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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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CoAl2O4 nanoparticles modified carbon nanofibers as high-efficiency bifunctional electrocatalyst: An efficient electrochemical aqueous asymmetric supercapacitors and non-enzymatic electrochemical sensors

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Journal of Alloys and Compounds 2023年 931卷 1页

作者： Chinnapaiyan, Sathishkumar Das, Himadri Tanaya Chen, Shen-Ming Govindasamy, Mani Alshgari, Razan A. Fan, Chi-Hsuan Huang, Chi-Hsien Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Centre for Advanced Materials and Applications Utkal University Vani vihar Odisha Bhubaneswar751004 India Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Chemistry Department College of Science King Saud University Riyadh11451 Saudi Arabia Korea University of Technology and Education Chungcheongnam-do Cheonan-si31253 Korea Republic of Division of Rheumatology Allergy and Immunology Chang Gung Memorial Hospital Taoyuan33378 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

The thriving energy demand of the gradually increasing population and modernized life style requires development in energy storage devices for usage in commercial electronic devices. In this particular work, we have explored electrochemical performances of bimetallic oxide CoAl2O4 and tuned its performance by decorating it on the carbon nanofibers. The CoAl2O4/CNFs are synthesized by deep eutectic solvents based hydrothermal method. The synthesized CoAl2O4 nanoparticle was found electrochemically active and the incorporation of CNFs end up boosting, its electrochemical performances as battery-type electrode. The obtained nanocomposites were characterized by various techniques. The electrochemically active CoAl2O4/CNFs exhibited 2.2-fold higher charge storage capacity than CoAl2O4. The CoAl2O4/CNFs exhibited specific capacity as high as 132 C/g at a constant applied current density of 1 A/g in 1 M KOH. The asymmetric device fabricated with CoAl2O4/CNFs electrodes exhibited excellent energy density of 20 Wh/kg at power density of 3000 W/kg. The CoAl2O4/CNFs electrode long-term stability has been minutely observed;the high Coulombic efficiency of 90% and high rate of capacity retention 95 %. In this work, an enzyme-free electrochemical sensor based on CoAl2O4/CNFs composite was developed for the detection of luteolin (LUT). Further modification of CoAl2O4/CNFs composite can improve the high surface area and catalytic capability of the composites. Under the optimal detection conditions, the prepared sensor has good linearity in the detection of LUT within range 30 nM − 73.5 μM with a limit of detection (LOD) of 0.0124 μM (12.4 nM). The stability and selectivity of the sensor is high, and can be used to detect LUT in various real samples. © 2022 Elsevier B.V.

关键词： Electrochemical sensors

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Synthesis of Gadolinium-Doped Molybdenum Diselenide Nanospheres for Ultrasensitive Electrochemical Determination of Essential Amino Acid in Human Serum and Milk Samples

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Journal of the Electrochemical Society 2023年第5期170卷 057501-057501页

作者： Jeromiyas, Nithiya Govindasamy, Mani Alothman, Asma A. Ouladsmane, Mohamed Huang, Chi-Hsien National Kaohsiung University of science and Technology Kaohsiung City81157 Taiwan Department of Chemistry Korea University Seongbuk-gu Seoul Korea Republic of Faculty International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Thandalam Chennai602105 India Chemistry Department College of Science King Saud University Riyadh11451 Saudi Arabia Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan Biochemical Technology R&D Center Ming Chi University of Technology New Taipei City243303 Taiwan

