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33rd Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBS 2011

作者： Villa, Emanuel White, Alayne Stewart Liao, Jun De Jongh Curry, Amy L. Joint Graduate Program in Biomedical Engineering University of Memphis University of Tennessee Health Science Center Memphis TN 38152 United States Department of Agricultural and Biological Engineering Mississippi State University Mississippi State MS 39762 United States

ISBN: (纸本)9781424441211

A tissue bath system, to be used as an alternative to complex perfusion chambers, was constructed for use in cardiac electrophysiological studies. This system consists of an acrylic chamber to hold circulating physiological medium such as DMEM, suspended in a water bath warmed by a hot plate. Temperature and pH were controlled to mimic physiological conditions. Rat and porcine cardiac tissues, were used to test viability of the conditions presented in the bath system. Using a cardiac mapping system, the tissues were stimulated and responses recorded. From the recordings we were able to calculate conduction velocities and spatial dispersion of activation indices. The results are comparable to previous in-vivo work, which suggests that the tissue bath system design can maintain tissue viability. This tissue bath system is a relatively simple alternative for ex-vivo testing of cardiac tissues. © 2011 IEEE.

关键词： Tissue

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压缩传感可以缩短临床上1H-MRI代谢成像时间

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国际医学放射学杂志 2012年第3期 276-276页

作者： S.Geethanath H.M.Baek S.K.Ganji E.A.Maher R.D.Sims 董龙春 Joint Graduate Program in Biomedical Engineering at UT Arlington and UT Southwestern Medical Center DallasTex

目的回顾性地评价通过压缩传感实现的加速磁共振波谱成像(MRS)数据保存的保真性。材料与方法在数据采集前,这项实验获得了机构审查委员会的认可以及书面同意书,对项目中所获得的MRS数据进行采集和分析。这项研究符合HIPAA。回顾性地对1... 详细信息

目的回顾性地评价通过压缩传感实现的加速磁共振波谱成像(MRS)数据保存的保真性。材料与方法在数据采集前,这项实验获得了机构审查委员会的认可以及书面同意书,对项目中所获得的MRS数据进行采集和分析。这项研究符合HIPAA。回顾性地对10例临床MRS数据集进行压缩

关键词：压缩传感回顾性原始数据加速因子体素 MRI

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An Inexpensive Alternative Bath System for Electrophysiological Characterization of Isolated Cardiac Tissue

An Inexpensive Alternative Bath System for Electrophysiologi...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Emanuel Villa Alayne Stewart White Jun Liao Amy L. de Jongh Curry Joint Graduate Program in Biomedical Engineering at The University of Memphis and University of Tennessee Health Science Center Department of Agricultural and Biological Engineering Mississippi State University

ISBN: (纸本)9781424441211

关键词： Isolated tissue Ex-vivo characterization Cardiac mapping

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Simultaneous identification for synergistic transcription factors and their transcription factor binding sites

Simultaneous identification for synergistic transcription fa...

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5th International Conference on Complex, Intelligent and Software Intensive Systems, CISIS 2011

作者： Tsai, Zing Tsung-Yeh Huang, Grace Tzu-Wei Tsai, Huai-Kuang Institute of Information Science Academia Sinica Taipei 115 Taiwan Bioinformatics Program Taiwan International Graduate Program Taiwan Institute of Biomedical Informatics National Yang-Ming University Taiwan Joint CMU-Pitt PhD Program in Computational Biology University of Pittsburgh Carnegie Mellon University Pittsburgh PA United States Research Center for Information Technology Innovation Taipei 115 Taiwan Computer Science and Engineering National Taiwan Ocean University Keelung 202 Taiwan

