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Visual Representations of the Water Cycle in science Textbooks

Contemporary Education dialogue 2017年第1期10卷 7 - 36页

作者： K. Vinisha J. Ramadas K. Vinisha has a master’s degree in environmental science and a bachelor’s degree in education from Bangalore University. She has taught at both the primary and secondary school levels in Mumbai and Bangalore. Her research interests are environmental and science education and gender studies. She has participated in research projects that analysed textbooks for content enrichment pertaining to the environment. At the Homi Bhabha Centre for Science Education (HBCSE) Tata Institute of Fundamental Research (TIFR) Mumbai she studied aspects of gender represented in school textbooks and prepared resource material for teachers at the primary level. E-mail: J. Ramadas is Professor of science education and Centre Director of the HBCSE TIFR Mumbai India. She received an M.Sc. in physics from the Indian Institute of Technology (IIT) Kanpur in 1976 and a Ph.D. in science education from the HBCSE in 1981. Professor Ramadas is interested in cognitive studies of science learning and school science curricula. She led the development of the Homi Bhabha Curriculum for Primary Science titled ‘Small Science’ published in four languages for which she was awarded the Third World Academy of Sciences Regional Prize in 2011. Professor Ramadas served on the National Curriculum Framework 2005 Science Focus Group. She is a member of the International Union of Pure and Applied Physics (IUPAP) International Commission on Physics Education. Her research is concerned with visuospatial thinking in science including the use of diagrams and gestures. She guest-edited a special issue of the in 2009 on this emerging area of research. E-mail:

Visual representations, including photographs, sketches and schematic diagrams, are a valuable yet often neglected aspect of textbooks. Visual means of communication are particularly helpful in introducing abstract concepts in science. For effective communication, visuals and text need to be appropriately integrated within the *** study is based on an analysis of the science textbooks of the National Council of Educational Research and Training (NCERT) and the Maharashtra State Board (MSB) for Classes 3–10. We first assess these textbooks for the use of visual representations generally. Then we focus on the water cycle, looking at how this topic is treated in the school science curriculum, at the types of visual representations used, and how effectively text and visuals are integrated to teach the water cycle over the course of the school years. We conclude with some observations on the visual treatment of the water cycle in two exemplar textbooks, and examine the implications for the use of visualisation to understand the concept of the water cycle.

关键词： diagram visual communication water cycle textbook

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Correlating Reiff scores with clinical, functional, and prognostic factors: characterizing noncystic fibrosis bronchiectasis severity: validation from a nationwide multicenter study in Taiwan

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European journal of medical research 2024年第1期29卷 286页

作者： Wen-Chien Cheng Chia-Ling Chang Chau-Chyun Sheu Ping-Huai Wang Meng-Heng Hsieh Ming-Tsung Chen Wei-Fan Ou Yu-Feng Wei Tsung-Ming Yang Chou-Chin Lan Cheng-Yi Wang Chih-Bin Lin Ming-Shian Lin Yao-Tung Wang Ching-Hsiung Lin Shih-Feng Liu Meng-Hsuan Cheng Yen-Fu Chen Chung-Kan Peng Ming-Cheng Chan Ching-Yi Chen Lun-Yu Jao Ya-Hui Wang Chi-Jui Chen Shih-Pin Chen Yi-Hsuan Tsai Shih-Lung Cheng Horng-Chyuan Lin Jung-Yien Chien Hao-Chien Wang Wu-Huei Hsu Division of Pulmonary and Critical Care Medicine Department of Internal Medicine China Medical University Hospital Taichung Taiwan. wcchengdr@***. Critical Medical Center China Medical University Hospital Taichung Taiwan. wcchengdr@***. School of Medicine College of Medicine China Medical University Taichung Taiwan. wcchengdr@***. Department of Internal Medicine National Taiwan University Hospital Hsin-Chu Branch Hsin-Chu Taiwan. Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan. Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan. Department of Internal Medicine School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan. Division of Thoracic Medicine Far Eastern Memorial Hospital Taipei Taiwan. Department of Thoracic Medicine Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan. College of Medicine Chang Gung University Taoyuan Taiwan. Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan. Division of Chest Medicine Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan. Department of Internal Medicine E-Da Cancer Hospital I-Shou University Kaohsiung Taiwan. School of Medicine for International Students College of Medicine I-Shou University Kaohsiung Taiwan. Division of Pulmonary and Critical Care Medicine Chiayi Chang Gung Memorial Hospital Chiayi Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei City Taiwan Republic of China. Department of Internal Medicine Cardinal Tien Hospital and School of Medicine College of Medicine Fu Jen Catholic University New Taipei City Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Hualien Tzu Chi Hospital Buddhi

