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Authors’ Response to Peer Reviews of “The Role of Animal-Assisted Therapy in Enhancing Patients’ Well-Being: Systematic Study of the Qualitative and Quantitative Evidence”

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JMIRx Med 2024年 5卷

作者： Ramendra Pati Pandey Himanshu Gunjan Riya Mukherjee Chung-Ming Chang School of Health Sciences & Technology University of Petroleum and Energy Studies Dehradun Uttarakhand India Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Taiwan Master & PhD Program in Biotechnology Industry Chang Gung University Taoyuan Taiwan Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan Taiwan

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The Role of Animal-Assisted Therapy in Enhancing Patients' Well-Being: Systematic Study of the Qualitative and Quantitative Evidence

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JMIRx med 2024年 5卷 e51787页

作者： Ramendra Pati Pandey Riya Mukherjee Chung-Ming Chang School of Health Sciences & Technology University of Petroleum and Energy Studies Dehradun Uttarakhand India. Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Taiwan. Master & PhD Program in Biotechnology Industry Chang Gung University Taoyuan Taiwan. Department of Medical Biotechnology and Laboratory Science Chang Gung University Taoyuan Taiwan.

Background:Animal-assisted therapy, also known as pet therapy, is a therapeutic intervention that involves animals to enhance the well-being of individuals across various populations and settings. Objective:This systematic study aims to assess the outcomes of animal-assisted therapy interventions and explore the associated policies. Methods:A total of 16 papers published between 2015 and 2023 were selected for analysis. These papers were chosen based on their relevance to the research topic of animal-assisted therapy and their availability in scholarly databases. Thematic synthesis and meta-analysis were used to synthesize the qualitative and quantitative data extracted from the selected papers. Results:The analysis included 16 studies that met the inclusion criteria and were deemed to be of moderate or higher quality. Among these studies, 4 demonstrated positive results for therapeutic mediation and one for supportive mediation in psychiatric disorders. Additionally, all studies showed positive outcomes for depression and neurological disorders. Regarding stress and anxiety, 3 studies indicated supportive mediation, while 2 studies showed activating mediation. Conclusions:The overall assessment of animal-assisted therapy shows promise as an effective intervention in promoting well-being among diverse populations. Further research and the establishment of standardized outcome assessment measures and comprehensive policies are essential for advancing the field and maximizing the benefits of animal-assisted therapy.

关键词： animal-assisted therapy outcome assessment pet therapy policies systematic study

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How Microbes Shape Their Communities? A Microbial Community Model Based on Functional Genes

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Genomics, Proteomics & Bioinformatics 2019年第1期17卷 91-105页

作者： Xiaoqing Jiang Xin Li Longshu Yang Chunhong Liu Qi Wang Weilai Chi Huaiqiu Zhu State Key Laboratory for Turbulence and Complex Systems Department of Biomedical Engineering College of Engineering Peking University Center for Quantitative Biology Peking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Biological (PTN) PhD Program and College of Life Sciences Peking University Center for Protein Science Peking University

Exploring the mechanisms of maintaining microbial community structure is important to understand biofilm development or microbiota dysbiosis. In this paper, we propose a functional gene-based composition prediction(FCP) model to predict the population structure composition within a microbial community. The model predicts the community composition well in both a low-complexity community as acid mine drainage(AMD) microbiota, and a complex community as human gut microbiota. Furthermore, we define community structure shaping(CSS) genes as functional genes crucial for shaping the microbial community. We have identified CSS genes in AMD and human gut microbiota samples with FCP model and find that CSS genes change with the conditions. Compared to essential genes for microbes, CSS genes are significantly enriched in the genes involved in mobile genetic elements, cell motility, and defense mechanisms, indicating that the functions of CSS genes are focused on communication and strategies in response to the environment factors. We further find that it is the minority, rather than the majority, which contributes to maintaining community structure. Compared to health control samples, we find that some functional genes associated with metabolism of amino acids, nucleotides, and lipopolysaccharide are more likely to be CSS genes in the disease group. CSS genes may help us to understand critical cellular processes and be useful in seeking addable gene circuitries to maintain artificial self-sustainable communities. Our study suggests that functional genes are important to the assembly of microbial communities.

