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Biomedical Optics, BIOMED 2012

作者： Lin, Zi-Jing Ren, Ming Li, Lin Yang, Shaohua Liu, Hanli Department of Bioengineering Joint Graduate Program b/w Univ. of Texas Southwestern Medical University of Texas TX 76019 United States Department of Pharmacology and Neuroscience Institute for Aging and Alzheimer's Disease Research University of North Texas Health Science Center Fort Worth TX 76107 United States

We investigated hyper-acute cerebral ischemia using diffuse optical tomography with the depth compensation algorithm (DCA) in pre-clinical rat models. Results suggest that this methodology has a great potential to mon... 详细信息

ISBN: (纸本)9781557529428

关键词： Rats

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A DUAL-MODALITY OPTICAL BIOPSY APPROACH FOR IN VIVO DETECTION OF PROSTATE CANCER IN RAT MODEL

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 269-277页

作者： VIKRANT SHARMA NIMIT PATEL JINHUI SHEN LIPING TANG GEORGE ALEXANDRAKIS HANLI LIU Department of Bioengineering Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center University of Texas at Arlington TX 76019USA

Ultrasound-guided biopsy procedure for prostate cancer diagnosis,which is the current gold standard,involves quasi-random sampling of prostate tissue without any functional *** this study,we discuss the possibility to augment the detection of prostate cancer using a dual-modality optical approach,which can be coupled with the current needle biopsy *** techniques are light reflectance spectroscopy(LRS)that uses a broadband light source and a CCD array spectrometer,and auto-fluorescence lifetime measurement(AFLM)that uses a custom-designed,time-correlated single photon counting(TCSPC)*** LRS and AFLM were employed sequentially in this study to measure cancer tissue along with control tissue on a rat prostate tumor *** an excitation wavelength of 447 nm,we investigated auto-fluorescence decay curves at the emission wavelengths of 532,562,632 and 684 nm for in vivo and ex vivo *** results show that auto-fluorescence lifetimes at all measured emission wavelengths differ between control and cancerous tissues with 100% specificity and ***,absolute values of hemoglobin derivatives and scattering coe±cient were quantified using in vivo *** part of study also demonstrates that light scattering and absorption are significantly different between the control and cancerous ***,the study demonstrates that both LRS and AFLM may provide several intrinsic biomarkers for in vivo detection of prostate cancer.

关键词： Prostate cancer light reflectance spectroscopy auto-fluorescence lifetime

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31st Annual Meeting and Associated programs of the Society for Immunotherapy of Cancer (SITC 2016): part one: National Harbor, MD, USA. 9-13 November 2016

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J Immunother Cancer 2016年第SUPPL 1期4卷 1-1页

