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15th IEEE international Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment, and Management, HNICEM 2023

作者： Alquiza, Laurence Keith P. Recto, King Harold A. Loresco, Pocholo James M. Villalobos, Jesus Ateneo de Manila University Department of Electronics Computer and Communications Engineering Quezon City Philippines Feu Institute of Technology Department of Electronics Engineering Manila Philippines Institut Catholique d'Arts et Métiers International Program in General Engineering Toulouse France

ISBN: (纸本)9798350381177

The Republic of the Philippines is confronted with rebuilding its energy landscape, which now depends heavily on imported fossil fuels for a substantial supply. The Department of Energy (DOE) has established lofty objectives to enhance the nation's renewable energy (RE) capability;nevertheless, these objectives are still to be achieved. This research supports DOE's goals by studying other possible renewable energy sources. In particular, the primary aim of this research is to examine the viability of Offshore Wind Converters (OWCs) and Wave Energy Converters (WECs) as viable sustainable energy options for the Philippines. Ocean wave converters (OWCs) provide inherent benefits in terms of dependability and have widespread societal acceptance. Conversely, wave energy converters (WECs) harness the vast energy potential contained within ocean waves. A comparative evaluation was undertaken to analyze the differences between these two potential renewable energy sources. The assessment concludes that OWCs possess a minor advantage over WECs regarding their economic viability and higher societal acceptability. It recommended that the government adopts a diversified energy portfolio, which may include the incorporation of WECs to effectively navigate the changing dynamics of the energy sector, enhance sustainability, and ensure the long-term security of the nation's energy supply. © 2023 IEEE.

关键词： Water waves

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Complexity Analysis based on Parietal Fuzzy Entropy to Facilitate ADHD Diagnosis in Young Children 46

Complexity Analysis based on Parietal Fuzzy Entropy to Facil...

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46th Annual international Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Huang, I-Wen Jheng, Yu-Ci Chen, I-Chun Ko, Li-Wei National Yang Ming Chiao Tung University Institute of Biomedical Engineering Hsinchu300040 Taiwan National Yang Ming Chiao Tung University Institute of Electrical and Control Engineering Hsinchu300040 Taiwan National Yang Ming Chiao Tung University International Program in Interdisciplinary Neuroscience College of Biological Science and Technology Hsinchu300040 Taiwan Ton-Yen General Hospital Department of Physical Medicine and Rehabilitation Hsinchu302048 Taiwan Kaohsiung Medical University Drug Development and Value Creation Research Center Kaohsiung807378 Taiwan

ISBN: (纸本)9798350371499

Attention deficit hyperactivity disorder (ADHD) is the most common condition affecting the development of neurons in children. Therefore, early and accurate diagnosis of ADHD in young children is of paramount importance. In this study, the 8-channel wireless wearable EEG measurement device was employed to record EEG data from 30 children diagnosed with ADHD and 30 typical development (TD) young children aged 4-7 years. The data was collected both during rest and while the children performed a Kiddie Continuous Performance Test (K-CPT). We extract relative power spectral density (PSD) unaffected by factors like skull resistance and thickness. Additionally, a range of complex entropy values based on the time domain were extracted. These included sample entropy (SaEn), permutation entropy (PeEn), singular value decomposition entropy (SvdEn), and fuzzy entropy (FuEn). We compare the performance of k-Nearest Neighbors (kNN), Support Vector Machine (SVM), and XGBoost, and utilized the sequential forward selection (SFS) feature selection method in the wrapper approach. Through this process, the study identified the most effective EEG data segments and feature subsets. The findings indicated that using a combination of resting and K-CPT EEG data yielded greater discriminability. Notably, the study found that extracting beta power from the right occipital lobe along with fuzzy entropy from the parietal lobe resulted in optimal accuracy of 90% in distinguishing between children with ADHD and TD children. These outcomes highlight the potential of relative PSD and complexity metrics to support the clinical diagnosis of early ADHD. Furthermore, these metrics may contain unique neurobiomarkers that could be valuable for devising early intervention strategies. © 2024 IEEE.

