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Engineering vascularised organoid-on-a-chip:strategies,advances and future perspectives

Biomaterials Translational 2024年第1期5卷 21-32页

作者： Zhangjie Li Dingyuan Yu Chenyang Zhou Feifan Wang Kangyi Lu Yijun Liu Jiaqi Xu Lian Xuan Xiaolin Wang Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghaiChina Institute of Medical Robotics Shanghai Jiao Tong UniversityShanghaiChina National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong UniversityShanghaiChina National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghaiChina

In recent years,advances in microfabrication technology and tissue engineering have propelled the development of a novel drug screening and disease modelling platform known as *** platform integrates organoids and organ-on-a-chip technologies,emerging as a promising approach for in vitro modelling of human organ ***-on-a-chip devices leverage microfluidic systems to simulate the physiological microenvironment of specific organs,offering a more dynamic and flexible setting that can mimic a more comprehensive human biological ***,the lack of functional vasculature has remained a significant challenge in this *** is crucial for the long-term culture and in vitro modelling of organoids,holding important implications for drug development and personalised medical *** review provides an overview of research progress in developing vascularised organoid-on-a-chip models,addressing methods for in vitro vascularisation and advancements in vascularised *** aim is to serve as a reference for future endeavors in constructing fully functional vascularised organoid-on-a-chip platforms.

关键词： drug screening microfluidic chip organoids tissue engineering vascularisation

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Constructing Efficient Self-Supported Bifunctional Multiphase Heterostructure for Electrocatalytic Overall Water Splitting

SSRN

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SSRN 2023年

作者： Qian, Xingyue Fang, Jing Jiang, Lin Ye, Jingrui He, Guangyu Chen, Haiqun Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University Jiangsu Changzhou213164 China

Developing well-performed and stable bifunctional electrocatalysts is of great essential for efficient green hydrogen production through water electrolysis. Herein, the three-dimensional self-supported CoMoS3.13/FeS2/Co3S4 on carbon paper (FeCoMoS/CP) heterostructure with interconnected nanosheets for overall water splitting was fabricated by a facile hydrothermal method followed by vulcanization treatment. The FeCoMoS/CP heterostructure with high structural integrity and more accessible active sites can effectively optimize the electronic structure through component regulation to achieve enhanced catalytic activity. Significantly, the FeCoMoS/CP required overpotentials of 257 mV at 50 mA cm-2 for OER and 280 mV at 20 mA cm-2 for HER. Importantly, the assembled FeCoMoS/CP\\FeCoMoS/CP alkaline electrolyze achieved a superior cell voltage of 1.48 V at 10 mA cm-2 with superb long-term stability, which implied remarkable electrocatalytic performance of FeCoMoS/CP heterostructure for overall water splitting. This work provides an appliable route for synthesis high-performance bifunctional catalysts towards water electrolysis. © 2023, The Authors. All rights reserved.

关键词： Electrocatalysis

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Long-term oxidation behavior of sputtered double-layer TiAlCrY/TiAlCrNb coatings on TiAl alloys at 1000 ℃

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Journal of Alloys and Compounds 2025年 1032卷

作者： Sun, Tianfang Shen, Yun Niu, Yaran Chen, Yang Qi, Zhixiang Zheng, Xuebin Chen, Guang Jiangsu Belight Laboratory State Key Laboratory of Advanced Casting Technology Nanjing University of Science and Technology Nanjing210094 China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai200050 China Inner Mongolia North Heavy Industries Group Corporation Limited Inner Mongolia 014000 China

The double-layer TiAlCrY/TiAlCrNb and single-layer TiAlCrY coatings were fabricated on Ti45Al8Nb alloy by magnetron sputtering. The mechanical properties of the as-deposited coatings and their cyclic oxidation behavior at 1000 ℃ were studied. After 200 cycles, the double-layer coating exhibited 52 % lower mass gain and 76 % reduced parabolic rate constant compared to the single-layer coating, with no internal oxidation or interfacial delamination observed. The design strategy of the TiAlCrNb intermediate layer effectively reduced Cr diffusion and O penetration, avoiding internal oxidation and preventing the subsequent delamination of the coating system. © 2025

关键词： Magnetron sputtering

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Precise Synthesis of Hollow Mesoporous Palladium–Sulfur Alloy Nanoparticles for Selective Catalytic Hydrogenation

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CCS Chemistry 2022年第8期4卷 2854-2863页

作者： Hao Lv Lizhi Sun Dongdong Xu Wei Li Bolong Huang Ben Liu Key Laboratory of Green Chemistry and Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064 Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023 Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsiChEM and State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433 Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SAR 999077

Hollow mesoporous metals have unique potential for catalysis,but their precise synthesis and further elaboration of their structure–performance relationships are still huge ***,wereport a new synthetic strategy,named the Kirkendall effect in synergistic template(KEST),for the desired preparation of hollow mesoporous palladium–sulfur(h-mesoPdS)alloy nanoparticles.