BACKGROUNd:Our study aimed to confirm a simplified radiological scoring system, derived from a modified Reiff score, to evaluate its relationship with clinical symptoms and predictive outcomes in Taiwanese patients with noncystic fibrosis bronchiectasis (NCFB). METHOdS:This extensive multicenter retrospective study, performed in Taiwan, concentrated on patients diagnosed with NCFB verified through high-resolution computed tomography (HRCT) scans. We not only compared the clinical features of various types of bronchiectasis (cylindrical, varicose, and cystic). Furthermore, we established relationships between the severity of clinical factors, including symptom scores, pulmonary function, pseudomonas aeruginosa colonization, exacerbation and admission rates, and HRCT parameters using modified Reiff scores. RESULTS:data from 2,753 patients were classified based on HRCT patterns (cylindrical, varicose, and cystic) and severity, assessed by modified Reiff scores (mild, moderate, and severe). With increasing HRCT severity, a significant correlation was found with decreased forced expiratory volume in the first second (FEV1) (p < 0.001), heightened clinical symptoms (p < 0.001), elevated pathogen colonization (pseudomonas aeruginosa) (p < 0.001), and an increased annual hospitalization rate (p < 0.001). In the following multivariate analysis, elderly age, pseudomonas aeruginosa pneumonia, and hospitalizations per year emerged as the only independent predictors of mortality. CONCLUSION:Based on our large cohort study, the simplified CT scoring system (Reiff score) can serve as a useful adjunct to clinical factors in predicting disease severity and prognosis among Taiwanese patients with NCFB.

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Correction to: dNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

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Journal of experimental & clinical cancer research : CR 2020年第1期39卷 10页

作者： Ssu-Chuan Lai Yu-Ting Su Ching-Chi Chi Yung-Che Kuo Kam-Fai Lee Yu-Chih Wu Pei-Chi Lan Muh-Hwa Yang Te-Sheng Chang Yen-Hua Huang Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei 11031 Taiwan. Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. TMU Research Center for Cell Therapy and Regeneration Medicine Taipei Medical University Taipei 11031 Taiwan. Department of Dermatology Chang Gung Memorial Hospital Linkou Taoyuan 33305 Taiwan. College of Medicine Chang Gung University Taoyuan 33302 Taiwan. Department of Pathology Chang Gung Memorial Hospital Chiayi 61363 Taiwan. School of Respiratory Therapy College of Medicine Taipei Medical University Taipei 11031 Taiwan. Institute of Clinical Medicine College of Medicine National Yang Ming University Taipei 11221 Taiwan. Division of Medical Oncology Taipei Veterans General Hospital Taipei 11217 Taiwan. School of Traditional Chinese Medicine College of Medicine Chang Gung University Taoyuan 33382 Taiwan. cgmh3621@cgmh.org.tw. Division of Internal Medicine Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Chiayi 61363 Taiwan. cgmh3621@cgmh.org.tw. Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei 11031 Taiwan. rita1204@tmu.edu.tw. Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. rita1204@tmu.edu.tw. TMU Research Center for Cell Therapy and Regeneration Medicine Taipei Medical University Taipei 11031 Taiwan. rita1204@tmu.edu.tw. International PhD Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. rita1204@tmu.edu.tw. Center for Reproductive Medicine Taipei Medical University Hospital Taipei Medical University Taipei 11031 Taiwan. rita1204@tmu.edu.tw. Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031

In the original publication of this article [1], labelling within Fig. 7a was incorrect. The updated figure is shown below, with 'dMT1' now corrected to read 'dNMT1'.

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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

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Nature communications 2023年第1期14卷 3043页

