Helical 1,2-ethylene-silica nanofibers with lamellar mesopores on the surfaces and twisted rod-like mesopores inside were prepared according to literature procedures. After carbonization, helical carbon/ silica nanofi...
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Helical 1,2-ethylene-silica nanofibers with lamellar mesopores on the surfaces and twisted rod-like mesopores inside were prepared according to literature procedures. After carbonization, helical carbon/ silica nanofibers with lamellar mesopores on the surfaces and twisted rod-like micropores inside were obtained. The morphologies and pore architectures of the carbon]silica nanofibers were characterized using transmission electron microscopy, field-emission scanning electron microscopy, powder X-ray diffraction and N2 sorptions. Although the mesopores inside shrank into micropores, the helical nanostructure remained. Moreover, several carbon/silica nanofibers with lamellar mesopores on the surfaces and concentric circular micropores inside were also obtained. After being calcined in air, helical silica nanofibers with lamellar mesopores on the surfaces and twisted rod-like micropores inside were produced as well.
As one of the main therapeutic methods toward cancers,chemotherapy can efficiently inhibit tumor growth in a large extent [1].However,it is usually restricted with the severe cytotoxicity of antineoplastic agents agai...
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As one of the main therapeutic methods toward cancers,chemotherapy can efficiently inhibit tumor growth in a large extent [1].However,it is usually restricted with the severe cytotoxicity of antineoplastic agents against normal tissues and *** address this issue,various kinds of drug formulations have been fabricated to balance the minimization of undesirable adverse effects and the improvement of therapeutic efficacy [2,3].
作者：
Weiwei GuoMeng ZhengYinan ZhongFenghua MengChao Deng[*]Zhiyuan Zhong[*]Biomedical Polymers Laboratory
and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China Email: Chao Deng (cdeng@***)
Zhiyuan Zhong (zyzhong@***)[*]Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China Tel./Fax: 0086-0512-65880098
Water soluble poly(ethylene oxide)-graft-methotrexate (PEO-g-MTX) conjugates with a robust amide linkage via the amine or carboxylic acid groups of MTX were designed,prepared and investigated for in vitro anti-tumor *...
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Water soluble poly(ethylene oxide)-graft-methotrexate (PEO-g-MTX) conjugates with a robust amide linkage via the amine or carboxylic acid groups of MTX were designed,prepared and investigated for in vitro anti-tumor *** was conjugated to multi-functional PEO containing multiple pendant carboxylic acid (PEO-g-COOH)or amine groups (PEO-g-NH2) via the carbodiimide chemistry,which afforded PEO-g-MTX conjugates with an amide bond to the aminopteridine ring or carboxylic acid groups of MTX (denoted as PEO-g-MTX(COOH) and PEO-g-MTX(NH2),respectively).Dynamic light scattering (DLS) revealed that all PEO-g-MTX conjugates,with MTX contents varying from 4.8 to 19.6 wt％,existed as unimers in phosphate buffer (PB,pH 7.4,20 mmol·L-1).Interestingly,MTT assays showed that PEO-g-MTX(COOH) exhibited potent anti-tumor activity in HeLa,A549,KB and NIH3T3 cells with cytotoxicity profiles comparable to that of free *** contrast,PEO-g-MTX(NH2)revealed diminishing cytostatic effect with IC50 (half maximal inhibitory concentration) ten to hundred times higher than that of PEO-g-MTX(COOH).Moreover,PEO-g-MTX(COOH) conjugates allowed facile conjugation with targeting ***,folate-decorated PEO-g-MTX(COOH) macromolecular drugs showed apparent targetability to folate receptor-overexpressing KB cells with an IC50 over 12-fold lower than non-targeting PEO-g-MTX-(COOH) control and about 2-fold lower than free MTX under otherwise the same conditions.
Nowadays,cancers remain the most disastrous diseases worldwide with more than ten million new cases every *** one of the main therapeutic approaches,chemotherapy can destroy tumors and inhibit
Nowadays,cancers remain the most disastrous diseases worldwide with more than ten million new cases every *** one of the main therapeutic approaches,chemotherapy can destroy tumors and inhibit
As we known,star polymers generally posses several polymer arms emanating from a central *** to now,various controlled/living polymerizations have been employed to generate desired multi-armed
As we known,star polymers generally posses several polymer arms emanating from a central *** to now,various controlled/living polymerizations have been employed to generate desired multi-armed
Nowadays,cancers remain the most disastrous diseases worldwide with more than ten million new cases every *** one of the main therapeutic approaches,chemotherapy can destroy tumors and inhibit cancer ***,it is usually...
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Nowadays,cancers remain the most disastrous diseases worldwide with more than ten million new cases every *** one of the main therapeutic approaches,chemotherapy can destroy tumors and inhibit cancer ***,it is usually restricted by the severe cytotoxicity of anticancer drugs to normal tissues and *** this end,researchers have paid much attention to various drug formulations to reduce the side effects and improve the therapeutic efficacy of anticancer *** them,
As we known,star polymers generally posses several polymer arms emanating from a central *** to now,various controlled/living polymerizations have been employed to generate desired multi-armed macromolecular ***,since...
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As we known,star polymers generally posses several polymer arms emanating from a central *** to now,various controlled/living polymerizations have been employed to generate desired multi-armed macromolecular ***,since its first introduction by Sharpless in 2001,1"click"chemistry has recently become a powerful and versatile synthetic tool because of some unique
Stimuli-responsive polymeric aggregates have attracted wide attention due to their multipurpose applications involving the enhanced selectivity and efficiency of drug delivery to targeting sites.1-
Stimuli-responsive polymeric aggregates have attracted wide attention due to their multipurpose applications involving the enhanced selectivity and efficiency of drug delivery to targeting sites.1-
Stimuli-responsive polymeric aggregates have attracted wide attention due to their multipurpose applications involving the enhanced selectivity and efficiency of drug delivery to targeting sites.1-7 Some dually and mu...
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Stimuli-responsive polymeric aggregates have attracted wide attention due to their multipurpose applications involving the enhanced selectivity and efficiency of drug delivery to targeting sites.1-7 Some dually and multiply stimuli-sensitive copolymers have been synthesized and self-assembled into functional aggregates with great potential in smart release systems,in which various internal and external stimuli have been applied to induce the dissociation or morphology changes of copolymer aggregates and
The ever growing biomedical technology such as regenerative medicine and controlled drug release intimately relies on the development of advancedfunctional biomaterials,among which aliphatic polycarbonates and polype...
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The ever growing biomedical technology such as regenerative medicine and controlled drug release intimately relies on the development of advancedfunctional biomaterials,among which aliphatic polycarbonates and polypeptides due to their excellent biocompatibility and biodegradability have received the most *** the past years,various types of functional polycarbonates and polypeptides
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