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37th international Cosmic Ray Conference, ICRC 2021

作者： Yano, Takatomi Abe, K. Adrich, P. Aihara, H. Akutsu, R. Alekseev, I. Ali, A. Alj Hakim, Y.I. Ameli, F. Anthony, L.H.V. Araya, A. Asaoka, Y. Aushev, V. Ballester, F. Bandac, I. Barbi, M. Barr, G. Batkiewicz-Kwasniak, M. Bellato, M. Berardi, V. Bernard, L. Bernardini, E. Berns, L. Bhadra, S. Bian, J. Blanchet, A. Blondel, A. Boiano, A. Bolognesi, S. Bonavera, L. Booth, N. Bordoni, S. Borjabad, S. Boschi, T. Bose, D. Boyd, S.B. Bozza, C. Bravar, A. Bronner, C. Brown, L. Bubak, A. Buchowicz, A. Buizza Avanzini, M. Cafagna, F.S. Calabria, N.F. Calvo-Mozota, J.M. Cao, S. Carroll, A. Catanesi, M.G. Cebriàn, S. Chakraborty, S. Choi, J.H. Choubey, S. Cicerchia, M. Coleman, J. Collazuol, G. Cuen-Rochin, S. Danilov, M. Díaz López, G. De la Fuente, E. de Perio, P. De Rosa, G. Dealtry, T. Densham, C.J. Dergacheva, A. Deshmukh, N. Devi, M.M. Di Lodovico, F. Di Meo, P. Di Palma, I. Doyle, T.A. Drakopoulou, E. Drapier, O. Dumarchez, J. Eklund, L. El Hedri, S. Ellis, J. Emery, S. Esmaili, A. Esteve, R. Fedotov, S. Feng, J. Fernandez, P. Fernández-Martinez, E. Ferrario, P. Ferrazzi, B. Finch, A. Finley, C. Fiorillo, G. Fitton, M. Friend, M. Fujii, Y. Fujisawa, C. Fukuda, Y. Galinski, G. Gao, J. Garde, C. Garfagnini, A. Garode, S. Gialanella, L. Giganti, C. Gomez-Cadenas, J.J. Gonin, M. González-Nuevo, J. Gorin, A. Gornea, R. Gousy-Leblanc, V. Gramegna, F. Grassi, M. Grella, G. Guigue, M. Hadley, D.R. Harada, M. Hartz, M. Hassani, S. Hastings, N.C. Hayato, Y. Hernando-Morata, J.A. Herrero, V. Hiraide, K. Holin, A. Hoshina, K. Hultqvist, K. Iacob, F. Ichikawa, A.K. Idrissi Ibnsalih, W. Ieki, K. Ikeda, M. Ioannisian, A. Ishida, T. Ishidoshiro, K. Ishino, H. Ishitsuka, M. Israel, H.T. Ito, H. Itow, Y. Izumi, N. Izumiyama, S. Jakkapu, M. Jamieson, B. Jang, J.S. Jo, H.S. Jonsson, P. Joo, K.K. Kajita, T. Kakuno, H. Kameda, J. Kaneshima, R. Kano, Y. Karlen, D. Kataoka, Y. Kato, A. Katori, T. Kazarian, N. Khabibullin, M. Kamioka Observatory ICRR The University of Tokyo Mozumi Kamioka Hida Gifu456 Japan University of Tokyo Institute for Cosmic Ray Research Kamioka Observatory Kamioka Japan University of Tokyo Institutes for Advanced Study Kashiwa Japan University of Tokyo Next-generation Neutrino Science Organization Kamioka Japan National Centre for Nuclear Research Warsaw Poland University of Tokyo Department of Physics Tokyo Japan TRIUMF VancouverBC Canada P.N.Lebedev Physical Institute of the Russian Academy of Sciences Moscow Russia Kyoto University Department of Physics Kyoto Japan Imperial College London Department of Physics London United Kingdom INFN Sezione di Roma Università Sapienza Dipartimento di Fisica Roma Italy University of Tokyo Earthquake Research Institute Tokyo Japan Kyiv National University Department of Nuclear Physics Kyiv Ukraine Valencia Spain Laboratorio Subterráneo de Canfranc Estación Canfranc Spain University of Regina Department of Physics ReginaSK Canada Oxford University Department of Physics Oxford United Kingdom H. Niewodniczański Institute of Nuclear Physics PAN Cracow Poland INFN Sezione di Padova Università di Padova Dipartimento di Fisica Padova Italy INFN Sezione di Bari Università e Politecnico di Bari Bari Italy Ecole Polytechnique IN2P3-CNRS Laboratoire Leprince-Ringuet Palaiseau France Tokyo Institute of Technology Department of Physics Tokyo Japan York University Department of Physics and Astronomy TorontoON Canada University of California Irvine Department of Physics and Astronomy IrvineCA United States Laboratoire de Physique Nucleaire et de Hautes Energie IN2P3 CNRS Sorbonne Universitè Paris France INFN Sezione di Napoli Napoli Italy IRFU CEA Universitè Paris-Saclay Gif-sur-Yvette France University of Oviedo Applied Mathematical Modeling Group Department of Physics Oviedo Spain University of Victoria Department of Physics and Astronomy VictoriaBC Canada University of Geneva Section

