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Wireless,multimodal sensors for continuous measurement of pressure,temperature,and hydration of patients in wheelchair

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npj Flexible Electronics 2023年第1期7卷 479-493页

作者： Seokjoo Cho Hyeonseok Han Hyunwoo Park Sung-Uk Lee Jae-Hwan Kim Sung Woo Jeon Mengqiu Wang Raudel Avila Zhaoqian Xi Kabseok Ko Minsu Park Jungyup Lee Myungwoo Choi Je-Sang Lee Weon Gi Min Byeong-Ju Lee Soyeong Lee Jungrak Choi Jimin Gu Jaeho Park Min Seong Kim Junseong Ahn Osman Gul Chankyu Han Gihun Lee Seunghwan Kim Kyuyoung Kim Jeonghyun Kim Chang-Mo Kang Jahyun Koo Sung Soo Kwak Sungbong Kim Dong Yun Choi Seokwoo Jeon Hyung Jin Sung Yong Bae Park Minkyu Je Young Tae Cho Yong Suk Oh Inkyu Park Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Advanced 3D Printing Technology Development Division Korea Atomic Energy Research InstituteDaejeon 34057Republic of Korea Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalian 116023P.R.China Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA DUT-BSU Joint Institute Dalian University of TechnologyDalian 116023China Ningbo Institute of Dalian University of Technology Ningbo 315016China Department of Electronics Engineering Kangwon National UniversityChuncheon 24341Republic of Korea Querrey-Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Sibel Health Inc NilesIL 60714USA Department of Materials Science and Engineering KAIST Institute for The Nanocentury(KINC)Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Rehabilitation Medicine Gimhae Hansol Rehabilitation&Convalescent HospitalGimhae 50924Republic of Korea Department of planning and development Gimhae Hansol Rehabilitation&Convalescent HospitalGimhae 50924Republic of Korea Department of rehabilitation medicine Pusan national university hospitalBusan 49241Republic of Korea Department of AI Convergence Network Ajou UniversitySuwon 16499Republic of Korea Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897Republic of Korea Korea Photonics Technology Institute Gwangju 61007Republic of Korea School of Biomedical Engineering Korea UniversitySeoul 02841Republic of Korea Interdisciplinary Program in Precision Public Health Korea UniversitySeoul 02841Republic of Korea Center

Individuals who are unable to walk independently spend most of the day in a *** population is at high risk for developing pressure injuries caused by ***,early diagnosis and prevention of these injuries still remain ***,we introduce battery-free,wireless,multimodal sensors and a movable system for continuous measurement of pressure,temperature,and hydration at skin *** device design includes a crack-activated pressure sensor with nanoscale encapsulations for enhanced sensitivity,a temperature sensor for measuring skin temperature,and a galvanic skin response sensor for measuring skin hydration *** movable system enables power harvesting,and data communication to multiple wireless devices mounted at skin-cushion interfaces of wheelchair users over full body *** evaluations and numerical simulations of the devices,together with clinical trials for wheelchair patients,demonstrate the feasibility and stability of the sensor system for preventing pressure injuries caused by sitting.

关键词： injuries modal mounted

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Lifecycles, pipelines, and value chains: toward a focus on events in responsible artificial intelligence for health

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AI and Ethics 2024年 1-14页

作者： Donia, Joseph Oyefeso, Lola Embuldeniya, Gayathri Whyne, Cari Burns, David Boyer, Philip Razmjou, Helen Shaw, James A. Institute of Health Policy Management & Evaluation Dalla Lana School of Public Health University of Toronto Toronto Canada Department of Biology Faculty of Arts and Science University of Toronto Toronto Canada Department of Physical Therapy Temerty Faculty of Medicine University of Toronto Toronto Canada Holland Bone and Joint Program Sunnybrook Research Institute Sunnybrook Health Sciences Centre Toronto Canada Institute of Biomedical Engineering Faculty of Applied Science and Engineering University of Toronto Toronto Canada Institute of Medical Sciences Temerty Faculty of Medicine University of Toronto Toronto Canada Division of Orthopedic Surgery Department of Surgery Temerty Faculty of Medicine University of Toronto Toronto Canada Joint Centre for Bioethics Dalla Lana School of Public Health University of Toronto Toronto Canada

