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IEEE international Conference on Image Processing

作者： Tsung-Ming Tai Yun-Jie Jhang Wen-Jyi Hwang Free University of Bozen-Bolzano NVIDIA AI Technology Center International Intercollegiate Ph.D. Program National Tsing Hua University Department of Computer Science and Information Engineering National Taiwan Normal University

Supervised learning of deep neural networks heavily relies on large-scale datasets annotated by high-quality labels. In contrast, mislabeled samples can significantly degrade the generalization of models and result in memorizing samples, further learning erroneous associations of data contents to incorrect annotations. To this end, this paper proposes an efficient approach to tackle noisy labels by learning robust feature representation based on unsupervised augmentation restoration and cluster regularization. In addition, progressive self-bootstrapping is introduced to minimize the negative impact of supervision from noisy labels. Our proposed design is generic and flexible in applying to existing classification architectures with minimal overheads. Experimental results show that our proposed method can efficiently and effectively enhance model robustness under severely noisy labels.

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Ultra Wide dynamic Range High Power RF Rectifier

Ultra Wide Dynamic Range High Power RF Rectifier

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European Conference on Antennas and Propagation, EuCAP

作者： Xiaochen Yu Jinyao Zhang Minzhang Liu Yi Huang Ta-Jen Yen Jiafeng Zhou Department of Electrical Engineering and Electronics University of Liverpool Liverpool UK Department of Materials Science and Engineering National Tsing Hua University Hsinchu Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan

A high-power RF-to-dC rectifier applied to wireless power transfer (WPT) with ultra-wide input power dynamic range is proposed in this paper. A GaN (gallium nitride) HEMT (high electron mobility transistor) is utilized to realize rectification at high power up to 12 W and a Schottky diode is used for lower-power rectification. Excellent switching between the two circuits’ rectification modes is achieved by adding a circulator. The rectifier has a 30 dB dynamic range with an efficiency of over 50% at 2.4 GHz.

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A quantitative review of nanotechnology-based therapeutics for kidney diseases

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Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2024年第2期16卷 e1953页

作者： Cheng, Hui-Teng Ngoc Ta, Yen-Nhi Hsia, Tiffaney Chen, Yunching Department of Internal Medicine National Taiwan University Hospital Hsin-Chu Branch Zhu Bei City Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu Taiwan Department of Chemistry National Tsing Hua University Hsinchu Taiwan

Kidney-specific nanocarriers offer a targeted approach to enhance therapeutic efficacy and reduce off-target effects in renal treatments. The nanocarriers can achieve organ or cell specificity via passive targeting and active targeting mechanisms. Passive targeting capitalizes on the unique physiological traits of the kidney, with factors like particle size, charge, shape, and material properties enhancing organ specificity. Active targeting, on the other hand, achieves renal specificity through ligand-receptor interactions, modifying nanocarriers with molecules, peptides, or antibodies for receptor-mediated delivery. Nanotechnology-enabled therapy targets diseased kidney tissue by modulating podocytes and immune cells to reduce inflammation and enhance tissue repair, or by inhibiting myofibroblast differentiation to mitigate renal fibrosis. This review summarizes the current reports of the drug delivery systems that have been tested in vivo, identifies the nanocarriers that may preferentially accumulate in the kidney, and quantitatively compares the efficacy of various cargo-carrier combinations to outline optimal strategies and future research directions. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and drug discovery > Emerging Technologies. © 2024 Wiley Periodicals LLC.

关键词： Nanotechnology

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photothermal Temperature-Modulated Cancer Metastasis Harnessed Using Proteinase-Triggered Assembly of Near-Infrared II photoacoustic/photothermal Nanotheranostics

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ACS Applied Materials and Interfaces 2024年第31期16卷 40611-40627页

作者： Chuang, Yao-Chen Hsia, Yu Chu, Chia-Hui Maharajan, Sivasubramanian Hsu, Fang-Chi Lee, Hsin-Lun Chiou, Jeng Fong Ch’ang, Hui-Ju Liao, Lun-de Lo, Leu-Wei Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli Zhunan35053 Taiwan Department of Radiation Oncology Taipei Medical University Hospital Taipei110301 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu30013 Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei110301 Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei110301 Taiwan National Institute of Cancer Research National Health Research Institutes Miaoli Zhunan35053 Taiwan

