检索结果-内蒙古大学图书馆

第六届国际高分子化学学术讨论会

作者： Youliang Zhao Huanhuan Liu Cangxia Li Dandan Tang Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

Stimuli-responsive polymeric aggregates have attracted wide attention due to their multipurpose applications involving the enhanced selectivity and efficiency of drug delivery to targeting sites.1-

关键词：

来源：评论

学校读者我要写书评

暂无评论

Polylipopeptide-based multifunctional nanomedicines for targeted cancer delivery

Polylipopeptide-based multifunctional nanomedicines for targ...

引用

The 3rd International Conference on Nanomedicine of China（ChinaNanomedicine 2018）

作者： Chao Deng Min Qiu Jian Zhang Huanli Sun Fenghua Meng Ru Cheng Zhiyuan Zhong Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

Poly(ethylene glycol)-b-polypeptide copolymers with excellent safety,are one of the most clinically studied materials for anticancer drug delivery[1].For example,paclitaxel(PTX),doxorubicin(Dox),and cisplatin-loaded polypeptidebased nanotherapeutics have proceeded into phase Ⅱ and Ⅲ clinical trials,and achieved enhanced therapeutic efficacy against intractable tumors and reduced side effects in comparison with free *** should be noted,however,that these nanoformulations,mostly based on hydrophilic polypeptides,usually involve multistep synthesis,including protection and deprotection of functional groups and drug *** based on hydrophobic polypeptide often plagued with low drug loading and insufficient in vivo *** this end,we designed and prepared a series of poly(a-aminopalmitic acid)-based nanoplatforms,including micelles and polymersomes for targeted delivery of small anti-cancer drugs,protein,and siRNA[2-3].

关键词： Polylipopeptide-based multifunctional nanomedicines for targeted cancer delivery

来源：评论

学校读者我要写书评

暂无评论

Quasi-solid-state polymer plastic crystal electrolyte for subzero lithium-ion batteries

引用

Journal of Energy Chemistry 2020年第7期29卷 87-93,I0003页

作者： Yumei Zhou Fengrui Zhang Peixin He Yuhong Zhang Yiyang Sun Jingjing Xu Jianchen Hu Haiyang Zhang Xiaodong Wu i-Lab Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123JiangsuChina Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Key Laboratory for the Synthesis and Application of Organic Functional MoleculesMinistry of EducationCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062HubeiChina National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringResearch Center of Cooperative Innovation for Functional Organic/Polymer Material Micro/NanofabricationSoochow University199 Ren-Ai RoadSuzhou Industrial ParkSuzhou 215123JiangsuChina

Succinonitrile(SN)-based polymer plastic crystal electrolytes(PPCEs)have attracted considerable attention as solid-state electrolytes owing to their high ionic conductivities similar to those of liquid electrolytes,excellent contacts with the electrodes,and good mechanic *** a crucial property of a solid-state electrolyte,the ionic conductivity of the PPCE directly depends on the interactions between the constituent parts including the polymer,lithium salt,and SN.A few studies have focused on the effects of polymer–lithium–salt and polymer–SN interactions on the PPCE ionic ***,the impact of the lithium–salt–SN combination on the PPCE ionic conductivity has not been *** particular,tuning of the lithium-salt–SN interaction to fabricate a subzero PPCE with a high low-temperature ionic conductivity has not been *** this study,we design and fabricate five PPCE membranes with different weight ratios of Li N(SO2 CF3)2(Li TFSI)and SN to investigate the effect of the Li TFSI–SN interaction on the PPCE ionic *** ionic conductivities of the five PPCEs are investigated in the temperature range of–20 to 60°C by electro-chemical impedance *** interaction is analyzed by Fourier-transform infrared spectroscopy,Raman spectroscopy,and differential scanning *** Li TFSI–SN interaction significantly influences the melting point of the PPCE,dissociation of the Li TFSI salt,and thus the PPCE ionic *** tuning the Li TFSI–SN interaction,a subzero workable PPCE membrane having an excellent low-temperature ionic conductivity(6×10-4 S cm–1 at 0°C)is *** electro-chemical performance of the optimal PPCE is evaluated by using a Li Co O2/PPCE/Li4 Ti5 O12 cell,which confirms the application feasibility of the proposed quasisolid-state electrolyte in subzero workable lithium-ion batteries.