关键词： Metagenomics Dynamics model Community structure Acid mine drainage Human gut microbiota

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SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA

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Genome Instability & Disease 2021年第4期2卷 253-260页

作者： Xu, Chenzhong Zhang, Jin Zhang, Jie Liu, Baohua Shenzhen Key Laboratory for Systemic Aging and Intervention (SAI) Guangdong Key Laboratory of Genome Stability and Human Disease Prevention National Engineering Research Center for Biotechnology (Shenzhen) International Cancer Center School of Basic Medical Sciences Shenzhen University Shenzhen China Shenzhen University (SZU)-Friedrich Schiller University (FSU) Jena Joint PhD Program Shenzhen University Shenzhen China Shenzhen Bay Laboratory Shenzhen China

N-acetyltransferase 10 catalyzes RNA N4-acetylcytidine (ac4C) modifications and thus regulates RNA stability and translation efficiency. However, the deacetylase for ac4C is unknown. SIRT7 was initially identified as an NAD+-dependent protein deacetylase and plays essential roles in genome stability, circadian rhythms, metabolism, and aging. In this study, we identified SIRT7 as a deacetylase of the ac4C of ribosomal (r)RNA for the first time and found it to be NAD+-independent. Our data highlight the important role of SIRT7 in rRNA ac4C modification and suggest an additional epitranscriptional regulation of aging.

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Exploring the potential of the nano-based sunscreens and antioxidants for preventing and treating skin photoaging

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Chemosphere 2024年 347卷 140702页

作者： Lin, Chih-Hung Lin, Ming-Hsien Chung, Yu-Kuo Alalaiwe, Ahmed Hung, Chi-Feng Fang, Jia-You Center for General Education Chang Gung University of Science and Technology Kweishan Taoyuan Taiwan Department of Dermatology Chi Mei Medical Center Tainan Taiwan Graduate Institute of Biomedical Sciences Chang Gung University Kweishan Taoyuan Taiwan Department of Pharmaceutics College of Pharmacy Prince Sattam Bin Abdulaziz University Al Kharj Saudi Arabia School of Medicine Fu Jen Catholic University New Taipei City Taiwan PhD Program in Pharmaceutical Biotechnology Fu Jen Catholic University New Taipei City Taiwan School of Pharmacy Kaohsiung Medical University Kaohsiung Taiwan Pharmaceutics Laboratory Graduate Institute of Natural Products Chang Gung University Kweishan Taoyuan Taiwan Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine Chang Gung University of Science and Technology Kweishan Taoyuan Taiwan Department of Anesthesiology Chang Gung Memorial Hospital Kweishan Taoyuan Taiwan

Excessive exposure to sunlight, especially UV irradiation, causes skin photodamage. Sunscreens, such as TiO2 and ZnO, can potentially prevent UV via scattering, reflection, and absorption. Topical antioxidants are another means of skin photoprotection. Developing nanoparticles for sunscreens and antioxidants is recommended for photoaging prevention and treatment as it can improve uncomfortable skin appearance, stability, penetration, and safety. This study reviewed the effects of nano-sized sunscreens and antioxidants on skin photoprevention by examining published studies and articles from PubMed, Scopus, and Google Scholar, which explore the topics of skin photoaging, skin senescence, UV radiation, keratinocyte, dermal fibroblast, sunscreen, antioxidant, and nanoparticle. The researchers of this study also summarized the nano-based UV filters and therapeutics for mitigating skin photoaging. The skin photodamage mechanisms are presented, followed by the introduction of current skin photoaging treatment. The different nanoparticle types used for topical delivery were also explored in this study. This is followed by the mechanisms of how nanoparticles improve the UV filters and antioxidant performance. Lastly, recent investigations were reviewed on nanoparticulate sunscreens and antioxidants in skin photoaging management. Sunscreens and antioxidants for topical application have different concepts. Topical antioxidants are ideal for permeating into the skin to exhibit free radical scavenging activity, while UV filters are prescribed to remain on the skin surface without absorption to exert the UV-blocking effect without causing toxicity. The nanoparticle design strategy for meeting the different needs of sunscreens and antioxidants is also explored in this study. Although the benefits of using nanoparticles for alleviating photodamage are well-established, more animal-based and clinical studies are necessary. © 2023 Elsevier Ltd

关键词： Antioxidants

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Uncovering chromatin accessibility and cancer diagnostic potential via cell-free DNA utilization

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Science Bulletin 2024年第19期69卷 2987-2992页

作者： Jie Li Jiahui Chen Xin Sun Heli Yang Keyong Sun Chang Liu Yongwang Wang Mengyue Xu Xin Ji Ji Zhang Xiaojiang Wu Anqiang Wang Biao Fan Xiaolu Zhang Yue Wu Peilin Cui Junya Peng Yupei Zhao Wenming Wu Honghao Yu Zhaode Bu Jiafu Ji Xun Lan Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Center of Gastrointestinal CancerPeking University Cancer Hospital&InstituteBeijing 100142China Guangxi Key Laboratory of Drug Discovery and Optimization Guilin Medical UniversityGuilin 541001China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Internal Medicine International Medical Services(IMS)Beijing Tiantan Hospital of Capital Medical UniversityBeijing 100070China Institute of Clinical Medicine Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China Peking-Tsinghua-NIBS Joint Graduate Program Tsinghua UniversityBeijing 100084China Tsinghua-Peking Joint Center for Life Sciences Tsinghua UniversityBeijing 100084China Department of Anesthesiology Affiliated Hospital of Guilin Medical UniversityGuilin 541000China Key Laboratory of Medical Biotechnology and Translational Medicine Guilin Medical UniversityGuilin 541001China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China The Islands Healthcare Complex-Macao Medical Center of Peking Union Medical College Hospital Macao 999078China

Gene expression patterns of tumor cells can be inferred from features of circulating cell-free DNA(cfDNA),such as histone modifications and fragmentation patterns at ***,the direct relationship between cfDNA patterns and tumor-specific chromatin accessibility has not yet been experimentally established,limiting its current application to cancer diagnosis alone.