作者： Jianxin Shi Kouya Shiraishi Jiyeon Choi Keitaro Matsuo Tzu-Yu Chen Juncheng dai Rayjean J Hung Kexin Chen Xiao-Ou Shu Young Tae Kim Maria Teresa Landi dongxin Lin Wei Zheng Zhihua Yin Baosen Zhou Bao Song Jiucun Wang Wei Jie Seow Lei Song I-Shou Chang Wei Hu Li-Hsin Chien Qiuyin Cai Yun-Chul Hong Hee Nam Kim Yi-Long Wu Maria Pik Wong Brian douglas Richardson Karen M Funderburk Shilan Li Tongwu Zhang Charles Breeze Zhaoming Wang Batel Blechter Bryan A Bassig Jin Hee Kim demetrius Albanes Jason Y Y Wong Min-Ho Shin Lap Ping Chung Yang Yang She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young-Chul Kim Neil E Caporaso Jiang Chang James Chung Man Ho Michiaki Kubo Yataro daigo Minsun Song Yukihide Momozawa Yoichiro Kamatani Masashi Kobayashi Kenichi Okubo Takayuki Honda dean H Hosgood Hideo Kunitoh Harsh Patel Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Hidehito Horinouchi Masahiro Tsuboi Ryuji Hamamoto Koichi Goto Yuichiro Ohe Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Megumi Hara Yuichiro Nishida Kenji Takeuchi Kenji Wakai Koichi Matsuda Yoshinori Murakami Kimihiro Shimizu Hiroyuki Suzuki Motonobu Saito Yoichi Ohtaki Kazumi Tanaka Tangchun Wu Fusheng Wei Hongji dai Mitchell J Machiela Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Gee-Chen Chang Ying-Huang Tsai Kuan-Yu Chen Ming-Shyan Huang Wu-Chou Su Yuh-Min Chen Adeline Seow Jae Yong Park Sun-Seog Kweon Kun-Chieh Chen Yu-Tang Gao Biyun Qian Chen Wu daru Lu Jianjun Liu Ann G Schwartz Richard Houlston Margaret R Spitz Ivan P Gorlov Xifeng Wu Ping Yang Stephen Lam Adonina Tardon Chu Chen Stig E Bojesen Mattias Johansson Angela Risch Heike Bickeböller Bu-Tian Ji H-Erich Wichmann david C Christiani Gadi Rennert Susanne Arnold Paul Brennan James McKay John K Field Sanjay S Shete Loic Le Marchand Geoffrey Liu Angeline Andrew Lambertus A Kiemeney Shan Zienolddiny-Narui Kjell Grankvist Mikael Johansson Angela Cox Fiona Taylor Jian-Min Yuan philip Lazarus Matthew B Schabath Melinda C Aldrich Hyo-Sung Jeon Shih Sheng Jiang Jae Sook Sung C Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. jianxin.shi@nih.gov. Division of Genome Biology National Cancer Research Institute Tokyo Japan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Medicine Nanjing Medical University Nanjing China. Prosserman Centre for Population Health Research Lunenfeld-Tanenbaum Research Institute Sinai Health Toronto ON Canada. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University Tianjin China. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Cancer Research Institute Seoul National University College of Medicine Seoul Republic of Korea. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Epidemiology School of Public Health China Medical University Shenyang China. Department of Clinical Epidemiology and Center of Evidence Based Medicine The First Hospital of China Medical University Shenyang China. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China. S

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FAdS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

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Genomics 2020年第2期112卷 1223-1232页

作者： Jason Y Y Wong Han Zhang Chao A Hsiung Kouya Shiraishi Kai Yu Keitaro Matsuo Maria Pik Wong Yun-Chul Hong Jiucun Wang Wei Jie Seow Zhaoming Wang Minsun Song Hee Nam Kim I-Shou Chang Nilanjan Chatterjee Wei Hu Chen Wu Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Adeline Seow Neil E Caporaso Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Yang Yang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Qiuyin Cai Zhihua Yin Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Yataro daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda H dean Hosgood Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Michiaki Kubo Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Jianxin Shi Lei Song Xing Hua Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Fusheng Wei Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Wu-Chou Su Yu-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Li-Hsin Chien Yong-Bing Xiang Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Kyoung-Mu Lee Batel Blechter Haixin Li Yu-Tang Gao Biyun Qian daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Herbert Pang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu C H Kang Meng Zhu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Michael Hsin Ko-Yung Sit James Ho Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho Il Yoon Chien-Chung Lin In Kyu Park Ping Xu Yuzhuo Wang Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Tzu-Yu Chen Shih-Sheng Jiang Jie Liu Taiki Yamaji Belynda Hicks Kathleen Wyatt Shengchao A Li Juncheng dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Ping Cui Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Electronic address: jason.wong@nih.gov. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan. Department of Pathology Queen Mary Hospital The University of Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Saw Swee Hock School of Public Health National University of Singapore Singapore. Cancer Genomics Research Laboratory Leidos Biomedical Research Inc Gaithersburg MD USA Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.

