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Eff-SAM: SAM-based Efficient Method for Brain Tumor Segmentation in Multimodal 3D MRI Scans

IEEE Access 2025年 13卷 90063-90087页

作者： Ahmad, Nisar Chen, Yao-Tien Ming Chi University of Technology International Ph.D. Program in Innovative Technology of Biomedical Engineering Medical Devices New Taipei City243303 Taiwan

Accurate brain tumor segmentation in MRI scans is crucial for effective diagnosis and treatment planning, as even minor segmentation errors can lead to significant clinical concerns. However, this task is challenged by the complex anatomy of the brain, variable tumor shapes, and low contrast between tumor sub-regions. Moreover, existing methods often lack generalizability across diverse segmentation tasks and imaging modalities. Large Vision Model (LVM) like the Segment Anything Model (SAM) represents a foundational advancement in tumor segmentation. While SAM has shown impressive performance on natural images, its effectiveness in medical imaging, especially brain tumor segmentation, is limited due to domain differences and indistinct boundaries in MRI scans. To address these challenges, we propose Eff-SAM, a 3D brain tumor segmentation framework that adapts SAM for medical applications through Parameter-Efficient Fine-Tuning (PEFT) technique. The framework incorporates PEFT with adapters into SAM’s encoder to fine-tune the model effectively and optimize its performance for medical imaging while maintaining computational efficiency. Additionally, a Cross-Sliced Attention (CSA) mechanism captures semantic relationships, improves tumor localization, and is introduced into the encoder. Robust data preprocessing further enhances the model’s generalization across datasets. Eff-SAM demonstrates state-of-the-art performance and outperforms benchmark methods on the BraTS 2020 and BraTS 2021 datasets. It achieves Dice scores of 0.884 for Whole Tumor (WT), 0.853 for Tumor Core (TC), and 0.818 for Enhancing Tumor (ET) on the BraTS 2020 dataset, and 0.880 (WT), 0.861 (TC), and 0.821 (ET) on the BraTS 2021 dataset. This work highlights the potential of integrating vision models like SAM with lightweight, domain-specific modules to deliver accurate and efficient brain tumor segmentation offering a clinically valuable tool, especially in scenarios with limited data and complex tu

关键词： Semantic Segmentation

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Microwave dielectric and structural characteristics in Li2O-B2O3-SiO2 glass ceramics

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Ceramics international 2025年

作者： Qiu, Jun-Yan Tu, Chi-Shun Huang, Szu-Ting Li, Yongxiang Chen, Pin-Yi Chen, Cheng-Sao Montecillo, Rhys Feng, Kuei-Chih International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan Department of Physics Fu Jen Catholic University New Taipei City Taiwan Department of Mechanical Engineering Ming Chi University of Technology New Taipei City Taiwan School of Engineering RMIT University MelbourneVIC3000 Australia Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City Taiwan Department of Mechanical Engineering Hwa Hsia University of Technology New Taipei City Taiwan

Advancements in high-frequency communication devices have emphasized miniaturization and low energy consumption. This work focuses on developing microwave dielectric materials characterized by an ultra-low dielectric constant and low dielectric loss coefficient. In this study, B2O3 and Li2O were added into the SiO2 matrix to form the LBS glass-ceramics. The B2O3-added SiO2 shows a formation of α-cristobalite phase, and the Li2O additive in the B2O3-SiO2 glass-ceramics sintered at 900 °C reveal a primary quartz phase with a secondary phase Li2Si2O5, that partially transformed into Li2SiO3 in the specimen sintered at 950 °C. The LBS12 (x = 12 wt%) show stronger Raman peaks of Li2Si2O5 and Li2SiO3, indicating increase of highly-crystallized Si-O network. As the quartz phase diminishes, Li2Si2O5 and Li2SiO3 begin to develop in the glass-ceramic matrix. Dense microstructures and well-formed crystalline grains were observed in the LBS glass-ceramics. The quality factors were primarily affected by grain size and density. The Li2Si2O5 additive in the LBS glass-ceramics can reduce dielectric permittivity (Εr) and increase Q × f, particularly at higher frequencies. A low Εr of 4.7–5, a high Q × f of 2600 GHz, and a hardness of 249 MHV were achieved in the LBS12 sintered at 900 °C. These LBS glass-ceramics exhibit potential for use in low-temperature co-fired ceramic (LTCC) applications in high-frequency communication devices. © 2025