关键词： Diseases

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Comparative Assessment of Off-shore Wind Converters and Wave Energy Converters in the Philippines

Comparative Assessment of Off-shore Wind Converters and Wave...

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international Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment and Management (HNICEM)

作者： Laurence Keith P. Alquiza King Harold A. Recto Pocholo James M. Loresco Jesús Villalobos Department of Electronics Computer and Communications Engineering Ateneo de Manila University Quezon City Philippines Department of Electronics Engineering FEU Institute of Technology Manila Philippines International Program in General Engineering Institut Catholique d'Arts et Métiers Toulouse France

ISBN: (数字)9798350381177

ISBN: (纸本)9798350381184

The Republic of the Philippines is confronted with rebuilding its energy landscape, which now depends heavily on imported fossil fuels for a substantial supply. The Department of Energy (DOE) has established lofty objectives to enhance the nation's renewable energy (RE) capability; nevertheless, these objectives are still to be achieved. This research supports DOE's goals by studying other possible renewable energy sources. In particular, the primary aim of this research is to examine the viability of Offshore Wind Converters (OWCs) and Wave Energy Converters (WECs) as viable sustainable energy options for the Philippines. Ocean wave converters (OWCs) provide inherent benefits in terms of dependability and have widespread societal acceptance. Conversely, wave energy converters (WECs) harness the vast energy potential contained within ocean waves. A comparative evaluation was undertaken to analyze the differences between these two potential renewable energy sources. The assessment concludes that OWCs possess a minor advantage over WECs regarding their economic viability and higher societal acceptability. It recommended that the government adopts a diversified energy portfolio, which may include the incorporation of WECs to effectively navigate the changing dynamics of the energy sector, enhance sustainability, and ensure the long-term security of the nation's energy supply.

关键词： Renewable energy sources Wind energy Navigation Ocean waves Security Wave energy conversion Sustainable development

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Rapid Escherichia coli Cloned DNA Detection in Serum Using an Electrical Double Layer-Gated Field-Effect Transistor-Based DNA Sensor

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Analytical Chemistry 2023年第17期95卷 6871-6878页

作者： Paulose, Akhil K. Hou, Yueh-Ju Huang, Yu-Shan Chakkalaparambil Dileep, Navyamol Chiu, Chia-Lin Pal, Arnab Kalaimani, Vishal Mani Lin, Zong-Hong Chang, Chuang-Rung Chen, Cheng-Pin Lin, Yi-Chun Cheng, Chien-Yu Cheng, Shu-Hsing Cheng, Chao-Min Wang, Yu-Lin Institute of Nanoengineering and Microsystems National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan Department of Life Sciences National University of Kaohsiung Kaohsiung811726 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu30013 Taiwan Department of Infectious Diseases Taoyuan General Hospital Ministry of Health and Welfare Taoyuan32748 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan

In this study, a rapid diagnosis platform was developed for the detection of Escherichia coli O157:H7. An electrical double layer (EDL)-gated field-effect transistor-based biosensor (BioFET) as a point-of-care testing device is demonstrated with its high sensitivity, portability, high selectivity, quick response, and ease of use. The specially designed ssDNA probe was immobilized on the extended gate electrode to bind the target complementary DNA segment of E. coli, resulting in a sharp drain current change within minutes. The limit of detection for target DNA is validated to a concentration of 1 fM in buffer solution and serum. Meanwhile, the results of a Kelvin probe force microscope were shown to have reduced surface potential of the DNA immobilized sensors before and after the cDNA detection, which is consistent with the decreased drain current of the BioFET. A 1.2 kb E. coli duplex DNA synthesized in plasmid was sonicated and detected in serum samples with the sensor array. Gel electrophoresis was used to confirm the efficiency of sonication by elucidating the length of DNA. Those results show that the EDL-gated BioFET system is a promising platform for rapid identification of pathogens for future clinical needs. © 2023 American Chemical Society

关键词： DNA

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Modeling Subsystem for Optimizing Reforming Processes of an Intellectualized Decision Support System 5

Modeling Subsystem for Optimizing Reforming Processes of an ...