关键词： mesoporous material hollow cavity palladium hydrogenation selective catalysis

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Landing Area Prediction in Complex Terrains for Walking-assisted Lower-limb Exoskeleton Robot

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Procedia Computer Science 2023年 226卷 120-126页

作者： Yuexun Liu Du-Xin Liu Yue Ma Sheng Guo Xinyu Wu Robotics Research Center School of Mechanical Electronic and Control Engineering Beijing Jiaotong University Beijing 100044 China Guangdong Provincial Key Laboratory of Robotics and Intelligent System Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China

With the expansion of application scenarios, the walking-assisted lower-limb exoskeleton robot urgently needs to improve its walking ability in complex terrains. However, due to the lack of environmental understanding ability and decision-making ability, the exoskeleton can not meet the need of people with lower-limb disability in complex terrains. To improve the walking abillity, this paper proposes a method of predicting the landing area in complex terrains for walking-assisted lower-limb exoskeleton robot. Multiple sensors were used to obtain the terrain information, step length, and stride length of human walking, and a multi-type input convolutional network was built to establish the mapping relationship to learn the decision-making mechanism of human standing in a complex environment. The result shows that the established network effectively predicts the landing area. Under the condition of full training, the predicted position deviation of the landing area is controlled within 6%, and the prediction rationality of the landing area can reach 90%.

关键词： Landing area prediction Walking-assisted lower-limb exoskeleton robot Complex terrains

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Flower-Like S-Vacancy Znin2s4 is Combined with Ni-Nio@Cnfs Form a Dual-Channel Material with Schottky Barrier for Efficient Photothermal Synergistic Catalytic Hydrogen Production

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SSRN 2023年

作者： Zeng, Danni Shen, Tingzhe Hu, Yadong Liu, Fengjiao Guan, Rongfeng Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of Technology Jiangsu China School of Materials Science and Engineering Henan Polytechnic University Jiaozuo China

As a new type of energy conversion technology, photothermal synergistic catalysis entirely uses the synergistic effect of light and heat energy to achieve efficient energy conversion. In this study, ZnIn2S4 containing S-vacancy was coupled with Ni-NiO@CNFs to form a thermally assisted photocatalysis (TAPC) material with double Schottky barrier, dual-channel, and mixed photothermal conversion effects, and a local heating system was established. The photocatalytic reaction is carried out in a double-layer quartz photocatalytic reactor using a constant temperature heating circulating water device to achieve the purpose of global heating. By combining the advantages of global/local heating, the light effect of high-frequency photons, the thermal effect of low-frequency photons, and the heating of the entire reaction system are used to achieve high solar energy utilization efficiency. Under the condition of external heating at 45°C, the hydrogen production rate of the best sample (0.9-Ni@C/ZIS-Vs) is as high as 25.50mmol·g-1·h-1, which is 19.02 times that of bulk ZnIn2S4 (1.34mmol·g-1·h-1). In addition, DFT confirmed that Ni-NiO@CNFs can reduce ΔG*H to -0.07eV by Ni-NiO@CNFs, which promotes H* adsorption, which is also conducive to the formation of H2. Therefore, this study promotes the sustainable development of hydrogen energy and provides a valuable prototype for the design of efficient photothermal synergistic catalytic systems in the future. © 2023, The Authors. All rights reserved.

关键词： Nickel oxide

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Enhanced Optical IMDD Communication Through Real-Time Sensing of MZM Bias Drift 27

Enhanced Optical IMDD Communication Through Real-Time Sensin...

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27th OptoElectronics and Communications Conference/International Conference on Photonics in Switching and Computing, OECC/PSC 2022

作者： Sun, Lin Cai, Yi Zhang, Junwei Shen, Gangxiang Lu, Chao Liu, Gordon Ning Soochow University Suzhou Key Laboratory of Advanced Optical Communication Network Technology Jiangsu Suzhou215006 China Hongkong Polytechnic University Department of Electrical and Information Engineering Kowloon Hong Kong

Real-time sensing of MZM bias drift in an optical IMDD channel is realized by linear optical sampling and machine-learning clustering. Adaptive decoding of signals outperforms the conventional method especially when c... 详细信息

ISBN: (数字)9784885523366

ISBN: (纸本)9784885523366

关键词： Light transmission

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Design of magnetorheological brake with adjustable interdigitated comb for lower limb prostheses and exoskeletons

Design of magnetorheological brake with adjustable interdigi...