Process-oriented approaches to the responsible development, implementation, and oversight of artificial intelligence (AI) systems have proliferated in recent years. Variously referred to as lifecycles, pipelines, or value chains, these approaches demonstrate a common focus on systematically mapping key activities and normative considerations throughout the development and use of AI systems. At the same time, these approaches risk focusing on proximal activities of development and use at the expense of a focus on the events and value conflicts that shape how key decisions are made in practice. In this article we report on the results of an ‘embedded’ ethics research study focused on SPOTT– a ‘Smart Physiotherapy Tracking Technology’ employing AI and undergoing development and commercialization at an academic health sciences centre. Through interviews and focus groups with the development and commercialization team, patients, and policy and ethics experts, we suggest that a more expansive design and development lifecycle shaped by key events offers a more robust approach to normative analysis of digital health technologies, especially where those technologies’ actual uses are underspecified or in flux. We introduce five of these key events, outlining their implications for responsible design and governance of AI for health, and present a set of critical questions intended for others doing applied ethics and policy work. We briefly conclude with a reflection on the value of this approach for engaging with health AI ecosystems more broadly.

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Hairpin RF Resonators for Transceiver Arrays with High Inter-channel Isolation and B1 Efficiency at Ultrahigh Field 7T MR Imaging

arXiv

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arXiv 2022年

作者： Payne, Komlan Ying, Leslie L. Zhang, Xiaoliang Department of Biomedical Engineering State University of New York at Buffalo BuffaloNY14260 United States Department of Electrical Engineering State University of New York at Buffalo BuffaloNY14260 United States Univerity of California Berkeley UCSF Joint Bioengineering Program San FranciscoCA94158 United States

Electromagnetic decoupling among a close-fitting or high-density transceiver RF array elements is required to maintain the integrity of the magnetic flux density from individual channel for enhanced performance in detection sensitivity and parallel imaging. High-impedance RF coils have demonstrated to be a prominent design method to circumvent these coupling issues. Yet, inherent characteristics of these coils have ramification on the B1 field efficiency and SNR. In this work, we propose a hairpin high impedance RF resonator design for highly decoupled multichannel transceiver arrays at ultrahigh magnetic fields. Due to the high impedance property of the hairpin resonators, the proposed transceiver array can provide high decoupling performance without using any dedicated decoupling circuit among the resonant elements. Because of elimination of lumped inductors in the resonator circuit, higher B1 field efficiency in imaging subjects can be expected. In order to validate the feasibility of the proposed hairpin RF coils, systematical studies on decoupling performance, field distribution, and SNR are performed, and the results are compared with those obtained from existing high-impedance RF coil, e.g., "self-decoupled RF coil". To further investigate its performance, an 8-channel head coil array using the proposed hairpin resonators loaded with a cylindrical phantom is designed, demonstrating a 19 % increase of the B1+ field intensity compared to the self-decoupled coils at 7T. Furthermore, the characteristics of the hairpin RF coils are evaluated using a more realistic human head voxel model numerically. The proposed hairpin RF coil provides excellent decoupling performance and superior RF magnetic field efficiency compared to the "self-decoupled" high impedance coils. Bench test of a pair of fabricated hairpin coils prove to be in good accordance with numerical results. © 2022, CC BY.

关键词： Magnetic resonance imaging

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Detection of Low Back Physiotherapy Exercises With Inertial Sensors and Machine Learning: Algorithm Development and Validation

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JMIR Rehabilitation and Assistive Technologies 2022年第3期9卷 e38689页

作者： Alfakir, Abdalrahman Arrowsmith, Colin Burns, David Razmjou, Helen Hardisty, Michael Whyne, Cari Holland Bone and Joint Program Sunnybrook Research Institute Toronto ON Canada Institute of Biomedical Engineering University of Toronto Toronto ON Canada Halterix Corporation Toronto ON Canada Division of Orthopaedic Surgery Department of Surgery University of Toronto Toronto ON Canada