作者： Andreas Lundqvist Vincent van Hoef Xiaonan Zhang Erik Wennerberg Julie Lorent Kristina Witt Laia Masvidal Sanz Shuo Liang Shannon Murray Ola Larsson Rolf Kiessling Yumeng Mao John-William Sidhom Catherine A. Bessell Jonathan Havel Jonathan Schneck Timothy A. Chan Eliot Sachsenmeier David Woods Anders Berglund Rupal Ramakrishnan Andressa Sodre Jeffrey Weber Roberta Zappasodi Yanyun Li Jingjing Qi Philip Wong Cynthia Sirard Michael Postow Walter Newman Henry Koon Vamsidhar Velcheti Margaret K. Callahan Jedd D. Wolchok Taha Merghoub Lawrence G. Lum Minsig Choi Archana Thakur Abhinav Deol Gregory Dyson Anthony Shields Cara Haymaker Marc Uemura Ravi Murthy Marihella James Daqing Wang Julie Brevard Catherine Monaghan Suzanne Swann James Geib Mark Cornfeld Srinivas Chunduru Sudhir Agrawal Cassian Yee Jennifer Wargo Sapna P. Patel Rodabe Amaria Hussein Tawbi Isabella Glitza Scott Woodman Wen-Jen Hwu Michael A. Davies Patrick Hwu Willem W. Overwijk Chantale Bernatchez Adi Diab Erminia Massarelli Neil H. Segal Vincent Ribrag Ignacio Melero Tara C. Gangadhar Walter Urba Dirk Schadendorf Robert L. Ferris Roch Houot Franck Morschhauser Theodore Logan Jason J. Luke William Sharfman Fabrice Barlesi Patrick A. Ott Laura Mansi Shivaani Kummar Gilles Salles Cecilia Carpio Roland Meier Suba Krishnan Dan McDonald Matthew Maurer Xuemin Gu Jaclyn Neely Satyendra Suryawanshi Ronald Levy Nikhil Khushalani Jennifer Wu Jinyu Zhang Fahmin Basher Mark Rubinstein Mark Bucsek Guanxi Qiao Cameron MacDonald Bonnie Hylander Elizabeth Repasky Shilpak Chatterjee Anusara Daenthanasanmak Paramita Chakraborty Kyle Toth Megan Meek Elizabeth Garrett-Mayer Michael Nishimura Chrystal Paulos Craig Beeson Xuezhong Yu Shikhar Mehrotra Fei Zhao Kathy Evans Christine Xiao Alisha Holtzhausen Brent A. Hanks Nicole Scharping Ashley V. Menk Rebecca Moreci Ryan Whetstone Rebekah Dadey Simon Watkins Robert Ferris Greg M. Delgoffe Jonathan Peled Sean Devlin Anna Staffas Melissa Lumish Kori Porosnicu Rodriguez Katya Ahr Miguel Perales Sergio Giralt Ying Taur Eric Pam Karolinska Institutet Stockholm Stockholms Lan Sweden Weill Cornell Medical College New York NY USA Nova Southeastern University Cell Therapy Institute Fort Lauderdale FL USA Johns Hopkins University School of Medicine Baltimore MD USA Immunology Program Johns Hopkins University School of Medicine Columbia MD USA Memorial Sloan Kettering Cancer Center New York NY USA Johns Hopkins Medical Institute Baltimore MD USA University of Rochester Monrovia MD USA NYU Langone Medical Center New York NY USA H. Lee Moffitt Cancer Center Tampa FL USA Ludwig Collaborative Laboratory Memorial Sloan Kettering Cancer Center New York NY USA Immune Monitoring Core Facility Memorial Sloan Kettering Cancer Center New York NY USA Leap Therapeutics Cambridge MA USA Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA Case Western Reserve University Cleveland OH USA Cleveland Clinic Main Campus Cleveland OH USA University of Virginia Cancer Center Charlottesville VA USA Stony Brook University Medical Center Stony Brook NY USA Karmanos Cancer Institute Detroit MI USA University of Texas MD Anderson Cancer Center Houston TX USA Idera Pharmaceuticals Inc. Cambridge MA USA Institut Gustave Roussy Villejuif Ile-de-France France Center for Applied Medical Research (CIMA) University of Navarra Pamplona Navarra Spain University of Pennsylvania Philadelphia PA USA Earle A. Chiles Research Institute Providence Cancer Center Portland OR USA Universitätsklinikum Essen Essen Nordrhein-Westfalen Germany University of Pittsburgh Pittsburgh PA USA CHU Rennes Service Hématologie Clinique and INSERM 0203 Unité d’Investigation Clinique Rennes Bretagne France Centre Hospitalier Régional Universitaire de Lille Lille Nord-Pas-de-Calais France Simon Cancer Center Indiana University Indianapolis IN USA University of Chicago School of Medicine Chicago IL USA Johns Hopkins University School of Medicine Lutherville MD USA Multidisciplinary Oncology and Therapeuti

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Fabrication of charged nanopore channels using pulsed plasma deposition of methacrylic acid

Fabrication of charged nanopore channels using pulsed plasma...

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2011 11th IEEE International Conference on Nanotechnology, NANO 2011

作者： Asghar, Waseem Ilyas, Azhar Timmons, Richard B. Iqba, Samir M. Electrical Engineering Department Nanotechnology Research and Teaching Facility University of Texas Arlington TX 76019 United States Department of Chemistry and Biochemistry University of Texas Arlington TX 76019 United States Joint Graduate Committee of Bioengineering Program Medical Center at Dallas University of Texas at Arlington Arlington TX 76019 United States

ISBN: (纸本)9781457715143

Solid-state nanopore systems have emerged as novel platforms for DNA, RNA and protein analysis. In the state of the art, the nanopores are made using electron beam induced shrinking of larger pores, drilling in thin membranes or deposition of material on fabricated nanopores. These processes have slow deposition rates, provide poor control of surface composition of deposited layers and the membrane thickness defines whether a pore shrinks or expands. This paper reports a novel technique of pulsed plasma assisted polymer film deposition that offers a direct way to control shrinking of the nanopores and to impart defined surface properties to the nanopore walls. © 2011 IEEE.

关键词： Nanopores

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Detectability of hemodynamic response to thermal pain in pre-frontal cortex using diffuse optical tomography

Detectability of hemodynamic response to thermal pain in pre...

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Biomedical Optics, BIOMED 2010

作者： Krishnamurthy, Venkatagiri Kavuri, Venkaiah Tian, Fenghua Liu, Hanli Department of Bioengineering Joint Graduate Program between University of Texas at Arlington and University of Texas Southwestern Medical Center University of Texas Arlington TX 76019 United States

We have explored the possibility of using diffuse optical tomography as a potential non-invasive clinical tool to monitor hemodynamic changes induced by neurophysiological and cognitive activities in response to consc... 详细信息

ISBN: (纸本)9781557528872

关键词： Optical tomography

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Three-dimensional diffuse optical tomography in the human brain

Three-dimensional diffuse optical tomography in the human br...

