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The overexpression of Rps14 in Lgr5+progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea

Engineered Regeneration 2023年第3期4卷 328-336页

作者： Jingru Ai Pei Jiang Jingyuan Huang Hairong Xiao Yanqin Lin Mingchen Dai Yintao Wang Yuan Zhang Mengyao Tian Renjie Chai Shasha Zhang State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Department of Otolaryngology Head and Neck Surgery Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsu Provincial Key Medical Discipline(Laboratory)NanjingChina Research Institute of Otolaryngology NanjingChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduChina Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijingChina Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijing 100069China

Sensory hair cells(HCs)in the cochlea cannot regenerate spontaneously in adult mammals after being damaged by external or genetic ***,several genes and signaling pathways are reported to induce cochlear HC regeneration at the early neonatal ***14 encodes a ribosomal protein that is involved in the regulation of cell differentiation and proliferation in ***,its roles in the cochlea have not been reported in ***,we specifically overexpressed Rps14 in Lgr5+progenitor cells in the newborn mouse cochlea and found that Rps14 conditional overexpression(cOE)mice had significantly increased the ectopic HCs,including inner and outer *** further explored the source of these ectopic HCs and found no EdU+supporting cells observed in the Rps14 cOE *** lineage tracing results,on the other hand,revealed that Rps14 cOE mice had significantly more tdTomato+HCs in their cochleae than control *** results indicated that regenerated HCs by cOE of Rps14 are most likely derived from inducing the direct trans-differentiation of Lgr5+progenitor cells into ***,real-time qPCR results suggested that the transcription factor genes Atoh1 and Gfi1,which are important in regulating HC differentiation,were upregulated in the cochlear basilar membrane of Rps14 cOE *** summary,this study provides in vivo evidence that,in the postnatal mouse cochlea,Rps14 is a potential gene that can promote the spontaneous trans-differentiation of Lgr5+progenitor cells into *** gene may one day be exploited as a therapeutic target for treating hearing loss.

关键词： Rps14 Lgr5+progenitor cells Ectopic hair cells Regeneration Proliferation Trans-differentiation

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Preparation,characterization,and tribological properties of silicananoparticle-reinforced B–N-co-doped reduced graphene oxide as a multifunctional additive for enhanced lubrication

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Friction 2021年第2期9卷 239-249页

作者： Sang XIONG Baosen ZHANG Shuai LUO Hao WU Zhen ZHANG College of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing 211167China School of Materials Science and Engineering Shanghai UniversityShanghai 200000China

Microwave-synthesized SiO_(2)-reinforced B–N-co-doped reduced graphene oxide(SiO_(2)–B–N–GO)nanocomposites were characterized by X-ray photon spectroscopy(XPS),X-ray diffraction(XRD),infrared(IR)spectroscopy,and transmission electron microscopy/energy dispersive X-ray(TEM/EDX)*** tribological properties of the SiO2–B–N–GO prepared as anti-wear additives for enhanced lubrication were studied using a four-ball *** experiment results indicated that SiO_(2)–B–N–GO exhibits excellent load-carrying,anti-wear,and anti-friction properties in a base oil,especially at the optimal concentration of additives at 0.15 wt%.The wear scar diameter decreased from 0.70 to 0.37 mm and the coefficient of friction was reduced from 0.092 to 0.070,which reductions are attributed to the formation of B–N and graphene layer tribofilms of several tens of nanometers in thickness that prevented direct contact between metals.

