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Bone changes in early inflammatory arthritis assessed with High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT): A 12-month cohort study

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Revue du Rhumatisme (Edition Francaise) 2021年第6期88卷 450-458页

作者： Brunet, Scott C. Finzel, Stephanie Engelke, Klaus Boyd, Steven K. Barnabe, Cheryl Manske, Sarah L. McCaig Institute for Bone and Joint Health Cumming School of Medicine University of Calgary Calgary AB Canada Biomedical Engineering Graduate Program and Department of Radiology Cumming School of Medicine University of Calgary Calgary AB Canada Department of Rheumatology and Clinical Immunology Medical Center University of Freiburg Faculty of Medicine University of Freiburg Freiburg Germany Department of Medicine FAU University Erlangen-Nürnberg and Universitätsklinikum Erlangen Erlangen Germany Department of Medicine Cumming School of Medicine University of Calgary Calgary AB Canada Department of Community Health Sciences Cumming School of Medicine University of Calgary Calgary AB Canada

Objectifs: L'apparition d’érosions dans les arthropathies inflammatoires revêt une importance majeure car elles ont une incidence sur le pronostic et les décisions thérapeutiques. Notre étude visait à déterminer la sensibilité de la tomodensitométrie quantitative périphérique haute résolution (HR-pQCT) pour détecter des changements de la surface osseuse au cours du temps et identifier l'apparition d’érosions chez les patients présentant une arthrite inflammatoire précoce (AIP). Nous avons également exploré la contribution de facteurs de pronostic aux dommages osseux périarticulaires évalués par HR-pQCT dans l'année suivant le diagnostic. Méthodes: Quarante-six patients présentant des symptômes d'arthrites depuis moins d'un an et ayant reçu un diagnostic clinique d'arthrite inflammatoire ont passé un examen d'imagerie prospectif à l'inclusion et à 12 mois. Une HR-pQCT de la deuxième et de la troisième articulation MCP et des radiographies conventionnelles (RC) des mains et des pieds ont été réalisées. La largeur de l'interligne articulaire, la densité minérale osseuse totale (DMOt), la présence d’érosions et leur volume ont été évalués par HR-pQCT. La précision des analyses scan–rescan a été évaluée afin de définir un critère de plus petite variation significative (PPVS) au niveau individuel. Des analyses de régression ont exploré les facteurs de pronostic de progression des dommages osseux. Résultats: Nous n'avons pas constaté de changements significatifs au niveau du groupe concernant la largeur de l'interligne, la DMOt ou le volume des érosions. Jusqu’à 20 % d'articulations ont présenté des changements individuels supérieurs au critère PPVS pour la largeur d'interligne moyenne, la DMOt et le volume des érosions. L'HR-pQCT a détecté davantage d’érosions que la RC dans la 2e et la 3e MCP. Une durée des symptômes plus longue au moment du diagnostic a été faiblement associée (p < 0,10) à une largeur d'interligne minimale plus faible et à un écart-type d'interligne plu

关键词： Arthrite inflammatoire précoce Densité minérale osseuse Polyarthrite rhumatoïde Tomodensitométrie quantitative périphérique haute résolution (HR-pQCT) Érosions osseuses

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Investigating the utility of HR-pQCT for the assessment of joint space and bone mineral density in hand osteoarthritis

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Osteoarthritis Imaging 2024年第3期4卷 100233-100233页

作者： Michael T. Kuczynski Justin J. Tse Gurpreet Dhaliwal Christina Hiscox Martina Vergouwen Neil J. White Sarah L. Manske McCaig Institute for Bone and Joint Health University of Calgary Canada Biomedical Engineering Graduate Program Schulich School of Engineering University of Calgary Canada Department of Radiology Cumming School of Medicine University of Calgary Canada South Campus Research Unit for Bone and Soft Tissue University of Calgary Canada Department of Surgery Cumming School of Medicine University of Calgary Canada