关键词： Sintering

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Surface Interface Engineered and Sulfur Source Inspired Carbon Nanofiber Mediated Growth of NSMO Directly on Nickel Foam for Ultra-High Energy Density Aqueous Asymmetric Supercapacitors

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Advanced Sustainable Systems 2025年

作者： Tamilselvan, Arun Karuppanan, Aravinth Bhargav, Pamula Balaji Govindasamy, Mani Department of Physics SSN Research Centre Sri Sivasubramaniya Nadar College of Engineering Tamilnadu Kalavakam 603110 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei 243303 Taiwan

To advance energy storage technologies, the development of high-performance supercapacitor electrodes is paramount. This study presents a novel, binder-free electrode constructed from earth-abundant materials. A surface interfaced nanocomposite comprising Ni₃S₂ and MnO₂ hierarchical nanostructure (NSMO) is directly grown on carbon nanofibers (CNF) using hydrothermal method. This approach offers scalability and cost-effectiveness for large-scale applications. The electrode's exceptional electrochemical performance arises from the synergistic interactions between the mixed oxidation states and composite structure. It exhibits a maximum specific capacitance of 1470 F g⁻¹ at 1 A g⁻¹, coupled with remarkable stability, retaining 78.94% of its capacitance and delivering a Columbic efficiency of 99.5% after 15,000 cycles. When integrated into an asymmetric supercapacitor (ASC), the electrode demonstrated a specific capacitance of 215.7 F g⁻¹ at 1 A g⁻¹, an energy density of 67 Wh kg⁻¹ at a power density of 750 W kg⁻¹, and excellent cycle life. These results highlight the potential of the binder-free hybrid CNF@NSMO hierarchical nanostructure electrode as a sustainable and high-performance candidate for next-generation supercapacitor applications. © 2025 Wiley-VCH GmbH.

关键词： binder free CNF high energy density ASC MnO2 Ni3S2 supercapacitor

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Optical sensor for dissolved ammonia by embedding eosin Y in cellulose acetate and silicone rubber via the phase inversion method

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Microchemical Journal 2025年 213卷

作者： Putro, Dimas Trio Sari, Desy Purnama Chu, Cheng-Shane International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan Department of Mechanical Engineering Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology Taishan Dist. New Taipei City 24301 Taiwan

This study presents the phase inversion method for fabricating a new optical sensing membrane designed for dissolved ammonia detection. Eosin Y was embedded into composite materials of cellulose acetate (CA) and silicone rubber to enhance optical performance and modify the membrane structure. Sensing performance was evaluated using luminescence quenching, which involved measuring changes in both intensity and wavelength. The fabricated membrane exhibited a microporous structure with pore diameters ranging from 1 to 10 µm, a quenching response (I₀/I₄₀₀) of 15.15, a response time (↓t₉₀) of 53 s, and effective detection at a concentration of 400 mM, a room temperature (20–25 °C), and pH 6.02, with sensing response slightly decreasing at elevated temperatures (up to 50 °C) and at pH 3.17 and 9.29. The nonlinear quenching response plot was converted into a linear form using the decibel (dB) formula, significantly improving linearity (R² = 0.9862). The membrane also exhibited excellent selectivity and the ability to detect in both gas and dissolved phases. Additionally, the sensing mechanism was investigated, revealing a combination of static and dynamic quenching, which led to an intensity decrease and a bathochromic shift of 16.56 nm. These findings highlight the potential of the developed optical sensor for rapid and highly selective ammonia monitoring in various environments. © 2025 Elsevier B.V.

关键词： Bathochromic shift Dissolved ammonia detection Eosin Y Optical sensing membrane Phase inversion method

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Achieving high surface bioactivity and adhesion in Ti-6Al-4V alloy via anodic oxidation and electrophoretic deposition

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Ceramics international 2025年

作者： Wu, Yu-Jie Wang, Chi-Yun Mana-ay, Haidee Tu, Chi-Shun Lai, Po-Liang Chen, Pin-Yi International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Bone and Joint Research Center Department of Orthopedic Surgery Chang Gung Memorial Hospital Taoyuan City33305 Taiwan Department of Mechanical Engineering Chang Gung University Taoyuan City33302 Taiwan Department of Physics Silliman University Dumaguete City6200 Philippines