ISBN: (纸本)9780769543734

Identifying transcription factor binding sites (TFBSs) is crucial for understanding the mechanism of transcriptional regulation. It is known that transcription factors (TFs) often cooperate to regulate genes. While traditional approaches can be used to discover binding motifs of a group of co-regulated genes, they often fail to accurately assign motifs to the corresponding TFs. Here, we consider two TFs together to infer their TFBSs and their synergistic relationship simultaneously. The basic idea is that if two TFs interact, their TFBSs, if distinct, would be conserved across species and coincided in the promoter regions of the genes they co-regulated. Applying our method to Saccharomyces cerevisiae chromatin immunoprecipitation data, we predicted 110 TF pairs with statistically significant motif assignments. A majority of these TF pairs have literature support to be synergistic, and the designated motifs to TFs match well with their known consensus. We further examined the synergism of predicted TF pairs in seven experimental conditions using ANOVA, and identified significant interactions. © 2011 IEEE.

关键词： Yeast

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Tumour oxygen dynamics measured simultaneously by near-infrared spectroscopy and 19F magnetic resonance imaging in rats

Tumour oxygen dynamics measured simultaneously by near-infra...

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作者： Xia, Mengna Kodibagkar, Vikram Liu, Hanli Mason, Ralph P. Joint Biomedical Engineering Graduate Program University of Texas at Arlington University of Texas Southwestern Medical Center Dallas TX 76019 United States Cancer Imaging Program Department of Radiology University of Texas Southwestern Medical Center Dallas TX 75390 United States

Simultaneous near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI) were used to investigate the correlation between tumour vascular oxygenation and tissue oxygen tension dynamics in rat breast 13762NF tumours with respect to hyperoxic gas breathing. NIRS directly detected global variations in the oxygenated haemoglobin concentration (Δ[HbO 2]) within tumours and oxygen tension (pO2) maps were achieved using 19F MRI of the reporter molecule hexafluorobenzene. Multiple correlations were examined between rates and magnitudes of vascular (Δ[HbO2]) and tissue (pO2) responses. Significant correlations were found between response to oxygen and carbogen breathing using either modality. Comparison of results for the two methods showed a correlation between the vascular perfusion rate ratio and the mean pO2 values (R2 > 0.7). The initial rates of increase of Δ[HbO 2] and the slope of dynamic pO2 response, d(pO 2)/dt, of well-oxygenated voxels in response to hyperoxic challenge were also correlated. These results demonstrate the feasibility of simultaneous measurements using NIRS and MRI. As expected, the rate of pO2 response to oxygen is primarily dependent upon the well perfused rather than poorly perfused vasculature. © 2006 IOP Publishing Ltd.

关键词： Tumors

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Resolution of optical microscope redefined

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Biophotonics International 2006年第7期13卷 42-45页

作者： Ram, Sripad Ward, E. Sally Ober, Raimund J. Joint Biomedical Engineering Graduate Program University of Texas Arlington University of Texas Southwestern Medical Center Dallas Center for Immunology Southwestern Medical Center Department of Electrical Engineering University of Texas Dallas Center for Immunology

A resolution measure that overcomes the limitations of Rayleigh's criterion was proposed that predicted the resolution of an optical microscope was not limited and that it can be improved by increasing the number of detected photons. An interdisciplinary approach was used to obtain the new resolution measure in which tools of advanced statistical image processing address a classical problem in optical microscopy. Single-molecule imaging experiments have verified that distances between single molecules that are well below Rayleigh's criterion can be measured with an accuracy in accordance with that prediction. An analytical expression for the fundamental resolution measure (FREM) was obtained by assuming imaging conditions analogous to those of Rayleigh's criterion. The proposed resolution measure shows that certain single-molecule experiments can be performed that were once unfeasible with optical microscope.

关键词： Optical microscopy

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A stochastic analysis of performance limits for optical microscopes

A stochastic analysis of performance limits for optical micr...

