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Reader Comment Regarding Delta shock index in the emergency department as a predictor of clinical outcomes in traumatic injury

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The American journal of emergency medicine 2025年 92卷 187-188页

作者： Jen-Yu Hsu Kazuhiro Komine Fu-Shan Jaw Chien-Chieh Hsieh Department of Neurology Far Eastern Memorial Hospital New Taipei City Taiwan. Department of Emergency and Critical care Medicine Cheng Hsin General Hospital Taipei City Taiwan. Department of Biomedical Engineering National Taiwan University Taipei City Taiwan. Department of Emergency Medicine Far Eastern Memorial Hospital New Taipei City Taiwan Department of Biomedical Engineering National Taiwan University Taipei City Taiwan International Bachelor Program in Electrical and Communication Engineering Yuan Ze University Taoyuan Taiwan. Electronic address: hsiehchienchieh@***.

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Mitochondrial activation via calcium peroxide/carrageenan/soybean lecithin-derived polypyrrole phototherapeutic microparticles

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Colloids and Surfaces B: Biointerfaces 2025年 254卷 114787页

作者： Chuang, Sih-Chi Yu, Shih-An Hung, Pei-Chia Chuang, Andrew E.-Y. Liang, Jia-Wei Sun, Chia-Lu Rethi, Lekshmi Fang, Hsu-Wei Nguyen, Hieu Trung Tsai, Yao-Tung Weng, Pei-Wei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Doctoral Program of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei10608 Taiwan Taipei Medical University Derived Company-Hsuan Chen Technology CO. LTD. New Taipei City22055 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan WELLCARE Health Care Supply Co. Ltd. Taipei Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh city Ho Chi Minh City700000 Viet Nam Department of Orthopaedic Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist. Taipei City11490 Taiwan Division of Traumatology Department of Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist. Taipei City11490 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan

Mitochondria, often referred to as the "powerhouses" of eukaryotic cells, play a critical role in maintaining cellular homeostasis and supporting essential life functions, particularly in cell survival and apoptosis. This study introduces a composite formulation—combining carrageenan (Car), calcium peroxide (CaO2), and microparticles, derived from soybean oil lecithin, enhanced with photothermally active polypyrrole (PPy)—to create Car-Lec-PPy MP, aimed at promoting mitochondrial activation in cells. The investigation focuses on intercellular mitochondrial transfer and activation as a therapeutic strategy. The formulation seeks to stimulate mitochondrial biogenesis and enhance cellular resilience through targeted mitochondrial activation, leveraging the synergistic effects of near-infrared (NIR) therapy. In the in vivo experiment, phototherapeutic Car-Lec-PPy MP was administered to rodent muscle tissue. The results showed increased expression of heat-shock proteins and reduced oxidative stress in the treated muscle. Preliminary findings suggest that this approach not only boosts mitochondrial activity but also improves cell proliferation and survival, presenting significant potential for applications in regenerative medicine and cellular therapy. © 2025 Elsevier B.V.

关键词： Mitochondria

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Development of djenkol peel extract-loaded liposome as functional food ingredients: Physicochemical characteristic, antioxidant activities, and cytotoxicity

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Journal of Agriculture and Food Research 2025年 21卷

作者： Chotphruethipong, Lalita Sinthusamran, Sirima Benjakul, Soottawat Senphan, Theeraphol Nalinanon, Sitthipong Sriket, Chodsana Department of Food Science Faculty of Science Burapha University Mueang Chonburi 20131 Thailand Department of Agricultural Education School of Industrial Education and Technology King Mongkut's Institute of Technology Ladkrabang Bangkok 10520 Thailand International Center of Excellence in Seafood Science and Innovation Faculty of Agro-Industry Prince of Songkla University Hat Yai Songkhla 90110 Thailand Program in Food Science and Technology Faculty of Engineering and Agro-Industry Maejo University Sansai Chiangmai 50290 Thailand School of Food Industry King Mongkut's Institute of Technology Ladkrabang Ladkrabang Bangkok 10520 Thailand Food Innovation and Management Program Department of General Science and Liberal Arts King Mongkut's Institute of Technology Ladkrabang Prince of Chumphon Campus Pathiu Chumphon 86160 Thailand

