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Bridging from the Sequence to Architecture: Graft Copolymers Engineering via Successive Latent Monomer and Grafting-from Strategies

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Chinese Journal of Chemistry 2021年第5期39卷 1273-1280页

作者： Yajie Zhang Xiaohuan Cao Yang Gao Yujie Xie Zhihao Huang Zhengbiao Zhang Xiulin Zhu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China State Key Laboratory of Radiation Medicine and Protection Soochow UniversitySuzhouJiangsu 215123China Global Institute bf Software Technology No.5 Qingshan RoadSuzhou National Hi-Tech DistrictSuzhouJiangsu 215163China

The on-demand building copolymer structures,from sequence to architecture,is crucial in understanding the relation between pol-ymer structure and property,meanwhile motivating the innovation of polymer ***,the challenge is conspicuous for,complicated polymer structures from inherently intricate *** this work,copolymers with tailored grafting density and distributions were achieved using successive latent monomer and grafting-from *** hydroxyl group functionalized fu-ran/maleimide adduct(FMOH)was selected as the latent monomer for RAFT polymerization of an array of copolymers with tailored localization of hydroxyl group along the main *** hydroxyI group further initiated the ring opening polymerization(ROP)of L-lactide or ε-caprolactone,resulting in a library of multicomponent copolymers via grafting-from *** initiating efficiency reached to-100% with variable molecular weight(21300-58600 Da)and narrow distributions(Ð_(M)<1.25),indicating that such graft copolymers possessed controlled density and distribution of side chains as its linear *** investigation on thermal properties of the well-defined graft copolymers implied that the precise tailoring over copolymer structures at the molecule level could lead to tunable chemical/physical *** work bridged polymer from sequence to architecture,unveiled a new meth-od in creating graft copolymers with programmable structures and provided the insight into the structure/property relationship.

关键词： Sequence determination polymers Latent Monomer polymerization Maleimide

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CD38-Directed Vincristine Nanotherapy for Acute Lymphoblastic Leukemia (vol 23, pg 377, 2022)

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BIOMACROMOLECULES 2022年第7期23卷 3041-3041页

作者： Zhang, Yifan An, Jingnan Shao, Yu Yu, Na Yue, Shujing Sun, Huanli Zhang, Jubin Gu, Wenxing Xia, Yifeng Zhang, Jinping Xu, Yang Zhong, Zhiyuan Biomedical Polymers Laboratory Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application College of Chemistry Chemical Engineering and Materials Science and State Key Laboratory of Radiation Medicine and Protection Soochow University Suzhou 215123 P. R. China Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Collaborative Innovation Center of Hematology Soochow University Suzhou 215123 P. R. China Institutes of Biology and Medical Sciences Soochow University Suzhou 215123 P. R. China

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Although intensive chemotherapy greatly improved the survival rate, it is often accompanied by severe and lifelong side effects as a result of weak ALL selectivity. The intensive and poorly selective chemotherapy is also detrimental to patients’ immune system. There is an urgent need to develop more selective and less toxic chemotherapy for ALL. Here, we report daratumumab-polymersome-vincristine (DP-VCR) as a CD38-directed nanotherapy for ALL. DP-VCR showed selective uptake in CD38-positive 697 and Nalm-6-Luc ALL cells and potent anti-ALL activity with an IC50 as low as 0.06 nM VCR, which was 13.7-fold more potent than free VCR. In contrast, no toxicity to human peripheral blood mononuclear cells was detected for DP-VCR even at 108.3 nM VCR. The apoptotic assays confirmed a high selectivity of DP-VCR to CD38-positive ALL cells. DP-VCR exhibited superior treatment of both 697 and Nalm-6-Luc orthotopic ALL models to all controls, as revealed by significant survival benefit and marked reduction of leukemia burden in bone marrow, blood, spleen, and liver. Importantly, DP-VCR induced few side effects. DP-VCR emerges as a safe and potent nanotherapy for CD38-positive ALL.