Hyper-Kamiokande is a multi-purpose next generation neutrino experiment. The detector is a two-layered cylindrical shape ultra-pure water tank, with its height of 64 m and diameter of 71 m. The inner detector will be surrounded by tens of thousands of twenty-inch photosensors and multi-PMT modules to detect water Cherenkov radiation due to the charged particles and provide our fiducial volume of 188 kt. This detection technique is established by Kamiokande and Super-Kamiokande. As the successor of these experiments, Hyper-K will be located deep underground, 600 m below Mt. Tochibora at Kamioka in Japan to reduce cosmic-ray backgrounds. Besides our physics program with accelerator neutrino, atmospheric neutrino and proton decay, neutrino astrophysics is an important research topic for Hyper-K. With its fruitful physics research programs, Hyper-K will play a critical role in the next neutrino physics frontier. It will also provide important information via astrophysical neutrino measurements, i.e., solar neutrino, supernova burst neutrinos and supernova relic neutrino. Here, we will discuss the physics potential of Hyper-K neutrino astrophysics. © Copyright owned by the author(s).

关键词： Water tanks

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Publisher Correction: Landscape-scale benefits of protected areas for tropical biodiversity

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Nature 2024年第7996期625卷 E28页

作者： Jedediah F Brodie Jayasilan Mohd-Azlan Cheng Chen Oliver R Wearn Mairin C M Deith James G C Ball Eleanor M Slade David F R P Burslem Shu Woan Teoh Peter J Williams An Nguyen Jonathan H Moore Scott J Goetz Patrick Burns Patrick Jantz Christopher R Hakkenberg Zaneta M Kaszta Sam Cushman David Coomes Olga E Helmy Glen Reynolds Jon Paul Rodríguez Walter Jetz Matthew Scott Luskin Division of Biological Sciences University of Montana Missoula MT USA. jedediah.brodie@umontana.edu. Wildlife Biology Program University of Montana Missoula MT USA. jedediah.brodie@umontana.edu. Institute of Biodiversity and Environmental Conservation Universiti Malaysia Sarawak Kota Samarahan Malaysia. jedediah.brodie@umontana.edu. Institute of Biodiversity and Environmental Conservation Universiti Malaysia Sarawak Kota Samarahan Malaysia. Department of Forest Resources Management University of British Columbia Vancouver British Columbia Canada. Biodiversity Research Centre University of British Columbia Vancouver British Columbia Canada. Fauna and Flora International-Vietnam Programme Hanoi Vietnam. Institute for the Oceans and Fisheries University of British Columbia Vancouver British Columbia Canada. Department of Plant Sciences and Conservation Research Institute University of Cambridge Cambridge UK. Asian School of the Environment Nanyang Technological University Singapore Singapore. School of Biological Sciences University of Aberdeen Aberdeen UK. Wildlife Biology Program University of Montana Missoula MT USA. Division of Biological Sciences University of Montana Missoula MT USA. Leibniz Institute for Zoo and Wildlife Research Berlin Germany. School of Environmental Science and Engineering Southern University of Science and Technology Shenzhen China. School of Environmental Sciences University of East Anglia Norwich UK. School of Informatics Computing and Cyber Systems Northern Arizona University Flagstaff AZ USA. Department of Biological Sciences Northern Arizona University Flagstaff AZ USA. Wildlife Conservation Research Unit Department of Biology University of Oxford Oxford UK. School of Forestry Northern Arizona University Flagstaff AZ USA. Aldo Leopold Wilderness Research Institute United States Department of Agriculture Forest Service Rocky Mountain Research Station Missoula MT USA. The South East Asia Rainforest Research Partn

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Author Correction: Landscape-scale benefits of protected areas for tropical biodiversity

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Nature 2024年第8009期628卷 E5页

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CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity

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Cell death & disease 2024年第6期15卷 434页