Here we demonstrate that cancer metastasis could be modulated by the judicious tuning of physical parameters such as photothermal temperature in nanoparticle-mediated photothermal therapy (PTT). This is supported by theranostic nanosystem design and characterization, in vitro and in vivo analyses, and transcriptome-based gene profiling. In this work, the highly efficient near-infrared II (NIR-II) photoacoustic image (PA)-guided PTT are selectively activated using our developed matrix metalloproteinase (MMP)-triggered in situ assembly of gold nanodandelions (GNds@gelatin). Unlike other "always-on" NIR PTT agents lacking specific bioactivation and suffering from the intrinsic nonspecific pseudosignals and treatment-related side effects such as metastasis, our GNds@gelatin possesses important advantages while deployed in cancer PTT that include the following: (1) The theranostic effects could be "turned on" only after specific MMP-2/-9 activity and with acidity in the tumor microenvironment. (2) The quantitative PA diagnosis allows for precise PTT planning for better cancer treatment. (3) GNds@gelatin could noninvasively quantify MMP activity and efficiently harness NIR-I (808 nm) and NIR-II (1064 nm) energies for tumor ablation. (4) The multibranched nanostructures reabsorb scattered laser photons, thus enhancing the surface plasmons for the pronounced photothermal conversion of aggregated GNds@gelatin in situ. (5) It is noteworthy that in situ tumor eradication at higher PTT temperature (>55 °C) mediated by GNds@gelatin could induce subsequent metastasis, which could be otherwise abolished at lower PTT temperatures (50 °C > T > 43 °C). (6) Furthermore, the gene profiling using transcriptome-based microarray including GO and KEGG analyses revealed that 315 differentially expressed genes were identified in higher PTT temperature treated tumors compared with lower PTT temperature ones. These were enriched into some well-known cancer-related pathways, such as cell migrat

关键词： Plasmonics

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Two-phase cost-sensitive-learning-based framework on customer-side quality inspection for TFT-LCd industry

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Journal of Intelligent Manufacturing 2024年

作者： Shih, Ming-Sung Chen, James C. Chen, Tzu-Li Hsu, Ching-Lan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Department of Industrial Engineering and Engineering Management National Tsing Hua University Hsinchu30013 Taiwan Graduate Institute of Intelligent Manufacturing Technology National Taiwan University of Science and Technology Taipei106335 Taiwan

The Covid-19 outbreak in 2020 boosted the stay-at-home economy, causing a surge in electronics industry demand, especially benefiting the LCd panel sector. However, as the pandemic situation improved, countries revised policies, leading to the gradual discontinuation of remote work arrangements in various industries. This resulted in declining dividends for the stay-at-home economy. The decreased demand created intense competition within the TFT-LCd industry, urging panel companies to prioritize product quality enhancement to meet customer expectations. Panel quality inspection heavily relied on manual labor, causing varying inspection levels due to subjective judgments. Understanding and aligning with customer expectations regarding product quality inspections became imperative. Identifying defective products during inspection led to additional costs for the companies. Balancing customer product quality requirements and re-inspection costs became crucial for optimal benefits. This study addresses the binary classification problem of customer-side quality inspection through cost-sensitive learning. The predictive model considers panel process yield, production history, customer feedback, inspection capacity constraints, and cost minimization to predict panel quality as accepted or defective. To tackle the highly imbalanced data, a two-phase cost-sensitive-learning-based framework is proposed, combining data preprocessing methods and models, while considering re-inspection capacity constraints and costs to enhance accuracy. The model’s evaluation uses key performance indicators like AUC and G-mean. Actual inspection cost and defective parts per million (dPPM) are calculated based on the company’s practical assessment. Two products are used for experimentation to validate the proposed model, demonstrating over 50% reduction in inspection cost and over 10% improvement in dPPM. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Spr

