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Adhesion: Gecko-Inspired but Chemically Switched Friction and Adhesion on Nanofibrillar Surfaces (Small 9-10/2015)

Small 2015年第9-10期11卷

作者： Shuanhong Ma Daoai Wang Yongmin Liang Baoquan Sun Stanislav N. Gorb Feng Zhou State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China University of the Chinese Academy of Sciences Beijing 100049 China Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Soochow University Suzhou Industrial Park Suzhou 215123 China Department Functional Morphology and Biomechanics Zoological Institute of the University of Kiel Am Botanischen Garten 1–9 D-24098 Kiel Germany

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SYNTHESIS OF pH-RESPONSIVE AMPHIPHILIC DIBLOCK COpolymers CONTAINING POLYISOBUTYLENE via OXYANION-INITIATED POLYMERIZATION AND THEIR MULTIPLE SELF-ASSEMBLY MORPHOLOGIES

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Chinese Journal of Polymer Science 2013年第2期31卷 218-231页

作者： Huai-chao Wang Ming-zu Zhang 倪沛红 Jin-lin He Ying Hao Yi-xian Wu College of Chemistry Chemical Engineering and Materials Science Soochow University Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Soochow University State Key Lab of Chemical Resource Engineering Beijing University of Chemical Technology

Two pH-responsive amphiphilic diblock copolymers, namely polyisobutylene-block-poly[2-（N,N- dimethylamino）ethyl methaerylate] （PIB-b-PDMAEMA） and polyisobutylene-block-poly（metharylic acid）（PIB-b-PMAA）, were synthesized via oxyanion-initiated polymerization, and their multiple self-assembly behaviors have been studied. An exo-01efin-terminated highly reactive polyisobutylene （HRPIB） was first changed to hydroxyl-terminated PIB （PIB-OH） via hydroboration-oxidation of C =C double bond in the chain end, and then reacted with KH to yield a potassium alcoholate of PIB （PIB-O-K＋）. PIB-O-K＋ was immediately used as a macroinitiator to polymerize DMAEMA monomer, resulting in a cationic diblock copolymer PIB-b-PDMAEMA. With the similar synthesis procedure, the anionic diblock copolymer PIB-b- PMAA could be prepared via a combination of oxyanion-initiated polymerization of tert-butyl methacrylate （tBMA） and subsequent hydrolysis of tert-butyl ester groups in PtBMA block. The functional PIB and block copolymers have been fully characterized by 1H-NMR, FT-IR spectroscopy, and gel permeation chromatography （GPC）. These samples allowed us to systematically investigate the effects of block composition on the pH responsivity and various self-assembled morphologies of the copolymers in THF/water mixed solvent. Transmission electron microscopy （TEM） images revealed that these diblock copolymers containing small amount of original PIB without exo-olefin-terminated group are able to self-assemble into micelles, vesicles with different particle sizes and cylindrical aggregates, depending on various factors including block copolymer composition, solvent polarity and pH value.

关键词： Oxyanion-initiated polymerization Polyisobutylene Stimuli responsivity Amphiphilic copolymer Self- assembly.

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ANIONIC SYNTHESIS AND CHARACTERIZATION OF WELL-DEFINED POSS-BASED STAR polymers

ANIONIC SYNTHESIS AND CHARACTERIZATION OF WELL-DEFINED POSS-...

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第六届高分子化学国际学术研讨会

作者： Jinlin He Xuesheng Yan Wen-Bin Zhang Kan Yue Peihong Ni Stephen Z.D.Cheng College of Chemistry Chemical Engineeringand Materials ScienceJiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSoochow University Department of Polymer Science College of Polymer Science and Polymer EngineeringThe University of AkronAkronOH44325-3909USA

Star-shaped polymers refer to one kind of branched polymer in which multiple linear polymeric chains are attached to a central core1,*** unique chain topology imparts valuable properties depending critically on the molecular parameters such as number of arms,molecular weight of each arm,chemical identity of each arm,and *** general,with the growth of living anionic

