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Optical Tomography and Spectroscopy of Tissue XIV 2021

作者： Ioussoufovitch, Seva Diop, Mamadou Western University Faculty of Engineering School of Biomedical Engineering Collaborative Training Program in Musculoskeletal Health Research Bone and Joint Institute London Canada Western University Schulich School of Medicine and Dentistry Department of Medical Biophysics London Canada Lawson Health Research Institute Imaging Program London Canada

ISBN: (数字)9781510641143

ISBN: (纸本)9781510641136

Diffuse optical techniques have been used to assess joint inflammation in rheumatoid arthritis (RA);however, there is scant data on the use of time-domain (TD) techniques for this purpose. We conducted TD simulations in a realistic finger joint and investigated how TD parameters changed in response to simulated joint inflammation. An MRI image of a healthy human finger was segmented into 7 tissue types and manipulated to create 4 models representing various degrees of RA disease activity. NIRFAST was used to simulate TD light propagation through the models at 800nm using an array of light sources/detectors placed across the proximal interphalangeal (PIP) joint. Parameters were extracted from the resulting TPSFs using statistical moments (number of photons, mean time-of-flight, centralized variance), temporal binning (early, middle, late temporal windows), and Fourier decomposition to produce a series of 2D images. Spatial frequency components were then extracted from each of the images and used to detect differences between the 4 models of disease activity. Spatial frequency amplitudes of high-frequency temporal Fourier component images differentiated between models with 100% accuracy and with the highest percent differences (i.e., performance). However, once Poisson noise was added to the TPSFs, amplitudes of early photon and total number of photon images at the 0.14mm-1 spatial frequency had the highest performance for accuracy cut-offs of 95% and 100%, respectively. Future work will focus on validating results with experimental TD-DOI data and assessing how combinations of various parameters can be used to increase performance while maintaining accuracy. © 2021 SPIE

关键词： Photons

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Multi-modal Deep Learning for Assessing Surgeon Technical Skill on a Surgical Knot-tying Task

TechRxiv

引用

TechRxiv 2022年

作者： Kasa, Kevin Burns, David Goldenberg, Mitchell G. Selim, Omar Whyne, Cari Hardisty, Michael The Holland Bone and Joint Program The Sunnybrook Research Institute Canada The Holland Bone and Joint Program Sunnybrook Reserach Institute The Institute of Biomedical Engineering The University of Toronto The Department of Surgery Canada The Department of Surgery The University of Toronto Canada The Department of Surgery The Royal Victoria Regional Health Center Canada

Goal: This paper introduces a new dataset of a surgical knot-tying task, and a multi-modal deep learning model that achieves comparable performance to expert human raters on this skill assessment task. Methods: Seventy-two surgical trainees and faculty were recruited for the knot-tying task, and were recorded using video, kinematic, and image data. Three expert human raters conducted the skills assessment using the Objective Structured Assessment of Technical Skill (OSATS) Global Rating Scale (GRS). We also designed and developed three deep learning models: a ResNet-based image model, a ResNet-LSTM kinematic model, and a multi-modal model leveraging the image and timeseries kinematic data. Results: All three models demonstrate performance comparable to the expert human raters on most GRS domains. The multi-modal model demonstrates the best overall performance, as measured using the mean squared error (MSE) and intraclass correlation coefficient (ICC). Conclusion: Multi-modal deep learning has the potential to replicate human raters on a challenging human-performed knot-tying task. Significance: As objective assessment of technical skill continues to be a growing, but resource-heavy, element of surgical education, this study is an important step towards automated surgical skill assessment, ultimately leading to reduced burden on training faculty and institutes. © 2022, CC BY-NC-SA.

关键词： biomedical engineering

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Injectable citrate-based polyurethane-urea as a tug-of-war-inspired bioactive self-expansive and planar-fixing screw augmented bone-tendon healing

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Bioactive Materials 2024年第11期41卷 108-126页

作者： Meihan Tao Zhou Fang Yuting Zhu Yan Ju Zhiguo Hou Meimei Fu Zhihui Lu Daozhang Cai Jian Yang Jinshan Guo Department of Orthopedic Surgery Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou510630PR China Department of Histology and Embryology NMPA Key Laboratory for Safety Evaluation of CosmeticsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515PR China Regenerative Medicine and Tissue Repair Material Research Center Huangpu Institute of MaterialsGuangzhou New Materials Science CenterChangchun Institute of Applied ChemistryChinese Academy of Sciences88 Yonglong Avenue of Xinlong TownGuangzhou511363PR China Research Center for Industries of the Future Biomedical Engineering ProgramSchool of EngineeringWestlake UniversityHangzhouZhejiang310030PR China CAS Key Laboratory of High-Performance Synthetic Rubber and its Composite Materials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun130022PR China