关键词： Inspection

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Schwann cells acquire a repair phenotype after assembling into spheroids and show enhanced in vivo therapeutic potential for promoting peripheral nerve repair

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Bioengineering and Translational Medicine 2024年第2期9卷 e10635页

作者： Chen, Shih-Heng Wang, Hsin-Wen Yang, Pei-Ching Chen, Shih-Shien Ho, Chia-Hsin Yang, Pei-Ching Kao, Ying-Chi Liu, Shao-Wen Chiu, Han Lin, Yu-Jie Chuang, Er-Yuan Huang, Jen-Huang Kao, Huang-Kai Huang, Chieh-Cheng Department of Plastic and Reconstructive Surgery Linkou Chang Gung Memorial Hospital Taoyuan Taiwan School of Medicine College of Medicine Chang Gung University Taoyuan Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering International Ph.D. Program in Biomedical Engineering Taipei Medical University Taipei Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University–Wan Fang Hospital Taipei Taiwan Department of Chemical Engineering National Tsing Hua University Hsinchu Taiwan

The prognosis for postinjury peripheral nerve regeneration remains suboptimal. Although transplantation of exogenous Schwann cells (SCs) has been considered a promising treatment to promote nerve repair, this strategy has been hampered in practice by the limited availability of SC sources and an insufficient postengraftment cell retention rate. In this study, to address these challenges, SCs were aggregated into spheroids before being delivered to an injured rat sciatic nerve. We found that the three-dimensional aggregation of SCs induced their acquisition of a repair phenotype, as indicated by enhanced levels of c-Jun expression/activation and decreased expression of myelin sheath protein. Furthermore, our in vitro results demonstrated the superior potential of the SC spheroid-derived secretome in promoting neurite outgrowth of dorsal root ganglion neurons, enhancing the proliferation and migration of endogenous SCs, and recruiting macrophages. Moreover, transplantation of SC spheroids into rats after sciatic nerve transection effectively increased the postinjury nerve structure restoration and motor functional recovery rates, demonstrating the therapeutic potential of SC spheroids. In summary, transplantation of preassembled SC spheroids may hold great potential for enhancing the cell delivery efficiency and the resultant therapeutic outcome, thereby improving SC-based transplantation approaches for promoting peripheral nerve regeneration. © 2023 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

关键词： Regenerative Medicine

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dual-Module Ultrawide dynamic-Range High-Power Rectifier for WPT Systems

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Energies 2024年第11期17卷

作者： Yu, Xiaochen Zhang, Jinyao Liu, Minzhang Yang, Xiantao Huang, Yi Yen, Ta-Jen Zhou, Jiafeng Department of Electrical Engineering and Electronics University of Liverpool LiverpoolL69 3GJ United Kingdom International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu300044 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu300044 Taiwan

Rectifier plays a pivotal role in wireless power transfer systems. While numerous studies have concentrated on enhancing efficiency and bandwidth at specific high-power levels, practical scenarios often involve unpredictable power inputs. Consequently, a distinct need arises for a rectifier that demonstrates superior efficiency across a broad range of input power levels. This paper introduces a high-power RF-to-dC rectifier designed for WPT applications, featuring an ultrawide dynamic range of input power. The rectification process leverages a GaN (gallium nitride) high electron mobility transistor (HEMT) to efficiently handle high power levels up to 12.6 W. The matching circuit was designed to ensure that the rectifier will operate in class-F mode. A Schottky diode is incorporated into the design for relatively lower-power rectification. Seamless switching between the rectification modes of the two circuits is accomplished through the integration of a circulator. The proposed rectifier exhibits a 27.5 dB dynamic range, achieving an efficiency exceeding 55% at 2.4 GHz. Substantial improvement in power handling and dynamic range over traditional rectifiers is demonstrated. © 2024 by the authors.

关键词： Gallium nitride

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development of bionic invasion membrane for the study of multiple sclerosis

Development of bionic invasion membrane for the study of mul...