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5th international Conference on Information and Computer Technologies, ICICT 2022

作者： Orazbayev, Batyr Zhumadillayeva, Ainur Dyussekeyev, Kanagat Orazbayeva, Kulman Umarov, Timur Kurmangaziyeva, Lyailya Faculty of Information Technologies L.N. Gumilyov Eurasian National University Nur-Sultan Kazakhstan Finance and International Trade Department of Management Kazakh University of Economics Nur-Sultan Kazakhstan Faculty of General Education British Management University Tashkent Uzbekistan Atyrau State University Department of Program Engineering Atyrau Kazakhstan

ISBN: (数字)9781665469609

ISBN: (纸本)9781665469609

The creation of intellectualized decision support systems (IDSS) for managing various, complex and difficult to formalize objects is currently a topical issue of science and practice. In this work, a subsystem for modeling ISSPR is created, which makes it possible to determine the effective operating modes of the catalytic reforming unit reactors. Mathematical models of the investigated reactors are developed on the basis of statistical data and fuzzy information obtained by expert assessment methods. Accordingly, the models for determining the volume of products produced from the output of the reactors are built in the form of statistical models, and for assessing the quality of the target product of the reforming process, i.e., catalyzate, based on expert information in the form of fuzzy models. An IDSS structure has been created to control the operating modes of the investigated reactors, which differs from the known structures of similar systems in that it includes a package of models of the control object and heuristic methods for solving decision-making problems, which make it possible to take into account the fuzziness of the initial information. In addition, the proposed IDSS structure contains a knowledge and data base, identifiers of model parameters, an intellectualized user interface and a block for explaining the selected solutions, which make it possible to increase the efficiency of the system. Describe the functions of the main functional blocks of the created IDSS. © 2022 IEEE.

关键词： Decision support systems

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Reader Comment Regarding Delta shock index in the emergency department as a predictor of clinical outcomes in traumatic injury

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The American journal of emergency medicine 2025年 92卷 187-188页

作者： Jen-Yu Hsu Kazuhiro Komine Fu-Shan Jaw Chien-Chieh Hsieh Department of Neurology Far Eastern Memorial Hospital New Taipei City Taiwan. Department of Emergency and Critical care Medicine Cheng Hsin General Hospital Taipei City Taiwan. Department of Biomedical Engineering National Taiwan University Taipei City Taiwan. Department of Emergency Medicine Far Eastern Memorial Hospital New Taipei City Taiwan Department of Biomedical Engineering National Taiwan University Taipei City Taiwan International Bachelor Program in Electrical and Communication Engineering Yuan Ze University Taoyuan Taiwan. Electronic address: hsiehchienchieh@***.

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Exercise-Induced miR-210 Promotes Cardiomyocyte Proliferation and Survival and Mediates Exercise-Induced Cardiac Protection against Ischemia/Reperfusion Injury

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Research 2024年第4期2024卷 396-412页

作者： Yihua Bei Hongyun Wang Yang Liu Zhuhua Su Xinpeng Li Yujiao Zhu Ziyi Zhang Mingming Yin Chen Chen Lin Li Meng Wei Xiangmin Meng Xuchun Liang Zhenzhen Huang Richard Yang Cao Lei Wang Guoping Li Dragos Cretoiu Junjie Xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People's Hospital of Nantong)and School of Life ScienceShanghai UniversityNantong 226011China Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair(Ministry of Education) Shanghai UniversityShanghai 200444China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of MedicineShanghai UniversityShanghai 200444China Department of Cardiology Shanghai Tongji HospitalTongji University School of MedicineShanghai 200065China School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200444China Cardiac Rehabilitation Program Shanghai Xuhui Central Hospital/Zhongshan-Xuhui HospitalFudan University/Shanghai Clinical Research CenterShanghai 200031China Department of Rehabilitation Medicine Nanjing University of Chinese MedicineNanjing 210023China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA Department of Medical Genetics Carol Davila University of Medicine and PharmacyBucharest 020031Romania Materno-Fetal Assistance Excellence Unit Alessandrescu-Rusescu National Institute for Mother and Child HealthBucharest 011062Romania