作者： Chan-Chuan Liu Wen-Bin Yang Chia-Hung Chien Cheng-Lin Wu Jian-Ying Chuang Pin-Yuan Chen Jui-Mei Chu Siao Muk Cheng Li-Ying Qiu Yung-Chieh Chang Daw-Yang Hwang Chih-Yuan Huang Jung-Shun Lee Kwang-Yu Chang National Institute of Cancer Research National Health Research Institutes Tainan Taiwan. Research Center for Neuroscience Taipei Medical University Taipei Taiwan. Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan. School of Medicine I-Shou University Kaohsiung Taiwan. Department of Pathology National Cheng Kung University Hospital College of Medicine National Cheng-Kung University Tainan Taiwan. International Master Program in Medical Neuroscience Taipei Medical University Taipei Taiwan. Department of Biomedical Science and Environmental Biology Kaohsiung Medical University Kaohsiung Taiwan. School of Medicine Chang Gung University Taoyuan Taiwan. Department of Neurosurgery Keelung Chang Gung Memorial Hospital Keelung Taiwan. TMU Research Center of Cancer Translational Medicine Taipei Cancer Center Taipei Medical University Hospital College of Medicine Taipei Medical University Taipei Taiwan. Division of Neurosurgery Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan. National Institute of Cancer Research National Health Research Institutes Tainan Taiwan. kwang2@nhri.edu.tw. Department of Oncology National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan. kwang2@nhri.edu.tw. Center of Cell Therapy National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan. kwang2@nhri.edu.tw.

The interaction between glioblastoma cells and glioblastoma-associated macrophages (GAMs) influences the immunosuppressive tumor microenvironment, leading to ineffective immunotherapies. We hypothesized that disrupting the communication between tumors and macrophages would enhance the efficacy of immunotherapies. Transcriptomic analysis of recurrent glioblastoma specimens indicated an enhanced neuroinflammatory pathway, with CXCL12 emerging as the top-ranked gene in secretory molecules. Single-cell transcriptome profiling of naïve glioblastoma specimens revealed CXCL12 expression in tumor and myeloid clusters. An analysis of public glioblastoma datasets has confirmed the association of CXCL12 with disease and PD-L1 expression. In vitro studies have demonstrated that exogenous CXCL12 induces pro-tumorigenic characteristics in macrophage-like cells and upregulated PD-L1 expression through NF-κB signaling. We identified CXCR7, an atypical receptor for CXCL12 predominantly present in tumor cells, as a negative regulator of CXCL12 expression by interfering with extracellular signal-regulated kinase activation. CXCR7 knockdown in a glioblastoma mouse model resulted in worse survival outcomes, increased PD-L1 expression in GAMs, and reduced CD8 T-cell infiltration compared with the control group. Ex vivo T-cell experiments demonstrated enhanced cytotoxicity against tumor cells with a selective CXCR7 agonist, VUF11207, reversing GAM-induced immunosuppression in a glioblastoma cell-macrophage-T-cell co-culture system. Notably, VUF11207 prolonged survival and potentiated the anti-tumor effect of the anti-PD-L1 antibody in glioblastoma-bearing mice. This effect was mitigated by an anti-CD8β antibody, indicating the synergistic effect of VUF11207. In conclusion, CXCL12 conferred immunosuppression mediated by pro-tumorigenic and PD-L1-expressing GAMs in glioblastoma. Targeted activation of glioblastoma-derived CXCR7 inhibits CXCL12, thereby eliciting anti-tumor immunity and enha

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Developing Expert Scientific Consensus on the environmental and Societal Effects of Marine Artificial Structures Prior to Decommissioning

SSRN

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SSRN 2023年

作者： Knights, Antony M. Lemasson, Anaëlle J. Firth, Louise B. Bond, Todd Claisse, Jeremy Coolen, Joop W.P. Copping, Andrea Dannheim, Jennifer De Dominicis, Michela Degraer, Steven Elliott, Michael Fernandes, Paul G. Fowler, Ashley M. Frost, Matt Henry, Lea-Anne Hicks, Natalie Hyder, Kieran Jagerroos, Sylvia Jones, Daniel O.B. Love, Milton Lynam, Chris Macreadie, Peter I. Marlow, Joseph Mavraki, Ninon McLean, Dianne Montagna, Paul A. Paterson, David M. Perrow, Martin Porter, Joanne Russell, Debbie J.F. Bull, Ann Scarborough Schratzberger, Michaela Shipley, Brooke van Elden, Sean Vanaverbeke, Jan Want, Andrew Watson, Stephen C.L. Wilding, Thomas A. Somerfield, Paul University of Plymouth School of Biological and Marine Sciences Drake Circus PlymouthPL4 8AA United Kingdom The UWA Oceans Institute The University of Western Australia PerthWA6009 Australia School of Biological Sciences The University of Western Australia PerthWA6009 Australia Department of Biological Sciences California State Polytechnic University PomonaCA91768 United States Vantuna Research Group Occidental College Los AngelesCA90041 United States Wageningen Marine Research Ankerpark 27 Den Helder1781 AG Netherlands Pacific Northwest National Laboratory US Department of Energy Seattle United States Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Am Handelshafen 12 Bremerhaven27570 Germany National Oceanography Centre Joseph Proudman Building 6 Brownlow Street LiverpoolL3 5DA United Kingdom Royal Belgian Institute of Natural Sciences Operational Directory Natural Environment Marine Ecology and Management Brussels Belgium Energy and Environment Institute University of Hull HU6 7RX United Kingdom Heriot-Watt University The Lyell Centre Research Avenue South EdinburghEH14 4AP United Kingdom New South Wales Department of Primary Industries Sydney Institute of Marine Science MosmanNSW2088 Australia Plymouth Marine Laboratory The Hoe Plymouth Prospect Place DevonPL13DH United Kingdom School of GeoSciences University of Edinburgh King's Buildings Campus James Hutton Road EdinburghEH9 3FE United Kingdom School of Life Sciences University of Essex Essex Colchester United Kingdom Lowestoft United Kingdom Thuwal23955 Saudi Arabia National Oceanography Centre European Way SouthamptonSO14 3ZH United Kingdom Marine Science Institute University of California Santa Barbara United States Deakin University School of Life and Environmental Sciences Burwood Australia Oban United Kingdom Perth Australia Texas A&M University-Corpus Christi Corpus ChristiTX United States School of Biology University of St Andr