关键词： Lung adenocarcinoma Lung cancer Mendelian randomization Pathway analysis Tuberculosis

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An initiative on the safety and management of food flavorings in Taiwan

Taiwan Journal of Public Health

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Taiwan Journal of Public Health 2016年第1期35卷 9-16页

作者： Yu, Hsu-Sheng Chiang, Hung-Che Li, Jih-Heng Department of Food Science College of Agriculture National Pingtung University of Science and Technology Pingtung Taiwan National Institute of Environmental Health Sciences National Health Research Institutes Miaoli Taiwan School of Pharmacy and Ph.D. Program in Toxicology Kaohsiung Medical University No. 100 Shih-Chuan 1st Rd. Sanmin Dist. Kaohsiung Taiwan

Food flavorings are preparations widely used for food processing and home cooking to enhance the smell and taste of food. Because of increasing demand for consumer protection, the general population has recently paid much greater attention to the safety of food flavors. Legislation controlling the use of food flavors vary among countries. The US Flavor and Extract Manufacturers Association (FEMA) has evaluated and approved near 3, 000 substances as FEMA GRAS (Generally Recognized as Safe) flavors. In Taiwan, there are only 90 items of food flavorings complying with the safety rules of the US FEMA, and Taiwan FdA has officially approved these substances for use as food flavors. Currently, many of flavors used in food businesses and industries, and home cooks remain unevaluated and not fully regulated in Taiwan. Information on daily intakes or exposures to these flavorings are yet unavailable for a risk assessment. In line with the international standards, the Ministry of Health and Welfare has started to propose an updated additive list with a greater variety of flavors. To better consolidate the safety of food flavoring use in Taiwan, it is imperative in the future to update the items of food flavorings for control and to establish the safety criteria by conducting a risk assessment for all flavoring substances.

关键词： FEMA Food flavoring Food safety Safety assessment Toxicity

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Blogger effect: User behavior during the theme park selection process

Blogger effect: User behavior during the theme park selectio...

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Portland international Conference on Management of Engineering and technology (PICMET)

作者： Chia-Ko Lee Yi-Chih Lee Wei-Li Wu Yang-Chu Lin Feng Chia University Department of Administration Feng Chia University Ph.D. Program in Business Taiwan Department of International Business Chien Hsin University of Science and Technology Taiwan Department of Business Administration Soochow University Taiwan

Taiwan depends heavily on its tourist trade. The purpose of this study is to use the online platform of blogs to investigate whether emotional contagion, blog attraction and customer perceived value would affect the consumer's intent. The number of valid questionnaire samples is 312, and PLS is used to conduct linear structural equation model analysis. Research results show that blog attraction and customer perceived value have positive effects on purchase intention. Therefore, blog is an important channel to attract consumer's attention.

关键词： Blogs Mathematical model Educational institutions Reliability Analytical models Psychology Media

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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

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Human molecular genetics 2017年第2期26卷 454-465页

作者： Wei Jie Seow Keitaro Matsuo Chao Agnes Hsiung Kouya Shiraishi Minsun Song Hee Nam Kim Maria Pik Wong Yun-Chul Hong H dean Hosgood Zhaoming Wang I-Shou Chang Jiu-Cun Wang Nilanjan Chatterjee Margaret Tucker Hu Wei Tetsuya Mitsudomi Wei Zheng Jin Hee Kim Baosen Zhou Neil E Caporaso demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Ping Wang Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro daigo Hidemi Ito Yukihide Momozawa Kyota Ashikawa Yoichiro Kamatani Takayuki Honda Hiromi Sakamoto Hideo Kunitoh Koji Tsuta Shun-Ichi Watanabe Hiroshi Nokihara Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Jianxin Shi Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jason Y Y Wong Fumihiko Matsuda Jian Su Yeul Hong Kim In-Jae Oh Fengju Song Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Pan-Chyr Yang Hsien-Chih Lin Yong-Bing Xiang Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Haixin Li Yu-Tang Gao Chen Wu Biyun Qian daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Wen-Chang Wang Charles C Chung Charles Lawrence Laurie Burdett Meredith Yeager Kevin B Jacobs Amy Hutchinson Sonja I Berndt Xingzhou He Wei Wu Junwen Wang Yuqing Li Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Lingmin Hu Chung-Hsing Chen Tsung-Ying Yang Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan dart Loon Sihoe Ying Chen Yi Young Choi Jen-Yu Hung Jun Suk Kim Ho-Il Yoon Qiuyin Cai Chien-Chung Lin In Kyu Park Ping Xu Jing dong Christopher Kim Qincheng He Reury-Perng Perng Chih-Yi Chen Roel Vermeulen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Minjie Chu Yao-Jen Li Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Yen-Li Lo Ying-Hsiang Chen Joseph F Fraumeni Jie Liu Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA. Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore. Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Genome Biology National Cancer Center Research Institute Tokyo Japan. Department of Statistics Sookmyung Women's University Seoul Republic of Korea. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN 38105 USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai People's Republic of China. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai People's Republic of China. Division of Thoracic Surgery Kinki University School of Medicine Sayama Japan. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Integrative Bioscience & Biotechnology Sejong University Seoul Republic of Korea. Department of Epidemiology School of Public Health China Medical University Shenyang People's Republic of China. Guangdong Lung Cancer Institute Medical Research Center and Cancer Center of Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou People's Republic

