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A Foldable Hybrid Supercapacitor with High Energy Density Driven by Cu-BDC@fMWCNT// Cashew De-Oiled Shell Derived Activated Carbon

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Advanced Sustainable Systems 2025年

作者： Prasath, Jeeva Sengottaiyan, Chinnasamy Arivanandhan, Mukannan Govindasamy, Mani Jayavel, Ramasamy Centre for Nanoscience and Technology Anna University Chennai600025 India International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Toyota Technological Institute Tempaku Aichi Nagoya468-8511 Japan Centre for Energy Storage Technologies Anna University Chennai600025 India Research Centre for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Crystal Growth Centre Anna University Chennai600025 India

The development of lightweight and foldable energy storage systems is pivotal for advancing next-generation automotive technologies. A high-performance foldable pouch cell supercapacitor is fabricated using Cu-BDC@fMWCNT as the positive electrode, cashew de-oiled shell-derived activated carbon as the negative electrode and a PVA-KOH/Super-P gel electrolyte. The device demonstrates an outstanding specific capacity of 163 C g−1 at 1 A g−1, achieving a remarkable energy density of 36.22 W h kg−1 and a peak power density of 4000 W kg−1. Rigorous mechanical evaluations, including 90° and 360° folding tests, confirm excellent foldability and mechanical stability with negligible performance degradation. The superior electrochemical performance arises from the synergistic charge storage mechanisms of the hybrid electrodes, enhancing ion transport and redox activity. The foldable supercapacitor combines exceptional energy storage capabilities with robust mechanical endurance, setting a new benchmark for advanced, high-performance energy storage devices tailored to the stringent demands for automotive applications. © 2025 Wiley-VCH GmbH.

关键词： Capacitor storage

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Correction: Biomass derived nitrogen functionalized carbon nanodots for nanomolar determination of levofloxacin in pharmaceutical and water samples

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Mikrochimica acta 2023年第7期190卷 269页

作者： Velusamy Arul Natarajan Sampathkumar Sindhuja Kotteeswaran Ponnusamy Arul Ahmed Muteb Aljuwayid Mohamed A Habila Mani Govindasamy Department of Chemistry Sri Eshwar College of Engineering (Autonomous) Coimbatore 641 202 Tamil Nadu India. kvarulchem6@***. Department of Chemistry Korea University 145 Anam-Ro Seongbuk-Gu Seoul South Korea. kvarulchem6@***. Department of Chemistry SSM College of Arts and Science Dindigul 624002 Tamil Nadu India. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. Department of Chemical Engineering and Biotechnology Institute of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei 106 Taiwan ROC. vpsarul@***. Department of Chemistry College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Department of Research and Innovation Saveetha School of Engineering SIMATS 602105 Chennai India. govindasamy420700@***.

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Corrigendum to “Metal ratio and bimetal nanoarchitectonics of ammonia-based fluoride complex induced nickel hydroxide and manganese oxide composites as active materials of an energy storage device” [J. Energy Storage 80 (2024) 110316]

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Journal of Energy Storage 2025年 108卷

作者： Chuan-Chih Hsu You Zher Yu Chung-Hsien Wu Pin-Yan Lee Hung-Ming Chen Sadang Husain Chutima Kongvarhodom Yu-Cheng Hsiao Lu-Yin Lin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei 11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin 70124 Indonesia Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok 10140 Thailand Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei 11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA 94305-5428 USA Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan

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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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Molecular Cell 2025年

作者： Chenzhong Xu Cong Yu Jie Zhang Zhen Zhang Jin Zhang Yuan Meng Ming Wang Minting Wen Junhao Chen Yuping Ning Xinchun Chen Jinke Gu Wen Su Baohua Liu Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI) Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine (SKL-ARM) Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention Marshall Laboratory of Biomedical Engineering International Cancer Center School of Basic Medical Sciences Shenzhen University Medical School Shenzhen 518055 China Shenzhen University-Friedrich Schiller Universität Jena Joint PhD Program Friedrich Schiller Universität Jena 07743 Germany Department of Physiology Wannan Medical College Wuhu 241002 China Guangdong Provincial Key Laboratory of Regional Immunity and Diseases School of Basic Medical Sciences Shenzhen University Medical School Shenzhen 518055 China