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IEEE international Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

作者： Chia-Yi Lee Kin Fong Lei Cheng-Lung Ku Chia-Hao Huang Ph.D. Program in Biomedical Engineering Chang Gung University Taiwan Department of Mechanical Engineering Chang Gung University Taiwan Graduate Institute of Clinical Medical Science Chang Gung University Taiwan Graduate Institute of Medical Mechatronics Chang Gung University Taiwan

ISBN: (纸本)9781509019489

Multiple sclerosis (MS) is an autoimmune disease and leads to many inflammations. Cause of this disease is autoreactive T cells invade the blood-brain-barrier and attack the myelin sheath. Because MS infringes upon young human and has gradual loss of bodily functions, the disease has a burden on society and economy. Traditional treatment is to use immune-suppressant, but it has many side effects. Currently, the most effective treatment of MS is to use Natalizumab. Target molecule of this agent is α4-integrin of T cells. The mechanism is to prevent invasion of activated lymphocytes across the blood-brain-barrier. However, this agent affects the overall immune response and easily generates side effects of progressive multifocal leukoencephalopathy (PML). Transwall systems are often used to investigate cell invasion, but there is no specific protein immobilizing on the isolation membrane of these systems. In this work, we have successfully developed a bionic invasion membrane for the study of MS. different chemokines were applied to the system for the demonstration of drug screening application. The bionic invasion membrane was a PP/PTEE membrane coated with VCAM-1 protein. Jurkat T cell was used to evaluate the feasibility of using the membrane for the study of MS. Results indicated that the invasion ability of T cells was reduced by VCAM-1 protein. The current work provides bionic invasion membrane for the study of MS in vitro.

关键词： Biomembranes Proteins Multiple sclerosis Immune system Microfluidics Color

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ROBUST FEATURE LEARNING AGAINST NOISY LABELS

arXiv

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arXiv 2023年

作者： Tai, Tsung-Ming Jhang, Yun-Jie Hwang, Wen-Jyi Free University of Bozen-Bolzano Italy NVIDIA AI Technology Center Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Taiwan Department of Computer Science and Information Engineering National Taiwan Normal University Taiwan

关键词： Image classification

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diversity and Suitability of the State-of-the-Art Wearable and Wireless EEG Systems Review

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IEEE Journal of biomedical and Health Informatics 2023年第8期27卷 3830-3843页

作者： He, Congying Chen, Yu-Yi phang, Chun-Ren Stevenson, Cory Chen, I-Ping Jung, Tzyy-Ping Ko, Li-Wei Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Institute of Applied Arts National Yang Ming Chiao Tung University Hsinchu30010 Taiwan International Ph.D. Program in Interdisciplinary Neuroscience National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Institute for Neural Computation and Institute of Engineering in Medicine University of California San DiegoCA90093 United States National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Institute of Electrical and Control Engineering Department of Electronics and Electrical Engineering Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Department of Biomedical Science and Environment Biology Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung80708 Taiwan

Wireless electroencephalography (EEG) systems have been attracting increasing attention in recent times. Both the number of articles discussing wireless EEG and their proportion relative to general EEG publications have increased over years. These trends indicate that wireless EEG systems could be more accessible to researchers and the research community has recognized the potential of wireless EEG systems. To explore the development and diverse applications of wireless EEG systems, this review highlights the trends in wearable and wireless EEG systems over the past decade and compares the specifications and research applications of the major wireless systems marketed by 16 companies. For each product, five parameters (number of channels, sampling rate, cost, battery life, and resolution) were assessed for comparison. Currently, these wearable and portable wireless EEG systems have three main application areas: consumer, clinical, and research. To address this multitude of options, the article also discussed the thought process to find a suitable device that meets personalization and use cases specificities. These investigations suggest that low-price and convenience are key factors for consumer applications, wireless EEG systems with FdA or CE-certification may be more suitable for clinical settings, and devices that provide raw EEG data with high-density channels are important for laboratory research. This article presents an overview of the current state of the wireless EEG systems specifications and possible applications and serves as a guide point as it is expected that more influential and novel research will cyclically promote the development of such EEG systems. © 2023 IEEE.

关键词： Electroencephalography

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