Thousands of artificial (‘human-made’) structures are present in the marine environment, many at or approaching end-of-life and requiring urgent decisions regarding their decommissioning. No consensus has been reached on which decommissioning option(s) result in optimal environmental and societal outcomes, in part, owing to a paucity of evidence from real-world decommissioning case studies. To address this significant challenge, we asked a worldwide panel of scientists to provide their expert opinion. They were asked to identify and characterise the ecosystem effects of artificial structures in the sea, their causes and consequences, and to identify which, if any, should be retained following decommissioning. Experts considered that most of the pressures driving ecological and societal effects from marine artificial structures (MAS) were of medium severity, occur frequently, and are dependent on spatial scale with local-scale effects of greater magnitude than regional effects. The duration of many effects following decommissioning were considered to be relatively short, in the order of days. Overall, environmental effects of structures were considered marginally undesirable, while societal effects marginally desirable. Experts therefore indicated that any decision to leave MAS in place at end-of-life to be more beneficial to society than the natural environment. However, some individual environmental effects were considered desirable and worthy of retention, especially in certain geographic locations, where structures can support improved trophic linkages, increases in tourism, habitat provision, and population size, and provide stability in population dynamics. The expert analysis consensus that the effects of MAS are both negative and positive for the environment and society, gives no strong support for policy change whether removal or retention is favoured until further empirical evidence is available to justify change to the status quo. The combination of desira

关键词： environmental management

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First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC

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Physical Review Letters 2025年第16期134卷 162301-162301页

作者： S. Acharya A. Agarwal G. Aglieri Rinella L. Aglietta M. Agnello N. Agrawal Z. Ahammed S. Ahmad S. U. Ahn I. Ahuja A. Akindinov V. Akishina M. Al-Turany D. Aleksandrov B. Alessandro H. M. Alfanda R. Alfaro Molina B. Ali A. Alici N. Alizadehvandchali A. Alkin J. Alme G. Alocco T. Alt A. R. Altamura I. Altsybeev J. R. Alvarado C. O. R. Alvarez M. N. Anaam C. Andrei N. Andreou A. Andronic E. Andronov V. Anguelov F. Antinori P. Antonioli N. Apadula L. Aphecetche H. Appelshäuser C. Arata S. Arcelli R. Arnaldi J. G. M. C. A. Arneiro I. C. Arsene M. Arslandok A. Augustinus R. Averbeck D. Averyanov M. D. Azmi H. Baba A. Badalà J. Bae Y. W. Baek X. Bai R. Bailhache Y. Bailung R. Bala A. Balbino A. Baldisseri B. Balis Z. Banoo V. Barbasova F. Barile L. Barioglio M. Barlou B. Barman G. G. Barnaföldi L. S. Barnby E. Barreau V. Barret L. Barreto C. Bartels K. Barth E. Bartsch N. Bastid S. Basu G. Batigne D. Battistini B. Batyunya D. Bauri J. L. Bazo Alba I. G. Bearden C. Beattie P. Becht D. Behera I. Belikov A. D. C. Bell Hechavarria F. Bellini R. Bellwied S. Belokurova L. G. E. Beltran Y. A. V. Beltran G. Bencedi A. Bensaoula S. Beole Y. Berdnikov A. Berdnikova L. Bergmann M. G. Besoiu L. Betev P. P. Bhaduri A. Bhasin B. Bhattacharjee L. Bianchi J. Bielčík J. Bielčíková A. P. Bigot A. Bilandzic G. Biro S. Biswas N. Bize J. T. Blair D. Blau M. B. Blidaru N. Bluhme C. Blume G. Boca F. Bock T. Bodova J. Bok L. Boldizsár M. Bombara P. M. Bond G. Bonomi H. Borel A. Borissov A. G. Borquez Carcamo E. Botta Y. E. M. Bouziani L. Bratrud P. Braun-Munzinger M. Bregant M. Broz G. E. Bruno V. D. Buchakchiev M. D. Buckland D. Budnikov H. Buesching S. Bufalino P. Buhler N. Burmasov Z. Buthelezi A. Bylinkin S. A. Bysiak J. C. Cabanillas Noris M. F. T. Cabrera M. Cai H. Caines A. Caliva E. Calvo Villar J. M. M. Camacho P. Camerini F. D. M. Canedo S. L. Cantway M. Carabas A. A. Carballo F. Carnesecchi R. Caron L. A. D. Carvalho J. Castillo Castellanos M. Castoldi F. Catalano S. Cattaruzzi R. Cerri I. Chakaberia P. Chakraborty S. Chandra S. Cha Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France Variable Energy Cyclotron Centre Homi Bhabha National Institute Kolkata India European Organization for Nuclear Research (CERN) Geneva Switzerland Dipartimento di Fisica dell’Università and Sezione INFN Turin Italy Dipartimento DISAT del Politecnico and Sezione INFN Turin Italy Dipartimento di Fisica e Astronomia dell’Università and Sezione INFN Bologna Italy Department of Physics Aligarh Muslim University Aligarh India Korea Institute of Science and Technology Information Daejeon Republic of Korea Faculty of Science P.J. Šafárik University Košice Slovak Republic Affiliated with an institute covered by a cooperation agreement with CERN Frankfurt Institute for Advanced Studies Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany Research Division and ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Darmstadt Germany INFN Sezione di Torino Turin Italy Central China Normal University Wuhan China Instituto de Física Universidad Nacional Autónoma de México Mexico City Mexico University of Houston Houston Texas USA Sungkyunkwan University Suwon City Republic of Korea Department of Physics and Technology University of Bergen Bergen Norway INFN Sezione di Cagliari Cagliari Italy Institut für Kernphysik Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany INFN Sezione di Bari Bari Italy Physik Department Technische Universität München Munich Germany High Energy Physics Group Universidad Autónoma de Puebla Puebla Mexico Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest Romania University of Derby Derby United Kingdom Universität Münster Institut für Kernphysik Münster Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany INFN Sezione di Padova Padova Italy INFN Sezione di Bologna Bologna Italy Lawrence Berkeley National Laboratory Berkeley California USA SUBATECH I

