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Study on the interaction mechanism of virgin olive oil polyphenols with mucin and α-amylase

Food Bioscience 2022年第3期47卷 728-735页

作者： Gangcheng Wu Ruobing Mao Yiren Zhang Ling Zhu Emad Karrar Hui Zhang Qingzhe Jin Xingguo Wang State Key Laboratory of Food Science and Technology School of Food Science and TechnologyNational Engineering Research Center for Functional FoodInternational Joint Research Laboratory for Lipid Nutrition and SafetyCollaborative Innovation Center of Food Safety and Quality Control in Jiangsu ProvinceJiangnan UniversityChina International Joint Laboratory on Food Safety Jiangnan UniversityChina Department of Chemistry School of Physical ScienceUniversity of LiverpoolUK

The interaction mechanism of mucin and α-amylase with virgin olive oil (VOO) polyphenols (oleuropein (OL),tyrosol (TY),hydroxytyrosol (HT)) was analyzed by fluorescence,ultraviolet (UV) absorption,attenuated total reflection Fourier transform infrared (ATR-FTIR),circular dichroic (CD) spectroscopy and molecular docking.A total of 17 polyphenols have been identified in the selected VOO,and the TY,HT and OL were the main *** quenching mechanism between mucin/α-amylase and three VOO polyphenols was static,mainly through van der Waals forces and hydrogen *** results of UV absorption,ATR-FTIR,and CD spectroscopy revealed that the conformation of mucin changed after combining with the three polyphenols,while that of the α-amylase changed *** docking predicted the interaction sites of the three polyphenols with human salivary mucin and α-*** present study could provide the theoretical foundation for further research on the interaction between human salivary protein and phenolic compounds in VOO.

关键词： Mucin α-amylase Spectroscopy Molecular docking Virgin olive oil polyphenols

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通过共晶工程的选择性外延生长有机异质结构实现光信号定向转换

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Science China Materials 2023年第10期66卷 3968-3976页

作者：吕强王雪东余悦俞燕君郑敏廖良生 Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringResearch Center of Cooperative Innovation for Functional Organic/Polymer Material Micro/NanofabricationSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyTaipa 999078Macao SARChina

分层有机纳米结构(HONs)是一种将具有不同功能的多个成分集成在一个系统中的纳米结构,其在光电子应用中引起了极大的关注.然而,由于不同材料之间结构不相容性的难题,构建具有超低晶格失配率(η)的HONs仍然面临巨大挑战.共晶工程提供了... 详细信息

分层有机纳米结构(HONs)是一种将具有不同功能的多个成分集成在一个系统中的纳米结构,其在光电子应用中引起了极大的关注.然而,由于不同材料之间结构不相容性的难题,构建具有超低晶格失配率(η)的HONs仍然面临巨大挑战.共晶工程提供了探索合理制备HONs的有力手段,但迄今为止尚未得到系统的证明.在这里,我们展示了一种用于HONs的超低晶格失配异质外延的共晶工程策略.该策略具备足够的通用性,可实现多种材料的集成从而得到不同空间取向的异质结构.通过实验合成了一系列典型HONs,包括三嵌段(η_(1)=0.7%)、分支(η_(2)=0.8%)和核/壳(η_(3)=0.6%)纳米结构,其晶格失配率远低于先前报道的HONs(5%-10%).此外,我们选择性地合成了核/壳的子结构,包括三嵌段和三明治状纳米线,揭示了界面能在HONs形成过程中的诱导作用.作为概念验证,制备所得的不同异质结构成功实现了光子信号的定向转换,为构建下一代集成光电器件奠定了坚实的基础.

关键词： organic heterostructures epitaxy lattice mismatch cocrystal integrated photonics

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Enhancing performance of fullerene-based organic electrochemical transistors via side-chain engineering

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Nano research 2025年第2期18卷 905-912页

作者： Wenxin Fang Zijie Li Chengdong Wang Xiaowei Zhao Junyu Li Gang Ye Fengwei Huo Li Qiu Yanxi Zhang Wei Huang Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Yunnan Key Laboratory of Electromagnetic Materials and Devices National Center for International Research on Photoelectric and Energy MaterialsSchool of Materials and EnergyYunnan UniversityKunming 650091China Sinopec Shanghai Research Institute of Petrochemical Technology Shanghai 201028China Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan 430062China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(NanjingTech)Nanjing 211800China Frontiers Science Center for Flexible Electronics MIIT Key Laboratory of Flexible Electronics(KLoFE)Northwestern Polytechnical UniversityXi'an 710072China