Djenkol peel is an agricultural by-product containing valuable bioactive compounds. The direct use of its extract faces challenges related to stability and sensory acceptance. This study aimed to investigate the effect of djenkol peel extract (DPE) on the encapsulation efficiency (EE) using liposomes. The physicochemical properties, antioxidant activities, and cytotoxicity of the obtained liposomes were evaluated. DPE (0, 0.25, 0.50, 0.75, and 1.00 %, w/v) was encapsulated using phospholipid/cholesterol as the wall material. The highest EE (66.69 %) was observed in the liposomes loaded with 0.25 % (w/v) DPE (LE-0.25DPE) (P < 0.05). All DPE-loaded liposomes displayed nanometer-scale particle sizes (78.94–135.60 nm) and negative zeta potentials (−52.60 to −57.50 mV). Encapsulation of DPE in liposomes can mask its undesirable color. Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and differential scanning calorimetry (DSC) revealed changes in the physicochemical and thermal properties of LE-0.25DPE. Additionally, LE-0.25DPE showed increased DPPH radical-scavenging activity (DPPH-RSA) and ferric reducing antioxidant power (FRAP) in a dose-dependent manner (250–2000 μg/mL). In vitro Caco-2 cell viability test, LE-0.25DPE at 0.1–1 μg/mL exhibited no cytotoxicity compared to the control (P < 0.05). Thus, DPE-loaded liposomes demonstrate potential as a functional food ingredient with high bioactivity. © 2025 The Authors

关键词： Bioactivity Encapsulation Nanocarriers Plant extract Waste utilization

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Comparative Assessment of Off-shore Wind Converters and Wave Energy Converters in the Philippines 15

Comparative Assessment of Off-shore Wind Converters and Wave...

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15th IEEE international Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment, and Management, HNICEM 2023

作者： Alquiza, Laurence Keith P. Recto, King Harold A. Loresco, Pocholo James M. Villalobos, Jesus Ateneo de Manila University Department of Electronics Computer and Communications Engineering Quezon City Philippines Feu Institute of Technology Department of Electronics Engineering Manila Philippines Institut Catholique d'Arts et Métiers International Program in General Engineering Toulouse France

ISBN: (纸本)9798350381177

The Republic of the Philippines is confronted with rebuilding its energy landscape, which now depends heavily on imported fossil fuels for a substantial supply. The Department of Energy (DOE) has established lofty objectives to enhance the nation's renewable energy (RE) capability;nevertheless, these objectives are still to be achieved. This research supports DOE's goals by studying other possible renewable energy sources. In particular, the primary aim of this research is to examine the viability of Offshore Wind Converters (OWCs) and Wave Energy Converters (WECs) as viable sustainable energy options for the Philippines. Ocean wave converters (OWCs) provide inherent benefits in terms of dependability and have widespread societal acceptance. Conversely, wave energy converters (WECs) harness the vast energy potential contained within ocean waves. A comparative evaluation was undertaken to analyze the differences between these two potential renewable energy sources. The assessment concludes that OWCs possess a minor advantage over WECs regarding their economic viability and higher societal acceptability. It recommended that the government adopts a diversified energy portfolio, which may include the incorporation of WECs to effectively navigate the changing dynamics of the energy sector, enhance sustainability, and ensure the long-term security of the nation's energy supply. © 2023 IEEE.

关键词： Water waves

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Modeling Subsystem for Optimizing Reforming Processes of an Intellectualized Decision Support System 5

Modeling Subsystem for Optimizing Reforming Processes of an ...

