To the Editor:Breast cancer(BC)is the most common cancer in women,which affects 2.26 million people annually,with 680,000 *** 70%of cases involve estrogen-activated estrogen receptors(ER),which promote tumor growth th...
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To the Editor:Breast cancer(BC)is the most common cancer in women,which affects 2.26 million people annually,with 680,000 *** 70%of cases involve estrogen-activated estrogen receptors(ER),which promote tumor growth through gene regulation and cellular *** reactivation without ligands contributes to therapy *** resistance in estrogen receptor-positive(ER+)breast tumors can result from mutations in ER,altered interactions with coactivators/corepressors,or crosstalk with growth factor receptors and oncogenic pathways.[1]Additionally,long non-codingrnas(lncrnas)are diverse molecules with distinct expression patterns in different cancer types,playing critical roles in tumorigenesis.[2]Notably,actin gamma 1 pseudogene(AGPG)is emerging as a noteworthy lncrna that holds promise as a new therapeutic target intended for the effective management of endocrine-resistant BC.
In this paper, a pump-free and multi-channel surface-enhanced Raman scattering (SERS) microfluidic chip proposed for the rapid and sensitive detection of miR-92a and miR-339-3p, two micrornas (mirnas) related to non-s...
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Studies have greatly explored the role of micrornas (mirnas) in cerebral ischemia/reperfusion injury (CI/RI). But the specific mechanism of miR-326-5p in CI/RI is still elusive. Hence, this study was to unmask the mec...
Studies have greatly explored the role of micrornas (mirnas) in cerebral ischemia/reperfusion injury (CI/RI). But the specific mechanism of miR-326-5p in CI/RI is still elusive. Hence, this study was to unmask the mechanism of miR-326-5p/signal transducer and activator of transcription-3 (STAT3) axis in CI/RI. Two models (oxygen and glucose deprivation [OGD] in primary rat cortical neurons and middle cerebral artery occlusion [MCAO] in Sprague–Dawley rats) were established to mimic CI/RI in vitro and in vivo, respectively. Loss- and gain-of function assays were performed with OGD-treated neurons and with MCAO rats. Afterward, viability, apoptosis, oxidative stress and mitochondrial membrane potential in OGD-treated neurons were tested, as well as pathological changes, apoptosis and mitochondrial membrane potential in brain tissues of MCAO rats. Mitofusin-2 (Mfn2), miR-326-5p and STAT3 expression in OGD-treated neurons and in brain tissues of MCAO rats were detected. Mfn2 and miR-326-5p were reduced, and STAT3 was elevated in OGD-treated neurons and brain tissues of MCAO rats. miR-326-5p targeted and negatively regulated STAT3 expression. Restoring miR-326-5p or reducing STAT3 reinforced viability, inhibited apoptosis and oxidative stress, increased mitochondrial membrane potential and increased Mfn2 expression in OGD-treated neurons. Up-regulating miR-326-5p or down-regulating STAT3 relieved pathological changes, inhibited apoptosis and elevated mitochondrial membrane potential and Mfn2 expression in brain tissues of rats with MCAO. This study elucidates that up-regulated miR-326-5p or down-regulated STAT3 protects against CI/RI by elevating Mfn2 expression.
Chimeric antigen receptor (CAR) T cell treatment is an emerging subject following its curative response in hematological metastasis. However, solid tumors present a number of obstructions which have been a bull's ...
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