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Iron-mediated AGET ATRP of Styrene and Methyl Methacrylate Using Ascorbic Acid Sodium Salt as Reducing Agent

Chinese Journal of Polymer Science 2014年第8期32卷 1010-1018页

作者： Jin-long Pan Zhen Li Li-fen Zhang 程振平朱秀林 Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University

Atom transfer radical polymerization of styrene （St） and methyl methacrylate （MMA） in bulk and in different solvents using activators generated by electron transfer （AGET ATRP） were investigated in the presence of a limited amount of air using FeC13-6H2O as the catalyst, ascorbic acid sodium salt （AsAc-Na） as the reducing agent, and a cheap and commercially available tetrabutylammonium bromide （TBABr） as the ligand. It was found that polymerization in THF resulted in shorter induction period than that in bulk and in toluene for AGET ATRP of St, while referring to AGET ATRP of MMA, polymerization in THF showed three advantages compared with that in bulk and toluene：1） shortening the induction period, 2） enhancing the polymerization rate and 3） having better controllability. The living features of the obtained polymers were verified by chain end analysis and chain-extension experiments.

关键词： Atom transfer radical polymerization （ATRP） AGET ATRP Iron catalyst Kinetics （polym.）.

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Photo-induced Living Cationic Copolymerization of Isobutyl Vinyl Ether and Vinyl Ether with Carbazolyl Groups

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Chinese Journal of Polymer Science 2014年第11期32卷 1564-1574页

作者： Ming Li 张丽芬 Mei-xia Tao 程振平 Xiu-lin Zhu Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationDepartment of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

In this work, a fluorescent monomer 2-（9-carbazolyl） ethyl vinyl ether（CEVE） was synthesized in our lab, and its photo-induced living cationic copolymerization behavior with isobutyl vinyl ether（IBVE） was investigated in detail using diphenyliodonium chloride（DPICl）/2,2-dimethoxy-2-phenylacetophenone（DMPA） and zinc bromide（Zn Br2） initiating system in dichloromethane solution at 5 °C, -5 °C, and -15 °C, respectively. The living nature of this copolymerization system was confirmed by adding fresh comonomer method after the copolymerization almost finished. In addition, the obtained fluorescent copolymer poly（IBVE-co-CEVE） has a low glass transition temperature（Tg）, below -10 °C.

关键词： Photopolymerization Kinetics（polym.） Copolymerization Cationic polymerization Living cationic polymerization.

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Poly(ethylene oxide)-graft-methotrexate Macromolecular Drugs Conjugating via Aminopteridine Ring Exhibit Potent Anticancer Activity

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Chinese Journal of Chemistry 2014年第1期32卷 57-65页

作者： Weiwei Guo Meng Zheng Yinan Zhong Fenghua Meng Chao Deng[*] Zhiyuan Zhong[*] Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China Email: Chao Deng (cdeng@***) Zhiyuan Zhong (zyzhong@***)[*]Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou Jiangsu 215123 China Tel./Fax: 0086-0512-65880098

Water soluble poly(ethylene oxide)-graft-methotrexate (PEO-g-MTX) conjugates with a robust amide linkage via the amine or carboxylic acid groups of MTX were designed,prepared and investigated for in vitro anti-tumor *** was conjugated to multi-functional PEO containing multiple pendant carboxylic acid (PEO-g-COOH)or amine groups (PEO-g-NH2) via the carbodiimide chemistry,which afforded PEO-g-MTX conjugates with an amide bond to the aminopteridine ring or carboxylic acid groups of MTX (denoted as PEO-g-MTX(COOH) and PEO-g-MTX(NH2),respectively).Dynamic light scattering (DLS) revealed that all PEO-g-MTX conjugates,with MTX contents varying from 4.8 to 19.6 wt％,existed as unimers in phosphate buffer (PB,pH 7.4,20 mmol·L-1).Interestingly,MTT assays showed that PEO-g-MTX(COOH) exhibited potent anti-tumor activity in HeLa,A549,KB and NIH3T3 cells with cytotoxicity profiles comparable to that of free *** contrast,PEO-g-MTX(NH2)revealed diminishing cytostatic effect with IC50 (half maximal inhibitory concentration) ten to hundred times higher than that of PEO-g-MTX(COOH).Moreover,PEO-g-MTX(COOH) conjugates allowed facile conjugation with targeting ***,folate-decorated PEO-g-MTX(COOH) macromolecular drugs showed apparent targetability to folate receptor-overexpressing KB cells with an IC50 over 12-fold lower than non-targeting PEO-g-MTX-(COOH) control and about 2-fold lower than free MTX under otherwise the same conditions.

关键词： functional poly(ethylene oxide) methotrexate macromolecular drug folate drug delivery

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A low-toxic and bioreducible polymeric nanocarrier for glutathione-mediated intracellular release of antineoplastic agent

A low-toxic and bioreducible polymeric nanocarrier for gluta...

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The 6th International Conference on Nanoscience and Technology, China 2015 (第六届中国国际纳米科学技术会议)

作者： Jinlin He Fei Li Pengfei Ju Dongling Cao Mingzu Zhang Peihong Ni College of Chemistry Chemical Engineering and Materials ScienceSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisJiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSoochow UniversitySuzhou 215123P.R.China

As one of the main therapeutic methods toward cancers,chemotherapy can efficiently inhibit tumor growth in a large extent [1].However,it is usually restricted with the severe cytotoxicity of antineoplastic agents against normal tissues and *** address this issue,various kinds of drug formulations have been fabricated to balance the minimization of undesirable adverse effects and the improvement of therapeutic efficacy [2,3].