Objective Osteoarthritis affects joints of the hand and is radiographically characterized by joint space narrowing and changes in volumetric bone mineral density (vBMD). High-resolution peripheral computed tomography (HR-pQCT) allows for three-dimensional analysis of joint space width (JSW) changes but has yet to be applied to hand OA (HOA). The purpose of this study was to assess the utility of HR-pQCT in quantifying JSW and vBMD changes in HOA. Design The 2nd and 3rd distal interphalangeal (DIP2, DIP3) and trapeziometacarpal (TMC) joints of 20 women (10 controls, 10 HOA) were scanned using HR-pQCT. The Diseases of the Arm, Shoulder, and Hand (DASH) questionnaire and the Jebsen Hand Function Test (JHFT) were obtained. Radiographs were scored using the Eaton-Littler classification. We assessed between-group differences in HR-pQCT outcomes, and relationships between HR-pQCT outcomes and patient and radiographic characteristics. Results JSW maximum (***) was higher in OA patients in the DIP2 (OA median [interquartile rage]: 2.07 mm [1.90–2.18], controls: 1.88 mm [1.84–1.89]) and DIP3 joints (OA: 2.01 mm [1.89–2.24], controls: 1.86 mm [1.82–1.95]). DIP3 JS volume was higher in OA (30.36 mm 3 , 19.35–34.57 mm 3 , controls: 17.05 mm 3 , 15.53–18.52 mm 3 ). DASH scores were positively associated with DIP2 JSW asymmetry (***), and JHFT times were positively associated with DIP3 ***, ***, and proximal DIP2 vBMD. Worsening radiographic TMC OA was associated with first metacarpal vBMD, JSW minimum, ***, and ***. Conclusions These preliminary findings suggest that HR-pQCT may be useful in investigating JS changes in HOA and warrants further investigation.

关键词： Hand osteoarthritis HR-pQCT joint space

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Uncovering chromatin accessibility and cancer diagnostic potential via cell-free DNA utilization

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Science Bulletin 2024年第19期69卷 2987-2992页

作者： Jie Li Jiahui Chen Xin Sun Heli Yang Keyong Sun Chang Liu Yongwang Wang Mengyue Xu Xin Ji Ji Zhang Xiaojiang Wu Anqiang Wang Biao Fan Xiaolu Zhang Yue Wu Peilin Cui Junya Peng Yupei Zhao Wenming Wu Honghao Yu Zhaode Bu Jiafu Ji Xun Lan Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Center of Gastrointestinal CancerPeking University Cancer Hospital&InstituteBeijing 100142China Guangxi Key Laboratory of Drug Discovery and Optimization Guilin Medical UniversityGuilin 541001China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Internal Medicine International Medical Services(IMS)Beijing Tiantan Hospital of Capital Medical UniversityBeijing 100070China Institute of Clinical Medicine Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China Peking-Tsinghua-NIBS Joint Graduate Program Tsinghua UniversityBeijing 100084China Tsinghua-Peking Joint Center for Life Sciences Tsinghua UniversityBeijing 100084China Department of Anesthesiology Affiliated Hospital of Guilin Medical UniversityGuilin 541000China Key Laboratory of Medical Biotechnology and Translational Medicine Guilin Medical UniversityGuilin 541001China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China The Islands Healthcare Complex-Macao Medical Center of Peking Union Medical College Hospital Macao 999078China

Gene expression patterns of tumor cells can be inferred from features of circulating cell-free DNA(cfDNA),such as histone modifications and fragmentation patterns at ***,the direct relationship between cfDNA patterns and tumor-specific chromatin accessibility has not yet been experimentally established,limiting its current application to cancer diagnosis alone.

关键词： diagnosis cancer alone

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A consensus protocol for functional connectivity analysis in the rat brain (vol 26, pg 673, 2023)

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NATURE NEUROSCIENCE 2023年第6期26卷 1127-1128页