The mechanistic target of rapamycin (mTOR) serves as an essential hub in sensing metabolic stress and regulating aging, although the differential contributions of mTOR-regulated protein and cholesterol synthesis are unclear. Post-transcriptional modifications of mRNAs, such as N6-methyladenosine (m6A), occur rapidly in response to acute environmental changes to maintain tissue homeostasis. Here, we showed that loss of YTH m6A RNA-binding protein 1 (YTHDF1) accelerated murine aging. Mechanistically, YTHDF1 is anchored to the lysosome surface by lysosome-associated membrane protein (LAMP2), whereby it recruits tuberous sclerosis complex (TSC2) to inhibit mTOR complex 1 (mTORC1). Ythdf1 loss activated mTORC1-sterol regulatory element-binding protein 2 (SREBP2)-axis-mediated cholesterol biosynthesis but not m6A-reader-regulated protein translation. Rapamycin restored murine healthspan in contrast to the maximum lifespan shortening caused by Ythdf1 depletion. Our data reveal an m6A-independent function of YTHDF1, which differentiates the contributing roles of mTORC1 in the regulation of aging.

关键词： YTHDF1 aging mTORC1 TSC2 SREBP2 m6A rapamycin

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Front Cover: Emergence of Non-photoresponsive Catalytic Techniques for Environmental Remediation and Energy Generation (Chem. Asian J. 9/2023)

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Chemistry – An Asian Journal 2023年第9期18卷

作者： Manish Kumar Sharma Dr. Imran Khan Kuldeep Kaswan Dr. Snigdha Roy Barman Prof. Dr. Subhajit Saha Wu-Chiao Hsieh Prof. Dr. Yu-Lun Chueh Prof. Dr. Yu-Lin Wang Prof. Dr. Sangmin Lee Prof. Dr. Dukhyun Choi Prof. Dr. Zong-Hong Lin Department of Materials Science and Engineering National Tsing Hua University Hsinchu 30013 Taiwan Institute of NanoEngineering and Microsystems National Tsing Hua University Hsinchu 30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu 30013 Taiwan Department of Renewable Energy Maulana Abul Kalam Azad University of Technology West Bengal 741249 India Department of Obstetrics and Gynecology Chang Gung Memorial Hospital and College of Medicine Chang Gung University Taoyuan 333 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu 30013 Taiwan School of Mechanical Engineering Chung-Ang University Seoul 06974 South Korea Department of Mechanical Engineering Sungkyunkwan University Suwon 16419 South Korea Department of Biomedical Engineering National Taiwan University Taipei 10617 Taiwan

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Identification of gene expression signatures for psoriasis classification using machine learning techniques

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Medicine in Omics 2021年 1卷

作者： Nguyen Quoc Khanh Le Duyen Thi Do Trinh-Trung-Duong Nguyen Ngan Thi Kim Nguyen Truong Nguyen Khanh Hung Nguyen Thi Thu Trang Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei City 106 Taiwan Research Center for Artificial Intelligence in Medicine Taipei Medical University Taipei City 106 Taiwan Graduate Institute of Biomedical Informatics Taipei Medical University Taipei City 106 Taiwan Department of Computer Science and Engineering Yuan Ze University Chung-Li 32003 Taiwan School of Nutrition and Health Sciences Taipei Medical University Taipei City 110 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan Orthopedic and Trauma Department Cho Ray Hospital Ho Chi Minh City Viet Nam International PhD Program for Cell Therapy and Regeneration Medicine College of Medicine Taipei Medical University Taipei City 110 Taiwan

Psoriasis classification requires the accurate identification of the lesional types for the early and effective diagnosis and it is worth interesting that the normal and psoriasis cell tissues exhibit different gene expression. Therefore, gene expression data is an effective source for psoriasis classification and there is a challenge regarding the selection of suitable gene signatures for its purpose. In this present study, the gene expression-based microarray data were used and 35 expression features linked with psoriasis were utilized to feed into our machine learning model. Overall, the performance of our model based on 35 mentioned-above features surpassed that of other state-of-the-art classifiers with an average accuracy of 98.3%, recall of 98.6%, and precision of 98% in 5-fold cross-validation tests. We also validate our model on two different sets of psoriasis and the performance results are significant. These results have suggested that our 35 expression signatures have been identified as key features for classifying samples between lesion and non-lesion. More specifically, the expression levels of few genes i.e., FABP5 , TGM1 , or BCAR3 are discovered as newly potential biomarkers for psoriasis classification and treatment with high confidence. This study, therefore, could shed light on developing the prediction models for psoriasis classification and treatment using gene expression profiles.