The performance of organic electrochemical transistors(OECTs)relies on the interaction between organic semiconductors and ***,hydrophilic ethylene glycol(EG)side chains are incorporated into organic semiconductors to improve the channel’s capacity to absorb ***,the EG substituted organic semiconductors tend to swell when immersed in aqueous electrolytes and exhibit microstructural changes induced by dopant *** our research,we introduce an alkyl spacer to create distance between the fullerene and EG *** approach is designed to reduce the negative effects of swelling and balance the ion and electron *** conducted an analysis of OECTs using four fullerene derivatives:no alkyl spacer,butyl,hexyl,and octyl *** OECTs based on fullerene derivatives with butyl and hexyl spacers exhibit enhanced transconductance(g_(m)=11.8 and 19.4 mS)compared to the ones without alkyl *** has also been observed that the butyl and hexyl spacers lead to a more than tenfold increase in volumetric *** increasing the alkyl spacer(octyl group)leads to no transistor *** study uncovers the relationship between alkyl spacers and the performance of OECTs based on fullerene *** will serve as a guideline for designing n-type small molecules for ***,we showcased the potential of utilizing OECTs based on these fullerene derivatives in cation sensing,which is promising for developing sweat sensors.

关键词： organic electrochemical transistors fullerene derivatives ethylene glycol side chains ion and electron conduction

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Fabrication of Monolithic Omniphobic Pvdf Membranes Based on Particle Stacking Structure for Robust and Efficient Membrane Distillation

SSRN

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SSRN 2024年

作者： Ma, Zhong Chen, Xiaorong Mao, Hengyang Zhang, Dongqiang Zhou, Shouyong Li, Meisheng Zhao, Yijiang Peng, Wenbo Xin, John H. Jiangsu Engineering Research Center of Environmental Functional Materials Jiangsu Regional Collaborative Innovation Center of Modern Agriculture and Environmental Protection School of Chemistry and Chemical Engineering Huaiyin Normal University Jiangsu Huaian223300 China College of Petrochemical Technology Lanzhou University of Technology Lanzhou730050 China Jiangsu Jiuwu Hi-tech Co. Ltd No.9 Huqiao East Road Jiangsu Nanjing211808 China School of Fashion and Textiles The Hong Kong Polytechnic University 999077 Hong Kong

Robust omniphobic membranes have attracted great attention in improving the continuous service performance of the membrane distillation (MD) in treating high salinity wastewater. However, the fabrication of omniphobic membranes commonly undergoes complex procedures of modification including the construction of rough structures and post-modification using low-surface-energy substances. Herein, monolithic omniphobic polyvinylidene fluoride (PVDF) membranes were conveniently constructed by the combination of porous membranes with particle stacking structure generated by a one-step vapor-induced phase separation (VIPS) procedure and subsequent surface perfluorination modification. The water contact angle of the membrane after perfluorinated modification increased from 139.6° of the original membrane to 153°, and its soybean oil contact angle increased from 45° of the original membrane to 141°. In addition, the LEP of the perfluorinated membrane is as high as 0.32 MPa, which is higher than the 0.22 MPa of the original membrane. More importantly, the monolithic omniphobic membrane can maintain a stable water flux without deteriorating salt rejection rate during the entire MD testing due to its high specific surface area, high porosity, three-dimensional micro/nano hierarchical structure, and adjustable pore size. This study offers useful insights for constructing monolithic omniphobic membranes for efficient and robust MD processes without additional nanoparticle loading procedure. © 2024, The Authors. All rights reserved.

关键词： Wetting

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Base-controlled annulation of tryptamine-derived isocyanides with nitrile imines for access to polycyclic spiroindoline derivatives

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Green Synthesis and Catalysis 2023年第2期4卷 181-185页

作者： Xiaofeng Wang Luorong Yuan Xiaoping Xu Shunjun Ji Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials Science&Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215123China Innovation Center for Chemical Science Soochow UniversitySuzhou 215144China Suzhou Baolidi Functional Materials Research Institute Suzhou 215144China

An annulation reaction of tryptamine-derived isocyanides with hydrazonyl chlorides in the presence of bases was *** by different bases,[1+2+3]annulation and[1+2+3]/[2+3]annulation cascade were *** the latter reaction,five new chemical bonds as well as three new heterocycles were formed in one *** showed extremely high efficiency,relatively broad substrate scope,milder reaction conditions,good tolerance of functional groups and good chemoselectivity.