作者： Grandjean, Joanes Desrosiers-Gregoire, Gabriel Anckaerts, Cynthia Angeles-Valdez, Diego Ayad, Fadi Barriere, David A. Blockx, Ines Bortel, Aleksandra Broadwater, Margaret Cardoso, Beatriz M. Celestine, Marina Chavez-Negrete, Jorge E. Choi, Sangcheon Christiaen, Emma Clavijo, Perrin Colon-Perez, Luis Cramer, Samuel Daniele, Tolomeo Dempsey, Elaine Diao, Yujian Doelemeyer, Arno Dopfel, David Dvorakova, Lenka Falfan-Melgoza, Claudia Fernandes, Francisca F. Fowler, Caitlin F. Fuentes-Ibanez, Antonio Garin, Clement M. Gelderman, Eveline Golden, Carla E. M. Guo, Chao C. G. Henckens, Marloes J. A. G. Hennessy, Lauren A. Herman, Peter Hofwijks, Nita Horien, Corey Ionescu, Tudor M. Jones, Jolyon Kaesser, Johannes Kim, Eugene Lambers, Henriette Lazari, Alberto Lee, Sung-Ho Lillywhite, Amanda Liu, Yikang Liu, Yanyan Y. Lopez-Castro, Alejandra Lopez-Gil, Xavier Ma, Zilu MacNicol, Eilidh Madularu, Dan Mandino, Francesca Marciano, Sabina McAuslan, Matthew J. McCunn, Patrick McIntosh, Alison Meng, Xianzong Meyer-Baese, Lisa Missault, Stephan Moro, Federico Naessens, Daphne M. P. Nava-Gomez, Laura J. Nonaka, Hiroi Ortiz, Juan J. Paasonen, Jaakko Peeters, Lore M. Pereira, Mickael Perez, Pablo D. Pompilus, Marjory Prior, Malcolm Rakhmatullin, Rustam Reimann, Henning M. Reinwald, Jonathan Del Rio, Rodrigo Triana Rivera-Olvera, Alejandro Ruiz-Perez, Daniel Russo, Gabriele Rutten, Tobias J. Ryoke, Rie Sack, Markus Salvan, Piergiorgio Sanganahalli, Basavaraju G. Schroeter, Aileen Seewoo, Bhedita J. Selingue, Erwan Seuwen, Aline Shi, Bowen Sirmpilatze, Nikoloz Smith, Joanna A. B. Smith, Corrie Sobczak, Filip Stenroos, Petteri J. Straathof, Milou Strobelt, Sandra Sumiyoshi, Akira Takahashi, Kengo Torres-Garcia, Maria E. Tudela, Raul van den Berg, Monica van der Marel, Kajo van Hout, Aran T. B. Vertullo, Roberta Vidal, Benjamin Vrooman, Roel M. Wang, Victora X. Wank, Isabel Watson, David J. G. Yin, Ting Zhang, Yongzhi Zurbruegg, Stefan Achard, Sophie Alcauter, Sarael Auer, Dorothee P. Barbier, Emmanuel L. Baudewig, Juergen Beckmann, Chri Donders Institute for Brain Behaviour and Cognition Radboud University Nijmegen The Netherlands Department for Medical Imaging Radboud University Medical Center Nijmegen The Netherlands Cerebral Imaging Centre Douglas Mental Health University Institute Verdun QC Canada Integrated Program in Neuroscience McGill University Montreal QC Canada Bio-imaging Lab University of Antwerp Antwerp Belgium µNEURO Research Centre of Excellence University of Antwerp Antwerp Belgium Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Mexico Biological and Biomedical Engineering McGill University Montreal QC Canada McConnell Brain Imaging Centre McGill University Montreal QC Canada Montreal Neurological Institute McGill University Montreal QC Canada UMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction Physiologie de la reproduction et des comportements Centre de recherche INRAE de Nouzilly Tours France Department of Neurology and Neurosurgery McGill University Montreal QC Canada Center for Animal MRI University of North Carolina at Chapel Hill Chapel Hill NC USA Department of Neurology University of North Carolina at Chapel Hill Chapel Hill NC USA Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC USA Preclinical MRI Champalimaud Research Champalimaud Centre for the Unknown Lisbon Portugal Laboratoire des Maladies Neurodégénératives Molecular Imaging Research Center (MIRCen) Université Paris-Saclay Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA) CNRS Fontenay-aux-Roses France Departamento de Neurobiología Conductual y Cognitiva Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro México Translational Neuroimaging and Neural Control Group High-Field Magnetic Resonance Max Planck Institute for Biological Cybernetics Tuebingen Germany Graduate Training Centre of Neuroscience International Max

Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

关键词： Databases Neural circuits

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biomedical data and AI

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Science China Life Sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

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A Dual-Modality nanozyme Exploiting ROS-Responsive oxygen Catalysis for Precision NF-κB pathway Suppression in gouty arthritis

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Chemical engineering Journal 2025年 516卷