Inspired by tug-of-war,a game-changing bone-tendon fixation paradigm was ***,injectable citrate-based bioactive self-expansive and planar-fixing screw(iCSP-Scr)consisting of reactive isocyanate(NCO)terminalized citrate-based polyurethane,proanthocyanidin modified hydroxyapatite(HAp)and water(with/without porogen)was developed and administrated in the bone-tendon *** of the“point to point”tendon fixation by traditional interface screws,along with the moisture-induced crosslinking and expansion of iCSP-Scr within the confined space of the irregularly shaped bone-tendon gap,the tendon graft was evenly squeezed into the bone tunnel in a“surface to surface”manner to realize strong and stable bone-tendon fixation via physical expansion,mechanical interlocking and chemical bonding(between–NCO and the–NH2,–SH groups on bone matrix).The optimized iCSP-Scr exhibited rapid crosslinking,moderate expansion rate,high porosity after crosslinking,as well as tunable elasticity and *** iCSP-Scr possessed favorable biodegradability,biocompatibility,and osteoinductivity derived from citrate,PC and HAp,it was able to promote osteogenesis and new bone growth inward of bone tunnel thus further enhanced the bone/iCSP-Scr mechanical interlock,ultimately leading to stronger tendon fixation(pull-out force 106.15±23.15 N)comparing to titanium screws(93.76±17.89 N)after 14 weeks’ACL reconstruction in a rabbit *** iCSP-Scr not only can be used as a self-expansive screw facilitating bone-tendon healing,but also can be expanded into other osteogenic application scenarios.

关键词： Polyurethane Injectable Self-expansive Planar-fixing Citrate

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Noggin expression in human nucleus pulposus cells: A comparative study of degenerative and traumatic intervertebral discs

Advanced Orthopaedics

引用

Advanced Orthopaedics 2025年 1卷 55-62页

作者： Shuimu Chen Sebastian F. Bigdon Sonja Häckel Zhen Li Christoph E. Albers Benjamin Gantenbein Department of Orthopaedic Surgery & Traumatology Inselspital Bern University Hospital Faculty of Medicine University of Bern Bern CH-3010 Switzerland Tissue Engineering for Orthopaedics & Mechanobiology (TOM) Bone & Joint Program Department for BioMedical Research (DBMR) Faculty of Medicine University of Bern Bern CH-3008 Switzerland Graduate School for Cellular and Biomedical Sciences (GCB) University of Bern Bern CH-3012 Switzerland Graduate School for Health Sciences (GHS) University of Bern CH-3012 Bern Switzerland AO Research Institute Davos Davos CH-7270 Switzerland

Low back pain (LBP) is a health issue that leads to considerable disability and socioeconomic burdens. The degeneration of the human intervertebral disc (IVD) is a key factor in the pathogenesis of LBP. During disc degeneration, the nucleus pulposus (NP), a critical component of IVD, undergoes significant alterations in structural composition and function. Recent studies have highlighted the importance of various genes in IVD health. Noggin has been described as an essential gene in nucleus pulposus cells (NPCs) and a central role in inhibiting osteogenesis. In this study, we conducted a comparative analysis of Noggin expression in human NPCs from degenerative and healthy IVD. Twenty-six IVD samples (nineteen from degeneration and seven from trauma) were collected to separate NPCs for RNA extraction. Noggin expression was quantified at the transcript level by qPCR to analyze the difference between degenerative and traumatic IVD. Results indicated that Noggin expression was lower in NPCs from degenerated IVD compared to trauma cases. The severity of IVD degeneration correlated with decreased Noggin levels. Traumatic males exhibited higher Noggin expression than traumatic females and those with IVD degeneration. Noggin expression peaked in young adults (18–45 years), decreased in middle age (46–69 years), and rose again in the elderly (over 69 years), but remained lower than in the youth. Furthermore, upper lumbar discs (T12/L1-L2/3) showed higher Noggin levels than lower lumbar discs (L3/4/-L5/S1). This research elucidates valuable insights into the variability of Noggin concerning sex, age, degree of disc degeneration, and disc segment. It provides implications for IVD health and LBP treatment.

