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Cochlear implant/MXene-based electroacoustic stimulation modulates the growth and maturation of spiral ganglion neurons

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Engineered Regeneration 2024年第4期5卷 443-451页

作者： Yangnan Hu Hao Wei Menghui Liao Shanying Han Xin Gao Yusong Wang Shan Zhou Dongyu Xu Xugang Zhuang Ye Yang Hong Cheng Bin Zhang Qingyue Cui Jieyu Qi Lei Tian Wenyan Li Xia Gao Renjie Chai State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing210096China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Department of Otolaryngology Head and Neck Surgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityJiangsu Provincial Key Medical Discipline(Laboratory)Nanjing 210008China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Otolaryngology-Head and Neck Surgery Shandong Provincial ENT HospitalShandong UniversityJinanShandongChina State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of MedicineAdvanced Institute for Life and HealthSoutheast UniversityNanjing210096China ENT institute and Department of Otorhinolaryngology Eye&ENT HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai200031China Department of Neurology Aerospace Center HospitalSchool of Life ScienceBeijing Institute of TechnologyBeijing 100081China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijingChina Southeast University Shenzhen Research Institute Shenzhen 518063China

Cochlear implantation(CI)offers a dependable treatment for sensorineural hearing loss,with precision electroa-coustic stimulation parameters showing great potential in improving auditory outcomes in CI ***,we report the attachment of MXene into CI systems which effectively mimic the neural electrode interface due to MXene’s excellent electrical conductivity and ***-frequency short-term biphasic electrical pulses emitted by the MXenes-based CI promoted the outgrowth of spiral ganglion neuron(SGN)neurites and growth cones,substantially boosting the calcium activity in *** study lays a theoretical foundation for the precision medicine approaches in CI patient care,and informs the selection of materials for cochlear implant electrode materials in the future.

关键词： Cochlear implant MXene Electroacoustic stimulation Cellular response

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Recent progress of flexible rechargeable batteries

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Science Bulletin 2024年第23期69卷 3730-3755页

作者： Xiao Zhu Haoran Zhang Yongxin Huang Er He Yun Shen Gang Huang Shouyi Yuan Xiaoli Dong Ye Zhang Renjie Chen Xinbo Zhang Yonggang Wang Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsInstitute of Fiber Electronic Materials and DevicesCollaborative Innovation Center of Chemistry for Energy Materials(iChEM)Fudan UniversityShanghai 200433China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Beijing Key Laboratory of Environmental Science and Engineering School of Material Science&EngineeringBeijing Institute of TechnologyBeijing 100081China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsChemistryBiomedicine Innovation CenterCollaborative Innovation Center of Advanced MicrostructuresCollege of Engineering&Applied ScienceNanjing UniversityNanjing 210023China National and Local Joint Engineering Laboratory for Lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China

The rapid popularization of wearable electronics,soft robots and implanted medical devices has stimulated extensive research in flexible batteries,which are bendable,foldable,knittable,wearable,and/or *** from these distinct characteristics,flexible batteries can be seamlessly integrated into various wearable/implantable devices,such as smart home systems,flexible displays,and implantable *** contrast to conventional lithium-ion batteries necessitating the incorporation of stringent current collectors and packaging layers that are typically rigid,flexible batteries require the flexibility of each component to accommodate diverse shapes or ***,significant advancements have been achieved in the development of flexible electrodes,current collectors,electrolytes,and flexible structures to uphold superior electrochemical performance and exceptional *** this review,typical structures of flexible batteries are firstly introduced and classified into mono-dimensional,twodimensional,and three-dimensional structures according to their ***,five distinct types of flexible batteries,including flexible lithium-ion batteries,flexible sodium-ion batteries,flexible zinc-ion batteries,flexible lithium/sodium-air batteries,and flexible zinc/magnesium-air batteries,are discussed in detail according to their configurations,***,related comprehensive analysis is introduced to delve into the fundamental design principles pertaining to electrodes,electrolytes,current collectors,and integrated structures for various flexible ***,the developments and challenges of flexible batteries are summarized,offering viable guidelines to promote the practical applications in the future.

关键词： Typical structure of flexible batteries Flexible lithium-ion batteries Flexible sodium-ion batteries Flexible zinc-ion batteries Flexible lithium/sodium-air batteries Flexible zinc/magnesium-air batteries

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Mechanism Analysis of Fault Interaction Effects Between the Positive and Negative Poles in Bipolar MMC-HVDC Systems 6

Mechanism Analysis of Fault Interaction Effects Between the ...