关键词： SiO2-B-N-GO nanocomposites material characterization tribological properties

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Porous-structure engineered spacer for high-throughput and rapidgrowth of high-quality graphene films

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Nano Research 2022年第11期15卷 9741-9746页

作者： Ziteng Ma Heng Chen Xiaofeng Song Buhang Chen Qin Li Yanglizhi Li Haiyang Liu Kaicheng Jia Shenghong Huang Luzhao Sun Zhongfan Liu Center for Nanochemistry Beijing Science and Engineering Center for NanocarbonsBeijing National Laboratory for Molecular SciencesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing Graphene Institute Beijing 100095China College of Materials Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China College of Energy Soochow Institute for Energy and Materials InnovationS(SIEMIS)Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China

Chemical vapor deposition(CVD)in conjunction with batch-to-batch manufacturing process is considered as the most promising technical route for mass-production of high-quality graphene *** improve the space utilization of the CVD chamber and increase the throughput per batch,stacking of the Cu foil substrates is efficient,but suffers from the problems of adjacent fusion and the poor ***,we demonstrate an efficient strategy for high-throughput and rapid growth of high-quality graphene by alternate stacking of Cu foils and porous carbon fiber paper(CFP).Relying on the unhindered mass-transfer through the pores of CFPs,full-covered high-quality graphene films on compact-stacked Cu foils were achieved within 2 *** fluid dynamics(CFD)simulation and isotope labeling technique were performed to explore the gas diffusion and graphene growth process in the confined space of the Cu-CFP *** work provides a feasible method for industrial production of graphene films,which may also be used for batch production of other two-dimensional materials.

关键词： graphene chemical vapor deposition fast growth high-throughput batch-to-batch production

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Observation of Topological Transition in Floquet Non-Hermitian Skin Effects in Silicon Photonics

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Physical Review Letters 2024年第7期133卷 073803-073803页

作者： Zhiyuan Lin Wange Song Li-Wei Wang Haoran Xin Jiacheng Sun Shengjie Wu Chunyu Huang Shining Zhu Jian-Hua Jiang Tao Li National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and Manipulations Jiangsu Key Laboratory of Artificial Functional Materials School of Physics College of Engineering and Applied Sciences School of Physical Science and Technology & Collaborative Innovation Center of Suzhou Nano Science and Technology School of Biomedical Engineering Suzhou Institute for Advanced Research School of Physics

Non-Hermitian physics has greatly enriched our understanding of nonequilibrium phenomena and uncovered novel effects such as the non-Hermitian skin effect (NHSE) that has profoundly revolutionized the field. NHSE has been predicted in systems with nonreciprocal couplings which, however, are challenging to realize in experiments. Without nonreciprocal couplings, the NHSE can also emerge in systems with coexisting gauge fields and loss or gain (e.g., in Floquet non-Hermitian systems). However, such Floquet NHSE remains largely unexplored in experiments. Here, we realize the Floquet NHSEs in periodically modulated optical waveguides integrated on a silicon photonic platform. By engineering the artificial gauge fields induced by the periodical modulation, we observe various Floquet NHSE phases and unveil their rich topological transitions. Remarkably, we discover the transitions between the unipolar NHSE phases and an unconventional bipolar NHSE phase, which is accompanied by the directional reversal of the NHSEs. The underlying physics is revealed by the band winding in complex quasienergy space which undergoes a topology change from isolated loops with the same winding to linked loops with opposite windings. Our work unfolds a new route toward Floquet NHSEs originating from the interplay between gauge fields and dissipation effects, and thus offers fundamentally new ways for steering light and other waves.

关键词： Edge states Integrated optics Topological effects in photonic systems Floquet systems Non-Hermitian systems Waveguide arrays

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Multi-Satellite-Enabled Edge Computing: An Offloading and Computation Integration Approach 3

Multi-Satellite-Enabled Edge Computing: An Offloading and Co...