In this Letter, the first evidence of the He¯Λ¯4 antihypernucleus is presented, along with the first measurement at the LHC of the production of (anti)hypernuclei with mass number A=4, specifically (anti)HΛ4 and (anti)HeΛ4. In addition, the antiparticle-to-particle ratios for both hypernuclei (H¯Λ¯4/HΛ4 and He¯Λ¯4/HeΛ4) are shown, which are sensitive to the baryochemical potential of the strongly interacting matter created in heavy-ion collisions. The results are obtained from a data sample of central Pb-Pb collisions, collected during the 2018 LHC data taking at a center-of-mass energy per nucleon pair of sNN=5.02 TeV. The yields measured for the average of the charge-conjugated states are found to be [0.78±0.19(stat)±0.17(syst)]×10−6 for the (anti)HΛ4 and [1.08±0.34(stat)±0.20(syst)]×10−6 for the (anti)HeΛ4, and the measured antiparticle-to-particle ratios are in agreement with unity. The presence of (anti)HΛ4 and (anti)HeΛ4 excited states is expected to strongly enhance the production yield of these hypernuclei. The yield values exhibit a combined deviation of 3.3σ from the theoretical ground-state-only expectation, while the inclusion of the excited states in the calculations leads to an agreement within 0.6σ with the present measurements. Additionally, the measured (anti)HΛ4 and (anti)HeΛ4 masses are compatible with the world-average values within the uncertainties.

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Data on lung and intestinal microbiome after air pollution exposure in ageing rats

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Data in brief 2023年 47卷 109004页

作者： Vincent Laiman Yu-Chun Lo Hsin-Chang Chen Tzu-Hsuen Yuan Ta-Chih Hsiao Jen-Kun Chen Ching-Wen Chang Ting-Chun Lin Ssu-Ju Li You-Yin Chen Didik Setyo Heriyanto Kian Fan Chung Kai-Jen Chuang Kin-Fai Ho Jer-Hwa Chang Hsiao-Chi Chuang International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Anatomical Pathology Faculty of Medicine Public Health and Nursing Universitas Gadjah Mada - Dr. Sardjito Hospital Yogyakarta Indonesia. Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan. Department of Chemistry College of Science Tunghai University Taichung Taiwan. Department of Health and Welfare College of City Management University of Taipei Taipei Taiwan. Graduate Institute of Environmental Engineering National Taiwan University Taipei Taiwan. Institute of Biomedical Engineering & Nanomedicine National Health Research Institutes Miaoli Taiwan. Industrial Ph.D. Program of Biomedical Science and Engineering National Yang Ming Chiao Tung University Taipei Taiwan. Department of Biomedical Engineering National Yang Ming Chiao Tung University Taipei Taiwan. National Heart and Lung Institute Imperial College London London UK. School of Public Health College of Public Health Taipei Medical University Taipei Taiwan. Department of Public Health School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. School of Public Health and Primary Care the Chinese University of Hong Kong Hong Kong. School of Respiratory Therapy College of Medicine Taipei Medical University 250 Wuxing Street Taipei 11031 Taiwan. Division of Pulmonary Medicine Departments of Internal Medicine Wan Fang Hospital Taipei Medical University Taipei Taiwan. Division of Pulmonary Medicine Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan. Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei Taiwan. Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei Taiwan.

