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One-pot growth of triangular SnS nanopyramids for photoacoustic imaging and photothermal ablation of tumors

New Journal of Chemistry 2019年第33期43卷 13256-13262页

作者： Dongliang Yang Fei Chen Shili He Haifeng Shen Yanling Hu Ning Feng Siyu Wang Lixing Weng Zhimin Luo Lianhui Wang School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 China Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts and Telecommunications 9 Wenyuan Road Nanjing 210023 China Laboratory of Polymer Materials and Engineering Ningbo Institute of Technology Zhejiang University Ningbo 315100 China School of Electrical and Control Engineering Nanjing Polytechnic Institute No. 625 Geguan Road Nanjing City Jiangsu China College of Geography and Biological Information Nanjing University of Posts and Telecommunications 9 Wenyuan Road Nanjing 210023 China

Recently, metal sulfides have received great attention in biomedical applications due to their fascinating properties. Herein, poly(vinylpyrollidone)-modified triangular SnS nanopyramids were synthesized via a simple one-pot hydrothermal process. The as-prepared SnS nanopyramids exhibit low toxicity, and a high extinction coefficient (14.25 L g⁻¹ cm⁻¹) and photothermal conversion efficiency (35.4%), enabling effective eradication of tumors in mice. Furthermore, photoacoustic imaging experiments suggest that SnS nanopyramids can be used for tumor photoacoustic imaging. These results indicate that SnS nanopyramids can serve as a nanoplatform for photoacoustic imaging and photothermal therapy in biomedical applications.

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An Improved Master-Slave control for Three-port Converter Based Distributed DC Grid-connected PV System 8

An Improved Master-Slave Control for Three-port Converter Ba...

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8th International Power Electronics Conference, IPEC-Niigata - ECCE Asia 2018

作者： Jiang, Siyue Sun, Kai Wu, Hongfei Shi, Haixu Dong, Xiaofeng Raza Kazmi, Syed Muhammad State Key Lab of Control and Simulation of Power Systems and Generation Equipment Tsinghua University Beijing China Jiangsu Key-Laboratory of New Energy Generation and Power Conversion Nanjing University of Aeronautics and Astronautics Nanjing Jiangsu Province China United States Pakistan Center for Advanced Studies in Energy National University of Sciences and Technology Islamabad Pakistan

ISBN: (纸本)9784886864055

With the development of DC grid technology, it has become a trend to introduce photovoltaic(PV) as a power source to the DC power distribution network. In this paper, an improved master-slave control strategy is proposed to realize power splitting and voltage sharing in a modular system with PV connected. Each module is a three-port converter: Input port connects distributed PV, output port connects to DC grid, and intermediate port is connected in parallel with other modules as a bus to realize the power splitting. For a single module, input voltage, intermediate bus voltage and output voltage should all be controlled to reference but only duty ratio and phase-shifting angel can be regulated hence it may occur the multi-objective variables control problem. While using the proposed strategy, this problem can be solved effectively and the system stability is ensured during the voltage sharing process. This control strategy is verified by simulation and experiment. © 2018 IEEJ Industry Application Society.

关键词： System stability

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Detection of Picric Acid by Terpy-Based Metallo- Supramolecular Fluorescent Coordination Polymers in Aqueous Media

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Chinese Journal of Chemistry 2017年第4期35卷 447-456页

作者： Zhongyu Ding Hongqing Li Wanqing Gao Yiquan Zhang Chunhua Liu Yuanyuan Zhu School of Chemistry and Chemical Engineering Hefei University of Technology and Anhui Key Laboratory of Advanced Functional Materials and Devices Hefei Anhui 230009 China Jiangsu Provincial Key Laboratory for Numerical Simulation of Large Scale Complex Systems (NSLSCS) School of Physical Science and Technology Nanjing Normal University Nanjing Jiangsu 210023 China

