检索结果-内蒙古大学图书馆

SSRN 2025年

作者： Chen, Ting-Yu Chang, Chi-Yuan Wen, Ting-Chun Xu, Li Lin, Yu-Han Peng, Cheng-Liang Yeh, Yi-Qi Chen, Chueh-Hsuan Chuang, Kuo-Hsiang Wu, Si-Han Graduate Institute of Pharmacognosy Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan Department of Isotope Application National Atomic Research Institute Taoyuan Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Research Center for Applied Science Academia Sinica Taiwan PhD Program in Clinical Drug Development of Chinese Herbal Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

The immunogenicity of polyethylene glycol (PEG) remains a critical challenge in nanomedicine, as pre-existing anti-PEG antibodies can compromise therapeutic efficacy through accelerated blood clearance (ABC) and life-threatening hypersensitivity. Here, we address this challenge by engineering the PEG architecture, creating short-chain dense brush PEGylation (PEG500) on rigid mesoporous silica nanoparticles (MSNs). Unlike conventional PEG2000-liposomes, MSN-PEG500 evades antibodies via three synergistic mechanisms: (1) short-chain PEG500 reduces epitope accessibility, (2) high grafting density (4.43 chains/nm2, according to TGA) forms an dense steric shield, and (3) the rigid silica surface prevents PEG burial. ELISA studies demonstrated that, at equivalent nanoparticle concentrations, MSN-PEG500 exhibits a 26-fold reduction in anti-PEG IgG (6.3) binding and a 1000-fold reduction in anti-PEG IgM (AGP3) binding compared to Lipodox (PEG2000), both of which target the PEG backbone. Furthermore, radiolabeled MSN-PEG500 achieved prolonged circulation and 25% tumor accumulation (ID/g) at 24 hours. In strongly immunized mice, doxorubicin-loaded MSN-PEG500 preserved therapeutic efficacy and 100% survival, whereas Lipodox induced fatal hypersensitivity. Mechanistic investigations revealed that complement activation drives PEG2000 immunotoxicity, and pretreatment with the C3 inhibitor compstatin effectively mitigated temperature drops from 10°C to 2°C in immunized hosts. By demonstrating that nanoscale control of polymer conformation dictates immunological fate, this work provides a clinically translatable blueprint for developing immune-evasive nanomedicines. © 2025, The Authors. All rights reserved.

关键词： Silica nanoparticles

来源：评论

学校读者我要写书评

暂无评论

Overcoming Cytosolic Delivery Barriers of Proteins Using Denatured Protein-Conjugated Mesoporous Silica Nanoparticles

引用

ACS Applied Materials and Interfaces 2023年第1期15卷 432-451页

作者： Dembélé, Julien Liao, Jou-Hsuan Liu, Tsang-Pai Chen, Yi-Ping Graduate Institute of Biomedical Materials & Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Laboratory of Toxicology Environment and Health Doctorate School of Health University Joseph Ki-Zerbo Ouaga03 BP 7021 Burkina Faso Department of Chemistry National Taiwan University Taipei10617 Taiwan Department of Surgery Mackay Memorial Hospital Taipei10449 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Intracellular delivery of therapeutic proteins has increased advantages over current small-molecule drugs and gene therapies, especially in therapeutic efficacies for a broad spectrum of diseases. Hence, developing the protein therapeutics approach provides a needed alternative. Here, we designed a mesoporous silica nanoparticle (MSN)-mediated protein delivery approach and demonstrated effective intracellular delivery of the denatured superoxide dismutase (SOD) protein, overcoming the delivery challenges and achieving higher enzymatic activity than native SOD-conjugated MSNs. The denatured SOD-conjugated MSN delivery strategy provides benefits of reduced size and steric hindrance, increased protein flexibility without distorting its secondary structure, exposure of the cell-penetrating peptide transactivator of transcription for enhanced efficient delivery, and a change in the corona protein composition, enabling cytosolic delivery. After delivery, SOD displayed a specific activity around threefold higher than in our previous reports. Furthermore, the in vivo biosafety and therapeutic potential for neuron therapy were evaluated, demonstrating the biocompatibility and the effective antioxidant effect in Neuro-2a cells that protected neurite outgrowth from paraquat-induced reactive oxygen species attack. This study offers an opportunity to realize the druggable possibility of cytosolic proteins using MSNs. © 2022 American Chemical Society.