关键词： Succinonitrile polymer plastic crystal electrolyte Ionic conductivity Lithium-salt–succinonitrile interaction Subzero lithium-ion battery

来源：评论

学校读者我要写书评

暂无评论

BIODEGRADABLE GRAFT COpolymer MICELLES AS SUPERIOR NANO-CARRIERS FOR “SMART” DOXORUBICIN RELEASE

BIODEGRADABLE GRAFT COPOLYMER MICELLES AS SUPERIOR NANO-CARR...

引用

第五届高分子化学国际学术研讨会

作者： Ru Cheng Wei Chen Fenghua Meng Chao Deng Zhiyuan Zhong Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

In recent years,biodegradable micelles based on amphiphilic di-or tri-block copolymers have emerged as one of the most promising nano-carrier systems for the controlled release of anticancer drugs.

关键词：

来源：评论

学校读者我要写书评

暂无评论

ACID AND REDUCTION DUALLY CLEAVABLE AGGREGATES BASED ON GRAFT COpolymerS FOR CONTROLLED DRUG DELIVERY

ACID AND REDUCTION DUALLY CLEAVABLE AGGREGATES BASED ON GRAF...

引用

第六届高分子化学国际学术研讨会

作者： Youliang Zhao Huanhuan Liu Cangxia Li Dan Tang Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

Stimuli-responsive polymeric aggregates have attracted wide attention due to their multipurpose applications involving the enhanced selectivity and efficiency of drug delivery to targeting sites.1-7 Some dually and multiply stimuli-sensitive copolymers have been synthesized and self-assembled into functional aggregates with great potential in smart release systems,in which various internal and external stimuli have been applied to induce the dissociation or morphology changes of copolymer aggregates and

关键词： ACID AND REDUCTION DUALLY CLEAVABLE AGGREGATES BASED ON GRAFT COpolymerS FOR CONTROLLED DRUG DELIVERY

来源：评论

学校读者我要写书评

暂无评论

A low-toxic and bioreducible polymeric nanocarrier for glutathione-mediated intracellular release of antineoplastic agent

A low-toxic and bioreducible polymeric nanocarrier for gluta...

引用

The 6th International Conference on Nanoscience & Technology, China 2015

作者： Jinlin He Fei Li Pengfei Ju Dongling Cao Mingzu Zhang Peihong Ni College of Chemistry Chemical Engineering and Materials ScienceSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisJiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSoochow University

As one of the main therapeutic methods toward cancers, chemotherapy can efficiently inhibit tumor growth in a large extent [1]. However, it is usually restricted with the severe cytotoxicity of antineoplastic agents against normal tissues and organs. To address this issue, various kinds of drug formulations have been fabricated to balance the minimization of undesirable adverse effects and the improvement of therapeutic efficacy [2,3]. Method: A stimuli-responsive amphiphilic triblock copolymer poly(ethylethylene phosphate)-blockpoly(disulfide)s-block-poly(ethylethylene phosphate)(PEEP-b-PDS-b-PEEP) is prepared via a combination of polycondensation and ring-opening polymerization, which serves as a low-toxic nanocarrier for the loading and triggered release of clinically used doxorubicin(DOX). Results: The spherical micelles are fabricated from the self-assembly of these amphiphilic triblock copolymers in aqueous solution. As a representative antineoplastic agent, DOX is efficiently encapsulated in thehydrophobic core of micelles. The DOX release is proceeded in a cytoplasmic glutathione-mediated way, which facilitates the triggered release inside the tumor tissues. In addition, the MTT tests indicate that these copolymers exhibit low cytotoxicity. Conclusions: The preliminary in vitro drug release and cytotoxicity assays reveal that this novel reduction-responsive polymeric nanocarrier shows great potential in cancer chemotherapy.

关键词： Cancer chemotherapy,polymeric nanocarrier,Biosafety,Biodegradability

来源：评论

学校读者我要写书评

暂无评论

PHOTO-CATALYST FREE LIGHT INDUCED LIVING RADICAL polymerIZATION MEDIATED BY XANTHATE AND ORGANOSELENIUM COMPOUNDS

PHOTO-CATALYST FREE LIGHT INDUCED LIVING RADICAL POLYMERIZAT...