引用

2023 IEEE International Conference on robotics and Biomimetics, ROBIO 2023

作者： Shi, Qiuyu Zhao, Xuan Liao, Haisu Lin, Yongji Huang, Ruisen Wu, Xinyu Gao, Fei Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Guangdong Provincial Key Laboratory of Robotics and Intelligent System Shenzhen518055 China Guangdong-Hong Kong-Macao Joint Laboratory of Human-Machine Intelligence-Synergy Systems Shenzhen518055 China The Chinese University of Hong Kong Department of Mechanical and Automation Engineering Shatin 999077 Hong Kong

ISBN: (纸本)9798350325706

Magnetorheological (MR) fluids-based devices such as MR dampers and brakes can output a continuously controllable damping force via modulating the magnitude of the applied magnetic field. Owing to low energy consumption and fast response, recently vast MR dampers and brakes are widely studied and explored for lower limb prostheses and exoskeletons. This paper proposed a novel MR brake with adjustable interdigitated comb for lower limb prostheses. Through actively adjusting the area the of the comb engagement, the maximum viscous and field-induced damping torque can be increased or decreased. Because of that, the dynamic adjustment interval of the output damping torque can be increased to meet the function requirements of the prosthetic knee in different walking modes. Magnetic analysis via ANSYS is performed to check the magnetic density of the MR fluid under different excitations. Mathematical models of the damping torque are built. Finally, a prototype of the novel MR brake is fabricated. © 2023 IEEE.

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An Electromagnetic Generator for Self-powered Wireless Sensor Node on Transmission Line

An Electromagnetic Generator for Self-powered Wireless Senso...

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Electronics and Electrical Engineering technology (EEET), International Conference on

作者： Zizhao Wang Manjuan Huang Tianyi Tang Tingting Zhao Zhenming Li Huicong Liu School of Mechanical and Electrical Engineering Soochow University Jiangsu Provincial Key Laboratory of Advanced Robotics Suzhou China School of Mechanical and Electrical Engineering Harbin Institute of Technology Jiangsu Provincial Key Laboratory of Advanced Robotics Suzhou China Energy Storage and Novel Technology of Electrical Engineering Department China Electric Power Research Institute Beijing China

Transmission lines are susceptible to breeze vibration, threatening the operation of power grid. The self-powered system based on electromagnetic generator (EMG) provides an ideal method for online monitoring of various parameters of transmission lines and has the potential for large-scale deployment. This paper reports a miniature EMG having high energy output, with a volume of only 62 cm 3 . The vibration pickup unit in this generator has multimodal characteristics, which can harvest the vibration energy from arbitrary direction and multiple frequencies. The EMG uses two magnets coupled by winding coil to generate electricity. At 0.5g acceleration excitation along X-axis and Y-axis directions, the peak voltages of the EMG reach 1 and 0.8 V, respectively. While along Z-axis direction under the same acceleration excitation, the peak voltage and power of the EMG reaches as high as 2.4 V and 35.5 mW, respectively.

关键词： Vibrations Wireless communication Resistance Wireless sensor networks Electric potential Power transmission lines Windings

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Ablation-resistant Yttrium-modified high-entropy refractory metal silicide (NbMoTaW)Si2 coating for oxidizing environments up to 2100 ℃

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SSRN 2024年

作者： Shen, Baolong Kuang, Juan Wang, Qianqian Jia, Zhe Yi, Guoming Sun, Bo Yang, Yiyuan Sun, Ligang Zhang, Ping He, Pengfei Xing, Yue Liang, Xiubing Lu, Yang School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic Materials Southeast University Jiangsu Nanjing211189 China School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing Institute of Technology Nanjing Jiangsu 211167 China School of Science Harbin Institute of Technology Shenzhen518055 China School of Material Science and Engineering China University of Mining and Technology Jiangsu Xuzhou221116 China Department of Mechanical Engineering The University of Hong Kong Pokfulam Road Hong Kong

Refractory high-entropy alloys (RHEAs) are pivotal in ultra-high temperature applications, such as rocket nozzles, aerospace engines, and leading edges of hypersonic vehicles due to their exceptional mechanical ability to withstand severe thermal environments (in excess of 2000 ℃). However, the selection of materials that satisfy the stringent criteria required for effective ablation resistance remains notably restricted. Here, a novel yttrium-modified high-entropy refractory metal silicide (Y-HERMS) coated on a refractory high-entropy NbMoTaW alloy is developed via pack cementation process. The developed Y-HERMS coating with lattice distortion and sluggish diffusion effects demonstrates extraordinary ablation resistance, maintaining near-zero damage at sustained temperatures up to 2100 °C for a duration of 180 seconds, surpassing state-of-the-art high-performance silicide coatings. Such exceptional ultra-high ablation performance is primarily ascribed to the in-situ development of a high viscosity Si-Y-O oxide layer with increased thermal stability and the presence of high-melting Y(Nb0.5Ta0.5)O4 oxides as skeleton structure. Theoretical results elucidate that the Y-HERMS promotes the formation of SiO2 impedes the diffusion of O into metal silicide layer, synergistically contributing to the superior ablation resistance. These findings highlight the potential of utilizing high-entropy materials with excellent ablation resistance in extreme thermal environments. © 2024, The Authors. All rights reserved.

关键词： Entropy

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