关键词： ANIONIC SYNTHESIS AND CHARACTERIZATION OF WELL-DEFINED POSS-BASED STAR polymers

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PROTEIN ADSORPTION AND CELL ADHESION ON RGD-functionalIZED SILICON SUBSTRATE SURFACES

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Chinese Journal of Polymer Science 2013年第3期31卷 495-502页

作者： Wei-fang Tong Xiao-li Liu Fei Pan 武照强 Wen-wen Jiang Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow University College of Chemistry and Material Sciences South-Central University for Nationalities

A method was developed to modify silicon surfaces with good protein resistance and specific cell attachment. A silicon surface was initially deposited using a block copolymer of N-vinylpyrrolidone （NVP） and 2-hydroxyethyl methacrylate （HEMA）（PVP-b-PHEMA） film through surface-initiated atom transfer radical polymerization and then further immobilized using a short arginine-glycine-aspartate （RGD） peptide. Our results demonstrate that the RGD-modified surfaces （Si-RGD） can suppress non-specific adsorption of proteins and induce the adhesion of L929 cells. The Si-RGD surface exhibited higher cell proliferation rates than the unmodified silicon surface. This research established a simple method for the fabrication of dual-functional silicon surface that combines antifouling and cell attachment promotion.

关键词： Cell adhesion Protein adsorption RGD Poly（N-vinylpyrrolidone） ATRP.

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ANIONIC SYNTHESIS OF A “CLICKABLE” MIDDLE-CHAIN AZIDE-functionalIZED POLYSTYRENE AND ITS application IN SHAPE AMPHIPHILES

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Chinese Journal of Polymer Science 2013年第1期31卷 71-82页

作者： Kan Yue Jinlin He Chang Liu Mingjun Huang Xue-Hui Dong Kai Guo Peihong Ni Chrys Wesdemiotis Roderic P. Quirk Stephen Z. D. Cheng Wen-Bin Zhang Department of Polymer Science College of Polymer Science and Polymer EngineeringThe University of Akron College of Chemistry Chemical Engineeringand Materials ScienceJiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSoochow University Department of Chemistry The University of Akron

＂Click chemistry＂ is, by definition, a general functionalization methodology （GFM） and its marriage with living anionic polymerization is particularly powerful in precise macromolecular synthesis. This paper reports the synthesis of a ＂clickable＂ middle-chain azide-functionalized polystyrene （mPS-N3） by anionic polymerization and its application in the preparation of novel shape amphiphiles based on polyhedral oligomeric silsesquioxane （POSS）. The mPS-N3 was synthesized by coupling living poly（styryl）lithium chains （PSLi） with 3-chloropropylmethyldichlorosilane and subsequent nucleophilic substitution of the chloro group in the presence of sodium azide. Excess PSLi was end-capped with ethylene oxide to facilitate its removal by flash chromatography. The raPS-N3 was then derived into a giant lipid-like shape amphiphile in two steps following a sequential ＂click＂ strategy. The copper（I）-catalyzed azide-alkyne cycloaddition between mPS-N3 and alkyne-functionalized vinyl-substituted POSS derivative （VPOSS-alkyne） ensured quantitative ligation to give polystyrene with VPOSS tethered at the middle of the chain （mPS-VPOSS）. The thiol-ene reaction with 1-thioglycerol transforms the vinyl groups on the POSS periphery to hydroxyls, resulting in an amphiphilic shape amphiphile, mPS-DPOSS. This synthetic approach is highly efficient and modular. It demonstrates the ＂click＂ philosophy of facile complex molecule construction from a library of simple building blocks and also suggests that mPS-N3 can be used as a versatile ＂clickable＂ motif in polymer science for the precise synthesis of complex macromolecules.

关键词： Living anionic polymerization Polyhedral oligomeric silsesquioxane （POSS）＂Click＂ chemistry Generalfimctionalization methodology （GFM）.

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"Smart" Degradable Nano-Vehicles for Active and Site-Specific Anti-Cancer Drug Delivery

"Smart" Degradable Nano-Vehicles for Active and Site-Specifi...