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6th International Conference on Power and Energy Applications, ICPEA 2023

作者： Zhou, Xiao Yang, Yuexi Du, Zhenyu Sun, Tongyue Bai, Yu Lv, Zhenhua State Key Laboratory of Advanced Power Transmission Technology State Grid Smart Grid Research Institute Co. Ltd Beijing China State Grid Jiangsu Electric Power Co. Ltd. Research Institute Nanjing China

ISBN: (纸本)9798350359053

Modular multilevel converter (MMC) based high-voltage direct current (HVDC) is an effective solution for achieving large-scale coordination, complementarity, and reliable transmission of renewable energy, and is an important application direction for future high-voltage and large-capacity DC transmission. However, at the DC side of the bipolar VSC-HVDC system, if the pole-to-ground fault occurs in one pole, it will not only lead to the rapid rise of fault current that may damage the power electronic devices, but also affect the operation of the other pole. Therefore, it is of great importance to investigate the characteristics of the pole-to-ground fault at DC side and the mechanism of fault interaction effects between two poles. In this paper, the operation principle of the MMC and the bipolar VSCHVDC system are introduced firstly. Then, the characteristics of the pole-to-ground fault are analysed and the interaction effects is studied. Finally, the fault characteristics and mechanism of interaction effects are verified by electromagnetic transient (EMT) simulations. © 2023 IEEE.

关键词： Poles

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GS-Matching: Reconsidering Feature Matching task in Point Cloud Registration

arXiv

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arXiv 2024年

作者： Zhang, Yaojie Huang, Tianlun Wang, Weijun Feng, Wei Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen518055 China Guangdong Provincial Key Laboratory of Construction Robotics and Intelligent Construction Shenzhen518055 China

Traditional point cloud registration (PCR) methods for feature matching often employ the nearest neighbor policy. This leads to many-to-one matches and numerous potential inliers without any corresponding point. Recently, some approaches have framed the feature matching task as an assignment problem to achieve optimal one-to-one matches. We argue that the transition to the Assignment problem is not reliable for general correspondence-based PCR. In this paper, we propose a heuristics stable matching policy called GS-matching, inspired by the Gale-Shapley algorithm. Compared to the other matching policies, our method can perform efficiently and find more non-repetitive inliers under low overlapping conditions. Furthermore, we employ the probability theory to analyze the feature matching task, providing new insights into this research problem. Extensive experiments validate the effectiveness of our matching policy, achieving better registration recall on multiple datasets. © 2024, CC BY.

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Na+ Migration Mediated Phase Transitions Induced by Electric Field in the Framework Structured Tungsten Bronze

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Journal of Physical Chemistry Letters 2023年第13期14卷 3152-3159页

作者： Jiang, Renhui Li, Pei Guan, Xiaoxi Zheng, He Jia, Shuangfeng Zhao, Ligong Wang, Huaiyuan Huang, Shuangshuang Zhao, Peili Meng, Weiwei Wang, Jianbo School of Physics and Technology Center for Electron Microscopy MOE Key Laboratory of Artificial Micro- and Nano-structures Institute for Advanced Studies Wuhan University Wuhan430072 China Suzhou Institute of Wuhan University Jiangsu Suzhou215123 China Wuhan University Shenzhen Research Institute Guangdong Shenzhen518057 China Core Facility of Wuhan University Wuhan430072 China

Framework structured tungsten bronzes serve as promising candidates for electrode materials in sodium-ion batteries (SIBs). However, the tungsten bronze framework structure changes drastically as mediated by the sodium ion concentration at high temperatures. While the three-dimensional ion channels facilitate fast ion storage and transport capabilities, the structural instability induced by Na+ migration is a big concern regarding the battery performance and safety, which unfortunately remains elusive. Here, we show the real-time experimental evidence of the phase transitions in framework structured Na0.36WO3.14 (triclinic phase) by applying different external voltages. The Na+-rich (Na0.48WO3, tetragonal phase) or -deficient (NaxWO3, x + migration are directly uncovered. Our work sheds light on the phase instability in sodium tungsten bronzes and paves the way for designing advanced SIBs with high-stability. © 2023 American Chemical Society.