The electrocatalytic activity and electronic conductivity of 2D transition metal chalcogenides are usually enhanced by as follows the ideal strategy such as doping or substitution heterogeneous atoms. Here, a rare Earth metal ion of gadolinium (Gd3+) was doped with MoSe2 and synthesized through the hydrothermal method. The morphology and nanostructure of Gd3+ with MoSe2 spheres were analyzed under X-ray diffraction, Fourier-transform infrared spectroscopy, X-ray photoelectron, High-resolution transmission electron microscopy analysis, Field emission scanning electron microscopy, and energy-dispersive spectroscopy. Furthermore, the Gd3+ doped MoSe2 sphere modified glassy carbon electrode (Gd@MoSe2/GCE) was used for the sensing of tryptophan. The Gd@MoSe2 modified GCE shows remarkable sensing performance of tryptophan resulting in a linear range (20 nM-220 μM) with a low detection limit (6.7 nM). Under the optimal condition, the developed electrochemical sensor was successfully used to determine tryptophan (TRP) in blood serum and milk samples. The electrochemical biosensing results suggest that the doping of the Gd3+ doped MoSe2 sensor is a promising electrocatalyst in biological and food samples. © 2023 The Electrochemical Society ("ECS"). Published on behalf of ECS by IOP Publishing Limited.

关键词： Amino acids

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The effect of Zentangle on cognitive focus, emotional well-being, and stress levels: A neural perspective

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Brain and Behavior 2024年第8期14卷 e3628页

作者： Usman, Muhammad Jung, Tzzy-Ping Hsin, Ding-Yun Lin, Chun-Ling International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City Taiwan Institute for Neural Computation and Institute of Engineering in Medicine University of California San Diego San Diego CA United States Taipei Municipal Yangming High School Taipei City Taiwan Department of Electrical Engineering Ming Chi University of Technology New Taipei City Taiwan Department of Electronic Engineering National Taipei University of Technology Taipei Taiwan

Purpose: This study aimed to assess how a Zentangle intervention influences cognitive focus, emotional well-being, stress levels, and neural activity patterns across brain regions and frequency bands. Method: A cohort of 30 healthy adults, all without prior Zentangle experience, participated in this study. Electroencephalography (EEG) was used to measure their brain activity, and self-reported data were collected through questionnaires to assess subjects’ concentration levels, emotional calm, and stress and anxiety. Findings: Participants reported enhanced cognitive focus and emotional well-being, evidenced by increased self-reported concentration and emotional calmness, and reduced stress and anxiety levels during the intervention. EEG analyses revealed notable changes in neural activity patterns, including decreased delta power and increased theta, alpha, beta, and gamma bands. Functional connectivity analysis also highlighted alterations in the brain's functional connectivity, suggesting potential effects on neural communication and information processing. Conclusion: This study provides compelling evidence of Zentangle's impact on EEG data, aligning it with equanimity and tranquility consistent with previous mindfulness research. These findings underscore Zentangle as an effective mindfulness practice, potentially enhancing cognitive focus and emotional well-being, and emerging as a valuable intervention for improving mental health and overall well-being. © 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.

关键词： art therapy electroencephalography mediation mindfulness well-being Zentangle

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Facile synthesis of cobalt, nickel and manganese-based metal organic framework derived layered double hydroxides on Ni foam as effective binder-free electrodes of energy storage devices

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Journal of Energy Storage 2024年 78卷

作者： Kuo, Tsung-Rong Huang, Jing-Mei You, Xiang-Yu Subbiramaniyan, Kubendhiran Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Metal organic framework (MOF) derivatives have attracted intensive attention as the active material of energy storage devices. Layered double hydroxide (LDH) with large surface area, high redox capability and good cycling stability is regard as one of efficient active materials. Developing MOF-derived LDH with multiple metals can possibly achieve excellent surface properties, high electrical conductivity and abundant redox reactions. However, synthesizing MOF-derived LDH is time-consuming and requires high temperature environments. In this work, a simple and time-effective precipitation and etching process is proposed to synthesize MOF-derived LDH on nickel foam (NF) as binder-free electrodes of energy storage devices. The cobalt, nickel and manganese are utilized to design MOF-derived LDH with different metal species and numbers. The trimetallic MOF-derived LDH based on Co, Ni and Mn presents a high specific capacitance (CF) of 1113.7 F/g at 20 mV/s, due to abundant electroactive sites and multiple redox states for carrying out large numbers of redox reactions. The energy storage device composed of the trimetallic MOF-derived LDH and carbon on NF as electrodes presents the maximum energy density of 61.5 Wh/kg at the power density of 750 W/kg, and the CF retention of 92.5% and Coulombic efficiency of 95% after 10,000 charge/discharge cycles. © 2023 Elsevier Ltd