关键词： Low back pain Human intervertebral disc Nucleus pulposus cells Noggin

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Mechanobiology of Collective Cell Migration in 3D Microenvironments

arXiv

引用

arXiv 2022年

作者： Hruska, Alex M. Yang, Haiqian Leggett, Susan E. Guo, Ming Wong, Ian Y. School of Engineering Center for Biomedical Engineering Joint Program in Cancer Biology Brown University ProvidenceRI02912 United States Department of Mechanical Engineering Massachusetts Institute of Technology CambridgeMA02139 United States Department of Chemical and Biological Engineering Princeton University Princeton NJ08540 United States

Tumor cells invade individually or in groups, mediated by mechanical interactions between cells and their surrounding matrix. These multicellular dynamics are reminiscent of leader-follower coordination and epithelial-mesenchymal transitions (EMT) in tissue development, which may occur via dysregulation of associated molecular or physical mechanisms. However, it remains challenging to elucidate such phenotypic heterogeneity and plasticity without precision measurements of single cell behavior. The convergence of technological developments in live cell imaging, biophysical measurements, and 3D biomaterials are highly promising to reveal how tumor cells cooperate in aberrant microenvironments. Here, we highlight new results in collective migration from the perspective of cancer biology and bioengineering. First, we review the biology of collective cell migration. Next, we consider physics-inspired analyses based on order parameters and phase transitions. Further, we examine the interplay of metabolism and heterogeneity in collective migration. We then review the extracellular matrix, and new modalities for mechanical characterization of 3D biomaterials. We also explore epithelial-mesenchymal plasticity and implications for tumor progression. Finally, we speculate on future directions for integrating mechanobiology and cancer cell biology to elucidate collective migration. © 2022, CC BY-NC-ND.

关键词： Cytology

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Sensitivity of time-domain near-infrared imaging to rheumatoid arthritis disease activity: an in silico and phantom study

Sensitivity of time-domain near-infrared imaging to rheumato...

引用

Clinical and Translational Biophotonics, Translational 2022

作者： Ioussoufovitch, Seva Diop, Mamadou Western University School of Biomedical Engineering Collaborative Training Program in Musculoskeletal Health Research Bone & Joint Institute 1151 Richmond St. LondonONN6A 5C1 Canada Western University Department of Medical Biophysics 1151 Richmond St. LondonONN6A 5C1 Canada Lawson Health Research Institute Imaging Program 268 Grosvenor St. LondonONN6A 4V2 Canada

Virtual models and solid phantoms were created to simulate rheumatoid arthritis (RA) disease states. Time-domain datasets from simulations and phantom measurements were processed to extract parameters sensitive to sim... 详细信息

ISBN: (纸本)9781557528209

关键词： Diseases

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Temperature-sensitive polymeric nanogels encapsulating withβ-cyclodextrin and ICG complex for high-resolution deep-tissue ultrasound-switchable fluorescence imaging

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Nano Research 2020年第4期13卷 1100-1110页

作者： Ruilin Liu Tingfeng Yao Yang Liu Shuai Yu Liqin Ren Yi Hong Kytai T.Nguyen Baohong Yuan Ultrasound and Optical Imaging Laboratory Department of Bioengineeringthe University of Texas at ArlingtonArlingtonTX 76019USA Joint Biomedical Engineering Program the University of Texas at Arlington and the University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Bioengineering the University of Texas at ArlingtonArlingtonTX 76019USA

One of the thorny problems currently impeding the applications of the fluorescence imaging technique is the poor spatial resolution in deep ***-switchable fluorescence(USF)imaging is a novel imaging tool that has recently been explored to possibly surmount the above-mentioned ***,αβ-cyclodextrin/indocyanine green(ICG)complex-encapsulated poly(N-isopropylacrylamide)(PNIPAM)nanogel was synthesized and studied for ex vivo/in vivo deep tissue/high-resolution near infrared USF(NIR-USF)*** be specific,our results revealed that the average diameter of the as-prepared nanogels was significantly decreased to-32 nm from-335 nm compared to the reported ICG-PNIPAM ***,the excitation/emission characteristics of the ICG itself in present nanogels were almost completely retained,and the resultant nanogel exhibited high physiological stability and positive *** particular,the signal-to-noise ratio of the USF image for the PNIPAM/P-cyclodextrin/ICG nanogel(33.01±2.42 dB)was prominently higher than that of the ICG-PNIPAM nanoparticles(18.73±0.33 dB)in 1.5-cm-thick chicken breast *** NIR-USF imaging in 3.5-cm-thick chicken breast tissues was achieved using this new *** e x v iv o NIR-USF imaging of the mouse liver was also successfully *** experiments showed that the present nanogels were able to be effectively accumulated into U87 tumor-bearing mice via enhanced permeability and retention effects,and the high-resolution NIR-USF imaging of in v ivo tumor was efficiently *** metabolism and in vivo biodistribution of the nanogels were ***,the results suggest that the current nanogel is a highly promising NIR-USF probe for deep tissue and high-resolution USF imaging.