关键词： Psoriasis classification Random forest Gene expression Feature selection Machine learning FABP5 Dermatology

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Multifaceted regenerative lives of ‘expired’ platelets

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ISBT Science Series 2018年第3期13卷

作者： T. Burnouf Graduate Institute of Biomedical Materials and Tissue Engineering & International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan

There is great interest in using expired platelet concentrates for producing human platelet lysates (hPLs) for cell therapy procedures and, potentially, regenerative medicine. The scientific rationale lies in the richness of platelets in growth factors and cytokines and other cell growth-promoting biomolecules. The main use of hPL is to replace fetal bovine serum (FBS) for cell therapy protocols for clinical-grade xeno-free nutritional supplementation of propagation media. To improve consistency, hPLs may be currently manufactured by pooling the lysates from approximately 16 to 50 frozen platelet concentrates, depending upon jurisdiction. hPL is used as growth medium supplement to expand primary mesenchymal stromal cells (MSCs) from different tissues, as well as various differentiated primary cells. hPLs avoid immunological and zoonotic infectious risks linked to FBS, exhibit potent capacity at expanding cells, shortening the cell population doubling time while maintaining cell physiological, biochemical and functional properties, and, for MSCs, capacity to differentiate. Nonexpired autologous or allogeneic platelet-derived biomaterials are used in regenerative medicine to enhance the healing and repair of damaged or injured tissues. However, the variability in these products does not generally allow to draw evidence-based conclusions, and recommendations on best clinical practices remain needed. Future trends may include the development of large-scale virally inactivated hPLs manufactured following controlled conditions meeting specifications tailored-made for dedicated clinical applications. In conclusion, there is a scientific rationale for making optimal use of expired platelets to produce standardized growth factor preparations for both cell therapy procedures and dedicated regenerative medicine applications.

关键词： cellular therapy platelet concentrates platelet lysates regenerative medicine

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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Nanofiltration of extracellular vesicles from human plasma & their on-chip qualification and quantification with a NanoBioAnalytical platform

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Meta Gene 2018年 17卷 S7-S7页

作者： Obeid Sameh Benoît Le Roy de Boiseaumarie Celine Elie-Caille Wilfrid Boireau Ming Li Chou Thierry Burnouf Pei-Shan Sung Shie-Liang Hsieh Institut FEMTO-ST Univ. Bourgogne Franche Comté CNRS France Graduate Institute of Biomedical Material and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taiwan Institute of Clinical Medicine National Yang Ming University Taipei Taiwan Genomic Research Center Academia Sinica Taiwan Department of Medical Research Taipei Veterans General Hospital Taiwan

One complication of plasma transfusion is non-immune transfusion related acute lung injury (TRALI), which is associated with the formation of neutrophil extracellular traps (NETs) resulting from polymorphonuclear neutrophil (PMN) activation. Activated platelets have recently been shown to trigger NETs formation. We hypothesized that (a) NETs could be promoted by platelet derived microparticles (PMPs) and (b) that 75 nm-nanofiltration of plasma, by removing parts of PMPs, could avoid NETs formation. To better characterize the large spectrum of size and concentration of PMPs in complex media, we combined conventional approaches (Flow Cytometry, TRPS) with an original nanobioanalytical (NBA) platform based on Surface Plasmon Resonance imaging (SPRi) and Atomic Force Microscopy (AFM) techniques. We will demonstrate that this new analytic solution allows: • a label-free follow-up of PMPs capture in real time from various complex media, • a multiplex detection of different PMPs subpopulations, • the determination of the size and morphology of captured PMPs in a range of 20 nm to 1 μm their proteomic studies. We expect that such platform will contribute to (i) a better understanding of the physiological function of Evs subpopulations, (ii) the discovery of specific biomarkers and (iii) to therapeutic follow-up.

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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