关键词： Electrodes

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Graphene Nanoribbons/Manganese Oxide Nanocomposite Modified Electrode for Detection of Antimicrobial Drug Nitrofurantoin

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Journal of Nanomaterials 2023年第1期2023卷

作者： Nagarajan, Ramila D. Magesh, Vasanth Sundramoorthy, Ashok K. Murugan, Preethika Atchudan, Raji Ganapathy, Dhanraj Arya, Sandeep Mahmoud Karami, Abdulnasser Govindasamy, Mani Department of Chemistry V.V.Vanniaperumal College for Women Tamil Nadu Virudhunagar626001 India Centre for Nano-Biosensors Department of Prosthodontics Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences Poonamallee High Road Velappanchavadi Tamil Nadu Chennai600077 India Augsburg University Am Technologiezentrum 8 Augsburg86159 Germany School of Chemical Engineering Yeungnam University Gyeongsan38541 Korea Republic of Department of Physics University of Jammu Jammu and Kashmir Jammu180006 India Department of Chemistry College of Science King Saud University Riyadh11451 Saudi Arabia International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

The design and development of a new kind of cost-effective electrode material with excellent selectivity and stability are still a great challenge in the field of electrochemical sensors. Recently, researchers have paid more attention to the electrochemical reduction of nitro compounds due to their hazardous nature. Nitro compounds play a vital role in various industrial applications. However, the direct discharge of nitro compounds to the environment as industrial wastewater is harmful. In this study, a nanocomposite made of 1D graphene nanoribbons decorated with manganese dioxide (GNR-MnO2) was prepared to fabricate an electrochemical transducer for the determination of nitrofurantoin (NFT) in biofluids. First, 1D GNR was prepared by unzipping of multiwalled carbon nanotubes. Second, the GNR was decorated with MnO2 by the hydrothermal reduction method. As-prepared GNR-MnO2 nanocomposite was comprehensively characterized by field emission scanning electron microscopy with EDX, XRD, UV-visible, electrochemical impedance spectroscopy, and cyclic voltammetry. Moreover, GNR-MnO2-coated glassy carbon electrode (GCE) exhibited good electrocatalytic activity toward NFT. The electroreduction of NFT was found at -0.40 V which was 50 mV lower than bare GCE. GNR-MnO2 nanocomposite modified GCE showed a well-defined linear reduction peak current for NFT from 10 nM to 1,000 μM. The selectivity of the sensor was also analyzed in the presence of other nitro compounds which confirmed that NFT can be selectively detected at -0.4 V. The GNR-MnO2 modified electrode was also able to separate reduction peaks of other nitro compounds. In addition, the detection of NFT was carried out in human urine samples with a good recovery of 99.60%-98.60%. © 2023 Ramila D. Nagarajan et al.

关键词： Scanning electron microscopy

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Boron carbide decorated tungsten disulfide nanosheet composite for determination of chloramphenicol in food and pharmaceutical samples

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Microchemical Journal 2024年 203卷