Background: Physiotherapy is a critical element in the successful conservative management of low back pain (LBP). A gold standard for quantitatively measuring physiotherapy participation is crucial to understanding physiotherapy adherence in managing recovery from LBP. Objective: This study aimed to develop and evaluate a system with wearable inertial sensors to objectively detect the performance of unsupervised exercises for LBP comprising movement in multiple planes and sitting postures. Methods: A quantitative classification design was used within a machine learning framework to detect exercise performance and posture in a cohort of healthy participants. A set of 8 inertial sensors were placed on the participants, and data were acquired as they performed 7 McKenzie low back exercises and 3 sitting posture positions. Engineered time series features were extracted from the data and used to train 9 models by using a 6-fold cross-validation approach, from which the best 2 models were selected for further study. In addition, a convolutional neural network was trained directly on the time series data. A feature importance analysis was performed to identify sensor locations and channels that contributed the most to the models. Finally, a subset of sensor locations and channels was included in a hyperparameter grid search to identify the optimal sensor configuration and best performing algorithms for exercise and posture classification. The final models were evaluated using the F₁ score in a 10-fold cross-validation approach. Results: In total, 19 healthy adults with no history of LBP each completed at least one full session of exercises and postures. Random forest and XGBoost (extreme gradient boosting) models performed the best out of the initial set of 9 engineered feature models. The optimal hardware configuration was identified as a 3-sensor setup—lower back, left thigh, and right ankle sensors with acceleration, gyroscope, and magnetometer channels. The

关键词： activity recognition inertial measurement units low back pain machine learning rehabilitation wearables

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Ubiquitin carboxyl-terminal hydrolase 11 promotes autophagy by de-ubiquitinating and stabilizing Beclin-1

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Genome Instability & Disease 2022年第1期3卷 47-55页

作者： Li, Zheng Rao, Shaohong Song, Chunwei Zhu, Min Zhao, Hongchang Yuan, Shuping Peng, Bin Xu, Xingzhi Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center Marshall Laboratory of Biomedical Engineering Shenzhen University School of Medicine Shenzhen China College of Life Sciences Capital Normal University Beijing China Institute of Translational Medicine College of Medicine Qingdao University Qingdao China Shenzhen University-Friedrich Schiller Universität Jena Joint PhD Program in Biomedical Sciences Shenzhen University School of Medicine Shenzhen China

Autophagy is a major degradation process that degrades and recycles cytoplasmic materials through lysosome for maintaining cellular homeostasis. Dysregulated autophagy is linked with numerous human diseases including cancer. Autophagy marker protein B-cell lymphoma-2 interacting protein 1 (Beclin-1) is essential for autophagosome initiation and maturation. Recently, Ubiquitin carboxyl-terminal hydrolase 11 (USP11) has been reported to promote or inhibit autophagy without identification of any direct target. Here through biochemical reaction in vitro, we demonstrate that USP11 directly interacts with Beclin-1. Both in vitro and in vivo de-ubiquitination assays revealed that USP11 de-ubiquitinates Beclin-1. USP11-mediated de-ubiquitination stabilized Beclin-1 and enhanced the formation of the autophagy-specific class III phosphatidylinositol 3-kinase complexes 1 and 2, thereby promoting autophagy. Together, our results demonstrated that USP11 promotes autophagy under unperturbed conditions by de-ubiquitinating and stabilizing Beclin-1 which may serve as a therapeutic target for autophagy-related diseases.

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Achieving high surface bioactivity and adhesion in Ti-6Al-4V alloy via anodic oxidation and electrophoretic deposition

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Ceramics International 2025年

作者： Wu, Yu-Jie Wang, Chi-Yun Mana-ay, Haidee Tu, Chi-Shun Lai, Po-Liang Chen, Pin-Yi International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Bone and Joint Research Center Department of Orthopedic Surgery Chang Gung Memorial Hospital Taoyuan City33305 Taiwan Department of Mechanical Engineering Chang Gung University Taoyuan City33302 Taiwan Department of Physics Silliman University Dumaguete City6200 Philippines

This study combines 3D printing, anodic oxidation (AO), and electrophoretic deposition (ED) technologies to develop Ti-6Al-4V alloy (abbreviated as Ti64) with high hydrophilicity, adhesion, and bioactivity. Titanium oxide nanotubes formed by AO treatment on the Ti64 surface exhibited reduced contact angles from 53 ° to 10 °. The adhesion of the calcium (Ca) layer through the integrated technology of the AO and ED treatments (herein abbreviated as AED) displays an optimal adhesive force of over 30 N on the Ti64 surface, which is attributed to the stable chemical bond due to the formation of OH− ions on the substrate after the AO treatment and the subsequent oxidation reaction of the Ca2+ ions to form a predominantly Ca(OH)2 layer after the ED treatment. Moreover, the AED treatment forms tiny needle-like structures that can effectively promote osteogenic differentiation. The expressions of the osteocyte marker genes (i.e., OCN, OPN, and DMP1) were improved after the AED treatment, showing increased osteogenic differentiation into mature bone tissue. This work presents the AED treatment as a valuable surface modification technique to boost the surface bioactivity of Ti64 for clinical orthopedic applications. © 2025