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3rd International Conference on Intelligent Communications and Computing, ICC 2023

作者： Xi, Shiyu Shang, Bodong Zhang, Hongxia Ma, Junchao Fan, Pingzhi Eastern Institute for Advanced Study Eastern Institute of Technology Ningbo315200 China Qingdao266580 China School of Electrical and Information Engineering Jiangsu University of Technology Changzhou213001 China Southwest Jiaotong University Key Laboratory of Information Coding and Transmission Chengdu610031 China

ISBN: (纸本)9798350308327

The computational capability and energy of user equipment (UE) is always facing new challenges, with the continuous and dramatic emergence of computation-intensive and latency-sensitive applications. low earth orbit (LEO) satellite-assisted/enabled edge computing aggregates powerful computational capabilities, provides new solutions to the problem of insufficient computing power and energy in UEs. In this paper, we propose a multi-satellite-enabled edge computing system, where satellites provide computation offloading services to terrestrial UEs. We design a joint offloading and computing resource allocation algorithm to offload tasks efficiently and utilize LEO satellites' computing resources rationally. The formulated problem is a mixed-integer nonlinear programming (MINLP) problem which aims to minimize system energy consumption. We decompose the original problem into three subproblems including user association, task scheduling, and computing resource allocation. Simulation results show that the proposed scheme reduces much system energy consumption effectively compared to benchmarks, validating the impact of rational allocation of computing resource on reducing system energy consumption. © 2023 IEEE.

关键词： Computation offloading

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Design of FeSiBPCu soft magnetic alloys with good amorphous forming ability and ultra-wide crystallization window

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Journal of Materials Science & technology 2023年第16期147卷 124-131页

作者： Xingdu Fan Tao Zhang Weiming Yang Junhua Luan Zengbao Jiao Hui Li Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Institute of Massive Amorphous Metal Science China University of Mining and TechnologyXuzhou 221116China Center for Advanced Structural Materials Department of Mechanical and Biomedical EngineeringCollege of Science and EngineeringCity University of Hong KongKowloonHong KongChina Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong KongChina School of Materials Science and Engineering Shanghai UniversityShanghai 200444China

The Fe_(81.3)Si_(4)B_(13–x)PxCu_(1.7) soft magnetic alloys with high Cu and proper P elements addition were synthesized with the aim of ensuring the amorphous forming ability(AFA)while expanding the crystallization window(CW).It is found that the atomic ratio of P/Cu of∼3 is advantageous for AFA whereas a small amount of P addition promotes the precipitation ofα-Fe grains and excessive P addition induces surface crystallization behavior of the present *** Cu concentration can expand the annealing temperature(Ta)window whereas proper P addition effectively expands the annealing time(ta)*** Fe_(81.3)Si_(4)B_(13-x)PxCu_(1.7) soft magnetic alloy was successfully synthesized with a large Ta window of up to 130°C and ta window of 90 min,which is a breakthrough for nanocrystalline alloys with high saturation *** analysis reveals that the ultra-wide CW is related to the unique nucleation mechanism,that is,theα-Fe grains are precipitated attaching to the Cu or CuP clusters and enveloping the Cu clusters,resulting in the high number density ofα-Fe *** ultra-wide CW promises the potential material in flexibly choosing the annealing process according to the performance.

关键词： Nanocrystalline alloys Amorphous forming ability Crystallization window Soft magnetic properties

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A NOVEL ARTIFICIAL POTENTIAL FIELD APPROACH CONSIDERING ANGULAR ACCELERATION CONSTRAINT

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International Journal of robotics and Automation 2024年第1期39卷 24-30页

作者： Sun, Mingxiao Yuan, Zhangjie Zhang, Yongde Zhen, Liqiang Luan, Tiantian Yuan, Xiaoliang Li, Xiaogang School of Automation Harbin University of Science and Technology No. 52 Xuefu Road Nangang District Heilongjiang Province Harbin City150080 China Heilongjiang Provincial Key Laboratory of Complex Intelligent System and Integration Harbin University of Science and Technology No. 52 Xuefu Road Nangang District Heilongjiang Province Harbin City150080 China Key Laboratory of Advanced Manufacturing and Intelligent Technology Ministry of Education Harbin University of Science and Technology No. 52 Xuefu Road Nangang District Heilongjiang Province Harbin City150080 China Wuxi CREG Urban Rail Transit Equipment Co. Ltd. No. 1061 Jiaoshan Road Xishan Development Zone Jiangsu Province Wuxi City214000 China