Exercise can stimulate physiological cardiac growth and provide cardioprotection effect in ischemia/reperfusion(I/R)***-210 is regulated in the adaptation process induced by exercise;however,its impact on exercise-induced physiological cardiac growth and its contribution to exercise-driven cardioprotection remain *** investigated the role and mechanism of miR-210 in exercise-induced physiological cardiac growth and explored whether miR-210 contributes to exercise-induced protection in alleviating I/R ***,we first observed that regular swimming exercise can markedly increase miR-210 levels in the heart and blood samples of rats and *** miR-210 levels were also elevated after a programmed cardiac rehabilitation in patients that were diagnosed of coronary heart *** 8-week swimming model in wild-type(WT)and miR-210 knockout(KO)rats,we demonstrated that miR-210 was not integral for exercise-induced cardiac hypertrophy but it did influence cardiomyocyte proliferative *** neonatal rat cardiomyocytes,miR-210 promoted cell proliferation and suppressed apoptosis while not altering cell ***,miR-210 promoted cardiomyocyte proliferation and survival in human embryonic stem cell-derived cardiomyocytes(hESC-CMs)and AC16 cell line,indicating its functional roles in human *** further identified miR-210 target genes,cyclin-dependent kinase 10(CDK10)and ephrin-A3(EFNA3),that regulate cardiomyocyte proliferation and ***,miR-210 KO and WT rats were subjected to swimming exercise followed by I/R *** demonstrated that miR-210 crucially contributed to exercise-driven cardioprotection against I/R *** summary,this study elucidates the role of miR-210,an exercise-responsive miRNA,in promoting the proliferative activity of cardiomyocytes during physiological cardiac ***,miR-210 plays an essential role in mediating the protective effects of exercise against cardiac I/R injury.

关键词： Survival protective markedly

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Complexity Analysis based on Parietal Fuzzy Entropy to Facilitate ADHD Diagnosis in Young Children

Complexity Analysis based on Parietal Fuzzy Entropy to Facil...

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Annual international Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： I-Wen Huang Yu-Ci Jheng I-Chun Chen Li-Wei Ko Institute of Biomedical Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan Institute of Electrical and Control Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan International Program in Interdisciplinary Neuroscience College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Physical Medicine and Rehabilitation Ton-Yen General Hospital Hsinchu Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

关键词： Support vector machines Performance evaluation Pediatrics Accuracy Aging Feature extraction Entropy Electroencephalography Complexity theory Time-domain analysis

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A Chemoimmunotherapy Nanogel Enables Efficient Delivery of Interleukin-2 and Induction of Immunogenic Cell Death for Effective Cancer Therapy

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Advanced Functional Materials 2024年第1期34卷

作者： Mu, Hsuan-Yu Ta, Yen-Nhi Ngoc Tham, Max Jing Rui Hsu, Fu-Fei Lin, Yu-Chieh Huang, Hsi-Chien Sung, Yun-Chieh Huang, Chih-I Wu, Ching-Ling Chang, Chao-Hung Yang, Sheng Lee, Tsung-Ying Wan, Dehui Wang, Jane Duda, Dan G. Boucher, Yves Huang, Jen-Huang Ang, Wee Han Chen, Yunching Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Chemical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Department of Chemistry National University of Singapore Singapore117544 Singapore NUS Graduate School for Integrative Sciences and Engineering National University of Singapore Singapore119077 Singapore Institute of Biomedical Sciences Academia Sinica Taipei11529 Taiwan Steele Laboratories for Tumor Biology Department of Radiation Oncology Massachusetts General Hospital and Harvard Medical School BostonMA02114 United States Department of Chemistry National Tsing Hua University Hsinchu30013 Taiwan