关键词： Anatomy Cell uptake Rodent models Apoptosis Chemotherapy

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Phase Behaviors of Multi-tailed B_(2)AB_(2)-Type Regio-isomeric Giant Surfactants at the Columnar-Spherical Boundary

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Chinese Journal of Chemistry 2021年第12期39卷 3261-3268页

作者： Yu Shao Di Han Xiaojin Yan Bo Hou Yiwen Li Jinlin He Qiang Fu Wen-Bin Zhang Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry&Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China College of Polymer Science&Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduSichuan 610065China College of Chemistry Chemical Engineering and Materials ScienceState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsJiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisSoochow UniversitySuzhouJiangsu 215123China

We report herein the precision synthesis and phase behaviors of multi-tailed B_(2)AB_(2)-type regio-isomeric giant surfactants consisting of a hydrophilic polyhedral oligomeric silsesquioxane(POSS)head tethered with four hydrophobic polystyrene(PS)*** synthesis was accomplished through two sequential"click"reactions to give a series of regio-isomeric giant surfactants S2DS2(where S is short for PS tails and D for hydroxyl-functionalized POSS)in para-,meta-,and *** phase structures and phase be-haviors at the columnar-spherical boundary were investigated with a single PS tail molecular weight of 1.4 ***,the para-and meta-isomers show hexagonally packed cylinders phases with slightly different order-disorder transition temperatures(~120℃ and~130℃)and the ortho-isomer exhibits an order-order transition from a kinetically favored,metastable dodecagonal quasi-crystal phase to a thermodynamically stable sigma phase at~120℃,as well as a further transition into the disordered state at~140℃.The phase diagram was constructed and their differences were rationalized based on the calculated interfacial area per *** work demonstrates that tiny structural disparity could not only lead to unconventional phase formation in single-component macro-molecules,but also render dynamic and rich phase behaviors in these macromolecular assemblies.

关键词： Isomers Self-assembly Giant surfactants Phase transitions Frank-Kasper phase

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Agarose hydrogel doped with soluble Se-chitosan for Se-enriched cultivation of sprouts

Advanced Agrochem

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advanced Agrochem 2023年第4期2卷 356-363页

作者： Yun Wang Wei Yang Jian Zhu Qifei Chen Na Li Suzhou Key Laboratory of Green Chemical Engineering School of Chemical and Environmental EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China Faculty of Food Science and Technology Suzhou Polytechnic Institute of AgricultureSuzhou215008China Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationDepartment of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China China Shenhua Coal to Liquid and Chemical Co.Ltd. Beijing100011China

Se-chitosan with a high Se content of 139 mg/g was successfully synthesized using the glacial acetic acid-sodium selenite(HAc-Na2SeO3)*** chemical structure of Se-chitosan was characterized by FTIR,XRD,TGA,UV–vis and 13C NMR,confirming that selenite acid was introduced into chitosan via the esterification reaction of the hydroxyl group at C6 and the electrostatic interaction of the amino group at C2 of *** hydrogels were designed as an efficient carrier of Se-chitosan for Se-enriched cultivation of *** hydrogels exhibited a porous structure,which is beneficial for Se diffusion in *** growth indexes of sprouts grown in Agar/Se-chitosan composite hydrogels with different Se concentrations,including plant weight,plant height and Se content,were *** results showed that in the Se-enriched cultivation of sprouts,Se-chitosan possessed an excellent Se enrichment *** the Se concentration in Agar/Se-chitosan composite hydrogels increases from 0 to 1600μg/L,the Se content of the sprouts will also increase from 0.92 mg/kg to 6.79 mg/kg ***,it is necessary to control the amount of Se-chitosan added to the hydrogels;otherwise,the growth of sprouts will be *** research provided a simple and effective method for the fabrication of Secontaining hydrogels for Se-enriched cultivation of sprouts.

关键词： Hydrogel Se-chitosan Agarose hydrogel Sprouts Se enrichment

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Polyphosphoester-modified Cellulose Nanocrystals for Stabilizing Pickering Emulsion polymerization of Styrene

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Chinese Journal of polymer Science 2020年第9期38卷 921-931,I0005页

作者： Kun-Ming Che Ming-Zu Zhang Jin-Lin He Pei-Hong Ni College of Chemistry Chemical Engineering and Materials ScienceState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsJiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisSoochow UniversitySuzhou 215123China