作者： Senthilkumar, Dhayanithi Kuo, Chih-Yu Aldossari, Samar A. Govindasamy, Mani Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Department of Chemistry P. O. Box 2455 College of Science King Saud University Riyadh 11451 Saudi Arabia Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Making the nanocomposites of metal oxides or metal sulfides with carbon source materials has a huge impact on the electrochemical determination of toxic chemicals. To determine the adverse side effects of the antibiotics, electrochemical sensors have been used as they can peek into the sensitivity of the drug sample. This work has done the sensitive amperometric evaluation of a chloramphenicol antibiotic by modifying the electrode of tungsten disulfide decorated boron carbide. Here, tungsten disulfide (WS₂) nanosheets and boron carbide (B₄C) materials were synthesized by conventional methods which give a good amount of yield. The composite was prepared by the green and cost-effective sonochemical approach with good morphology. The conductivity of the nanocomposite and the response to chloramphenicol were determined by cyclic voltammetry. The sensitivity, limit of detection (LOD), and the linear range were observed by the highly sensitive amperometric technique. From the amperometric analysis, the prepared nanocomposite shows nominal LOD as a 17.4 nM, a broad linear range (0.025–1134.6 µM), and good sensitivity of 1.52 µA µM⁻¹ cm⁻². Practicability of the modified sensor was studied in food and pharmaceutical samples with adequate recovery performances. Moreover, the modified electrode shows good stability, repeatability, reproducibility, and anti-interfering properties against the array of food and biological interferences. © 2024 Elsevier B.V.

关键词： Amperometric technique Antibiotic detection Boron carbide Food quality test Health analysis Tungsten disulfide

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Ti-6al-4v Intervertebral Fusion Cage with Compatible Stiffness, Enhanced Fatigue Life, and Osteogenic Differentiation

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SSRN 2023年

作者： Wu, Yu-Jie Wang, Chi-Yun Feng, Kuei-Chih Chien, R.R. Mana-Ay, Haidee Kung, Shyang-Yih Hou, Kuang-Hua Tu, Chi-Shun Chen, Pin-Yi Lai, Po-Liang International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Mechanical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Taoyuan City33305 Taiwan Department of Physics Silliman University Dumaguete City6200 Philippines Department of Mechanical Engineering Chang Gung University Taoyuan City33302 Taiwan

The 3D-printed Ti-6Al-4V intervertebral fusion cage is fabricated to be biocompatible with improved stiffness, fatigue life, and osteogenic differentiation, which are greatly enhanced by heat treatment and surface modification. The flexible cage’s life, which exceeds the standard dynamic fatigue requirement of 5x106 cycles based on the ASTM F2077 and F2267 test methods, is achieved by heat treatment at 800 ℃ in argon atmosphere, shot peening, and adjusting the α to β phase ratio to increase mechanical toughness. Surface modification via sandblasting and chemical etching removes the surface oxide layer and forms submicron pores on the surface of the cage, which significantly boosts cell proliferation, differentiation, and osteoblast mineralization. This work exhibits a novel design of Ti-6Al-4V intervertebral fusion cage with biocompatible stiffness, enhanced fatigue life, and improved osteogenic differentiation achieved by reducing residual stress, modifying surface micro-pores, and optimizing microstructure. © 2023, The Authors. All rights reserved.

关键词： Aluminum alloys

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CCL5 Protects Cortical Neuron Function by Regulating M2 Microglia Activation After Mild Traumatic Brain Injury

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SSRN 2022年

作者： Tsai, Yih-Jeng Ho, Man-Hau Yen, Chia-Hung Wang, Jia-Yi Burnouf, Thierry Chen, Chia-Yen Wang, Yun Chiang, Yung-Hsiao Hoffer, Barry J. Chou, Szu-Yi Department of Otolaryngology Head and Neck Surgery Shin Kong Wu HoSu Memorial Hospital Taipei Taiwan School of Medicine Fu Jen Catholic University New Taipei City Taiwan Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University National Health Research Institute Taiwan Graduate Institute of Neural Regenerative Medicine College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Biological Science and Technology National Pingtung University of Science and Technology Neipu Pingtung91201 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Neurosurgery Taipei Medical University Hospital Taipei11031 Taiwan Neuroscience Research Center Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan NeuroTMULille International Laboratory Taipei Medical University Taipei Taiwan International PhD Program in Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei Taiwan Brain and Consciousness Research Centre TMU Shuang Ho Hospital New Taipei City Taiwan Center for Neuropsychiatric Research National Health Research Institutes Zhunan Miaoli County Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University 11031 Taiwan Department of Neurosurgery Case Western Reserve University School of Medicine ClevelandOH United States Scientist Emeritus National Institutes of Health United States International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei Taiwan