作者： Sathiyamoorthy Padmanaban Sree Samanvitha Kuppa Omkar Sangabathula Amal Babu Adityanarayan Mohapatra Sung Sun Kim Hong Yeol Yang Aravindkumar Sundaram Hyung Keun Kim Jong Keun Seon In-Kyu Park Department of Biomedical Sciences and BioMedical Sciences Graduate Program (BMSGP) Chonnam National University Medical School Hwasun 58128 Republic of Korea Department of Orthopaedics Surgery Center for Joint Disease of Chonnam National University Hwasun Hospital 322 Seoyang-ro Hwasun-eup Jeonnam 519-763 Republic of Korea Korea Biomedical Materials and Devices Innovation Research Center of Chonnam National University Hospital 42 Jebong-ro Dong-gu Gwangju 501-757 Republic of Korea Department of Chemical Engineering Indian Institute of Technology Hyderabad Kandi 502284 Telangana India DRCure Inc. Hwasun 58128 Republic of Korea Department of Pathology Chonnam National University Medical School Gwangju 61469 Republic of Korea

Gout is characterized by urate deposition in joints leading to immune cell recruitment and inflammatory cytokine release. This condition poses significant therapeutic challenges due to its association with the activation of the nuclear factor (NF)-κB pathway, which promotes inflammation. Traditional treatment modalities often fall short of effectively targeting gout pathophysiology. To address this gap, nanoparticles present a promising avenue by improving drug bioavailability and reducing toxicity. This study explores the therapeutic potential of hollow cerium oxide (CeO) nanoparticles loaded with alpha-lipoic acid (α-LA) in alleviating NF-κB pathway activation. Synthesized through the solvothermal method, hollow CeO nanoparticles were loaded with α-LA through solvent evaporation. Characterization revealed a hollow spherical morphology, uniform size distribution, and sustained α-LA release in vitro . Treatment with CeO nanoparticles, α-LA, and CeO-loaded α-LA resulted in decreased levels of reactive oxygen species (ROS), hydrogen peroxide (H 2 O 2 ), and nitric oxide (NO), alongside increased antioxidant enzyme activities (superoxide dismutase and catalase). Moreover, the nanoparticle efficacy was evaluated in RAW 264.7 macrophage cells stimulated with monosodium urate (MSU) and in a murine model of MSU-induced joint inflammation. While CeO nanoparticles and α-LA individually exhibited moderate reductions in inflammatory mediator release and NF-κB pathway activity, CeO-loaded α-LA synergistically suppressed MSU-induced NF-κB pathway activation. Notably, CeO-loaded α-LA also ameliorated MSU-induced joint inflammation in mice. These findings explore the therapeutic potential of α-LA-loaded CeO nanoparticles, a novel formulation combining antioxidant and anti-inflammatory nanocarriers, to mitigate MSU-induced NF-κB activation. The hollow spherical nanoparticles enable controlled α-LA release, enhancing bioavailability and targeting dual pathways of oxidative stress an

关键词： Alpha lipoic acid Cerium oxide Drug release Gout Inflammation

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Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines

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细胞研究（英文版） 2021年第7期31卷 732-741页

作者： Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie Beijing Advanced Innovation Center for Genomics (ICG) Peking UniversityBeijingChina Biomedical Pioneering Innovation Center (BIOPIC) Peking UniversityBeijingChina Beijing Advanced Innovation Center for Genomics (ICG) Peking UniversityBeijingChina Biomedical Pioneering Innovation Center (BIOPIC) Peking UniversityBeijingChina School of Life Sciences Peking UniversityBeijingChina Beijing Advanced Innovation Center for Genomics (ICG) Peking UniversityBeijingChina Joint Graduate Program of Peking-Tsinghua-NIBS School of Life SciencesTsinghua UniversityBeijingChina Division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of BiologicalsBeijingChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijingChina Beijing Advanced Innovation Center for Genomics (ICG) Peking UniversityBeijingChina School of Life Sciences Peking UniversityBeijingChina Beijing Advanced Innovation Center for Genomics (ICG) Peking UniversityBeijingChina Biomedical Pioneering Innovation Center (BIOPIC) Peking UniversityBeijingChina Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina Beijing Youan Hospital Capital Medical UniversityBeijingChina Beijing Advanced Innovation Center for Genomics (ICG) Peking UniversityBeijingChina Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina School of Pharmaceutical Sciences IDG/McGovern Institute for Brain ResearchTsinghua UniversityBeijingChina Vazyme Biotech Co. LtdNanjingJiangsuChina CAS Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of SciencesBeijingChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina

SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain (RBD) and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2 (B.1.351),of the plasma and neutralizing antibodies (NAbs) elicited by CoronaVac (inactivated vaccine),ZF2001 (RBD-subunit vaccine) and natural *** 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant ***3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining *** contrast,the 242-244 deletion (242-244A) would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD *** of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242-244△,with the effects being ***,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD ***,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose ***,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite.