关键词： Peptides

来源：评论

学校读者我要写书评

暂无评论

Universal nanocomposite coating with antifouling and redox capabilities for electrochemical affinity biosensing in complex biological fluids

引用

Nanoscale Horizons 2024年第5期9卷 843-852页

作者： Bharti, Aditya Manu Rakesh Kumar, R.K. Chuang, Cheng-Hsin Shaikh, Muhammad Omar International PhD Program for Science National Sun Yat-sen University Kaohsiung80424 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung80424 Taiwan Department of Chemical Engineering National Taiwan University Taipei City10617 Taiwan Institute of Biomedical Engineering and Nanomedicine National Healthcare Research Institutes Miaoli County350 Taiwan National Sun Yat-sen University Kaohsiung80424 Taiwan Sustainability Science and Management Program Tunghai University Taichung407224 Taiwan

Electrochemical affinity biosensors have the potential to facilitate the development of multiplexed point-of-care diagnostics in complex biological fluids. However, their commercial viability has been hindered by challenges such as electrode biofouling and the lack of inherent redox properties. To address this unmet need, we have developed a universal nanocomposite coating which is unique in its ability to not only allow oriented conjugation of the biorecognition element but also specific detection directly in complex biological fluids like serum and urine owing to its built-in antifouling and redox capabilities, thus improving suitability for point of care testing. This multifunctional coating comprises a 3D porous crosslinked bovine serum albumin matrix for oriented conjugation and antifouling properties with embedded graphene nanosheets modified with amino-ferrocene for enhanced conductivity and mediator-free biosensing. The coating showed minimal signal degradation despite prolonged exposure to 1% bovine serum albumin, artificial urine and untreated human serum for up to 30 days. To demonstrate its utility, we fabricated and tested proof-of-concept electrochemical immunosensors for bladder cancer protein biomarkers, specifically interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF). The practical feasibility was highlighted by the excellent sensitivity and specificity observed for IL-8 and VEGF with a limit of detection of 41 pg mL−1 and 67 pg mL−1, respectively. Consequently, this universal nanocomposite-based electrochemical biosensing platform can be extended to the point of care testing of a broad spectrum of biomarkers present in complex biological fluids, thus enabling reliable and early diagnostics. © 2024 The Royal Society of Chemistry

关键词： Biomarkers

来源：评论

学校读者我要写书评

暂无评论

Enhanced light-driven photoelectrochemical catalysis of water splitting by TiO2 nanotubes grown on acid-etched titanium foils

引用

international Journal of Hydrogen Energy 2024年第PartA期51卷 1483-1493页

作者： Hsiao, Yu-Cheng Lai, Jhih-Hong Fan, Yu-Min Chen, Hung-Ming Yougbaré, Sibidou Saukani, Muhammad Chen, Chih-Yu Wu, Yung-Fu Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City23561 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

Titanium dioxide with suitable band edges is one of promising photocatalysts for water splitting. Nanotubes with one-dimensional structure can induce efficient charge transfers and hollow centers can provide large surface area for surface reactions. Modifying Ti foils for anodization can enhance light utilization of TiO2 nanotube photoelectrodes. In this work, it is firstly to fabricate TiO2 nanotube photoelectrodes on acid-etched Ti foils by anodization (MNT) for photoelectrochemical catalyzing water splitting. Different acid-etching durations are applied on Ti foils to induce various rugged surfaces. The resulting photoelectrodes present largely enhanced light utilization than that fabricated by the pristine Ti foil. The anodization duration is also optimized to find suitable lengths of MNT. The smallest overpotential of 524.7 mV at 10 mA/cm2 and Tafel slope of 167 mV/dec are obtained for the optimal MNT photoelectrode. The TiO2 nanotubes grown on the pristine Ti foil shows the overpotential of 679.3 mV at 10 mA/cm2 and Tafel slope of 285 mV/dec. This result opens a blueprint for raising the photocatalytic ability by simply modifying the surface property of the conductive substrate. Other modifications may be applicable to enhance the roughness of Ti foils for growing more efficient MNT array as photocatalysis of water splitting. © 2023 Hydrogen Energy Publications LLC

关键词： Titanium dioxide

来源：评论

学校读者我要写书评

暂无评论

Heterojunction and co-catalyst engineering of bismuth vanadate by nickel molybdenum oxide and carbon quantum dot decorations for photoelectrochemical water splitting