关键词： Sodium-ion batteries

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Flexible Wing Dynamics of an Underwater Gliding Robot

Flexible Wing Dynamics of an Underwater Gliding Robot

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ASME/IFToMM International Conference on Reconfigurable Mechanisms and Robots, ReMAR

作者： Aihu Jia Rui Sun Yuntao Guan Xiaobin Qin Yongxi Liu Shangkui Yang Zheming Zhuang Rongjie Kang Jian S. Dai International Centre for Advanced Mechanisms and Robotic MOE Key Laboratory for Mechanism Theory and Equipment Design School of Mechanical Engineering Tianjin University Tianjin PRChina Mechanisms and Robotics Centre for Robotics Research Institute for Robotics Southern University of Science and Technology Shenzhen PRChina

ISBN: (数字)9798350395969

ISBN: (纸本)9798350395976

Biological flapping wing propulsion is known for its high efficiency, high mobility and high stability. The pectoral fins of fish contains nerves, muscle contraction, power transmission, biomaterials, etc., providing thrust and steering to the fish. Many scholars have studied the physiology and ecology of fish fins. Investigations have shown that the structure and size of the pectoral fins have an important influence on the swimming performance of fish, and also the flapping wing robots. This paper designed a special underwater gliding robot, manta-ray inspired robot, analyzed the motion mechanism of the flapping wing propulsion, designed a new flexible wing propulsion device - tensegrity structure, and used the Euler-Lagrange equation to establish its dynamics model, and derived the static stiffness of the tensegrity structure. The cycle variation rules of the fluid force applied to the system and the tension applied to the structure were obtained through MATLAB. A prototype was fabricated, and the feasibility of the flexible wing mounted on a manta-ray inspired robot was verified through tests.

关键词： Analytical models Biological system modeling Dynamics Prototypes Propulsion Fish Mathematical models

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Development of Chinese herbal medicine for sensorineural hearing loss

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Acta Pharmaceutica Sinica B 2024年第2期14卷 455-467页

作者： Yunhao Wu Jingwen Zhang Qiuping Liu Zhuang Miao Renjie Chai Wenyong Chen State Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province HighTech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Department of Otolaryngology-Head and Neck the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Department of Otolaryngology-Head and Neck Surgery Affiliated Hospital of Jiangnan UniversityWuxi 214000China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610000China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijing 100085China Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijing 100069China

According to the World Health Organization’s world report on hearing,nearly 2.5 billion people worldwide will suffer from hearing loss by 2050,which may contribute to a severe impact on individual life quality and national *** hearing loss(SNHL)occurs commonly as a result of noise exposure,aging,and ototoxic drugs,and is pathologically characterized by the impairment of mechanosensory hair cells of the inner ear,which is mainly triggered by reactive oxygen species accumulation,inflammation,and mitochondrial *** recent advances have been made in understanding the ability of cochlear repair and regeneration,there are still no effective therapeutic drugs for *** herbal medicine which is widely distributed and easily accessible in China has demonstrated a unique curative effect against SNHL with higher safety and lower cost compared with Western *** we present trends in research for Chinese herbal medicine for the treatment of SNHL,and elucidate their molecular mechanisms of action,to pave the way for further research and development of novel effective drugs in this field.

关键词： Sensorineural hearing loss Chinese herbal medicine Molecular mechanism Active ingredients Prescriptions Ototoxic drugs Noise Hair cells

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Oxidized Dopamine Acrylamide Primer to Achieve Durable Resin-Dentin Bonding

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Research 2023年第4期2023卷 539-555页

作者： Leping Wu Hui Shao Yang Tao Jingya Wu Xinhui Wang Qiufeng Nian Shunli Zheng Chris Ying Cao Yuancong Zhao Zheng Zhou Hai Ming Wong Quan-Li Li Key Laboratory of Oral Diseases Research of Anhui Province College and Hospital of StomatologyAnhui Medical University81 Meishan RoadHefei 230032China The Affiliated Jiangning Hospital with Nanjing Medical University NanjingJiangsu 211100China Key Laboratory of Advanced Technology for Materials of Education Ministry School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China School of Dentistry University of Detroit MercyDetroitMI 48208-2576USA Faculty of Dentistry The University of Hong Kong34 Hospital RoadThe Prince Philip Dental HospitalHong Kong 999077China

The durability of the resin-dentin bonding interface is a key issue in clinical esthetic *** by the extraordinary bioadhesive properties of marine mussels in a wet environment,we designed and synthetized N-2-(3,4-dihydroxylphenyl)acrylamide(DAA)according to the functional domain of mussel adhesive ***’s properties of collagen cross-linking,collagenase inhibition,inducing collagen mineralization in vitro,and as a novel prime monomer for clinical dentin adhesion use,its optimal parameters,and effect on the adhesive longevity and the bonding interface’s integrity and mineralization,were evaluated in vitro and in *** results showed that oxide DAA can inhibit the activity of collagenase and cross collagen fibers to improve the anti-enzymatic hydrolysis of collagen fibers and induce intrafibrillar and interfibrillar collagen *** a primer used in the etch-rinse tooth adhesive system,oxide DAA can improve the durability and integrity of the bonding interface by anti-degradation and mineralization of the exposed collagen *** DAA(OX-DAA)is a promising primer for improving dentin durability;using 5%OX-DAA ethanol solution and treating the etched dentin surface for 30 s is the optimal choice when used as a primer in the etch-rinse tooth adhesive system.