Cytokines and chemokines play important roles in inflammation and repair following brain injury. M1 microglia are pro-inflammatory which produce cytokines and lead to neural injury;in contrast, M2 microglia are anti-inflammatory, release neurotrophic factors, and promote neural repair processes. Chemokine CCL5, increased after TBI, shows a neuroprotective function by reducing oxidative stress. CCL5 may contribute to the balance between oxidative stress and immune responses after brain injury. Herein, we investigated the role of CCL5 in microglial polarization after mild traumatic brain injury, focusing on the cerebral cortex.C57BL/6 and CCL5 knockout (CCL5-KO) mice were given a mild traumatic brain injury (TBI) using weight-drop. Neurological parameters such as motor and sensory functions were analyzed by mNSS score, accelerating rotarod, beam walking, and adhesive removal tests. Oxidative stress and neuron damage were measured by NADPH oxidase activity, hypoxyloprobe staining and FJC. Performance of motor and sensory functions in both WT and CCL5-KO mice were impaired after brain injury which recovered after 7 days-post-injury (dpi) in the WT group but only after 14 days in the CCL5-KO mouse group. RT-qPCR analysis revealed that pro-inflammation cytokines - IL-1β, TNF-α, and IL-6 were higher in CCL5-KO mice compared to WT mice at 4 and 14 dpi. In contrast, M2-like microglia markers - IL-10 and Agr-1 were increased in WT mouse cortical tissue at 4 dpi. Oxidative stress increased both M1 and M2- related cytokine expression in BV2 cells treated with H 2 O 2;CCL5 treatment increased M2- but suppressed M1- related cytokine gene activation. Intranasal delivery of CCL5 reduced neuronal oxidative stress, increased IL-10 expression and improved motor and sensory functions in CCL5-KO mice after brain *** summary, CCL5, which alters immune responses and protects neurons from TBI damage, has an important function in regulating M2-like microglial polarization during post-

关键词： Polarization

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Novel synthesis of manganese cobalt layered double hydroxide and sulfur-doped nickel cobalt layered double hydroxide composite as efficient active material of battery supercapacitor hybrids

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Journal of Energy Storage 2023年 57卷

作者： Hsiao, Yu-Cheng Liao, Chen-Hao Hsu, Chia-Shuo Yougbaré, Sibidou Lin, Lu-Yin Wu, Yung-Fu International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106 Taiwan /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Nickel and cobalt layered double hydroxide (NiCo-LDH) is one of promising active materials of battery supercapacitor hybrids (BSH) as the clean renewable energy. Designing composites and doping heteroatoms are widely applied to solve poor conductivity, serious agglomeration, and structural defects of NiCo-LDH. In this work, manganese cobalt LDH (MnCo-LDH) is firstly incorporated in sulfur-doped NiCo-LDH (S-NiCo-LDH) on Ni foam (NF) via the hydrothermal process as a binder-free electrode of BSH. Favorable morphology with nanowires covered on the vertical grown nanosheet array is successfully designed for MnCo-LDH/S-NiCo-LDH with the large specific surface area and the well-established pore structure. The specific capacitances (CF) of 681.4, 953.9 and 1581.3 F/g are respectively achieved for the NiCo-LDH, S-NiCo-LDH, MnCo-LDH/S-NiCo-LDH electrodes at the current density of 1 A/g. The larger CF value of MnCo-LDH/S-NiCo-LDH is due to larger conductivity and effective charge transfer paths. A BSH assembled using MnCo-LDH/S-NiCo-LDH/NF and graphene/NF electrodes shows a wide potential window of 1.6 V, a large maximum energy density of 46.6 Wh/kg at 0.8 kW/kg, and an excellent cyclic stability with the CF retention of 81% and the Coulombic efficiency higher than 87% after 10,000 times charge/discharge process at the current density of 7 A/g. © 2022

关键词： Supercapacitor

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