关键词： Cancer chemotherapy Polymeric nanocarrier Biosafety Biodegradability

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Characterization of single-handed,coiled,carbonaceous,tubular nanoribbons

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Chinese Chemical Letters 2014年第6期25卷 879-882页

作者： Dan Liu Yong-Min Guo Yi Li Bao-Zong Li Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

Left-handed, coiled, 4,4＇-biphenylene bridged polybissilsesquioxane, tubular nanoribbons were prepared according to the published literature. After carbonization and removal of silica using HF aqueous solution, left-handed, coiled, carbonaceous, tubular nanoribbons were obtained. The left- handed, coiled, carbonaceous, tubular nanoribbons were characterized using field-emission scanning electron microscopy, transmission electron microscopy, powder X-ray diffraction, Raman spectropho- tometer, diffuse reflectance circular dichroism （DRCD）, and N2 adsorptions. Micropores were formed due to the removal of silica. The nitrogen BET surface area is 1727 m2/g. A broad, positive DRCD signal, identified at 400-800 rim, indicates the carbonaceous, tubular nanoribbons exhibit optical activity. The helical pitch is proposed to play an important role in the position of the DRCD signal.

关键词： Nanoparticles Carbon/silica Sol-gel preparation Structural

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Preparation and characterization of helical carbon/silica nanofibers with lamellar mesopores on the surfaces

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Chinese Chemical Letters 2014年第2期25卷 253-256页

作者： Qing Wang Bao-Zong Li Yi Li Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

Helical 1,2-ethylene-silica nanofibers with lamellar mesopores on the surfaces and twisted rod-like mesopores inside were prepared according to literature procedures. After carbonization, helical carbon/ silica nanofibers with lamellar mesopores on the surfaces and twisted rod-like micropores inside were obtained. The morphologies and pore architectures of the carbon]silica nanofibers were characterized using transmission electron microscopy, field-emission scanning electron microscopy, powder X-ray diffraction and N2 sorptions. Although the mesopores inside shrank into micropores, the helical nanostructure remained. Moreover, several carbon/silica nanofibers with lamellar mesopores on the surfaces and concentric circular micropores inside were also obtained. After being calcined in air, helical silica nanofibers with lamellar mesopores on the surfaces and twisted rod-like micropores inside were produced as well.

关键词： Nanoparticles Mesoporous Carbon/silica Sol-gel preparation Structural

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Preparation of single-handed helical phenolic resin nanoflbers using a supramolecular templating method

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Chinese Chemical Letters 2014年第10期25卷 1363-1366页

作者： Li-Qing Ma Hao Chen Yong-Min Guo Bao-Zong Li Yi Li Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

Single-handed helical phenolic resin nanofibers were synthesized through a supramolecular templating approach using the supramolecular self-assemblies of a pair of chiral low-molecular-weight amphiphiles as the templates and 2,4-dihydroxybenzoic acid and formaldehyde as the *** phenolic resin nanofibers were characterized using field-emission scanning electron microscopy,transmission electron microscopy and diffused reflection circular *** results indicated that the chirality of the supramolecular self-assemblies was successfully transferred to the phenolic resin *** left- and right-handed helical phenolic resin nanofibers exhibited opposite optical activity.

关键词： Supramolecular template Chirality Phenolic resins Nanofibers

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functional BIODEGRADABLE POLYCARBONATES AND POLYPEPTIDES:FACILE SYNTHESIS AND EMERGING BIOMEDICAL applicationS

FUNCTIONAL BIODEGRADABLE POLYCARBONATES AND POLYPEPTIDES:FAC...

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第六届高分子化学国际学术研讨会

作者： Chao Deng Fenghua Meng Ru Cheng Jian Zhang Zhiyuan Zhong Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationDepartment of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

The ever growing biomedical technology such as regenerative medicine and controlled drug release intimately relies on the development of advanced functional biomaterials,among which aliphatic polycarbonates and polypeptides due to their excellent biocompatibility and biodegradability have received the most *** the past years,various types of functional polycarbonates and polypeptides

关键词： functional BIODEGRADABLE POLYCARBONATES AND POLYPEPTIDES:FACILE SYNTHESIS AND EMERGING BIOMEDICAL applicationS

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functional BIODEGRADABLE POLYCARBONATES AND POLYPEPTIDES:FACILE SYNTHESIS AND EMERGING BIOMEDICAL applicationS

FUNCTIONAL BIODEGRADABLE POLYCARBONATES AND POLYPEPTIDES:FAC...

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第六届国际高分子化学学术讨论会

The ever growing biomedical technology such as regenerative medicine and controlled drug release intimately relies on the development of advanced functional biomaterials,among which aliphatic polyc

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FACIAL SYNTHESIS OF NOVEL BIOCOMPATIBLE AND ACID-CLEAVABLE(MPEG-ACETAL-PCL-ACETAL-)3 STAR COpolymers FOR PH-TRIGGERED DRUG DELIVERY

FACIAL SYNTHESIS OF NOVEL BIOCOMPATIBLE AND ACID-CLEAVABLE(M...

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第六届国际高分子化学学术讨论会

作者： Jian Hu Jinlin He Mingzu Zhang Peihong Ni College of Chemistry Chemical Engineering and Materials ScienceJiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSoochow University

As we known,star polymers generally posses several polymer arms emanating from a central *** to now,various controlled/living polymerizations have been employed to generate desired multi-armed

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