Air pollution has been linked to respiratory diseases, and urban air pollution can be attributed to a number of emission sources. The emitted particles and gases are the primary components of air pollution that enter the lungs during respiration. Particulate matter with an aerodynamic diameter of ≤ 2.5 µm (PM) can deposit deep into the respiratory tract via inhalation and has been proposed as a causative agent for adverse respiratory health. In addition, the lung contains a diverse microbial community (microbiome) that maintains normal homeostasis and is significantly altered in a variety of pulmonary disorders. Air pollution, specifically PM, has previously been shown to significantly alter the composition of the lower airway microbiome, which has been linked to decreased lung function in chronic obstructive pulmonary disease (COPD) patients. Surprisingly, the intestinal microbiome has also been implicated in the modulation of pulmonary inflammatory diseases. Therefore, dysbiosis of the lung and intestinal microbiomes pose significant negative effects on human health. This dataset describes the microbial community profiles of the lungs and intestines of ageing rats exposed to ambient unconcentrated traffic-related air pollution for three months. The whole-body exposure system was equipped with and without high efficiency particulate air (HEPA) filtration (gaseous vs. PM pollution). The data can provide valuable information on lung and intestinal microbiome changes, including that which was only found after traffic-related air pollution exposure.

关键词： Air pollution Intestinal microbiome Lung microbiome PM2.5

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Measurement of ω meson production in pp collisions at = 13 TeV

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Journal of High Energy Physics 2025年第4期2025卷 1-30页

作者： Acharya, S. Adamová, D. Agarwal, A. Aglieri Rinella, G. Aglietta, L. Agnello, M. Agrawal, N. Ahammed, Z. Ahmad, S. Ahn, S. U. Ahuja, I. Akindinov, A. Akishina, V. Al-Turany, M. Aleksandrov, D. Alessandro, B. Alfanda, H. M. Alfaro Molina, R. Ali, B. Alici, A. Alizadehvandchali, N. Alkin, A. Alme, J. Alocco, G. Alt, T. Altamura, A. R. Altsybeev, I. Alvarado, J. R. Anaam, M. N. Andrei, C. Andreou, N. Andronic, A. Andronov, E. Anguelov, V. Antinori, F. Antonioli, P. Apadula, N. Aphecetche, L. Appelshäuser, H. Arata, C. Arcelli, S. Aresti, M. Arnaldi, R. Arneiro, J. G. M. C. A. Arsene, I. C. Arslandok, M. Augustinus, A. Averbeck, R. Azmi, M. D. Baba, H. Badalà, A. Bae, J. Baek, Y. W. Bai, X. Bailhache, R. Bailung, Y. Bala, R. Balbino, A. Baldisseri, A. Balis, B. Banerjee, D. Banoo, Z. Barbasova, V. Barile, F. Barioglio, L. Barlou, M. Barman, B. Barnaföldi, G. G. Barnby, L. S. Barreau, E. Barret, V. Barreto, L. Bartels, C. Barth, K. Bartsch, E. Bastid, N. Basu, S. Batigne, G. Battistini, D. Batyunya, B. Bauri, D. Bazo Alba, J. L. Bearden, I. G. Beattie, C. Becht, P. Behera, D. Belikov, I. Bell Hechavarria, A. D. C. Bellini, F. Bellwied, R. Belokurova, S. Beltran, L. G. E. Beltran, Y. A. V. Bencedi, G. Bensaoula, A. Beole, S. Berdnikov, Y. Berdnikova, A. Bergmann, L. Besoiu, M. G. Betev, L. Bhaduri, P. P. Bhasin, A. Bhat, M. A. Bhattacharjee, B. Bianchi, L. Bianchi, N. Bielčík, J. Bielčíková, J. Bigot, A. P. Bilandzic, A. Biro, G. Biswas, S. Bize, N. Blair, J. T. Blau, D. Blidaru, M. B. Bluhme, N. Blume, C. Boca, G. Bock, F. Bodova, T. Bok, J. Boldizsár, L. Bombara, M. Bond, P. M. Bonomi, G. Borel, H. Borissov, A. Borquez Carcamo, A. G. Bossi, H. Botta, E. Bouziani, Y. E. M. Bratrud, L. Braun-Munzinger, P. Bregant, M. Broz, M. Bruno, G. E. Buckland, M. D. Budnikov, D. Buesching, H. Bufalino, S. Buhler, P. Burmasov, N. Buthelezi, Z. Bylinkin, A. Bysiak, S. A. Cabanillas Noris, J. C. Cabrera, M. F. T. Cai, M. Caines, H. Caliva, A. Calvo Villar, E. Camacho, J. M. M. Camerini, P. Canedo, F. D. M. Cantway, S. L. Carabas, M. Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France Nuclear Physics Institute of the Czech Academy of Sciences Husinec-Řež Czech Republic Variable Energy Cyclotron Centre Homi Bhabha National Institute Kolkata India European Organization for Nuclear Research (CERN) Geneva Switzerland Dipartimento di Fisica dell’Università and Sezione INFN Turin Italy Dipartimento DISAT del Politecnico and Sezione INFN Turin Italy Dipartimento di Fisica e Astronomia dell’Università and Sezione INFN Bologna Italy Department of Physics Aligarh Muslim University Aligarh India Korea Institute of Science and Technology Information Daejeon Republic of Korea Faculty of Science P.J. Šafárik University Košice Slovak Republic Frankfurt Institute for Advanced Studies Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany Research Division and ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Darmstadt Germany INFN Sezione di Torino Turin Italy Central China Normal University Wuhan China Instituto de Física Universidad Nacional Autónoma de México Mexico City Mexico University of Houston Houston United States Sungkyunkwan University Suwon City Republic of Korea Department of Physics and Technology University of Bergen Bergen Norway INFN Sezione di Cagliari Cagliari Italy Institut für Kernphysik Johann Wolfgang Goethe-Universität Frankfurt Frankfurt Germany INFN Sezione di Bari Bari Italy Physik Department Technische Universität München Munich Germany High Energy Physics Group Universidad Autónoma de Puebla Puebla Mexico Horia Hulubei National Institute of Physics and Nuclear Engineering Bucharest Romania University of Derby Derby United Kingdom Universität Münster Institut für Kernphysik Münster Germany Physikalisches Institut Ruprecht-Karls-Universität Heidelberg Heidelberg Germany INFN Sezione di Padova Padova Italy INFN Sezione di Bologna Bologna Italy Lawrence Berkeley National Laboratory Berkeley United Sta