Interleukin-2 (IL-2) is one of the first FDA-approved immunotherapeutics, but its use is limited by toxicity and low efficacy. In addition, all immunotherapies are limited by the immunosuppressive and desmoplastic microenvironment of "immunologically cold" tumors, such as pancreatic ductal adenocarcinoma (PDAC) or hepatocellular carcinoma (HCC) with advanced liver fibrosis. Here, a new chemoimmunotherapy nanogel (IL2-Pt@Nanogel) for dual delivery of IL-2 and the type II immunogenic cell death inducer Pt-NHC that reduces the immunosuppressive phenotype of tumor-associated macrophages and diminishes regulatory T cell infiltration by inducing the production of type I interferon (IFN) by cancer cells is reported. Combining the angiotensin II receptor blocker losartan with IL2-Pt@Nanogel treatment reduces desmoplasia and reprogrammes the microenvironment of PDAC and HCC toward an immunostimulatory one. These effects result in potent anti-tumor efficacy in models of primary and metastatic PDAC and HCC with underlying liver fibrosis. This study presents a strategy for IL-2-based chemoimmunotherapy with the potential for clinical translation to treat solid tumors. © 2023 Wiley-VCH GmbH.

关键词： Nanogels

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Fabrication of tantalum silicate films with low TCR and low resistivity by magnetron sputtering

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Vacuum 2024年 226卷

作者： Chen, Cheng-Lung Huang, Cheng Chen, Sheng-Chi Liu, Yen-Chen Chuang, Min-Chen Wen, Chao-Kuang Huang, Wei-Sheng Yang, Wen-Sheng Chen, Yang-Yuan Graduate School of Materials Science National Yunlin University of Science and Technology Yunlin64002 Taiwan Department of Materials Engineering and Center for Plasma and Thin Film Technologies Ming Chi University of Technology 243 New Taipei City Taiwan College of Engineering and Center for Green Technology Chang Gung University 333 Taoyuan Taiwan International Ph.D. Program in Plasma and Thin Film Technology Ming Chi University of Technology 243 New Taipei City Taiwan TPH Research & Develop Dept. Chien Hwa Coating Technology Inc. Hsinchu300 Taiwan National Engineering Research Center for Rare Earth Materials Grirem Advanced Materials Co. Ltd. General Research Institute for Nonferrous Metals Beijing100088 China Institute of Physics Academia Sinica 115 Taipei Taiwan

Tantalum silicate (Ta–Si–O) thin film materials have gained significant interest in hybrid renewable energy systems and thin-film resistors due to their exceptional thermal stability and adjustable electrical properties. In this study, we investigated the effects of target compositions and sputtering power densities on the material structures, chemical compositions, microstructures, and electrical properties of Ta–Si–O films. Two target compositions, Ta65(SiO2)35 and Ta80(SiO2)20, were utilized in the deposition process. Notably, we observed substantial variations in the temperature coefficient of resistance (TCR) value and resistivity of Ta–Si–O thin films with different Ta concentrations. Most importantly, when the Ta content of the film is controlled at 62 ± 0.6 % by using this target, the resistivity of the Ta0.62Si0.20O0.18 film can be as small as 2.31 ± 0.05 × 10−4 Ω-cm and has an extremely small TCR of 22 ± 0.4 ppm/°C, which shows an excellent opportunity for the development of precision thin film resistors. A TCR value close to zero can be finely tuned by controlling the Ta concentration in the Ta–Si–O film. These intriguing electrical behaviors were found to be highly correlated with the predominant formation of metallic Ta5Si3 as the main structural phase in the films. This work presents a simple and effective approach to produce Ta–Si–O thin films with near-zero TCR, making them highly suitable for applications under high-temperature conditions. Our findings contribute to the development of tailored thin film materials with desirable electrical properties for advanced electronic and energy devices. © 2024 Elsevier Ltd

关键词： Thin films

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