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作者： Ram, Sripad Ward, E. Sally Center for Immunology NB9.106 University of Texas Southwestern Medical Center at Dallas 6000 Harry Hines Boulevard Dallas TX 75390-8576 United States Joint Biomedical Engineering Graduate Program University of Texas at Arlington University of Texas Southwestern Medical Center Dallas IEEE SPIE Biophysical Society Department of Microbiology Cancer Immunobiology Center University of Texas Southwestern Medical Center Dallas

The optical microscope is a powerful instrument for observing cellular events. Recently, the increased use of microscopy in quantitative biological research, including single molecule microscopy, has generated significant interest in determining the performance limits of an optical microscope. Here, we formulate this problem in the context of a parameter estimation approach in which the acquired imaging data is modeled as a spatio-temporal stochastic process. We derive formulations of the Fisher information matrix for models that allow both stationary and moving objects. The effects of background signal, detector size, pixelation and noise sources are also considered. Further, formulations are given that allow the study of defocused objects. Applications are discussed for the special case of the estimation of the location of objects, especially single molecules. Specific emphasis is placed on the derivation of conditions that guarantee block diagonal or diagonal Fisher information matrices.

关键词： Optical microscopy

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A mentoring program for women in the joint graduate biomedical engineering program of University of Memphis and University of Tennessee

A mentoring program for women in the joint graduate biomedic...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： S.S. Demir Joint Graduate Biomedical Engineering Program University of Memphis and University of Tennessee Memphis TN USA

Mentoring is significant personal and professional assistance given by a more experienced person to a less experienced person during a time of transition. Transitions from high school to university, from university to graduate school are difficult. Organizing and running mentoring programs in schools or in professional societies provide good recruitment and retention of female students in engineering. biomedical engineering (BME) is the engineering discipline that has the highest percentage of female degree recipients and tenure/tenure-track teaching faculty. Thus there is a great potential for female role models, mentors and mentees in BME. Recently, I have a developed a mentoring program for women at the joint graduate biomedical engineering program of University of Memphis (UM) and University of Tennessee (UT). Currently we are following the book "Giving Much/Gaining More: Mentoring for Success" by Dr. Wadsworth for our meetings and activities to provide a support and discussion group, and environment to women in their transition time of the BME graduate studies. Our future goal is to expand mentoring to female students in our engineering school.

关键词： Employee welfare biomedical engineering Educational institutions Books Agricultural engineering Education Chemical engineering Industrial engineering Recruitment Organizing

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Correlation of NIR spectroscopy with BOLD MR imaging of assessing breast tumor vascular oxygen status

Correlation of NIR spectroscopy with BOLD MR imaging of asse...

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biomedical Topical Meeting, BIOMED 2004

作者： Gu, Yueqing Xia, Mengna Liu, Hanli Kodibagkar, Vikram Constantinescu, Anca Mason, Ralph P. Joint Graduate Program in Biomedical Engineering University of Texas at Arlington ArlingtonTX76019 United States Department of Radiology University of Texas Southwestern Medical Center at Dallas DallasTX75390 United States

Dynamic changes of oxygenated and deoxygenated hemoglobin concentrations in response to hyperoxic gas interventions on rat breast tumors were simultaneously investigated by near infrared spectroscopy and BOLD (blood o... 详细信息

ISBN: (纸本)1557527695

关键词： Near infrared spectroscopy

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Investigation of tumor oxygen consumption and tumor vascular oxygen dynamics in response to pharmacological interventions by NIRS

Investigation of tumor oxygen consumption and tumor vascular...

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biomedical Topical Meeting, BIOMED 2002

作者： Kim, Jae G. Liu, Hanli Song, Yulin Constantinescu, Anca Mason, Ralph P. Joint Graduate Program in Biomedical Engineering University of Texas at Arlington ArlingtonTX76019 United States Department of Radiology University of Texas Southwestern Medical Center at Dallas DallasTX75390 United States

Estimation of tumor oxygen consumption and the effects of pharmacological interventions (carbogen, hydralazine and KCl) are studied by near infrared spectroscopy in mammary adenocarcinoma 13762NF tumors grown on Fishe... 详细信息

ISBN: (纸本)1557527024

关键词： Tumors

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