An improved artificial potential field approach (APFA) is proposed for unmanned surface vehicle (USV) in path planning. The proposed approach can effectively avoid easily falling into local minima, also, plan the optimal path. Firstly, a map of the Marine environment is established, and the obstacle is treated with circular expansion. Especially, the expansion coefficient is introduced to ensure the safety of navigation. Secondly, aiming at the local minimum problem, a rotation angle formula satisfying its own maximum rotation angle and angular acceleration constraints is constructed, so that a path to avoid local minimum is planned. Moreover, the local minimum of the complex environment is considered, the virtual repulsive force potential field is constructed to generate virtual repulsive force on USV to avoid local minimum. Numerical simulation results show that the proposed approach can complete path planning under different complex and special environments. © 2024 Acta Press. All rights reserved.

关键词： Motion planning

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Fe single atom trigger asymmetric In-In polarized site pairs boosting near-infrared N2 photoreduction

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Materials Today 2025年 86卷 96-103页

作者： Liang, Huimin Ye, Caichao Wu, Yao Li, Yezi Long, Ran Xiong, Jun Jiang, Wei Di, Jun School of Chemistry and Chemical Engineering National Special Superfine Powder Engineering Research Center Nanjing University of Science and Technology Nanjing210094 China Academy for Advanced Interdisciplinary Studies & Department of Materials Science and Engineering Guangdong Provincial Key Laboratory of Computational Science and Material Design Southern University of Science and Technology Shenzhen518055 China School of Materials Science & Engineering Nanyang Technological University Singapore639798 Singapore National Synchrotron Radiation Laboratory CAS Center for Excellence in Nanoscience School of Chemistry and Materials Science University of Science and Technology of China Hefei230026 China Institute for Energy Research Jiangsu University Zhenjiang212013 China

Building differentiated charge distributed polarized atomic pairs may be an alternative for N2 activation. In this work, CuInS2 atomic layers with asymmetric In-In polarized site pairs are prepared by doping Fe single atoms, as proved by X-ray absorption fine structure spectroscopy, quasi in situ X-ray photoelectron spectra and calculated atomic charge distribution. The engineered Fe single atoms tuned the surface atomic charge distribution, building local polarization center to boost directional surface charge separation. The formed In-In polarized site pairs with asymmetric charge distribution creates distinct interaction with two N atoms in N2 molecule, contributing to the enhanced activation of N2. The alternating pathway is regarded as hydrogenation pathway over Fe-CuInS2 with *NNH formation as rate-determining step. The charge-redistributed surface atomic structure after engineered Fe single atoms strengthens intermediate interaction and lower the rate-determining step energy barrier. Benefiting from these features, Fe-CuInS2 exhibits excellent photocatalytic activity under near-infrared (NIR) irradiation with an ammonia synthesis rate of 94.1 μmol g−1 h−1. In comparison, the N2-NH3 conversion rate of Fe-CuInS2 under ultraviolet–visible (UV–Vis) irradiation could reach 137.4 μmol g−1 h−1, which is about 6.8 times higher than that of CuInS2. The apparent quantum efficiencies of Fe-CuInS2-2 at 380, 400, 450, 500, 550, 650, 700, 800, 850 and 1064 nm were 3.0 %, 3.3 %, 2.7 %, 2.1 %, 2.0 %, 1.5 %, 1.3 %, 0.4 %, 0.7 % and 0.6 %, respectively. © 2025 Elsevier Ltd

关键词： X ray absorption fine structure spectroscopy

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Titanium nitride nanorod array/carbon cloth as flexible integrated host for highly stable lithium-sulfur batteries

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Rare Metals 2023年第12期42卷 4115-4127页