This study combines 3D printing, anodic oxidation (AO), and electrophoretic deposition (ED) technologies to develop Ti-6Al-4V alloy (abbreviated as Ti64) with high hydrophilicity, adhesion, and bioactivity. Titanium oxide nanotubes formed by AO treatment on the Ti64 surface exhibited reduced contact angles from 53 ° to 10 °. The adhesion of the calcium (Ca) layer through the integrated technology of the AO and ED treatments (herein abbreviated as AED) displays an optimal adhesive force of over 30 N on the Ti64 surface, which is attributed to the stable chemical bond due to the formation of OH− ions on the substrate after the AO treatment and the subsequent oxidation reaction of the Ca2+ ions to form a predominantly Ca(OH)2 layer after the ED treatment. Moreover, the AED treatment forms tiny needle-like structures that can effectively promote osteogenic differentiation. The expressions of the osteocyte marker genes (i.e., OCN, OPN, and DMP1) were improved after the AED treatment, showing increased osteogenic differentiation into mature bone tissue. This work presents the AED treatment as a valuable surface modification technique to boost the surface bioactivity of Ti64 for clinical orthopedic applications. © 2025

关键词： Anodic oxidation

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Doping ratio between ZnO/MgO tunes antimicrobial, osteogenic, and anti-osteoclast activity of CaO-MgO-ZnO-SiO2 bioactive glass-ceramics

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Ceramics international 2025年

作者： Hung, Guan-Yi Xia, Yun-Ze Chen, Pin-Yi Lai, Po-Liang Feng, Kuei-Chih Tu, Chi-Shun Cheng, I.-C. Wang, Chi-Yun International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Department of Mechanical Engineering Ming-Chi University of Technology New Taipei City24301 Taiwan Bone and Joint Research Center Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan City33305 Taiwan College of Medicine Chang Gung University Taoyuan City33305 Taiwan Department of Mechanical Engineering Chang Gung University Taoyuan City33305 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Limitations such as donor site morbidity hamper autologous bone grafts. On the other hand, allogeneic grafts, sourced from cadavers, pose risks of viral transmission and rejection. While hydroxyapatite is a prevalent synthetic graft material, antibiotic-laden fillers addressing infection face challenges with antibiotic-resistant pathogens, driving the emergence of nonantibiotic materials to combat persistent bone infections. Bioactive glass is a potential bone void filler superior to hydroxyapatite. Thus, to improve the antibacterial efficacy and bioactivity, we adjusted the doping ratio of the novel CaO-(1-x) MgO-(x) ZnO-SiO2 glass-ceramics (x = 0, 0.25, 0.50, 0.75, 1). Using XRD, we found a typical amorphous structure alongside polycrystalline diopside (CaMgSi2O6), hardystonite (Ca2ZnSi2O7), and petedunnite (CaZnSi2O6) formations. Raman spectroscopy revealed the silicate-glass matrix structure in all the Zn(100x) glass-ceramics and confirmed that the Zn ions replaced the Mg ions. Zn-doped glass-ceramics promoted apatite layer formation and had greater antibacterial efficacy against E. coli and S. aureus. Zn25 glass-ceramic were biocompatible with L929 and MC3T3-E1 cells. Furthermore, Zn25 glass-ceramic promoted bone cell mineralization and reduced osteoclast formation without affecting ALP activity. In vivo, the Zn25 glass-ceramic exhibited greater osteointegration ability than the HAP and Zn0 glass-ceramic. Taken together, the present study demonstrated that bioactive glass-ceramics with a doping ratio between ZnO and MgO (25:75) can enhance antibacterial and osteogenic activity while impeding osteoclastogenic activity. © 2025

关键词： Escherichia coli

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Advanced ZnFe₂O₄@f-CNF electrode: A robust electrochemical sensor for Tert-butyl hydroquinone detection in food and edible oil

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Food Chemistry 2025年 486卷 144648页

作者： Yemmi, Rajeshwari Swamy, B.E. Kumara Manjunath, Kumbar Mudakappa Yusuf, Kareem Aljuwayid, Ahmed M. Govindasamy, Mani 577451 India Division of Plant Breeding and Genetics Central Coffee Research Institute Karnataka Chikkamagaluru577117 India Department of Chemistry College of Science King Saud University Riyadh11451 Saudi Arabia International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Chemistry Korea University Seoul Seongbuk-gu Korea Republic of