The pT-differential cross section of ω meson production in pp collisions at $$ \sqrt{s} $$ = 13 TeV at midrapidity (|y| < 0.5) was measured with the ALICE detector at the LHC, covering an unprecedented transverse-momentum range of 1.6 < pT < 50 GeV/c. The meson is reconstructed via the ω → π+π−π0 decay channel. The results are compared with various theoretical calculations: PYTHIA8.2 with the Monash 2013 tune overestimates the data by up to 50%, whereas good agreement is observed with Next-to-Leading Order (NLO) calculations incorporating ω fragmentation using a broken SU(3) model. The ω/π0 ratio is presented and compared with theoretical calculations and the available measurements at lower collision energies. The presented data triples the pT ranges of previously available measurements. A constant ratio of Cω/π0 = 0.578 ± 0.006 (stat.) ± 0.013 (syst.) is found above a transverse momentum of 4 GeV/c, which is in agreement with previous findings at lower collision energies within the systematic and statistical uncertainties.

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Hazardous explosive eruptions of a recharging multi-cyclic island arc caldera

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Nature Geoscience 2024年 323-331页

作者： Jonas Preine Christian Hübscher Jens Karstens Steffen Kutterolf Katharina Pank Gareth Crutchley Tim Druitt Abigail Metcalfe Paraskevi Nomikou Dimitrios Papanikolaou Michael Manga Ralf Gertisser Sarah Beethe Carole Berthod Iona McIntosh Thomas Ronge Zenon Mateo Masako Tominaga Acacia Clark Susan DeBari Raymond Johnston Ally Peccia Christopher Jones Günther Kletetschka Alexis Bernard Hehe Chen Shun Chiyonobu Tatiana Fernandez-Perez Kumar Batuk Joshi Olga Koukousioura Molly McCanta Antony Morris Paraskevi Polymenakou Adam Woodhouse Yuzuru Yamamoto Kuo-Lung Wang Hao-Yang Lee Xiaohui Li Institute of Geophysics University of Hamburg Hamburg Germany GEOMAR Helmholtz Centre for Ocean Research Kiel Kiel Germany University Clermont-Auvergne CNRS IRD OPGC Laboratoire Magmas et Volcans Clermont-Ferrand France Department of Geology and Geoenvironment National and Kapodistrian University of Athens Athens Greece Department of Earth and Planetary Science University of California Berkeley CA USA School of Geography Geology and the Environment Keele University Keele UK College of Earth Ocean and Atmospheric Sciences Oregon State University Corvallis OR USA Institut De Physique Du Globe De Paris Centre National de la Recherche Scientifique (CNRS) Paris France Japan Agency for Marine-Earth Science and Technology Yokosuka Japan International Ocean Discovery Program Texas A&M University College Station TX USA Department of Geology and Geophysics Woods Hole Oceanographic Institution Woods Hole MA USA School of Natural Sciences/CODES University of Tasmania Hobart Tasmania Australia Geology Department Western Washington University Bellingham WA USA School of Geosciences University of South Florida Tampa FL USA Lamont-Doherty Earth Observatory Columbia University Palisades NY USA Department of Earth and Planetary Sciences University of California Riverside CA USA Geophysical Institute University of Alaska Fairbanks Fairbanks AK USA Charles University Faculty of Science Prague Czech Republic Laboratoire des Fluides Complexes et leurs Réservoirs Université de Pau et des Pays de l’Adour Pau France School of Ocean Sciences China University of Geosciences Beijing China Faculty of International Resource Sciences Akita University Akita Japan Department of Geology Kent State University Kent OH USA Solid Earth Research Group National Centre for Earth Science Studies Thiruvananthapuram India School of Geology Aristotle University of Thessaloniki Thessaloniki Greece University of Cologne Institute of Geology and Mineralogy Cologne Germany