关键词： deep tissue imaging high-resolution ultrasound-switchable NIR fluorescence imaging in vivo imaging

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Technology Roadmap for Flexible Sensors

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ACS NANO 2023年第6期17卷 5211-5295页

作者： Luo, Yifei Abidian, Mohammad Reza Ahn, Jong-Hyun Akinwande, Deji Andrews, Anne M. Antonietti, Markus Bao, Zhenan Berggren, Magnus Berkey, Christopher A. Bettinger, Christopher John Chen, Jun Chen, Peng Cheng, Wenlong Cheng, Xu Choi, Seon-Jin Chortos, Alex Dagdeviren, Canan Dauskardt, Reinhold H. Di, Chong-an Dickey, Michael D. Duan, Xiangfeng Facchetti, Antonio Fan, Zhiyong Fang, Yin Feng, Jianyou Feng, Xue Gao, Huajian Gao, Wei Gong, Xiwen Guo, Chuan Fei Guo, Xiaojun Hartel, Martin C. He, Zihan Ho, John S. Hu, Youfan Huang, Qiyao Huang, Yu Huo, Fengwei Hussain, Muhammad M. Javey, Ali Jeong, Unyong Jiang, Chen Jiang, Xingyu Kang, Jiheong Karnaushenko, Daniil Khademhosseini, Ali Kim, Dae-Hyeong Kim, Il-Doo Kireev, Dmitry Kong, Lingxuan Lee, Chengkuo Lee, Nae-Eung Lee, Pooi See Lee, Tae-Woo Li, Fengyu Li, Jinxing Liang, Cuiyuan Lim, Chwee Teck Lin, Yuanjing Lipomi, Darren J. Liu, Jia Liu, Kai Liu, Nan Liu, Ren Liu, Yuxin Liu, Yuxuan Liu, Zhiyuan Liu, Zhuangjian Loh, Xian Jun Lu, Nanshu Lv, Zhisheng Magdassi, Shlomo Malliaras, George G. Matsuhisa, Naoji Nathan, Arokia Niu, Simiao Pan, Jieming Pang, Changhyun Pei, Qibing Peng, Huisheng Qi, Dianpeng Ren, Huaying Rogers, John A. Rowe, Aaron Schmidt, Oliver G. Sekitani, Tsuyoshi Seo, Dae-Gyo Shen, Guozhen Sheng, Xing Shi, Qiongfeng Someya, Takao Song, Yanlin Stavrinidou, Eleni Su, Meng Sun, Xuemei Takei, Kuniharu Tao, Xiao-Ming Tee, Benjamin C. K. Thean, Aaron Voon-Yew Trung, Tran Quang Wan, Changjin Wang, Huiliang Wang, Joseph Wang, Ming Wang, Sihong Wang, Ting Wang, Zhong Lin Weiss, Paul S. Wen, Hanqi Xu, Sheng Xu, Tailin Yan, Hongping Yan, Xuzhou Yang, Hui Yang, Le Yang, Shuaijian Yin, Lan Yu, Cunjiang Yu, Guihua Yu, Jing Yu, Shu-Hong Yu, Xinge Zamburg, Evgeny Zhang, Haixia Zhang, Xiangyu Zhang, Xiaosheng Zhang, Xueji Zhang, Yihui Zhang, Yu Zhao, Siyuan Zhao, Xuanhe Zheng, Yuanjin Zheng, Yu-Qing Zheng, Zijian Zhou, Tao Zhu, Bowen Zhu, Ming Zhu, Rong Zhu, Yangzhi Zhu, Yong Zou, Guijin Chen, Xiaodong 08-03 Innovis Singapore 138634 Republic of Singapore Innovative Centre for Flexible Devices (iFLEX) School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Biomedical Engineering University of Houston Houston Texas 77024 United States School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 United States Microelectronics Research Center The University of Texas at Austin Austin Texas 78758 United States Department of Chemistry and Biochemistry California NanoSystems Institute and Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior and Hatos Center for Neuropharmacology University of California Los Angeles Los Angeles California 90095 United States Colloid Chemistry Department Max Planck Institute of Colloids and Interfaces 14476 Potsdam Germany Department of Chemical Engineering Stanford University Stanford California 94305 United States Laboratory of Organic Electronics Department of Science and Technology Campus Norrköping Linköping University 83 Linköping Sweden Wallenberg Initiative Materials Science for Sustainability (WISE) and Wallenberg Wood Science Center (WWSC) SE-100 44 Stockholm Sweden Department of Materials Science and Engineering Stanford University Stanford California 94301 United States Department of Biomedical Engineering and Department of Materials Science and Engineering Carnegie Mellon University Pittsburgh Pennsylvania 15213 United States Department of Bioengineering University of California Los Angeles Los Angeles California 90095 United States School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore 637457 Singapore Nanobionics Group Department of Chemical and Biological Engineering Monash University Clayton Australia 3800 Monash