关键词： Cryoelectron microscopy Immunology X-ray crystallography

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BIOMECHANICAL STUDY OF PEDICLE SCREW FIXATION STRENGTH: ASSOCIATION OF SCREW MALPOSITION AND SCREW INSERTION TORQUE

BIOMECHANICAL STUDY OF PEDICLE SCREW FIXATION STRENGTH: ASSO...

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作者： Tsai, Tsung-Ting Chen, Yu-Hung Liao, Chao-Yaug Lin, Hsin-Tzu Liu, Mu-Yi Chen, Jin-Kai Lai, Po-Liang Tai, Ching-Lung Department of Orthopaedic Surgery Spine Section Bone and Joint Research Center Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan33302 Taiwan Department of Medical Education Chang Gung Memorial Hospital Taoyuan33302 Taiwan Department of Mechanical Engineering National Central University Taoyuan32001 Taiwan Graduate Institute of Biomedical Engineering Chang Gung University Taoyuan33302 Taiwan Ph.D. Program in Biomedical Engineering Collage of Engineering Chang Gung University Taoyuan33302 Taiwan

Pedicle screws have been widely used for the treatment of spinal diseases, but improper screw placement is not uncommon and may lead to neurovascular injuries and reduced screw fixation strength. This study aimed to investigate the feasibility of using real-time screw insertion torque monitoring to prevent screw penetration. Commercially available synthetic L4 vertebrae were divided in to seven test groups based on different screw placements. Screw insertion torque and maximal pullout strength were compared among groups. The results indicated that the insertion torque gradually increased when the screw tip was within vertebral cancellous bone without penetration. However, an instantaneous decrease of torque value was observed once the screw tip penetrated the cortex wall. When compared to the control group, higher pullout strength was found for the groups with medial cortex penetration. However, vertebrae with medial cortex penetration may lead to the concern of neurovascular damage. Meanwhile, lower pullout strength was found for the groups with lateral cortex penetration and end-plate penetration, which may lead to the concern of screw loosening. We concluded that pedicle screw penetration can be judged using real-time screw insertion torque monitoring during surgery, which may aid surgeons in avoiding neurovascular injury and reduction of screw fixation strength. © 2019 World Scientific Publishing Company.

关键词： Screws

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Benchmark problems for transcranial ultrasound simulation: Intercomparison of compressional wave models

arXiv

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arXiv 2022年

作者： Aubry, Jean-Francois Bates, Oscar Boehm, Christian Pauly, Kim Butts Christensen, Douglas Cueto, Carlos Gélat, Pierre Guasch, Lluis Jaros, Jiri Jing, Yun Jones, Rebecca Li, Ningrui Marty, Patrick Montanaro, Hazael Neufeld, Esra Pichardo, Samuel Pinton, Gianmarco Pulkkinen, Aki Stanziola, Antonio Thielscher, Axel Treeby, Bradley Van't Wout, Elwin Physics for Medicine Paris INSERM U1273 ESPCI Paris PSL University CNRS UMR 8063 France Department of Bioengineering Imperial College London Exhibition Road LondonSW7 2AZ United Kingdom Institute of Geophysics ETH Zürich Sonneggstrasse 5 Zürich8092 Switzerland Department of Radiology Stanford University StanfordCA United States Department of Biomedical Engineering Department of Electrical and Computer Engineering University of Utah United States Department of Surgical Biotechnology Division of Surgery and Interventional Science University College London LondonNW3 2PF United Kingdom Earth Science and Engineering Department Imperial College London London United Kingdom Centre of Excellence IT4Innovations Faculty of Information Technology Brno University of Technology Bozetechova 2 Brno612 00 Czech Republic Graduate Program in Acoustics The Pennsylvania State University University Park PA16802 United States Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill North Carolina State University NC United States Department of Electrical Engineering Stanford University StanfordCA United States Zurich Switzerland Laboratory for Acoustics / Noise control Empa Swiss Federal Laboratories for Materials Science and Technology Dubendorf Switzerland Zurich Switzerland Radiology and Clinical Neurosciences Departments Cumming School of Medicine University of Calgary Canada Department of Applied Physics University of Eastern Finland Kuopio70211 Finland Department of Medical Physics and Biomedical Engineering University College London Gower Street LondonWC1E 6BT United Kingdom Technical University of Denmark Denmark Danish Research Center for Magnetic Resonance Copenhagen University Hospital Hvidovre Denmark Institute for Mathematical and Computational Engineering School of Engineering and Faculty of Mathematics Pontificia Universidad Catolica de Chile Santiago Chile

