichung407224 Taiwan International Ph.D. Program in Biomedical and Materials Science Tunghai University Taichung407224 Taiwan Department of Biosystems Engineering Institut Teknologi Sumatera Lampung Selatan35365 Indonesia Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Taipei112304 Taiwan

Cargo molecule-encapsulated dNA capsules synthesized with a solid sacrificial template have elicited significant interest in the last decade and have been used for active materials in applications ranging from biosensors to drug delivery. However, the correlation between template properties and the subsequent assembly and triggered release behavior of the resultant carriers remain uninvestigated. In this study, ethylene glycol (EG) was added during the CaCO3 precipitation synthesis to yield particles of various sizes and surface properties, and the adenosine triphosphate (ATP)-responsive release characteristics of the fabricated dNA capsules affected by these particle properties were investigated. The geometry, crystallization, and surface morphology of the CaCO3 particles co-precipitated at various EG concentrations were characterized. We discuss the integrity of cross-linking hybridization, fluorescent molecule internalization, degree of leakage, and release efficiency of the resulting dNA capsules and their relevance brought by particle properties. To achieve efficient encapsulation and cargo release, the surface roughness of the CaCO3 particles was explored and was deemed a key determinant of the compactness of the dNA shell after template removal. This effect was particularly strong in CaCO3 particles in connection with high EG concentrations. The dNA capsules fabricated using 83% EG exhibited low leakage, high loading, and moderate release efficiencies as well as a greater apparent association constant with ATP due to their small particle size and the high-integrity dNA shells. © 2023 American Chemical Society.

关键词： Ethylene glycol

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Bioinformatics

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IEEE Potentials 2004年第1期23卷 24-27页

作者： doom, Travis Raymer, Michael Krane, dan IEEE Wright State University United States Department of Computer Science and Engineering Graduate Faculty in Biomedical Sciences Dayton OH United States WSU Biomedical Sciences Ph.D. Program Forensic Bioinformatics Inc. United States Bioinformatics Research Group Computer Science Department Wright State University United States

No abstract available

关键词： Bioinformatics Biology computing Biological information theory data analysis Computational biology Proteins Biochemistry Sequences Genomics Large-scale systems

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deep Learning-Based Positioning Error Fault diagnosis of Wire Bonding Equipment and an Empirical Study for IC Packaging

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IEEE Transactions on Semiconductor Manufacturing 2023年第4期36卷 619-628页

作者： Kao, Sheng-Xiang Chien, Chen-Fu International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Intelligent Manufacturing and Circular Economy Research Center National Tsing Hua University Artificial Intelligence for Intelligent Manufacturing Systems Research Center National Science and Technology Council Department of Industrial Engineering and Engineering Management Hsinchu300044 Taiwan

Little research has been done for artificial intelligence applications of semiconductor backend. This study aims to develop a deep learning based fault diagnosis framework as prognostics and health management (phM) solutions with a comprehensive analytics process. A linear encoder sensor is employed to measure position, while data preparation is conducted to convert position information into a signal. Then, signal processing is used to extract the features, in which high pass filter is applied to normalize the signal and emphasize the features. High-dimensional features including time domain statistical features, time-frequency domain features obtained by continuous wavelet transform (CWT), and frequency domain features converted by fast Fourier transform (FFT) are extracted to prepare the dataset. An ensemble neural network model that integrates deep neural network (dNN) and convolutional neural network (CNN) is employed to recognize the pattern and diagnose the positioning errors. The accuracy and false alarm rate are considered to support maintenance decisions. An empirical study was conducted in a world leading IC assembly and testing company for validation. The results have shown that the proposed approach can effectively detect inappropriate installation of the bond head in wire bonding equipment for predictive maintenance and cost reduction. © 1988-2012 IEEE.