关键词： 3-(2-Isocyanoethyl)indoles Nitrile imines Tetracyclic spiroindolines Pentacyclic bispiroindolines Chemoselective cycloaddition

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Enhanced ethanol oxidation over Pd nanoparticles supported porous graphene-doped MXene using polystyrene particles as sacrificial templates

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Rare Metals 2022年第9期41卷 3170-3179页

作者： Yi-Zhe Chen Ming Zhou Yu-Fu Huang Yan-Yun Ma Luo-Yi Yan Xin-Wen Zhou Xin-Zhou Ma Xue-Ling Zhao Cheng Chen Juan Bai Dong-Hai Lin Shanghai Engineering Research Center of Advanced Thermal Functional Materials Shanghai Key Laboratory of Engineering Materials Application and EvaluationSchool of Energy and MaterialsShanghai Polytechnic UniversityShanghai201209China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China College of Biological and Pharmaceutical Sciences China Three Gorges UniversityYichang443002China School of Materials Science and Hydrogen Energy Foshan UniversityFoshan528000China School of Chemistry and Physics Queensland University of TechnologyBrisbaneQLD4000Australia

Fabrication of superior catalytic performance palladium-based catalysts with affordable cost is the key to develop direct ethanol fuel ***,Pd-decorated three-dimensional(3D)porous constructed from graphene oxide(GO)and MXene combining with polystyrene(PS)particles as sacrificial templates(Pd/GO-MXene-PS)to elevate the catalytic performance for ethanol oxidation was *** 3D porous interconnected structure of Pd/GO-MXene-PS was characterized by scanning electron microscope(SEM),transmission electron microscope(TEM)and Brunner−Emmet−Teller(BET).By optimizing the doping ratio of MXene to GO,the mass activity of Pd/GO_(5)-MXene_(5)-PS(2944.0 mA·mg^(−1))was 3.0 times higher than that of commercial Pd/C(950.4 mA·mg^(−1))toward ethanol oxidation in base ***,the rotating disk electrode(RDE)results demonstrated that Pd/GO5-MXene5-PS had a faster kinetics of ethanol *** enhanced ethanol oxidation over Pd/GO5-MXene5-PS could attribute to the excellent 3D interconnected porous structure,large surface area,good conductivity and homogeneous Pd *** work provided a new idea for creating 3D porous MXene composite materials in electrocatalysis.

关键词： Pd nanoparticles Ethanol oxidation Graphene MXene Polystyrene(PS)template Rotating disk electrode(RDE)

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Polycarcin V induces DNA-damage response and enables the profiling of DNA-binding proteins

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National Science Review 2022年第11期9卷 19-28页

作者： Zongwei Yue Fan Wu Fusheng Guo Jiyeong Park Jin Wang Liyun Zhang Daohong Liao Wenyang Li Orlando D.Sch?rer Xiaoguang Lei Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular Engineering Synthetic and Functional Biomolecules CenterPeking University Peking-Tsinghua Center for Life Science Academy for Advanced Interdisciplinary Studies Peking University Center for Genomic Integrity Institute for Basic Science Jiangsu JITRI Molecular Engineering Inst.Co. Ltd. Department of Biological Sciences School of Life Sciences Ulsan National Institute of Science and Technology Institute for Cancer Research Shenzhen Bay Laboratory

To maintain genomic integrity and avoid diseases, the DNA-damage response(DDR) not only detects and repairs DNA lesions, but also contributes to the resistance to DNA-damaging *** the DDR plays a significant role in drug discovery using the principle of synthetic lethality. The incomplete current knowledge of the DDR encouraged us to develop new strategies to identify and study its components and pathways. Polycarcin V, belonging to the C-aryl glycoside natural products, is a light-activatable DNA-intercalating agent that causes DNA damage by forming a covalent [2+2]cycloadduct with thymine residue under 365–450 nm of light irradiation in a DNA-sequence-independent manner. Taking advantage of the light-activatable feature and temporal control of DDR, we designed and synthesized polycarcin V-based bifunctional chemical probes, including one that cross-links DNA to DNA-binding protein to explore the DDR induced by polycarcin V and uncover novel DNA–protein interactions. Utilizing this chemical probe and activity-based protein profiling-stable isotope labeling with amino acids in cell culture, we identified 311 DNA-binding protein candidates, including known DDR factors and additional proteins that may be of interest in discovering new biology. We validated our approach by showing that our probe could specifically cross-link proteins involved in nucleotide excision repair(NER) that repair bulky DNA adducts. Our studies showed that the [2+2] cycloadduct formed by polycarcin V could indeed be repaired by NER in vivo. As a DNA-damaging agent, polycarcin V or its drug-like derivative plus blue light showed promising properties for psoriasis treatment, suggesting that it may itself hold promise for clinic applications.