Fabrication of a binary electrocatalyst is expounded in this study, which is based on a biocompatible ZnFe2O4 nanoparticles that is adorned onto the functionalized carbon nanofiber (f-CNF) through a straightforward ultrasonication technique. This electrocatalyst is applied for the reliable quantification of the food additive Tert-Butyl Hydroquinone (TBHQ) from various food samples and products. The electrochemical performance of the ZnFe2O4@f-CNF composite is investigated using cyclic voltammetry and electrochemical impedance spectroscopy analysis. The structural features of the composite, characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy which reveals its crystalline and porous attributes. Then electrochemical characteristics of the ZnFe2O4@f-CNF composite for TBHQ detection is evaluated employing cyclic voltammetry and differential pulse voltammetry methodologies. Notably, this composite demonstrates a remarkable low detection limit (LOD) of 0.026 μM with a good linear detection range, accompanied by a favorable sensitivity towards TBHQ. Lastly, the developed sensor system manifests a substantial recovery range for real sample analysis, suggesting its potential as a viable alternative to existing diagnostic tools for TBHQ detection. © 2025 Elsevier Ltd

关键词： Cyclic voltammetry

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Advanced highly precise simultaneous electrochemical detection of toxic azo dyes with Nanoengineered yttrium Iron oxide decorated functionalized carbon nanofibers

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Food Chemistry 2025年 486卷 144607页

作者： Senthilkumar, Dhayanithi Kuo, Chih-Yu Aldossari, Samar A. Govindasamy, Mani National Taipei University of Technology Taipei City10608 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Taipei10608 Taiwan Department of Chemistry P. O. Box 2455 College of Science King Saud University Riyadh11451 Saudi Arabia International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Tamil Nadu Chennai602105 India Department of Chemistry Korea University Seoul Seongbuk-gu Korea Republic of

It is essential to monitor the concentration of synthetic coloring agents in food and beverages due to their potential severe side effects on human health. In this study, yttrium iron oxide (YFO) nanoparticles were synthesized via a hydrothermal method, followed by modification with functionalized carbon nanofibers (f-CNF) through a simple sono-chemical process. The synthesized YFO/f-CNF was thoroughly characterized using various analytical techniques. Concurrent electrochemical detection of sunset yellow (SSY) and tartrazine (TRT) was achieved using a glassy carbon electrode modified with the YFO/f-CNF nanocomposite, enabling highly effective detection of SSY and TRT in food samples. Under optimized conditions, the modified electrode demonstrates a wide linear range (0.05 μM – 466.15 μM) and very low limits of detection (LOD) for SSY (1.5 nM) and TRT (3.2 nM). Additionally, the modified electrode exhibits significantly higher sensitivity (7.23 μAμM1cm−2) for SSY and (3.01 μAμM−1cm−2) for TRT compared to other reported values. This work showcases excellent sensitivity and selectivity, capable of identifying trace amounts of azo dyes in complex food matrices such as fruit juices, soft drinks, and packaged foods. The sensor's performance in real food samples, including both beverages and solid food products, was comparable to traditional high-performance liquid chromatography (HPLC), with a strong correlation in detection limits and accuracy (95.7–99.1 %). Furthermore, the sensor demonstrated exceptional stability and reproducibility in food matrix analysis, providing a reliable and efficient tool for routine monitoring of azo dye contamination in food and beverage industries. © 2025

关键词： Fruit juices

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Dextran-integrated polypyrrole-Cu2O composite for improved electrochemical quantification of melatonin in biological samples

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international Journal of Biological Macromolecules 2025年第Pt 2期310卷 143247页

作者： Aiswarya, B. Gopika, M.G. Saraswathyamma, Beena Kuo, Chih-Yu Jeridi, Mouna Alshahrani, Thamraa Govindasamy, Mani International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Polymer Science Central Institute of Petrochemical Engineering and Technology Kochi Eloor Udyogamandal P O Kochi683501 India Department of Chemistry Amrita Vishwa Vidyapeetham Amritapuri campus Clappana P O Kerala Kollam690525 India Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan High-Value Biomaterials Research and Commercialization Center National Taipei University of Technology Taipei106 Taiwan Biology Department College of Science King Khalid University Abha61413 Saudi Arabia Department of Physics College of Science Princess Nourah bint Abdulrahman University P. O. Box 84428 Riyadh11671 Saudi Arabia Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai602105 India