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Biomedical Optics, BIOMED 2010

作者： Niu, Haijing Lin, Zi-Jing Tian, Fenghua Dhamne, Sameer Liu, Hanli Department of Bioengineering Joint Graduate Program between University of Texas at Arlington University of Texas Southwestern Medical Center University of Texas at Arlington TX 76019 United States

we report the three-dimensional tomographic localization of the functional activation in the human brain. To this end we developed a new depth compensation algorithm (DCA), and its validity is illustrated by simulatio... 详细信息

ISBN: (纸本)9781557528872

关键词： Brain

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Vapor-phase facile coatings of nanotextured organic biocompatible films on solid-state substrates

Vapor-phase facile coatings of nanotextured organic biocompa...

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作者： Goyal, Swati Kim, Young-Tae Iqbal, Samir M. Life Technologies Corporation CA 92008 United States Department of Bioengineering Nanotechnology Research and Teaching Facility University of Texas Arlington Arlington TX 76019 United States Department of Electrical Engineering Nanotechnology Research and Teaching Facility University of Texas Arlington Arlington TX 76019 United States Joint Graduate Studies Committee Bioengineering Program University of Texas United States Arlington and University of Texas Southwestern Medical Center at Dallas University of Texas Arlington Arlington TX 76019 United States

Fluorinated coatings of solid surfaces are important for many applications ranging from corrosion resistance to low surface energy biological interfaces. We present a facile approach to coat solid-state surfaces directly from vapor phase without harsh chemical or plasma treatments. The coatings show nanostructures with high surface area, which is important for variety of surface functionalizations, for example, in molecule attachment and cell growth. The novel polymeric nanoporous film is achieved from the reaction and deposition of two molecules. The surface morphology and pore sizes of the coating on solid-state surfaces can be tuned with change in concentration of monomers in a simple reaction chamber. The X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy analyses show organic nature of the coating. Cell growth studies are done to gauge biocompatibility and adsorption of proteins and cells. The approach can be used to coat, functionalize, and treat nano- and microstructures for a variety of applications with minimal chemical footprint.© 2010 IEEE.

关键词： Nanostructures

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Theoretical and experimental study of electroporation of red blood cells using MEMS technology

Theoretical and experimental study of electroporation of red...

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IEEE International Conference on Nano/Micro Engineered and Molecular Systems

作者： Deng, Peigang Yin, Guangyao Zhang, Tong-Yi Chang, Donald C. Lee, Yi-Kuen KAUST-HKUST Joint Micro/Nanofluidics Lab. Hong Kong University of Science and Technology Hong Kong Hong Kong Bioengineering Graduate Program Hong Kong University of Science and Technology Hong Kong Hong Kong Dept. of Mechanical Engineering Hong Kong University of Science and Technology Hong Kong Hong Kong Dept. of Biology Hong Kong University of Science and Technology Hong Kong Hong Kong

ISBN: (纸本)9781424465439

A theoretical and experimental study of electroporation (EP) of red blood cells (RBCs) was presented in this paper. With additional strain energy, an energy-based model of an electropore induced on a RBC's membrane at different electric fields was proposed to predict the critical EP electric field strength. In addition, EP experiments with red blood cells at single-cell level was carried out on a micro EP chip. The measured critical EP electric field strengths are in agreement with the numerical predictions. ©2010 IEEE.

关键词： Strain energy

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Perception of 3-D layout in stereo displays

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Information Display 2009年第1期25卷 12-16页

作者： Banks, Martin S. Held, Robert T. Girshick, Ahna R. Science Program School of Optometry University of California at Berkeley Berkeley CA United States Joint Graduate Group in Bioengineering University of California San Francisco CA United States University of California at Berkeley Berkeley CA United States Department of Psychology Center for Neural Science New York University New York NY United States

As stereoscopic displays become more commonplace, it is more important than ever for those displays to create a faithful impression of the 3-D structure of the object or scene being portrayed. This article reviews cur... 详细信息

关键词： Chemicals

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Systematic study of electroporation of mouse myoblast cells on microchips

Systematic study of electroporation of mouse myoblast cells ...

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13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009

作者： Yin, Guang-Yao Lin, Ran Zhang, Tong-Yi Chang, Donald C. Lee, Yi-Kuen Bioengineering Graduate Program Hong Kong University of Science and Technology Hong Kong Hong Kong Dept of Mechanical Engineering Hong Kong University of Science and Technology Hong Kong Hong Kong Dept of Biology Hong Kong University of Science and Technology Hong Kong Hong Kong KAUST-HKUST Micro/Nanofluidic Joint Laboratory Hong Kong University of Science and Technology Hong Kong Hong Kong

ISBN: (纸本)9780979806421

In this study, a systematic single-cell electroporation (EP) of mouse myoblast cells was investigated using micro EP chip technology. Large statistical data of the single-cell EP at different electrical conditions were used to determine the critical electric field for both EP and electric cell lysing of mouse myoblast cells. In addition, the EP phase diagram from more than 900 single-cell EP data was also constructed to optimize the EP efficiency with high cell viability. © 2009 CBMS.

关键词： Phase diagrams

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