引用

international Journal of Hydrogen Energy 2024年 51卷 1099-1108页

作者： Kuo, Tsung-Rong Chiou, Yu-Tai Huang, Hsiao-Wen Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Improving the charge diffusion length and water oxidation kinetics of bismuth vanadate (BiVO4) is essential to achieve better photoelectrochemical catalytic ability for water oxidation. Establishing heterojunctions and incorporating co-catalysts with BiVO4 create facile charge transfer paths and generate more water oxidation reactions. In this work, nickel molybdenum oxide (NM) and carbon quantum dot (CQD) are firstly deposited on BiVO4 by hydrothermal and soaking processes to design an efficient co-catalyst/photocatalyst system for water oxidation. The depositing amount of CQD is optimized to balance contributions of CQD and NM as the hole sink and the light-to-electron generator, respectively. The highest photocurrent densities of 2.2 and 3.9 mA/cm2 are achieved for BiVO4/NM/CQD in the electrolyte without and with hole scavenger, respectively. The BiVO4 electrode only shows a photocurrent density of 1.2 mA/cm2 in the electrolyte without hole scavenger. The best photoelectrochemical catalytic ability of BiVO4/NM/CQD is approached by the reduced charge-transfer resistance and charge recombination as well as the enhancement on carrier densities. The excellent long-term stability with the photocurrent retention of 90% under illumination for 24 h is also obtained for BiVO4/NM/CQD. This study opens a blueprint on designing efficient catalysts for water oxidation by incorporating heterojunction and co-catalyst materials simultaneously. © 2023 Hydrogen Energy Publications LLC

关键词： Heterojunctions

来源：评论

学校读者我要写书评

暂无评论

Efficiently catalyzing photo-oxidation of water by surface engineering of bismuth vanadate with nickel molybdenum oxide coverages

引用

international Journal of Hydrogen Energy 2024年 51卷 613-622页

作者： Kuo, Tsung-Rong Huang, Hsiao-Wen Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Bismuth vanadate with suitable band edges is one of the efficient photocatalysts for water oxidation. Establishing heterojunction can improve electron diffusion lengths and photocatalytic ability of BiVO4. In this work, nickel molybdenum oxide (Ni–Mo–O) and BiVO4 heterojunction is established by the hydrothermal process with different nickel to molybdenum precursor ratios. The Ni–Mo–O/BiVO4 electrode is applied as photoanodes for water oxidation. The growth mechanism of Ni–Mo–O on BiVO4 surface is proposed. The Ni–Mo–O deposition amount is optimized regarding to light absorbance and charger transportation. The largest photocurrent density of 1.72 mA/cm2 at 1.23 VRHE is obtained for the optimal NiMoO4/BiVO4 electrode (NM12) in the electrolyte without hole scavenger, while the pure BiVO4 electrode only shows a photocurrent density of 0.90 mA/cm2. The NM12 electrode even presented an impressive photocurrent density of 5.39 mA/cm2 at 1.23 VRHE in the electrolyte with the hole scavenger, owing to the abundant active sites and higher light absorbance as well as the favorable synergistic effects from its suitable Ni to Mo ratio. The NM12 electrode also shows excellent long-term stability with the photocurrent retention of 83% after illumination for 6500 s. This work opens a blueprint for establishing a novel heterojunction with the adjustable metal ratio and coverage on BiVO4. © 2023 Hydrogen Energy Publications LLC

关键词： Heterojunctions

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to “Metal ratio and bimetal nanoarchitectonics of ammonia-based fluoride complex induced nickel hydroxide and manganese oxide composites as active materials of an energy storage device” [J. Energy Storage 80 (2024) 110316]

引用

Journal of Energy Storage 2025年 108卷

作者： Chuan-Chih Hsu You Zher Yu Chung-Hsien Wu Pin-Yan Lee Hung-Ming Chen Sadang Husain Chutima Kongvarhodom Yu-Cheng Hsiao Lu-Yin Lin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei 11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin 70124 Indonesia Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok 10140 Thailand Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei 11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA 94305-5428 USA Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan

来源：评论

学校读者我要写书评

暂无评论

Systematic designs of single metal compounds synthesized using ammonia fluoride-based complex as structure directing agents for energy storage

引用

Journal of Colloid and Interface Science 2023年第PartA期652卷 294-304页

作者： Kuo, Tsung-Rong Zher Yu, You Wu, Chung-Hsien Lee, Pin-Yan Kongvarhodom, Chutima Chen, Hung-Ming Husain, Sadang Yougbaré, Sibidou Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso

Tailoring morphology and composition of metal organic frameworks (MOF) can improve energy storage by establishing high surface area, large porosity and multiple redox states. Structure directing agents (SDA) is functional of designing surface properties of electroactive materials. Ammonium fluoride has functional abilities for designing MOF derivatives with excellent energy storage abilities. Systematic design of MOF derivatives using ammonia fluoride-based complex as SDA can essentially create efficient electroactive materials. Metal species can also play significant roles on redox reactions, which are the main energy storage mechanism for battery-type electrodes. In this work, 2-methylimidazole, two novel SDAs of NH4BF4 and NH4HF2, and six metal species of Al, Mn, Co, Ni, Cu and Zn are coupled to synthesize MOF derivatives for energy storage. Metal species-dependent compositions including hydroxides, oxides, and hydroxide nitrates are observed. The nickel-based derivative (Ni-HBF) shows the highest specific capacitance (CF) of 698.0F/g at 20 mV/s, due to multiple redox states and advanced flower-like surface properties. The diffusion and capacitive-control contributions of MOF derivatives are also analyzed. The battery supercapacitor hybrid with Ni-HBF electrode shows a maximum energy density of 27.9 Wh/kg at 325 W/kg. The CF retention of 170.9% and Coulombic efficiency of 93.2% are achieved after 10,000 cycles. © 2023 Elsevier Inc.

关键词： Supercapacitor

来源：评论

学校读者我要写书评

暂无评论

Simultaneous identification for synergistic transcription factors and their transcription factor binding sites

Simultaneous identification for synergistic transcription fa...

引用

5th international Conference on Complex, Intelligent and Software Intensive Systems, CISIS 2011

作者： Tsai, Zing Tsung-Yeh Huang, Grace Tzu-Wei Tsai, Huai-Kuang Institute of Information Science Academia Sinica Taipei 115 Taiwan Bioinformatics Program Taiwan International Graduate Program Taiwan Institute of Biomedical Informatics National Yang-Ming University Taiwan Joint CMU-Pitt PhD Program in Computational Biology University of Pittsburgh Carnegie Mellon University Pittsburgh PA United States Research Center for Information Technology Innovation Taipei 115 Taiwan Computer Science and Engineering National Taiwan Ocean University Keelung 202 Taiwan

ISBN: (纸本)9780769543734

Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While traditional approaches can be used to discover binding motifs of a group of co-regulated genes, they often fail to accurately assign motifs to the corresponding TFs. Here, we consider two TFs together to infer their TFBSs and their synergistic relationship simultaneously. The basic idea is that if two TFs interact, their TFBSs, if distinct, would be conserved across species and coincided in the promoter regions of the genes they co-regulated. Applying our method to Saccharomyces cerevisiae chromatin immunoprecipitation data, we predicted 110 TF pairs with statistically significant motif assignments. A majority of these TF pairs have literature support to be synergistic, and the designated motifs to TFs match well with their known consensus. We further examined the synergism of predicted TF pairs in seven experimental conditions using ANOVA, and identified significant interactions. © 2011 IEEE.

关键词： Yeast

来源：评论

学校读者我要写书评

暂无评论

Rapid Escherichia coli Cloned DNA Detection in Serum Using an Electrical Double Layer-Gated Field-Effect Transistor-Based DNA Sensor

引用

Analytical Chemistry 2023年第17期95卷 6871-6878页

作者： Paulose, Akhil K. Hou, Yueh-Ju Huang, Yu-Shan Chakkalaparambil Dileep, Navyamol Chiu, Chia-Lin Pal, Arnab Kalaimani, Vishal Mani Lin, Zong-Hong Chang, Chuang-Rung Chen, Cheng-Pin Lin, Yi-Chun Cheng, Chien-Yu Cheng, Shu-Hsing Cheng, Chao-Min Wang, Yu-Lin Institute of Nanoengineering and Microsystems National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan Department of Life Sciences National University of Kaohsiung Kaohsiung811726 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu30013 Taiwan Department of Infectious Diseases Taoyuan General Hospital Ministry of Health and Welfare Taoyuan32748 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan

In this study, a rapid diagnosis platform was developed for the detection of Escherichia coli O157:H7. An electrical double layer (EDL)-gated field-effect transistor-based biosensor (BioFET) as a point-of-care testing device is demonstrated with its high sensitivity, portability, high selectivity, quick response, and ease of use. The specially designed ssDNA probe was immobilized on the extended gate electrode to bind the target complementary DNA segment of E. coli, resulting in a sharp drain current change within minutes. The limit of detection for target DNA is validated to a concentration of 1 fM in buffer solution and serum. Meanwhile, the results of a Kelvin probe force microscope were shown to have reduced surface potential of the DNA immobilized sensors before and after the cDNA detection, which is consistent with the decreased drain current of the BioFET. A 1.2 kb E. coli duplex DNA synthesized in plasmid was sonicated and detected in serum samples with the sensor array. Gel electrophoresis was used to confirm the efficiency of sonication by elucidating the length of DNA. Those results show that the EDL-gated BioFET system is a promising platform for rapid identification of pathogens for future clinical needs. © 2023 American Chemical Society

关键词： DNA

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：