引用

第七届高分子化学国际学术研讨会

作者： Chunlai Ding Xiangqiang Pan Zhengbiao Zhang Jian Zhu Xiulin Zhu Suzhou key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University

Photo-induced RDRP has attracted more and more attentions due to its charming advantages,such as environmentally benign natural resource,widely available,noninvasive,*** the current abstract,an interesting photo-induced RDRP system was *** such system,no photo-catalyst was added,which showed benefits on the following points:simple(only monomer and mediate agent),improved

关键词： MALDI PHOTO-CATALYST FREE LIGHT INDUCED LIVING RADICAL polymerIZATION MEDIATED BY XANTHATE AND ORGANOSELENIUM COMPOUNDS

来源：评论

学校读者我要写书评

暂无评论

ROS-sensitive PD-L1 siRNA cationic selenide nanogels for self-inhibition of autophagy and prevention of immune escape

引用

Bioactive Materials 2024年第11期41卷 597-610页

作者： Jie Gao Yonghua Zhai Weihong Lu Xianghe Jiang Jingsheng Zhou Lili Wu Longhai Du Chunqing Ou Xinyi Zhang Hanliang He Jian Zhu Zhengbiao Zhang Meiyun Li Yan Wu Xiangqiang Pan State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai200433China Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices Shanghai200433China College of Life Science Mudanjiang Medical UniversityMudanjiang157011China Department of Orthopedics Jinshan HospitalFudan UniversityShanghai201508China The Department of Orthopedic Surgery Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou215028China

In the field of cancer therapy,inhibiting autophagy has emerged as a promising ***,pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1(PD-L1),enabling tumor immune *** address this issue,we developed innovative ROS-responsive cationic poly(ethylene imine)(PEI)nanogels using selenol chemistry-mediated multicomponent reaction(MCR)*** procedure involved simple mixing of low-molecular-weight PEI(LMW PEI),γ-selenobutylacetone(γ-SBL),and poly(ethylene glycol)methacrylate(PEGMA).Through high-throughput screening,we constructed a library of AxSeyOz nanogels and identified the optimized A1.8Se3O0.5/siPD-L1 nanogels,which exhibited a size of approximately 200 nm,excellent colloidal stability,and the most effective PD-L1 silencing *** nanogels demonstrated enhanced uptake by tumor cells,excellent oxidative degradation ability,and inhibited autophagy by alkalinizing *** A1.8Se3O0.5/siPD-L1 nanogels significantly downregulated PD-L1 expression and increased the expression of major histocompatibility complex class I(MHC-I),resulting in robust proliferation of specific CD8+T cells and a decrease in MC38 tumor *** a result,the A1.8Se3O0.5/siPD-L1 nanogels inhibited tumor growth through self-inhibition of autophagy,upregulation of MHC-I,and downregulation of *** with dynamic diselenide bonds,the A1.8Se3O0.5/siPD-L1 nanogels showed synergistic antitumor efficacy through self-inhibition of autophagy and prevention of immune escape.

关键词： Multicomponent reaction ROS sensitive Cationic nanogel Autophagy inhibition Immune escape

来源：评论

学校读者我要写书评

暂无评论

"Smart" Degradable Nano-Vehicles for Active and Site-Specific Anti-Cancer Drug Delivery

"Smart" Degradable Nano-Vehicles for Active and Site-Specifi...

引用

2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会

作者： Chao Deng Fenghua Meng Ru Cheng Zhiyuan Zhong Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

来源：评论

学校读者我要写书评

暂无评论

INITIATOR-REGULATOR COMBO IN LIVING RADICAL polymerIZATION

INITIATOR-REGULATOR COMBO IN LIVING RADICAL POLYMERIZATION

引用

第七届高分子化学国际学术研讨会

作者： Jian Zhu Chunlai Ding Jiajia Li Na Li Xiulin Zhu Suzhou key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of Chemistry Chemical Engineering and Materials Science Soochow University

Living radical polymerization has been developed over 20 *** than ionic polymerization,radical polymerization using precursors(initiator)to generate radical under stimulus during the ***,in living radical polymerization,multi-components,such as initiator,mediator,monomers,*** be *** multi-components system ultimately caused the complicating polymerization reaction and resulted in the difficulty for structure controlling,especially the precisely

关键词： INITIATOR-REGULATOR COMBO IN LIVING RADICAL polymerIZATION

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：