Monitoring the level of melatonin (MEL), a neurohormone that plays a vital role in governing the body's circadian rhythms and sleep cycles, is critical due to its physiological importance and potential adverse side effects during overexposure. This research deals with the design and development of a novel electrochemical sensor by modifying a glassy carbon electrode (GCE) with a composite of poly(vinyl alcohol) (PVA), dextran (Dex), polypyrrole (PPy) and copper oxide particles (Cu2O) forming the PDPC composite. The synthesized composite was analyzed using both structural and morphological characterization methods. Additionally, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were conducted to examine electrochemical behaviour of the composite. Significantly, the dextran inclusion, which is a biocompatible polysaccharide, makes the composite more hydrophilic, film forming, and stable enhancing sensor properties, more importantly, electrochemically. The sensor showed high electrocatalytic activity towards MEL oxidation as studied using CV and DPV. For MEL oxidation, the oxidation peak was found at +0.6 V in phosphate buffer (pH 7.0) with an increase in current with respect to melatonin concentration. The sensor has a detection limit of 5.2 nM with a linear range of 10.0 nM to 850.0 μM, found to be better than most reported sensors. Analysis of real samples, such as human serum and urine, demonstrated the ability to selectively, stably, and reproducibly detect MEL. These data confirm the potential possibilities of using the sensor for clinical and point-of-care testing showing a significant development in polysaccharide-based electrochemical sensors. © 2025 Elsevier B.V.

关键词： Dextran-based composite Electrochemical sensor Melatonin

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Dual functional antibacterial nanofiber membranes: Polyhexamethylene biguanide-integrated alginate-chitosan-dye modified polyamide 56 for single-use biomedical applications

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international Journal of Biological Macromolecules 2025年 310卷 143331页

作者： Liao, Ting-Cjia Le, Quang-Vinh Hanh, Nguyen The Duc Liu, Bing-Lan Srinophakun, Penjit Prapainainar, Paweena Chiu, Chen-Yaw Wang, Chi-Yun Ng, I-Son Chen, Kuei-Hsiang Chang, Yu-Kaung of Biochemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Center for Environmental Sustainability and Human Health Ming Chi University of Technology Taishan New Taipei City243303 Taiwan Department of Applied Chemistry Chaoyang University of Technology Taichung413310 Taiwan National Center of Excellence for Petroleum Petrochemicals and Advance Material Department of Chemical Engineering Faculty of Engineering Kasetsart University Chatuchak Bangkok10900 Thailand Center for Advanced Studies in Nanotechnology for Chemical Food and Agricultural Industries Kasetsart University Chatuchak Bangkok10900 Thailand Department of Chemical Engineering Ming Chi University of Technology New Taipei City243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Departmental of Chemical Engineering National Cheng Kung University Tainan70101 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Zhongli Dist. Taoyuan City320315 Taiwan

Polyamide 56 (PA56) nanofiber membranes were functionalized with alginate (AG), chitosan (CS), reactive dyes (RG19, RR141), and poly(hexamethylene biguanide) (PHMB) to develop multifunctional antimicrobial membranes for single-use applications. The resulting membranes, PA56-AG-CS-RG19-PHMB and PA56-AG-CS-RR141-PHMB, achieved high antibacterial efficiencies of 97.12 % and 90.65 %, respectively, against Escherichia coli, demonstrating potent bacterial inhibition. The antimicrobial performance results from a synergistic dual mechanism. Chitosan disrupts bacterial adhesion and biofilm formation through electrostatic interactions, while PHMB compromises membrane integrity and interferes with intracellular processes. This combined action enhances bactericidal efficacy. The functionalization strategy also maintained excellent biocompatibility, with minimal cytotoxicity observed in L929 fibroblasts. Optimized concentrations of AG and CS were systematically evaluated to ensure balanced antibacterial performance and mechanical stability. These membranes, designed for single-use, exhibited significantly reduced antibacterial activity upon reuse, supporting their intended application. Overall, the integration of chemical and physical antimicrobial strategies within a nanofiber matrix presents a novel and effective approach. This strategy enables the development of next-generation materials suitable for real-world single-use biomedical applications, including wound dressings, food packaging, and protective textiles. © 2025 Elsevier B.V.

关键词： Escherichia coli

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