Computational models of acoustic wave propagation are frequently used in transcranial ultrasound therapy, for example, to calculate the intracranial pressure field or to calculate phase delays to correct for skull distortions. To allow intercomparison between the different modeling tools and techniques used by the community, an international working group was convened to formulate a set of numerical benchmarks. Here, these benchmarks are presented, along with intercomparison results. Nine different benchmarks of increasing geometric complexity are defined. These include a single-layer planar bone immersed in water, a multi-layer bone, and a whole skull. Two transducer configurations are considered (a focused bowl and a plane piston), giving a total of 18 permutations of the benchmarks. Eleven different modeling tools are used to compute the benchmark results. The models span a wide range of numerical techniques, including the finite-difference time-domain method, angular-spectrum method, pseudospectral method, boundary-element method, and spectral-element method. Good agreement is found between the models, particularly for the position, size, and magnitude of the acoustic focus within the skull. When comparing results for each model with every other model in a cross comparison, the median values for each benchmark for the difference in focal pressure and position are less than 10% and 1 mm, respectively. The benchmark definitions, model results, and intercomparison codes are freely available to facilitate further comparisons. Copyright © 2022, The Authors. All rights reserved.

关键词： Bone

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Immobilization of poly(hexamethylene biguanide) to cellulose acetate- and cellulose-based nanofiber membranes for antibacterial and cytotoxic studies

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Biochemical engineering Journal 2024年 205卷

作者： Dinh Thi My Huong Chi-Yun Wang Pin-Yi Chen Chien Wei Ooi Xue Er Crystal Thew Bing-Lan Liu Chen-Yaw Chiu Shen-Long Tsai Kuei-Hsiang Chen Yu-Kaung Chang Department Chemical Technology and Environment University of Technology and Education the University of Da Nang Da Nang City Viet Nam Department Chemical Engineering/ Graduate School of Biochemical Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan Department Chemical Engineering National Taiwan University of Science and Technology Taipei City 10607 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Bone and Joint Research Centre Chang Gung Memorial Hospital Taoyuan City 333423 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Chemical Engineering Department School of Engineering Monash University Malaysia Jalan Lagoon Selatan Bandar Sunway Selangor 47500 Malaysia Advanced Engineering Platform School of Engineering Monash University Malaysia Jalan Lagoon Selatan 47500 Bandar Sunway Selangor Malaysia Department of Applied Chemistry Chaoyang University of Technology Taichung 413310 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Zhongli Dist Taoyuan City 320315 Taiwan

To develop the environmental antibacterial membrane, the physical attachments of poly (hexamethylene biguanide) hydrochloride (PHMB) on the cellulose acetate (CA) and regenerated cellulose (RC) electrospun nanofiber membranes were employed. The immobilization of PHMB increased the antibacterial efficacy ( AE , %) of nanofiber membranes from 65.67% to approximately 86.13% for CA-PHMB and from 35.09% to approximately 100% for RC-PHMB. The results of the chemical and physical characteristics indicate that the degree of deacetylation of CA nanofiber, the surface charge of the nanofiber, and the density of PHMB immobilized onto the nanofiber primarily affect the antibacterial efficacy. The use of mathematical models, such as the Temkin equilibrium model for PHMB immobilization and the Monod-type model for the relationship between antibacterial activity and immobilization density of PHMB provides a deeper understanding of the interactions and kinetics involved. The rapid achievement of ∼100% AE after only 10 min of contact with Escherichia coli ( E. coli ) is a notable finding, indicating the quick and efficient antibacterial action of RC-PHMB nanofiber membranes. Furthermore, maintaining approximately 100% AE after 20 days of storage underscores the long-term stability of PHMB immobilized on RC nanofiber membranes. The findings suggest that RC-PHMB holds great promise as an antibacterial material for biomedical applications, food packaging industries, and filtration or treatment of water.

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