关键词： durability bonding interface

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Valorization of Asparagus leafy by-product by ionic-liquid extraction and characterization of bioactive compounds in the extracts

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Food Bioscience 2022年第2期46卷 857-864页

作者： Bimal Chitrakar Min Zhang Sakamon Devahastin Benu Adhikari Xiaohu Zhang State Key Laboratory of Food Science and Technology Jiangnan University214122WuxiJiangsuChina College of Food Science and Technology Hebei Agricultural UniversityBaoding071001HebeiChina Jiangsu Province International Joint Laboratory on Fresh Food Smart Processing and Quality Monitoring Jiangnan University214122WuxiJiangsuChina Advanced Food Processing Research Laboratory Department of Food EngineeringFaculty of EngineeringKing Mongkut’s University of Technology Thonburi126 Pracha u-tid RoadBangkok10140Thailand School of Science RMIT UniversityMelbourneVIC3083Australia Nantong Shuangyang Ecological Agriculture Technology Co. Ltd.NantongJiangsuChina

Asparagus(Asparagus officinalis)is a high-value low-calorie vegetable with array of bioactive *** processing nevertheless generates substantial quantity of by-products;their valorization is of utmost importance for the sustainability of the ***,feasibility of using four imidazolium-based ionic liquids and their combinations as well as water and methanol to extract bioactive compounds from asparagus leafy by-product was *** of ultrasound-microwave-assisted heating to augment extraction was also assessed.1-ethyl-3-methylimidazolium-bromide(EMIMBr)resulted in the highest extraction yield of rutin(25.7 mg/g),which is the most abundant compound in the by-product;such a yield was comparable to that achievable via methanol ***-microwave-assisted extraction did not show significant improvement in rutin yield when EMIMBr was ***,although methanolic extract exhibited slightly higher content of rutin,it also contained the higher number of impurities;EMIMBr extract contained less impurities with higher relative content of rutin(70.9%)than that in methanolic extract(67.7%).This could be a milestone in extraction work for an efficient purification.

关键词： 1-Ethy-3-methylimidazolium bromide Ionic-liquid Methanol-extraction Rutin Ultrasound-microwave extraction

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Noninvasive Tracking of Every Individual in Unmarked Mouse Groups Using Multi-Camera Fusion and Deep Learning

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Neuroscience Bulletin 2023年第6期39卷 893-910页

作者： Feng Su Yangzhen Wang Mengping Wei Chong Wang Shaoli Wang Lei Yang Jianmin Li Peijiang Yuan Dong-Gen Luo Chen Zhang Department of Neurobiology School of Basic Medical SciencesBeijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijing100069China Chinese Institute for Brain Research Beijing102206China State Key Laboratory of Translational Medicine and Innovative Drug Development Nanjing210000China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing100871China School of Life Sciences Tsinghua UniversityBeijing100084China School of Biological Science and Medical Engineering Beihang UniversityBeijing100191China The Key Laboratory of Developmental Genes and Human Disease Institute of Life SciencesSoutheast UniversityNanjing210096JiangsuChina Institute for Artificial Intelligence the State Key Laboratory of Intelligence Technology and SystemsBeijing National Research Center for Information Science and TechnologyDepartment of Computer Science and TechnologyTsinghua UniversityBeijing100084China School of Mechanical Engineering and Automation Beihang UniversityBeijing100191China

Accurate and efficient methods for identifying and tracking each animal in a group are needed to study complex behaviors and social *** tracking methods(e.g.,marking each animal with dye or surgically implanting microchips)can be invasive and may have an impact on the social behavior being *** overcome these shortcomings,video-based methods for tracking unmarked animals,such as fruit flies and zebrafish,have been ***,tracking individual mice in a group remains a challenging problem because of their flexible body and complicated interaction *** this study,we report the development of a multi-object tracker for mice that uses the Faster region-based convolutional neural network(R-CNN)deep learning algorithm with geometric transformations in combination with multi-camera/multi-image fusion *** system successfully tracked every individual in groups of unmarked mice and was applied to investigate chasing *** proposed system constitutes a step forward in the noninvasive tracking of individual mice engaged in social behavior.

关键词： Noninvasive tracking Deep learning Multi-camera Mouse group Social interaction

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