To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/dCBLd1) and rs2179920 (HLA-dPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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The effect of plants on lead dissolution

The effect of plants on lead dissolution

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GeoFlorida 2010: Advances in Analysis, Modeling and design Conference

作者： Butler, A.d. Thomas, C.C. Medina, V.F. Larson, S.L. US Army Corps of Engineers Engineer Research and Development Center Environmental Laboratory 3909 Halls Ferry Road Vicksburg MS 39180 United States Jackson State University College of Science Engineering and Technology Environmental Science Ph.D. Program 1400 J.R. Lynch Street Jackson MS 39217 United States

ISBN: (纸本)9780784410950

Berm soils at small arms firing ranges (SAFRs) are contaminated with metals as bullets impact the soil and corrode. These berms generally lack vegetation and frequently suffer from erosion that may transport heavy metals (e.g. lead) into surface water and, occasionally, into groundwater. Plants are generally useful for stabilizing metals in SAFR soils by reducing particulate runoff. However, results have shown that plants appear to increase lead solubility in surface runoff and leachate. Studies were conducted to investigate this phenomenon that plants enhance lead solubility and complexation. Hydroponic bermuda plant culture solutions were prepared. Plant culture and soluble lead solutions were reacted to form lead complexes. Ion exchange filtration was performed to separate lead complexes based on relative molecular sizes. Results showed that bermuda cultures increased lead solubility and formed measurable lead complexes for fractionated sizes. Continued research will determine the effect of soluble plant organic compounds on metal dissolution. © 2010 ASCE.

关键词： Soil pollution

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Summary remarks and personal observations of the situation by an old hunter and researcher

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Wildlife Society Bulletin 2010年第1期32卷 119-122页

作者： Robert J. Robel R. J. (Bob) Robelreceived his B.S. in fisheries and wildlife management from Michigan State University an M.S. in forest and wildlife sciences from the University of Idaho and a Ph.D. in wildlife science from Utah State University. He joined the zoology faculty at Kansas State University in 1961 moving from assistant to associate to full professor. During his tenure at K-State he was a Senior Fulbright Research Scholar in the United Kingdom Project Manager of Energy Programs in the Office of Technology Assessment for the United States Congress and served as science advisor for two Kansas governors. He was on the National Rifle Association Board of Directors for 25 years chaired the International Shooter Development Fund and chaired the United States Shooting Team. A Boone and Crockett Club professional member since 1974 he has hunted in the United States Canada Europe and Asia. He retired from K-State in 2003 but still retains an interest in wildlife ecology especially grouse species. His major concern is the loss of wildlife habitat worldwide as the human population expands believing that environmental degradation and habitat destruction are the greatest challenges facing both game and nongame wildlife populations.

The precipitous drop in numbers of prairie grouse ( Tympanuchus spp.) in North America prompted convening a workshop to address the issue during the 9th Annual Meeting of The Wildlife Society. Speakers provided a historical perspective of the loss of the North American prairie ecosystem and concurrent declines of prairie grouse. Problems associated with managing isolated grouse populations were reviewed and a set of guidelines for the management of lesser prairie-chickens ( T. pallidicintus ) was presented. The need for a valid survey technique was highlighted, as was the lack of information on the impacts of parasites and diseases on prairie grouse populations. The take-away message: unless an aggressive plan to reverse the downward trend of prairie grouse populations is implemented in the very near future, the lesser prairie-chicken and possibly the greater prairie-chicken ( T. cupido pinnatus ) will follow the path of the Attwater's prairie-chicken ( T.c. attwateri ).

关键词： greater prairie-chicken lesser prairie-chicken prairie ecosystem prairie grouse sharp-tailed grouse Tympanuchus cupido Tympanuchus pallidicintus Tympanuchus phasianellus

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