作者： Rui-Qing Liu Feng Jin Min Gu Dong-Wen Zhang Lu-Lu He Wen-Xiu Liu Wen-Feng Zhu Kun Xie Jing-Yi Wu Yi-Ran Liu Wei-Wei Yang Xiu-Jing Lin Li Shi Xiao-Miao Feng Zhen Hou Ji-Gang Zhou Yan-Wen Ma State Key Laboratory of Organic Electronics and Information Displays and Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Department of Applied Physics The Hong Kong Polytechnic UniversityHung Hom 1000872Hong KongChina Canadian Light Source Inc. University of SaskatchewanSaskatoonSK S7N 2V3Canada Suzhou Vocational Institute of Industrial Technology Suzhou 215104China

Lithium-sulfur(Li-S)batteries have been regarded as promising energy-storage systems,due to their high theoretical capacity and energy ***,the carbonaceous sulfur hosts suffer from weak binding force between the hosts and polysulfides,restricting the cyclic stability of sulfur ***,the presence of binder and conductive agent in the traditional electrode reduces its energy *** study demonstrates that titanium nitride(TiN)nanorod array on carbon cloth(CC)is employed as a flexible host for highly stable Li-S batteries via solvothermal synthesis-nitridation *** the one hand,the flexible integrated network composed of three-dimensional TiN nanorod array and CC significantly improves the conductivity,increases the electron transport and electrolyte penetration of *** the other hand,the 3D structure of TiN/CC and the enhanced polarity of TiN effectively strengthen the physical and chemical double adsorption for *** a result,the combination of TiN nanorod array and CC synergistic ally promotes sulfur utilization and electrochemical performances of S@TiN/CC cathode.A discharge capacity of1015.2 mAh·g^(-1)at 0.5C after 250 cycles and 604.1mAh·g^(-1)at 3C after 250 cycles is *** a larger current density of 5C,the resulting S@TiN/CC cathode maintains a high discharge capacity of 666.6 mAh·g^(-1)and the Coulombic efficiency of about 100%.

关键词： Titanium nitride Nanorod array Integrated structure Chemical adsorption Lithium-sulfur batteries

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Path Tracking Control for Helical Microrobots Based on Fusion of Geometric and Model-Free Methods 13

Path Tracking Control for Helical Microrobots Based on Fusio...

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13th IEEE International Conference on CYBER technology in Automation, Control, and Intelligent Systems, CYBER 2023

作者： Zhong, Shihao Wang, Huaping Shi, Qing Hou, Yaozhen Qiu, Yukang Sun, Tao Huang, Qiang Fukuda, Toshio School of Medical Technology Beijing Institute of Technology Beijing100081 China Key Laboratory of Biomimetic Robots and Systems Beijing Institute of Technology Ministry of Education Beijing100081 China Beijing Advanced Innovation Center for Intelligent Robots and Systems Beijing Institute of Technology Beijing100081 China Intelligent Robotics Institute School of Mechatronical Engineering Beijing Institute of Technology Beijing100081 China

ISBN: (纸本)9798350315196

Helical micron-sized robots driven by magnetic fields have garnered significant interest, particularly in the field of tracking control. However, at the microscale, time-varying uncertain perturbations in both the environment and electromagnetic system can cause these robots to deviate from their preset state. Here, we propose a novel control method that combines geometric and model-free controllers in a complementary manner to achieve accurate path-tracking of a helical microrobot on underwater unstructured surfaces. The geometric controller acts as a feedforward controller handling path information and formulating guidance law, while the model-free controller responds directly to the lateral error. To compensate for unmodeled nonlinear dynamics and unknown disturbances and achieve system dynamic linearization, we employ an extended state observer. To validate the proposed method and determine suitable ranges for input parameters of the controllers, simulations were carried out. The effectiveness of our path-tracking control method is validated through experimental results. The control technique provides an initial investigation into addressing the effects of uncertainties and perturbation on the control capabilities of magnetic microrobots. © 2023 IEEE.

关键词： Controllers

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