关键词： Failure analysis

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engineering H2O2 Self-Supplying Platform for Xdynamic Therapies via Ru-Cu Peroxide Nanocarrier: Tumor Microenvironment-Mediated Synergistic Therapy

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ACS Applied Materials and Interfaces 2024年第19期16卷 24172-24190页

作者： dirersa, Worku Batu Kan, Tzu-Chun Chang, Jungshan Getachew, Girum Ochirbat, Sonjid Kizhepat, Shamsa Wibrianto, Aswandi Rasal, Akash Chen, Hung-An Ghule, Anil Vithal Chou, Tzung-Han Chang, Jia-Yaw Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106335 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Green Nanotechnology Laboratory Department of Chemistry Shivaji University Kolhapur416004 India Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin64002 Taiwan

Of the most common, hypoxia, overexpressed glutathione (GSH), and insufficient H2O2 concentration in the tumor microenvironment (TME) are the main barriers to the advancment of reactive oxygen species (ROS) mediated Xdynamic therapies (X = photo, chemodynamic, chemo). Maximizing Fenton catalytic efficiency is crucial in chemodynamic therapy (CdT), yet endogenous H2O2 levels are not sufficient to attain better anticancer efficacy. Specifically, there is a need to amplify Fenton reactivity within tumors, leveraging the unique attributes of the TME. Herein, for the first time, we design RuxCu1-xO2-Ce6/CPT (RCpCCPT) anticancer nanoagent for TME-mediated synergistic therapy based on heterogeneous Ru-Cu peroxide nanodots (RuxCu1-xO2 Nds) and chlorine e6 (Ce6), loaded with ROS-responsive thioketal (TK) linked-camptothecin (CPT). The Ru-Cu peroxide Nds (RCp Nds, x = 0.50) possess the highest oxygen vacancy (OV) density, which grants them the potential to form massive Lewis’s acid sites for peroxide adsorption, while the dispersibility and targetability of the Nds were improved via surface modification using hyaluronic acid (HA). In TME, RCpCCPT degrades, releasing H2O2, Ru2+/3+, and Cu+/2+ ions, which cooperatively facilitate hydroxyl radical (•OH) formation and deactivate antioxidant GSH enzymes through a cocatalytic loop, resulting in excellent tumor therapeutic efficacy. Furthermore, when combined with laser treatment, RCpCCPT produces singlet oxygen (1O2) for PdT, which induces cell apoptosis at tumor sites. Following ROS generation, the TK linkage is disrupted, releasing up to 92% of the CPT within 48 h. In vitro investigations showed that laser-treated RCpCCPT caused 81.5% cell death from PdT/CdT and chemotherapy (CT). RCpCCPT in cancer cells produces red-blue emission in images of cells taking them in, which allows for fluorescence image-guided Xdynamic treatment. The overall results show that RCp Nds and RCpCCPT are more biocompatible and have excellent Xdynamic the

关键词： Oxidation

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Utilizing a light image array with varying light intensities in optically-induced dielectrophoresis (odep)-based microfluidic system for a culture-free screen of bacteria with different responses to antibiotics treatment 23

Utilizing a light image array with varying light intensities...

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23rd international Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

作者： Chu, Po-Yu Chen, Chih-Yu Wu, Min-Hsien Ph.D. Program in Biomedical Engineering Chang Gung University Taoyuan City Taiwan Graduate Institute of Biomedical Engineering Chang Gung University Taoyuan City Taiwan Division of Haematology/Oncology Department of Internal Medicine Chang Gung Memorial Hospital at Linkou Taoyuan City Taiwan

ISBN: (纸本)9781733419000

Antibiotics resistance is regarded as a potential threat of bacterial infection, making certain bacteria survive and grow during therapy and thus resulting in therapeutic failure. To achieve a rapid screen of antibiotic-resistant bacteria, it is urgent to develop a bacteria culture-independent screening method. Integrating with properties of optically-induced dielectrophoresis (OdEP) in cell manipulation, this paper presented a culture-free screening method for bacteria with different responses to antibiotics treatment by using a light image array with varying light intensities. The results of microbial viability assay and OdEP-based bacteria manipulation have validated the concept proposed in this study. © 2019 CBMS-0001.