关键词： polycarcin V [2+2] DNA photoadduct light-activatable chemical probe ABPP for DNA-binding protein proteomics psoriasis treatment

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Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis

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Food Science and Human Wellness 2024年第4期13卷 1845-1855页

作者： Jiang Cao Leilei Yu Jianxin Zhao Hao Zhang Wei Chen Yuzheng Xue Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China Department of Gastroenterology Affiliated Hospital of Jiangnan UniversityWuxi 214122China

The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different ***,6 *** strains were tested in the present study using an irritable bowel syndrome(IBS)animal model to determine whether the IBS-alleviating effects of *** strains are *** results of this study showed that the ingestion of *** GBI-30,6086,and *** CCFM1041 significantly alleviated IBS symptoms in *** contrast,other *** strains showed no or limited alleviating effects on IBS *** to our experimental results,the two main common features of these strains were as follows:1)The resistance of vegetative cells to bile salts,and 2)ability to synthesize specific lipids and secondary *** strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional *** *** results also suggest that administration of *** could significantly regulate microbiota dysbiosis in animal ***,the close relationships between the gut microbiota,gut microbiota metabolites,and IBS were further confirmed in this study.

关键词： Baciillus coagulans Irritable bowel syndrome Resistance to bile salts Comparative genomic analysis Gut microbiota

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Cross-linked hole transport layers for high-efficiency perovskite tandem solar cells

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Science China Chemistry 2021年第11期64卷 2025-2034页

作者： Yurui Wang Shuai Gu Guoliang Liu Liping Zhang Zhou Liu Renxing Lin Ke Xiao Xin Luo Jianhua Shi Junling Du Fanying Meng Ludong Li Zhengxin Liu Hairen Tan National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing210093China Research Center for New Energy Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai201800China

Perovskite tandem solar cells have recently received extensive attention due to their promise of achieving power conversion efficiency(PCE)beyond the limits of single-junction ***,their performance is still largely constrained by the widebandgap perovskite solar cells which show considerable open-circuit voltage(VOC)***,we increase the VOCand PCE of wide-bandgap perovskite solar cells by changing the hole transport layer(HTL)from commonly used poly(bis(4-phenyl)(2,4,6-trimethylphenyl)amine)(PTAA)to in-situ cross-linked small molecule N_(4),N_(4)′-di(naphthalen-1-yl)-N_(4),N_(4)′-bis(4-vinylphenyl)biphenyl-4,4′-diamine(VNPB).The stronger interaction and lower trap density at the VNPB/perovskite interface improve the PCE and stability of wide-bandgap perovskite solar *** using the cross-linked HTL for front wide-bandgap subcells,PCEs of 24.9%and 25.4%have been achieved in perovskite/perovskite and perovskite/silicon tandem solar cells,*** results demonstrate that cross-linkable small molecules are promising for high-efficiency and cost-effective perovskite tandem photovoltaic devices.

关键词： perovskite solar cells tandem solar cells hole transport layer cross-linked

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Modulation of gut health using probiotics:the role of probiotic effector molecules

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Journal of Future Foods 2022年第1期2卷 1-12页

作者： Xiaoxiang Gao Jianxin Zhao Hao Zhang Wei Chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214122China

Probiotics affect intestinal metabolism and play a crucial role in gut *** on probiotic effector molecules—bacteriocins,peptidoglycan,teichoic acid,exopolysaccharides,secretory proteins,and short-chain fatty acids—describe their effect on the gut barrier;immune and nervous system;and gut ***,the detailed mechanism of how the intestinal microbiota changes after the intervention of effector molecules remains *** recently,owing to a rare systematic review about the function of effector molecules in the intestinal tract,it has become vital to discover the molecular model of action of how the gut environment is affected by ***,we review the characteristics of effector molecules from probiotics and the advances in understanding the interactive patterns between effector molecules and the gut microenvironment.

关键词： Effector Molecules Probiotics Gut regulation Microbiota

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