The structure and properties of functional nanoparticles are important for stabilizing Pickering emulsion ***,cellulose nanocrystals(CNCs)are increasingly favored as a bio-based stabilizer for Pickering *** this study,we reported a novel functionalized polyphosphoester-grafted CNCs for the stabilization of oil-in-water Pickering emulsions and the emulsion polymerization of ***,polyphosphoester containing an amino group at one end of the chain,abbreviated as PBYP-NH2,was prepared by ring-opening polymerization(ROP)and hydrolysis reaction,wherein PBYP represents poly[2-(but-3-yn-1-yloxy)-2-oxo-1,3,2-dioxaphospholane].Subsequently,CNC-COOH was obtained via 2,2,6,6-tetramethylpiperidine-1-oxyl(TEMPO)oxidation of *** functionalized nanocrystals CNC-PBYP-COOH with carboxyl groups and polyphosphoester on the surface were obtained by the amidation reaction of PBYP-NH2 with ***,we used CNC-PBYP-COOH as sole particle emulsifiers to stabilize styrene-in-water Pickering emulsions and studied its effects on the emulsions in details by using dynamic light scattering(DLS).The results indicated that the properties of these emulsions depended on the concentration of hydrophobically modified CNCs,volume ratios of oil to water,and pH *** modified CNCs had higher ability to stabilize the styrene-in-water emulsions relative to the unmodified CNCs,and a stable oil-in-water(o/w)Pickering emulsion with diameter of hundreds of nanometers could be *** resulting emulsions could be polymerized to yield nanosized *** polyphosphoester-modified CNCs as green particle emulsifiers can efficiently stabilize nanoemulsions and latexes,which would promote the development of novel environmentally friendly materials.

关键词： Cellulose nanocrystals(CNCs) Polyphosphoesters(PPEs) Pickering emulsion Emulsion polymerization

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A Nanomedicine Composed of polymer-ss-DOX and polymer-Ce6 Prodrugs with Monoclonal Antibody Targeting Effect for Anti-Tumor Chemo-Photodynamic Synergetic Therapy

SSRN

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SSRN 2023年

作者： Yu, Liang Zhang, Mingzu He, Jinlin Sun, Xingwei Ni, Peihong College of Chemistry Chemical Engineering and Materials Science State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis Soochow University Suzhou215123 China Soochow University China

Anticancer drugs used for systemic chemotherapy often exhibit off-target toxicity and uncontrolled drug release due to their lack of targeting. To improve the bioavailability of drugs and reduce side effects, we have developed a mixed micelle of nanomedicine composed of two prodrugs with surface modified monoclonal antibody for cancer therapy. In this system, Nimotuzumab was used as targeting ligands of the mixed micelles (named as DCMMs) that is composed of polymer-doxorubicin prodrug (abbreviated as PEG-b-P(GMA-ss-DOX)) and maleimide polyethylene glycol-chlorin e6 (abbreviated as Mal-PEG-Ce6). The mixed micelles modified with Nimotuzumab (named as NTZ-DCMMs) bind to overexpressed EGFR receptors on Hepatoma-22 (H22) cells. Disulfide bonds in PEG-b-P(GMA-ss-DOX) are disrupted in tumor microenvironment, inducing the reduction-responsive release of DOX and leading to tumor cell apoptosis. Simultaneously, Chlorin e6 (Ce6) produced plenty singlet oxygen (1O2) under laser irradiation to kill tumor cells. In vivo biological distribution and antineoplastic effect experiments demonstrate that NTZ-DCMMs enhanced drug enrichment at tumor sites through targeting function of antibody, dramatically suppressing tumor growth and mitigating cardiotoxicity of drugs. All results prove that NTZ-DCMMs have the ability to actively target H22 cells and quickly respond to tumor microenvironment, which is expected to become an intelligent and multifunctional drug delivery carrier for efficient chemotherapy and photodynamic therapy of hepatoma. © 2023, The Authors. All rights reserved.

关键词： Monoclonal antibodies

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A Novel design of Inorganic-polymer Gel Electrolyte/Anode Interphase in Quasi-Solid-State Lithium-Ion Batteries

SSRN

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SSRN 2023年

作者： Zhu, Yanan Liu, Caiyuan Yang, Yonggang Li, Yi Wu, Qi-Hui Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou215123 China College of Marine Equipment and Mechanical Engineering Xiamen Key Lab of Marine Corrosion and Smart Protective Materials Jimei University Xiamen361021 China