关键词： Anodic oxidation

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Nonprobability follow-up sample analysis: an application to SARS-CoV-2 infection prevalence estimation

arXiv

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arXiv 2023年

作者： Li, Yan Yee, Laura Hunsberger, Sally Memoli, Matthew J. Sadtler, Kaitlyn Graubard, Barry Joint Program in Survey Methodology Department of Epidemiology and Biostatistics University of Maryland College Park United States NIH United States NIH United States LID Clinical Studies Unit Laboratory of Infectious Diseases NIAID NIH United States Section on Immuno-Engineering National Institute of Biomedical Imaging and Bioengineering NIH United States Division of Cancer Epidemiology and Genetics NCI NIH United States

Public health policy makers are faced with making crucial decisions rapidly during infectious disease outbreaks such as that caused by SARS-CoV-2. Ideally, rapidly deployed representative health surveys could provide needed data for such decisions. Under the constraints of a limited timeframe and resources, it may be infeasible to implement random based (probability) sampling that yields a population representative survey sample with high response rates. As an alternative, a volunteer (nonprobability) sample is often collected using outreach methods such as social media and web surveys. Compared to a probability sample, a nonprobability sample is subject to selection bias. In addition, when participants are followed longitudinally nonresponse often occurs at later follow up timepoints. As a result, estimates of cross-sectional parameters at later timepoints will be subject to selection bias and nonresponse bias. In this paper, we create kernel-weighted pseudoweights (KW) for the baseline survey participants and construct nonresponse-adjusted kw (kwNR) for respondents at each follow-visit to estimate the population mean at the follow-up visits. We develop Taylor Linearization variance estimation that accounts for variability due to estimating both pseudoweights and the nonresponse adjustments. Simulations are conducted to evaluate the proposed kwNR-weighted estimates. We investigate covariate effects on each of the following: baseline sample participation propensity, follow-up response propensity and the mean of the outcome. We apply the proposed kwNR-weighted methods to the SARSCoV-2 antibody seropositivity longitudinal study, which begins with a baseline survey early in the pandemic, and collects data at six- and twelve-month post baseline follow-ups. Copyright © 2023, The Authors. All rights reserved.

关键词： Coronavirus

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Doping ratio between ZnO/MgO tunes antimicrobial, osteogenic, and anti-osteoclast activity of CaO-MgO-ZnO-SiO2 bioactive glass-ceramics

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Ceramics International 2025年

作者： Hung, Guan-Yi Xia, Yun-Ze Chen, Pin-Yi Lai, Po-Liang Feng, Kuei-Chih Tu, Chi-Shun Cheng, I.-C. Wang, Chi-Yun International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Physics Fu Jen Catholic University New Taipei City24205 Taiwan Department of Mechanical Engineering Ming-Chi University of Technology New Taipei City24301 Taiwan Bone and Joint Research Center Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan City33305 Taiwan College of Medicine Chang Gung University Taoyuan City33305 Taiwan Department of Mechanical Engineering Chang Gung University Taoyuan City33305 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

Limitations such as donor site morbidity hamper autologous bone grafts. On the other hand, allogeneic grafts, sourced from cadavers, pose risks of viral transmission and rejection. While hydroxyapatite is a prevalent synthetic graft material, antibiotic-laden fillers addressing infection face challenges with antibiotic-resistant pathogens, driving the emergence of nonantibiotic materials to combat persistent bone infections. Bioactive glass is a potential bone void filler superior to hydroxyapatite. Thus, to improve the antibacterial efficacy and bioactivity, we adjusted the doping ratio of the novel CaO-(1-x) MgO-(x) ZnO-SiO2 glass-ceramics (x = 0, 0.25, 0.50, 0.75, 1). Using XRD, we found a typical amorphous structure alongside polycrystalline diopside (CaMgSi2O6), hardystonite (Ca2ZnSi2O7), and petedunnite (CaZnSi2O6) formations. Raman spectroscopy revealed the silicate-glass matrix structure in all the Zn(100x) glass-ceramics and confirmed that the Zn ions replaced the Mg ions. Zn-doped glass-ceramics promoted apatite layer formation and had greater antibacterial efficacy against E. coli and S. aureus. Zn25 glass-ceramic were biocompatible with L929 and MC3T3-E1 cells. Furthermore, Zn25 glass-ceramic promoted bone cell mineralization and reduced osteoclast formation without affecting ALP activity. In vivo, the Zn25 glass-ceramic exhibited greater osteointegration ability than the HAP and Zn0 glass-ceramic. Taken together, the present study demonstrated that bioactive glass-ceramics with a doping ratio between ZnO and MgO (25:75) can enhance antibacterial and osteogenic activity while impeding osteoclastogenic activity. © 2025