The synthesis of two linear terpy-based metallo-supramolecular fluorescent coordination polymers through 1 ： 1 complexation of Zn^2＋ and Cd^2＋ ions with ditopic terpyridine ligand was reported. The dispersibility of P1 and P2 was significantly improved in organic solvent and water through the introduction of hydrophilic oligo-ethyoxy side chain. Two polymers displayed yellow light emission both in solution and the solid state due to the intra-ligand charge transfer （ILCT） between the d^10 metal ions and the conjugated spacer unit. These coordination polymers were explored as fluorescent chemosensors for detecting picric acid in aqueous media, displaying high sensitivity and good selectivity. In addition, test strips were prepared from these polymers and exhibited the practical potential of detecting the NACs pollutants in the outdoor water for public safety and security.

关键词： coordination polymer fluorescent chemosensors nitroaromatic explosives picric acid aqueous media

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Co-Assembly Induced Solid-State Stacking Transformation in Amino Acid-Based Crystals with Enhanced Physical Properties

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Angewandte Chemie 2022年第17期134卷

作者： Prof. Wei Ji Hui Yuan Dr. Bin Xue Dr. Sarah Guerin Dr. Hui Li Dr. Lei Zhang Yanqing Liu Dr. Linda J. W. Shimon Prof. Mingsu Si Prof. Yi Cao Prof. Wei Wang Prof. Damien Thompson Prof. Kaiyong Cai Prof. Rusen Yang Prof. Ehud Gazit Key Laboratory of Biorheological Science and Technology Ministry of Education The National “111” Project for Biomechanics and Tissue Repair Engineering College of Bioengineering Chongqing University Chongqing 400044 P. R. China School of Molecular Cell Biology and Biotechnology George S. Wise Faculty of Life Sciences Tel Aviv University Tel Aviv 6997801 Israel School of Advanced Materials and Nanotechnology Xidian University Xi'an 710126 China National Laboratory of Solid State Microstructure Department of Physics Nanjing University Nanjing 210093 Jiangsu China Department of Physics Bernal Institute University of Limerick Limerick V94 T9PX Ireland Science and Technology on Combustion and Explosion Laboratory Xi'an Modern Chemistry Research Institute Xi'an 710065 China CAEP Software Center for High Performance Numerical Simulation Beijing 100088 China Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou University Lanzhou 730000 China Department of Chemical Research Support Weizmann Institute of Science Rehovot 7610001 Israel

The physical characteristics of supramolecular assemblies composed of small building blocks are dictated by molecular packing patterns in the solid-state. Yet, the structure–property correlation is still not fully understood. Herein, we report the unexpected cofacial to herringbone stacking transformation of a small aromatic bipyridine through co-assembly with acetylated glutamic acid. The unique solid-state structural transformation results in enhanced physical properties of the supramolecular organizations. The co-assembly methodology was further expanded to obtain diverse molecular packings by different bipyridine and acetylated amino acid derivatives. This study presents a feasible co-assembly approach to achieve the solid-state stacking transformation of supramolecular organization and opens up new opportunities to further explore the relationship between molecular arrangement and properties of supramolecular assemblies by crystal engineering.

关键词： Amino Acids Co-Assembly Stacking Modes Supramolecular Chemistry

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I3−-Mediated Oxygen Evolution Activities to Boost Rechargeable Zinc-Air Battery Performance with Low Charging Voltage and Long Cycling Life

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Angewandte Chemie 2024年第4期137卷

作者： Dr. Xiaohong Zou Dr. Qian Lu Lizhen Wu Kouer Zhang Mingcong Tang Haijiao Xie Prof. Xiao Zhang Prof. Zongping Shao Prof. Liang An Department of Mechanical Engineering The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong SAR PR China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control School of Environmental Science and Technology Nanjing University of Information Science and Technology Nanjing 210044 PR China Department of Chemistry The Chinese University of Hong Kong Ma Lin building Shatin 999077 Hong Kong SAR PR China Hangzhou Yanqu Information Technology Co. Ltd. Y2 2 nd Floor Building 2 Xixi Legu Creative Pioneering Park No. 712 Wen'er West Road Xihu District Hangzhou City Zhejiang Province 310003 P.R.O.C. Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong SAR PR China Research Institute for Smart Energy The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong SAR PR China WA School of Mines: Minerals Energy and Chemical Engineering (WASM-MECE) Curtin University Perth WA-6102 Australia