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5th international Conference on Information and Computer Technologies, ICICT 2022

作者： Orazbayev, Batyr Zhumadillayeva, Ainur Dyussekeyev, Kanagat Orazbayeva, Kulman Umarov, Timur Kurmangaziyeva, Lyailya Faculty of Information Technologies L.N. Gumilyov Eurasian National University Nur-Sultan Kazakhstan Finance and International Trade Department of Management Kazakh University of Economics Nur-Sultan Kazakhstan Faculty of General Education British Management University Tashkent Uzbekistan Atyrau State University Department of Program Engineering Atyrau Kazakhstan

ISBN: (数字)9781665469609

ISBN: (纸本)9781665469609

The creation of intellectualized decision support systems (IDSS) for managing various, complex and difficult to formalize objects is currently a topical issue of science and practice. In this work, a subsystem for modeling ISSPR is created, which makes it possible to determine the effective operating modes of the catalytic reforming unit reactors. Mathematical models of the investigated reactors are developed on the basis of statistical data and fuzzy information obtained by expert assessment methods. Accordingly, the models for determining the volume of products produced from the output of the reactors are built in the form of statistical models, and for assessing the quality of the target product of the reforming process, i.e., catalyzate, based on expert information in the form of fuzzy models. An IDSS structure has been created to control the operating modes of the investigated reactors, which differs from the known structures of similar systems in that it includes a package of models of the control object and heuristic methods for solving decision-making problems, which make it possible to take into account the fuzziness of the initial information. In addition, the proposed IDSS structure contains a knowledge and data base, identifiers of model parameters, an intellectualized user interface and a block for explaining the selected solutions, which make it possible to increase the efficiency of the system. Describe the functions of the main functional blocks of the created IDSS. © 2022 IEEE.

关键词： Decision support systems

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Large language models for diabetes training:a prospective study

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Science Bulletin 2025年第6期70卷 934-942页

作者： Haoxuan Li Zehua Jiang Zhouyu Guan Yuqian Bao Yuexing Liu Tingting Hu Jiajia Li Ruhan Liu Liang Wu Di Cheng Hongwei Ji Yong Wang Ya-Xing Wang Carol Y.Cheung Yingfeng Zheng Jihong Wang Zhen Li Weibing Wu Cynthia Ciwei Lim Yong Mong Bee Hong Chang Tan Elif I.Ekinci David C.Klonoff Justin B.Echouffo-Tcheugui Nestoras Mathioudakis Leonor Corsino Rafael Simó Charumathi Sabanayagam Gavin Siew Wei Tan Ching-Yu Cheng Tien Yin Wong Huating Li Chun Cai Lijuan Mao Lee-Ling Lim Yih-Chung Tham Bin Sheng Weiping Jia Shanghai University of Sport Shanghai 200438China School of Clinical Medicine Beijing Tsinghua Changgung HospitalTsinghua MedicineTsinghua UniversityBeijing 100084China Beijing Visual Science and Translational Eye Research Institute(BERI) Tsinghua MedicineTsinghua UniversityBeijing 100084China Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Computer Science and EngineeringSchool of ElectronicInformationand Electrical EngineeringShanghai Jiao Tong UniversityDepartment of Endocrinology and MetabolismShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Diabetes InstituteShanghai Clinical Center for DiabetesShanghai 200240China MoE Key Lab of Artificial Intelligence Artificial Intelligence InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Cardiology the Affiliated Hospital of Qingdao UniversityQingdao 266011China CEMS NCMISHCMSMADISAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematics University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100049China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China k.Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060China Department of Renal Medicine Singapore General HospitalSingHealth-Duke Academic Medical CentreSingapore169