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2013年中国药物制剂大会

作者： Chao Deng Fenghua Meng Ru Cheng 钟志远 Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationChemical Engineering and Materials ScienceSoochow University

The clinical success of many chemotherapeutics and biotherapeutics intimately depends on the development of non-toxic and efficient tumor-targeting nano-carrier *** ideal drug and protein carriers should be able to retain and protect the payloads under extracellular settings(*** cell culture and during circulation) while dump them once arriving at the site of *** site-selective drug and protein release might on one hand maximize therapeutic effects and on the other hand minimize systemic side ***,despite significant progress has been made

关键词： Degradable Nano-Vehicles for Active and Site-Specific Anti-Cancer Drug Delivery Smart Active

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"Smart" Degradable Nano-Vehicles for Active and Site-Specific Anti-Cancer Drug Delivery

"Smart" Degradable Nano-Vehicles for Active and Site-Specifi...

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2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会

作者： Chao Deng Fenghua Meng Ru Cheng Zhiyuan Zhong Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

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Conference Scene: From innovative polymers to advanced nanomedicine: key challenges, recent progress and future perspectives

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Nanomedicine 2013年第2期8卷 177-180页

作者： Jan Feijen Wim E Hennink Zhiyuan Zhong Biomedical Polymers Laboratory & Jiangsu Key Laboratory of Advanced Functional Polymer Design & Application Department of Polymer Science & Engineering College of Chemistry Chemical Engineering & Materials Science Soochow University Suzhou 215123 PR China Department of Polymer Chemistry & Biomaterials Faculty of Science & Technology MIRA Institute for Biomedical Technology & Technical Medicine University of Twente PO Box 217 7500 AE Enschede The Netherlands Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences Utrecht University PO Box 80082 3508 TB Utrecht The Netherlands Biomedical Polymers Laboratory & Jiangsu Key Laboratory of Advanced Functional Polymer Design & Application Department of Polymer Science & Engineering College of Chemistry Chemical Engineering & Materials Science Soochow University Suzhou 215123 PR China.

Recent developments in polymer-based controlled delivery systems have made a significant clinical impact. The second Symposium on Innovative polymers for Controlled Delivery (SIPCD) was held in Suzhou, China to address the key challenges and provide up-to-date progress and future perspectives in the innovation of polymer-based therapeutics. At SIPCD, a stimulating panel discussion was introduced for the first time on “What is the future of nanomedicine?” This report highlights the most recent research and developments in biomedical polymers and nanomedicine made by 29 invited scientists from around the world, as well as important issues regarding clinical advancements of nanomedicine conferred during the panel discussion.

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Chirality and Chiral Amplication of Star and Hyperbranched π-Conjugated polymers Driven by Chiral Tersolvents

Chirality and Chiral Amplication of Star and Hyperbranched ...

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第八届全国暨华人有机分子和聚合物发光与光电特性学术会议

作者： Jiangfei Liu Shuangshuang Zhang Liang Li Wei Zhang Xiulin Zhu Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and Engineering College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 P.R.China

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ALTERED ENZYMATIC ACTIVITY OF LYSOZYMES BOUND TO VARIOUSLY SULFATED CHITOSANS

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Chinese Journal of Polymer Science 2012年第6期30卷 893-899页

作者：袁琳陈红 Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application Department of Polymer Science and EngineeringCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

The purpose of this research is to investigate the effects of the variously sulfated chitosans on lysozyme activity and structure. It was shown that the specific enzymatic activity of lysozyme remained almost similar to the native protein after being bound to 6-O-sulfated chitosan （6S-chitosan） and 3,6-O-sulfated chitosan （3,6S-chitosan）, but decreased greatly after being bound to 2-N-6-O-sulfated chitosan （2,6S-chitosan）. Meanwhile, among these sulfated chitosans, 2,6S-chitosan induced the greatest conformational change in lysozyme as indicated by the fluorescence spectra. These findings demonstrated that when sulfated chitosans of different structures bind to lysozyme, lysozyme undergoes conformational change of different magnitudes, which results in corresponding levels of lysozyme activity. Further study on the interaction of sulfated chitosans with lysozyme by surface plasmon resonance （SPR） suggested that their affinities might be determined by their molecular structures.

关键词： Lysozyme Sulfated chitosan Activity Structure Regioselective modification.

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