An effective strategy to facilitate oxygen redox chemistry in metal-air batteries is to introduce a redox mediator into the liquid electrolyte. The rational utilization of redox mediators to accelerate the charging kinetics while ensuring the long lifetime of alkaline Zn-air batteries is challenging. Here, we apply commercial acetylene black catalysts to achieve an I 3 − -mediated Zn-air battery by using ZnI 2 additives that provide I 3 − to accelerate the cathodic redox chemistry and regulate the uniform deposition of Zn 2+ on the anode. The Zn-air battery performs an ultra-long cycle life of over 600 h at 5 mA cm −2 with a final charge voltage of 1.87 V. We demonstrate that I − mainly generates I 3 − on the surface of carbon catalysts during the electrochemically charging process, which can further chemically react with OH − to generate oxygen and further revert to I − , thus obtaining a stable electrochemical system. This work offers a strategy to simultaneously improve the cycling life and reduce the charging voltage of Zn-air batteries through redox mediator methods.

关键词： Zinc-air batteries Redox mediators oxygen electrocatalysts Redox chemistry Stability

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Deep learning for smart agriculture:Concepts,tools,applications,and opportunities

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International Journal of Agricultural and Biological Engineering 2018年第4期11卷 32-44页

作者： Nanyang Zhu Xu Liu Ziqian Liu Kai Hu Yingkuan Wang Jinglu Tan Min Huang Qibing Zhu Xunsheng Ji Yongnian Jiang Ya Guo Key Laboratory of Advanced Process Control for Light Industry Ministry of EducationJiangnan UniversityWuxi 214122China School of Internet of Things Jiangnan UniversityWuxi 214122China Chinese Academy of Agricultural Engineering Beijing 100125China Department of Bioengineering University of MissouriColumbiaMO 65211USA Jiangsu Zhongnong IoT Technology Co. LTDYixing 214200China

In recent years,Deep Learning(DL),such as the algorithms of Convolutional Neural Networks(CNN),Recurrent Neural Networks(RNN)and Generative Adversarial Networks(GAN),has been widely studied and applied in various fields including *** in the fields of agriculture often use software frameworks without sufficiently examining the ideas and mechanisms of a *** article provides a concise summary of major DL algorithms,including concepts,limitations,implementation,training processes,and example codes,to help researchers in agriculture to gain a holistic picture of major DL techniques *** on DL applications in agriculture is summarized and analyzed,and future opportunities are discussed in this paper,which is expected to help researchers in agriculture to better understand DL algorithms and learn major DL techniques quickly,and further to facilitate data analysis,enhance related research in agriculture,and thus promote DL applications effectively.

关键词： deep learning smart agriculture neural network convolutional neural networks recurrent neural networks generative adversarial networks artificial intelligence image processing pattern recognition

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A resonant cavity based on birdcage coil for overhauser geomagnetic sensor

A resonant cavity based on birdcage coil for overhauser geom...

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2018 IEEE International Instrumentation and Measurement technology Conference, I2MTC 2018

作者： Bai, Bingjie Dong, Haobin Ge, Jian Liu, Huan Zhang, Cheng Wang, Luo Institute of Geophysics and Geomatics China University of Geosciences Hubei Wuhan China School of Automation China University of Geosciences Hubei Wuhan China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Hubei Wuhan China Science and Technology on Near-Surface Detection Laboratory Jiangsu Wuxi China

ISBN: (纸本)9781538622223

The resonant cavity is an important component of Overhauser magnetometer sensor. Its function is to make the working substance generate dynamic nuclear polarization effect in the sensor. An alternative design of resonant cavity based on the birdcage coil structure was proposed to make the resonant frequency in accordance with the polarization frequency of the working substance. The structure and equivalent circuit of resonant cavity were analyzed. The model of resonant cavity was established and S-parameter is calculated to verify the frequency consistency of the resonant cavity and working substance. In addition, output signal experiment and simultaneous comparison testing of sensor prototype were conducted. Overall, this design has the advantages of high performance and strong anti-interference. © 2018 IEEE.