Diabetes poses a considerable global health challenge,with varying levels of diabetes knowledge among healthcare professionals,highlighting the importance of diabetes *** Language Models(LLMs)provide new insights into diabetes training,but their performance in diabetes-related queries remains uncertain,especially outside the English language like *** first evaluated the performance of ten LLMs:ChatGPT-3.5,ChatGPT-4.0,Google Bard,LlaMA-7B,LlaMA2-7B,Baidu ERNIE Bot,Ali Tongyi Qianwen,MedGPT,HuatuoGPT,and Chinese LlaMA2-7B on diabetes-related queries,based on the Chinese National Certificate Examination for Primary Diabetes Care in China(NCE-CPDC)and the English Specialty Certificate Examination in Endocrinology and Diabetes of Membership of the Royal College of Physicians of the United ***,we assessed the training of primary care physicians(PCPs)without and with the assistance of ChatGPT-4.0 in the NCE-CPDC examination to ascertain the reliability of LLMs as medical *** found that ChatGPT-4.0 outperformed other LLMs in the English examination,achieving a passing accuracy of 62.50%,which was significantly higher than that of Google Bard,LlaMA-7B,and *** the NCE-CPFC examination,ChatGPT-4.0,Ali Tongyi Qianwen,Baidu ERNIE Bot,Google Bard,MedGPT,and ChatGPT-3.5 successfully passed,whereas LlaMA2-7B,HuatuoGPT,Chinese LLaMA2-7B,and LlaMA-7B ***-4.0(84.82%)surpassed all PCPs and assisted most PCPs in the NCE-CPDC examination(improving by 1%–6.13%).In summary,LLMs demonstrated outstanding competence for diabetes-related questions in both the Chinese and English language,and hold great potential to assist future diabetes training for physicians globally.

关键词： Diabetes Diabetestraining Largelanguagemodels Primarydiabetescare Prospectivestudy

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Comparative Assessment of Off-shore Wind Converters and Wave Energy Converters in the Philippines

Comparative Assessment of Off-shore Wind Converters and Wave...

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international Conference on Humanoid, Nanotechnology, Information Technology, Communication and Control, Environment and Management (HNICEM)

作者： Laurence Keith P. Alquiza King Harold A. Recto Pocholo James M. Loresco Jesús Villalobos Department of Electronics Computer and Communications Engineering Ateneo de Manila University Quezon City Philippines Department of Electronics Engineering FEU Institute of Technology Manila Philippines International Program in General Engineering Institut Catholique d'Arts et Métiers Toulouse France

ISBN: (数字)9798350381177

ISBN: (纸本)9798350381184

The Republic of the Philippines is confronted with rebuilding its energy landscape, which now depends heavily on imported fossil fuels for a substantial supply. The Department of Energy (DOE) has established lofty objectives to enhance the nation's renewable energy (RE) capability; nevertheless, these objectives are still to be achieved. This research supports DOE's goals by studying other possible renewable energy sources. In particular, the primary aim of this research is to examine the viability of Offshore Wind Converters (OWCs) and Wave Energy Converters (WECs) as viable sustainable energy options for the Philippines. Ocean wave converters (OWCs) provide inherent benefits in terms of dependability and have widespread societal acceptance. Conversely, wave energy converters (WECs) harness the vast energy potential contained within ocean waves. A comparative evaluation was undertaken to analyze the differences between these two potential renewable energy sources. The assessment concludes that OWCs possess a minor advantage over WECs regarding their economic viability and higher societal acceptability. It recommended that the government adopts a diversified energy portfolio, which may include the incorporation of WECs to effectively navigate the changing dynamics of the energy sector, enhance sustainability, and ensure the long-term security of the nation's energy supply.

关键词： Renewable energy sources Wind energy Navigation Ocean waves Security Wave energy conversion Sustainable development

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Rapid Escherichia coli Cloned DNA Detection in Serum Using an Electrical Double Layer-Gated Field-Effect Transistor-Based DNA Sensor

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Analytical Chemistry 2023年第17期95卷 6871-6878页

作者： Paulose, Akhil K. Hou, Yueh-Ju Huang, Yu-Shan Chakkalaparambil Dileep, Navyamol Chiu, Chia-Lin Pal, Arnab Kalaimani, Vishal Mani Lin, Zong-Hong Chang, Chuang-Rung Chen, Cheng-Pin Lin, Yi-Chun Cheng, Chien-Yu Cheng, Shu-Hsing Cheng, Chao-Min Wang, Yu-Lin Institute of Nanoengineering and Microsystems National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan Department of Life Sciences National University of Kaohsiung Kaohsiung811726 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu30013 Taiwan Department of Infectious Diseases Taoyuan General Hospital Ministry of Health and Welfare Taoyuan32748 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan

In this study, a rapid diagnosis platform was developed for the detection of Escherichia coli O157:H7. An electrical double layer (EDL)-gated field-effect transistor-based biosensor (BioFET) as a point-of-care testing device is demonstrated with its high sensitivity, portability, high selectivity, quick response, and ease of use. The specially designed ssDNA probe was immobilized on the extended gate electrode to bind the target complementary DNA segment of E. coli, resulting in a sharp drain current change within minutes. The limit of detection for target DNA is validated to a concentration of 1 fM in buffer solution and serum. Meanwhile, the results of a Kelvin probe force microscope were shown to have reduced surface potential of the DNA immobilized sensors before and after the cDNA detection, which is consistent with the decreased drain current of the BioFET. A 1.2 kb E. coli duplex DNA synthesized in plasmid was sonicated and detected in serum samples with the sensor array. Gel electrophoresis was used to confirm the efficiency of sonication by elucidating the length of DNA. Those results show that the EDL-gated BioFET system is a promising platform for rapid identification of pathogens for future clinical needs. © 2023 American Chemical Society

关键词： DNA

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Complexity Analysis based on Parietal Fuzzy Entropy to Facilitate ADHD Diagnosis in Young Children 46

Complexity Analysis based on Parietal Fuzzy Entropy to Facil...

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46th Annual international Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Huang, I-Wen Jheng, Yu-Ci Chen, I-Chun Ko, Li-Wei National Yang Ming Chiao Tung University Institute of Biomedical Engineering Hsinchu300040 Taiwan National Yang Ming Chiao Tung University Institute of Electrical and Control Engineering Hsinchu300040 Taiwan National Yang Ming Chiao Tung University International Program in Interdisciplinary Neuroscience College of Biological Science and Technology Hsinchu300040 Taiwan Ton-Yen General Hospital Department of Physical Medicine and Rehabilitation Hsinchu302048 Taiwan Kaohsiung Medical University Drug Development and Value Creation Research Center Kaohsiung807378 Taiwan

ISBN: (纸本)9798350371499

Attention deficit hyperactivity disorder (ADHD) is the most common condition affecting the development of neurons in children. Therefore, early and accurate diagnosis of ADHD in young children is of paramount importance. In this study, the 8-channel wireless wearable EEG measurement device was employed to record EEG data from 30 children diagnosed with ADHD and 30 typical development (TD) young children aged 4-7 years. The data was collected both during rest and while the children performed a Kiddie Continuous Performance Test (K-CPT). We extract relative power spectral density (PSD) unaffected by factors like skull resistance and thickness. Additionally, a range of complex entropy values based on the time domain were extracted. These included sample entropy (SaEn), permutation entropy (PeEn), singular value decomposition entropy (SvdEn), and fuzzy entropy (FuEn). We compare the performance of k-Nearest Neighbors (kNN), Support Vector Machine (SVM), and XGBoost, and utilized the sequential forward selection (SFS) feature selection method in the wrapper approach. Through this process, the study identified the most effective EEG data segments and feature subsets. The findings indicated that using a combination of resting and K-CPT EEG data yielded greater discriminability. Notably, the study found that extracting beta power from the right occipital lobe along with fuzzy entropy from the parietal lobe resulted in optimal accuracy of 90% in distinguishing between children with ADHD and TD children. These outcomes highlight the potential of relative PSD and complexity metrics to support the clinical diagnosis of early ADHD. Furthermore, these metrics may contain unique neurobiomarkers that could be valuable for devising early intervention strategies. © 2024 IEEE.

关键词： Diseases

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Information technology and the terrorist threat

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Survival 1997年第3期39卷 135-155页

作者： Hoo, Kevin Soo Goodman, Seymour Greenberg, Lawrence [a] A researcher at the Center for International Security and Arms Control (CISAC) Stanford University CA [b] Doctoral candidate in Engineering-Economic Systems [c] Director of the IT and National Security Program CISAC [d] Professor of Management Information Systems University of Arizona Tucson AZ [e] General Counsel for The Motley Fool Inc.

Present conditions do not seem to favor information technology terrorism, but the current trends of increasing societal vulnerability and decreasing technical difficulty might encourage it in the future.

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