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze continued...challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative

关键词： soft materials mechanics engineering flexible electronics conformable sensors bioelectronics human-machine interfaces body area sensor networks technology translation sustainable electronics

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ORMIR_XCT: A Python package for high resolution peripheral quantitative computed tomography image processing

arXiv

引用

arXiv 2023年

作者： Kuczynski, Michael T. Neeteson, Nathan J. Stok, Kathryn S. Burghardt, Andrew J. Espinosa Hernandez, Michelle A. Vicory, Jared Tse, Justin J. Durongbhan, Pholpat Bonaretti, Serena Wong, Andy Kin On Boyd, Steven K. Manske, Sarah L. McCaig Institute for Bone and Joint Health University of Calgary Calgary Canada Biomedical Engineering Graduate Program University of Calgary Calgary Canada Department of Biomedical Engineering The University of Melbourne Parkville Australia Department of Radiology and Biomedical Imaging University of California San Francisco United States Rehabilitation Sciences Institute The University of Toronto Toronto Canada Joint Department of Medical Imaging University Health Network Toronto Canada Kitware Inc. CarrboroNC United States Department of Radiology Cumming School of Medicine University of Calgary Calgary Canada Swiss Center for Musculoskeletal Imaging Balgrist Campus Zurich Switzerland Department of Epidemiology Dalla Lana School of Public Health University of Toronto Toronto Canada

High resolution peripheral quantitative computed tomography (HR-pQCT) is animaging technique capable of imaging trabecular bone in-vivo. HR-pQCT has awide range of applications, primarily focused on bone to improve ourunderstanding of musculoskeletal diseases, assess epidemiological associations,and evaluate the effects of pharmaceutical interventions. Processing HR-pQCTimages has largely been supported using the scanner manufacturer scriptinglanguage (Image Processing Language, IPL, Scanco Medical). However, byexpanding image processing workflows outside of the scanner manufacturersoftware environment, users have the flexibility to apply more advancedmathematical techniques and leverage modern software packages to improve imageprocessing. The ORMIR_XCT Python package was developed to reimplement someexisting IPL workflows and provide an open and reproducible package allowingfor the development of advanced HR-pQCT data processing workflows. © 2023, CC BY-SA.

关键词： High level languages

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Self-driven directional polypyrrole-polyethyleneimine nanopigment-infused medical textiles with potential asymmetrical ionic convection and biological effects for follicle restoration

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Journal of Polymer Research 2023年第11期30卷 403-403页

作者： Chuang, Sih-Chi Yu, Shih-An Hung, Pei-Chia Chiang, Chih-Wei Su, Wen-Ta Jheng, Pei-Ru Huang, Wei-Yung Hao, Ping-Chien Liang, Jia Wei Lin, Yung-Wei Fang, Hsu-Wei Chuang, Er-Yuan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Hsuan Chen Technology Co. Ltd. New Taipei22055 Taiwan Bone and Joint Research Center Department of Orthopedics Taipei Medical University Hospital School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University Taipei11031 Taiwan International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Taipei Medical University Taipei11031 Taiwan Department of Urology Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Hair loss is one of the most common and distressing conditions that can be traumatic for an individual. Many non-pharmacological and pharmacological treatments for hair loss have been developed. However, serious side effects or limitations in terms of the hair regeneration potential still exist. One of the non-pharmacological treatments, biophysical stimulation, has shown promise in hair regeneration. Nevertheless, the associated discomfort and the need for external components such as an electrical power supply pose challenges to its widespread use. In this study, we present an innovative cationic fabric that utilizes repeatable asymmetrical ionic flow of a physiological fluid to internally stimulate hair follicles and skin. Characterization, ultrasonic, biochemical, and histological experiments were conducted. The use of this developed treatment significantly increased expressions of heat shock proteins and potentially improved immunoregulation in the skin, as well as increased the number of hair follicles in skin defect animals, with no adverse risks. © 2023, The Polymer Society, Taipei.

关键词： Proteins

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