关键词： Equivalent circuits

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Unveiling microbial communities with EasyAmplicon: A user-centric guide to perform amplicon sequencing data analysis

iMetaOmics

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iMetaOmics 2024年第2期1卷

作者： Salsabeel Yousuf Hao Luo Meiyin Zeng Lei Chen Tengfei Ma Xiaofang Li Maosheng Zheng Xin Zhou Liang Chen Jiao Xi Hongye Lu Huiluo Cao Xiaoya Ma Bian Bian Pengfan Zhang Jiqiu Wu Renyou Gan Baolei Jia Linyang Sun Zhicheng Ju Yunyun Gao Waqar Afzal Malik Chuang Ma Hujie Lyu Yahui Li Huiyu Hou Yuanping Zhou Defeng Bai Yao Wang Haifei Yang Jiani Xun Shengda Du Tianyuan Zhang Xiulin Wan Kai Peng Shanshan Xu Tao Wen Tong Chen Yong-Xin Liu Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen Guangdong China Department of Vascular Surgery Fu Xing Hospital Capital Medical University Beijing China State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems Centre for Grassland Microbiome College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou Gansu China Centre for Agricultural Resources Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Shijiazhuang Hebei China College of Environmental Science and Engineering North China Electric Power University Beijing China State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences Beijing China Biomedical Innovation Center and Beijing Key Laboratory for Therapeutic Cancer Vaccines Beijing Shijitan Hospital Capital Medical University Beijing China College of Natural Resources and Environment Northwest A&F University Yangling Shaanxi China Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province Hangzhou Zhejiang China Department of Microbiology University of Hong Kong Pok Fu Lam Hong Kong China Center for Energy Metabolism and Reproduction Institute of Biomedicine and Biotechnology Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong China Department of Cardiology Shenzhen Guangming District People's Hospital Shenzhen Guangdong China Department of Computational Biology and Medical Sciences Graduate School of Frontier Sciences The University of Tokyo Kashiwa Chiba Japan Innovative Genomics Institute University of California Berkeley C

The advent of next-generation sequencing has revolutionized microbiome research, enabling in-depth exploration of microbial communities through amplicon sequencing. The widespread adoption of sequencing across diverse fields, coupled with decreasing costs, underscores the critical need for validated, fully automated, reproducible, and adaptable analysis pipelines. However, analyzing these high-throughput datasets often necessitates extensive bioinformatics expertize, hindering accessibility for many researchers. To address this challenge, in 2023 we developed EasyAmplicon, a comprehensive, user-friendly pipeline that integrates popular tools such as USEARCH and VSEARCH, offering a streamlined workflow from raw data to results. Remarkably, EasyAmplicon has garnered significant recognition within a year, as evidenced by 127 citations to date. To further facilitate the researchers and enhance usability, we present a detailed protocol with a video recording that guides users through each step of the pipeline, including data preprocessing (quality filtering, chimera removal), amplicon sequence variant analysis, diversity analysis, and data visualization. The protocol is designed for ease of use, with each step documented, allowing researchers to execute the workflow without requiring complex scripting skills. The EasyAmplicon pipeline is freely available on GitHub ( https://***/YongxinLiu/EasyAmplicon ). EasyAmplicon offers a fully automated, user-friendly pipeline for comprehensive amplicon sequencing analysis, seamlessly integrating various bioinformatics tools. The pipeline supports efficient data preprocessing, diversity analysis, and advanced visualization, making high-throughput data analysis accessible to a broader range of researchers. Each step is documented, along with troubleshooting tips and solutions, for users' convenience.