关键词： Bacteria

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Atrophy of the cholinergic regions advances from early to late mild cognitive impairment

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Neuroradiology 2024年第4期66卷 543-556页

作者： Lai, Ying-Liang Larry Hsu, Fei-Ting Yeh, Shu-Yi Kuo, Yu-Tzu Lin, Hui-Hsien Lin, Yi-Chun Kuo, Li-Wei Chen, Cheng-Yu Liu, Hua-Shan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei Taiwan Department of Biological Science and Technology China Medical University Taichung Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan CT/MR Division Rotary Trading CO. LTD Taipei Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli Taiwan Institute of Medical Device and Imaging National Taiwan University College of Medicine Taipei Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Medical Imaging Taipei Medical University Hospital Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan

Purpose: We investigated the volumetric changes in the components of the cholinergic pathway for patients with early mild cognitive impairment (EMCI) and those with late mild cognitive impairment (LMCI). The effect of patients’ apolipoprotein 4 (APOE-ε4) allele status on the structural changes were analyzed. Methods: Structural magnetic resonance imaging data were collected. Patients’ demographic information, plasma data, and validated global cognitive composite scores were included. Relevant features were extracted for constructing machine learning models to differentiate between EMCI (n = 312) and LMCI (n = 541) and predict patients’ neurocognitive function. The data were analyzed primarily through one-way analysis of variance and two-way analysis of covariance. Results: Considerable differences were observed in cholinergic structural changes between patients with EMCI and LMCI. Cholinergic atrophy was more prominent in the LMCI cohort than in the EMCI cohort (P < 0.05 family-wise error corrected). APOE-ε4 differentially affected cholinergic atrophy in the LMCI and EMCI cohorts. For LMCI cohort, APOE-ε4 carriers exhibited increased brain atrophy (left amygdala: P = 0.001;right amygdala: P = 0.006, and right Ch123, P = 0.032). EMCI and LCMI patients showed distinctive associations of gray matter volumes in cholinergic regions with executive (R² = 0.063 and 0.030 for EMCI and LMCI, respectively) and language (R² = 0.095 and 0.042 for EMCI and LMCI, respectively) function. Conclusions: Our data confirmed significant cholinergic atrophy differences between early and late stages of mild cognitive impairment. The impact of the APOE-ε4 allele on cholinergic atrophy varied between the LMCI and EMCI groups. © 2024, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： APOE-ε4 allele cholinergic pathway Early mild cognitive impairment (EMCI) mild cognitive impairment (MCI) nucleus basalis of Meynert

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Hyper flexible neural networks rapidly switch between logic operations in a compact four neuron circuit

npj Unconventional Computing

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npj Unconventional Computing 2025年第1期2卷 1-15页

作者： Alexander James White Belle Liu Ming-Ju Hsieh Chung-Chuan Lo Kuo-An Wu Meng-Fan Chang Institute of Systems Neuroscience National Tsing Hua University Hsinchu Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan Department of Physics National Tsing Hua University Hsinchu Taiwan Brain Research Center National Tsing Hua University Hsinchu Taiwan Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan Taiwan Semiconductor Manufacturing Company Hsinchu Taiwan

Biological neural circuits at various levels exhibit rapid adaptability to diverse environmental stimuli. Such fast response times imply that adaptation cannot rely solely on synaptic plasticity, which operates on a much slower timescale. Instead, circuits must be inherently hyper-flexible and receptive to switches in functionalities without changes in network structure. This biological flexibility is a fruitful mechanism for constructing artificial reconfigurable circuits, whether they are spiking or non-spiking. In this study, we demonstrate that a four-neuron circuit can rapidly and controllably switch between 24 unique logical functions while maintaining the same set of synaptic weights. Moreover, we show that this reconfigurability works for several different underlying neuronal architectures and strikingly can be applied to a network composed of any sigmoid-shaped activation function. We conclude with proof-of-concept applications showing that we can perform standard tasks, such as a full-adder, as well as event-based conditional computing, such as detecting unexpected motion.

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