Caldera-forming eruptions of silicic volcanic systems are among the most devastating events on Earth. By contrast, post-collapse volcanic activity initiating new caldera cycles is generally considered less hazardous. Formed after Santorini’s latest caldera-forming eruption of ~1600bce, the Kameni Volcano in the southern Aegean Sea enables the eruptive evolution of a recharging multi-cyclic caldera to be reconstructed. Kameni’s eruptive record has been documented by onshore products and historical descriptions of mainly effusive eruptions dating back to 197bce. Here we combine high-resolution seismic reflection data with cored lithologies from international Ocean Discovery program Expedition 398 at four sites to determine the submarine architecture and volcanic history of intra-caldera deposits from Kameni. Our shore-crossing analysis reveals the deposits of a submarine explosive eruption that produced up to 3.1 km3of pumice and ash, which we relate to a historical eruption in 726ce. The estimated volcanic explosivity index of magnitude 5 exceeds previously considered worst-case eruptive scenarios for Santorini. Our finding that the Santorini caldera is capable of producing large explosive eruptions at an early stage in the caldera cycle implies an elevated hazard potential for the eastern Mediterranean region, and potentially for other recharging silicic calderas.

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Author Correction: Anthropogenic modification of forests means only 40% of remaining forests have high ecosystem integrity

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Nature communications 2021年第1期12卷 592页

作者： H S Grantham A Duncan T D Evans K R Jones H L Beyer R Schuster J Walston J C Ray J G Robinson M Callow T Clements H M Costa A DeGemmis P R Elsen J Ervin P Franco E Goldman S Goetz A Hansen E Hofsvang P Jantz S Jupiter A Kang P Langhammer W F Laurance S Lieberman M Linkie Y Malhi S Maxwell M Mendez R Mittermeier N J Murray H Possingham J Radachowsky S Saatchi C Samper J Silverman A Shapiro B Strassburg T Stevens E Stokes R Taylor T Tear R Tizard O Venter P Visconti S Wang J E M Watson Wildlife Conservation Society Global Conservation Program Bronx New York NY USA. hgrantham@***. Wildlife Conservation Society Global Conservation Program Bronx New York NY USA. School of Earth and Environmental Sciences University of Queensland Brisbane Australia. Department of Biology Carleton University Ottawa Canada. Wildlife Conservation Society Canada Toronto Canada. United Nations Development Programme One United Nations Plaza New York NY USA. World Resources Institute Washington DC USA. Global Earth Observation & Dynamics of Ecosystems Lab School of Informatics Computing and Cyber Systems Northern Arizona University Flagstaff AZ USA. Landscape Biodiversity Lab Ecology Department Montana State University Bozeman MT USA. Rainforest Foundation Norway Oslo Norway. Global Wildlife Conservation Austin TX USA. School of Life Sciences Arizona State University Tempe AZ USA. Centre for Tropical Environmental and Sustainability Science College of Science and Engineering James Cook University Cairns QLD Australia. Environmental Change Institute School of Geography and the Environment University of Oxford Oxford UK. College of Science and Engineering James Cook University Townsville Queensland Australia. School of Biological Sciences University of Queensland St. Lucia QLD Australia. The Nature Conservancy Arlington VA USA. Jet Propulsion Laboratory California Institute of Technology Pasadena CA USA. World Wide Fund for Nature Germany Space+Science Berlin Germany. International Institute of Sustainability Rio de Janeiro Brazil. Natural Resource and Environmental Studies Institute University of Northern British Columbia Prince George Canada. International Institute for Applied Systems Analysis Laxenburg Austria.

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