The aim of this work is to improve the electrochemical performance of lithium-ion batteries by developing an inorganic-polymer gel electrolyte and anode electrode, which both use helical mesoporous silica nanofibers (HMSFs) as the skeletons. Based on this design, the electrolyte/anode interphase is naturally integrated, which consequently show excellent properties in electrochemical measurements. The HMSFs were synthesized by calcinating a resin/silica/gel composite using a supramolecular templating method, and then incorporated into P(VDF-HFP) matrix to form the electrolyte membranes (named as NPCGE), which exhibited high thermal stability (up to 372 °C), wide electrochemical window (5.30 V), and high room temperature ionic conductivity (1.2×10-3 S cm-1). Meanwhile, helical mesoporous silica/Fe-N-doped carbon composite nanofibers (HMSFs@Fe-N-C) was fabricated by carbonizing Fe3+-adsorbed resin/silica/gel composites and then acted as the anode material in lithium-ion batteries (LIBs). The assembled HMSFs@Fe-N-C|NPCGE|Li cell showed a high specific capacity around 1290 mAh g-1 over 500 cycles at a current density of 0.3 A g-1 and excellent rate performance, which was not only ascribed to the special composition and nanostructure of the electrolyte and electrode materials, but also to the benign interfacial contacts. © 2023, The Authors. All rights reserved.

关键词： Anodes

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Ionic Liquid/Poly(ionic liquid)-based Semi-solid State Electrolytes for Lithium-ion Batteries

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Chinese Journal of polymer Science 2020年第5期38卷 506-513,I0006页

作者： Deng-Zhou Zhang Yong-Yuan Ren Yin Hu Liang Li Feng Yan Hubei Key Laboratory of Plasma Chemistry and Advanced Materials College of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Ionic liquids(ILs)have appeared as the most promising electrolytes for lithium-ion batteries,owing to their unique high ionic conductivity,chemical stability and thermal stability ***(ionic liquid)s(PILs)with both IL-like characteristic and polymer structure are emerging as an alternative of traditional *** this review,recent progresses on the applications of IL/PIL-based semi-solid state electrolytes,including gel electrolytes,ionic plastic crystal electrolytes,hybrid electrolytes and single-ion conducting electrolytes for lithium-ion batteries are discussed.

关键词： Ionic liquids Poly(ionic liquid)s Semi-solid state electrolytes Lithium-ion batteries

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applications of organic solar cells in wearable electronics

Wearable Electronics

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Wearable Electronics 2024年 1卷 26-40页

作者： Juanyong Wan Ruopeng Zhang Yaowen Li Yongfang Li Laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductor-Optoelectronics Materials and Devices College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow University Suzhou 215123 China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Recently, wearable electronic devices have been drawing considerable interest because of their versatility in a wide range of applications, including motion detection, smart clothing, and health surveillance. Maintaining an adequate power supply is a critical factor in ensuring the continuous operation of wearable electronics. Organic solar cells (OSCs), with advantages that include high flexibility, portability, and low-cost solution-based processing, have achieved power conversion efficiencies of more than 19% and can thus serve as self-powered sources for sustainably powered wearable electronics. In this review, we outline the use of OSCs in wearable electronics, encompassing recent progress in the development of flexible OSCs, semitransparent OSCs, and scalable manufacturing techniques for OSCs. Additionally, we propose challenges for the development of specific OSCs to power wearable electronics.

关键词： Organic solar cells Wearable electronics Flexible transparent electrodes Scalable fabrication techniques

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Thermodynamics of Aromatic Cyclic Ester polymerization in Bulk

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Chinese Journal of polymer Science 2019年第1期37卷 89-93页

作者： Chong He Xiang Zhu Xiao-Hong Li Xiao-Ming Yang Ying-Feng Tu Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application College of Chemistry Chemical Engineering and Materials ScienceSoochow University

We present here the thermodynamic investigation of in situ cascade polycondensation-coupling ring-opening polymerization(PROP)for three cyclic aromatic ester monomers,i.e.,cyclic oligo(2-methyl-1,3-propylene terephthalate)s(COMPTs),cyclic oligo(neopentylene terephthalate)s(CONTs)and cyclic oligo(2-methyl-2-propyl-1,3-propylene terephthalate)s(COMPPTs).The equibrium monomer to polymer weight ratio in bulk at different polymerization temperatures for each monomer was estimated by the size exclusion chromatography(SEC),and the thermodynamic parameters were estimated by Dainton *** different from the thermodynamics of aliphatic lactones polymerization,which is an exothermic process with entropy reduction,our results showed the polymerization thermodynamics for three cyclic aromatic ester monomers was a weak exothermic process with slight entropy increment,i.e.,a both enthalpy and entropy driving *** them,CONTs showed the largest value of enthalpy change,due to its symmetric dimethyl substitution onβ-position of propandiol segments.

关键词： Lactone Polyester Polycondensation-coupling ring-opening polymerization Thermodynamic parameters

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