关键词： Escherichia coli

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Machine learning for improved current-density reconstruction from two-dimensional vector magnetic images

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Physical Review Applied 2025年第3期23卷 034035-034035页

作者： Niko R. Reed Danyal Bhutto Matthew J. Turner Declan M. Daly Sean M. Oliver Jiashen Tang Kevin S. Olsson Nicholas Langellier Mark J.H. Ku Department of Physics University of Maryland College Park Maryland USA Quantum Technology Center University of Maryland College Park Maryland USA Joint Quantum Institute University of Maryland College Park Maryland USA Department of Biomedical Engineering Boston University Boston Massachusetts USA A. A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Charlestown Massachusetts USA Department of Electrical and Computer Engineering University of Maryland College Park Maryland USA The MITRE Corporation McLean Virginia 22102 USA Intelligence Community Postdoctoral Research Fellowship Program University of Maryland College Park Maryland 20742 USA Department of Physics Harvard University Cambridge Massachusetts USA Present address: VideaHealth Inc. Boston MA. Department of Materials Science and Engineering University of Delaware Newark Delaware 19716 USA Department of Physics and Astronomy University of Delaware Newark Delaware 19716 USA Present address: Northrop Grumman Mission Systems Linthicum Maryland 21090 USA.

The reconstruction of electrical current densities from magnetic field measurements is an important technique with applications in materials science, circuit design, quality control, plasma physics, and biology. Analytic reconstruction methods exist for planar currents, but break down in the presence of high-spatial-frequency noise or large standoff distance, restricting the types of systems that can be studied. Here, we demonstrate the use of a deep convolutional neural network for current density reconstruction from two-dimensional images of vector magnetic fields acquired by a quantum diamond microscope . Trained network performance significantly exceeds analytic reconstruction for data with high noise or large standoff distances. This machine learning technique can perform quality inversions on lower-signal-to-noise-ratio data, significantly reducing the data collection time and permitting reconstructions of weaker and three-dimensional current sources.

关键词： Signal to noise ratio

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Differences in creep response of GBM cells migrating in confinement

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International Biomechanics 2020年第1期7卷 44-57页

作者： Khan, Ishan Bui, Loan Bachoo, Robert Kim, Young-Tae Chuong, Cheng-Jen University of Texas at Arlington and University of Texas Southwestern Medical Center at Dallas Joint Graduate Program in Biomedical Engineering United States Department of Neurology & Neurotherapeutics University of Texas Southwestern Medical Center at Dallas Dallas TX United States University of Texas at Arlington Department of Bioengineering TX United States

Using a microfluidic platform to apply negative aspiration pressure (–20, –25, –30, –35 and –40 cm H2O), we compared the differences in creep responses of Glioblastoma Multiforme (GBM) cells while migrating in co... 详细信息

Using a microfluidic platform to apply negative aspiration pressure (–20, –25, –30, –35 and –40 cm H₂O), we compared the differences in creep responses of Glioblastoma Multiforme (GBM) cells while migrating in confinement and at a stationary state on a 2D substrate. Cells were either migrating in a channel of 5 x 5 μm cross-section or stationary at the entrance to the channel. In response to aspiration pressure, we found actively migrating GBM cells exhibited a higher stiffness than stationary cells. Additionally, migrating cells absorbed more energy elastically with a relatively small dissipative energy loss. At elevated negative pressure loads up to–30 cm H₂O, we observed a linear increase in elastic deformation and a higher distribution in elastic storage than energy loss, and the response plateaued at further increasing negative pressure loads. To explore the underlying cause, we carried out immuno-cytochemical studies of these cells and found a polarized actin and myosin distribution at the front and posterior ends of the migrating cells, whereas the distribution of the stationary group demonstrated no specific regional differences. These differences in creep response and cytoskeletal protein distribution demonstrate the importance of a migrating cell’s kinematic state to the mechanism of cell migration. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

关键词： actomyosin contraction Cancer cell creep glioblastoma viscoelastic properties

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