关键词： computational biology EasyAmplicon metagenome microbiome

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Layer dependence of interlayer breathing and shear modes in ising ferromagnetic CrI3

arXiv

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arXiv 2019年

作者： Guo, Kai Deng, Bowen Shi, Zhongtai Li, Yue Wang, Xin Bi, Lei Zhang, Li Lu, Haipeng Zhou, Peiheng Zhang, Linbo Cheng, Yingchun Peng, Bo National Engineering Research Center of Electromagnetic Radiation Control Materials School of Electronic Science and Engineering University of Electronic Science and Technology of China Chengdu611731 Key Laboratory of Flexible Electronics Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced Materials Nanjing Tech University Nanjing211816 Department of Physics Broida Hall University of California Santa BarbaraCA93106-9530 Key Laboratory of Multi-spectral Absorbing Materials and Structures of Ministry of Education University of Electronic Science and Technology of China Chengdu611731

Long-range magnetic orders in atomically thin Ising ferromagnetic CrI3together with their promising electronic and optical properties give rise to new fascinating physics. However, to date, there has been no experimentally comprehensive understanding of the lattice dynamics in such 2D ferromagnets. Here, we report the layer, temperature and polarization dependence of Raman features in few-layer CrI3. The out-of-plane Ag(in-plane Eg) mode shifts to a higher (lower) frequency with an increased number of layers at 10 K. These modes simultaneously blueshift to higher energies due to phonon-phonon coupling as the temperature decreases from 200 to 60 K. Remarkably, a spin-phonon coupling emerges below 60 K (∼Tc), which causes an anomalous temperature-dependent behavior for both the Ag and Eg mode. The Ag(Eg) mode maintains (reverses) the helicity of incident light at 10 K, which is independent of the magnetic field and originates from the phonon symmetry. Our work provides insights into the spin-phonon coupling and lattice dynamics of Ising ferromagnets. Copyright © 2019, The Authors. All rights reserved.

关键词： Ferromagnetism

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Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report

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Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2024年第4期20卷 521-530页

作者： Batel Blechter Chao Agnes Hsiung Xiaoyu Wang Haoyu Zhang Wei Jie Seow Jianxin Shi Nilanjan Chatterjee Hee Nam Kim Maria Pik Wong Yun-Chul Hong Jason Yy Wong Juncheng Dai H Dean Hosgood Zhaoming Wang I-Shou Chang Jiyeon Choi Jiucun Wang Minsun Song Wei Hu Wei Zheng Jin Hee Kim Baosen Zhou Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Roel C H Vermeulen Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Yukihide Momozawa Yoichiro Kamatani Takayuki Honda Hideo Kunitoh Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Hsien-Chih Lin Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Tzu-Yu Chen Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Junwen Wang Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Chung-Hsing Chen Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jun Suk Kim Ho-Il Yoon Qiuyin Cai In Kyu Park Ping Xu Qincheng He Chih-Yi Chen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Joseph F Fraumeni Jie Liu Maria Teresa Landi Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Hongxia Ma Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Motoki Iwasaki Junjie Zhu Gening Jiang Ke Fei Guoping Wu Li-Hsin Chien Fang-Yu Tsai Jinming Yu Victoria L Stevens Pan-Chyr Yang Dongxin Lin Kexin Chen Yi-Long Wu Keitaro Matsuo Nathaniel Rothman Kouya Shiraishi Hongbing Shen Stephen J Chanock Takashi Kohno Qing Lan Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore. Department of Oncology School of Medicine Johns Hopkins University Baltimore MD USA Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore MD USA. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology Queen Mary Hospital Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Epidemiology and Community Health Branch National Heart Lung and Blood Institute Bethesda MD USA. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Epidemiology and Population Health Albert Einstein College of Medicine New York USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Department of Statistics & Research Institute of Natural Sciences Sookmyung Women's University Seoul 04310 Korea. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Environmental Health

We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the epidermal growth factor receptor (EGFR) gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4,544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared to EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (OR=8.63, 95% CI:5.67, 13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (OR=3.50, 95% CI: 2.44, 5.00) (p-heterogeneity=3.66x10). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications.

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