关键词： diagnosis cancer alone

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Reduction Reactions Dominate the Interactions between Metals and Cells: Understanding the Mechanisms

SSRN

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SSRN 2024年

作者： Kim, Jua Gilbert, Jeremy L. Lv, William W. Pan, Haobo Du, Ping Center for Human Tissues and Organs Degeneration China Shenzhen Key Laboratory of Marine Biomaterials CAS-HK Joint Lab of Biomaterials The Key Laboratory of Biomedical Imaging Science System Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen University Town 1068 Xueyuan Avenue Shenzhen518055 China Syracuse Biomaterials Institute Syracuse University Syracuse University 318 Bowne Hall SyracuseNY13244 United States Clemson- Medical University of South Carolina Bioengineering Program Department of Bioengineering Clemson University 68 Presidents St CharlestonSC39425 United States Department of Orthopaedics and Traumatology Li Ka Shing Faculty of Medicine The University of Hong Kong 999077 Hong Kong Shenzhen Healthemes Biotechnology Co. Ltd Shenzhen518102 China

Magnesium (Mg) alloys are popular biodegradable metals studied for orthopedic and cardiovascular applications, mainly because Mg ions are essential trace elements known to promote angiogenesis and osteogenesis. However, all metal corrosion, including Mg alloys, consists of oxidation and reduction reactions, where oxidation of metal is inevitably accompanied by reduction of water, oxygen, and other biomolecules nearby. It is still unclear how all these by-products and Mg ions concomitantly alter the microenvironment and cell behaviors spatially and temporally. By-products produced from reduction reactions like alkaline pH, hydrogen, and ROS/RNS are generally unwanted side effects;however, reduction reactions are inevitable. Depending on the rate, reduction reactions exhibit biphasic effects that can induce discrete biological responses. This study shows that Mg corrosion produces ROS both in vitro and in vivo, and ROS significantly affects HIF1A expression and signaling pathways like WNT and PI3K/AKT/mTOR, related to BMSC proliferation and differentiation. Furthermore, cells may respond to Mg ions and oxidative stress differently at different pH levels, which can vary in different pathological conditions. Therefore, this study provides a fundamental insight into the importance of reduction reactions in all metallic biomaterials. © 2024, The Authors. All rights reserved.

关键词： Magnesium alloys

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Development of a respiratory sound labeling software for training a deep learning-based respiratory sound analysis model

arXiv

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arXiv 2021年

作者： Hsu, Fu-Shun Huang, Chao-Jung Kuo, Chen-Yi Huang, Shang-Ran Cheng, Yuan-Ren Wang, Jia-Horng Wu, Yi-Lin Huang, Chien-Wen Tzeng, Tzu-Ling Lai, Feipei Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Heroic Faith Medical Science Corporation Limited New Taipei Taiwan National Taiwan University Stanford Joint Program Office of AI in Biotechnology Ministry of Science and Technology Joint Research Center for Artificial Intelligence Technology All Vista Healthcare Taipei Taiwan Department of Life Science College of Life Science National Taiwan University Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Department of Critical Care Far Eastern Memorial Hospital New Taipei City Taiwan

Respiratory auscultation can help healthcare professionals detect abnormal respiratory conditions if adventitious lung sounds are heard. The state-of-the-art artificial intelligence technologies based on deep learning show great potential in the development of automated respiratory sound analysis. To train a deep learning-based model, a huge number of accurate labels of normal breath sounds and adventitious sounds are needed. In this paper, we demonstrate the work of developing a respiratory sound labeling software to help annotators identify and label the inhalation, exhalation, and adventitious respiratory sound more accurately and quickly. Our labeling software integrates six features from MATLAB Audio Labeler, and one commercial audio editor, RX7. As of October, 2019, we have labeled 9,765 15-second-long audio files of breathing lung sounds, and accrued 34,095 inhalation labels,18,349 exhalation labels, 13,883 continuous adventitious sounds (CASs) labels and 15,606 discontinuous adventitious sounds (DASs) labels, which are significantly larger than previously published studies. The trained convolutional recurrent neural networks based on these labels showed good performance with F1-scores of 86.0% on inhalation event detection, 51.6% on CASs event detection and 71.4% on DASs event detection. In conclusion, our results show that our proposed respiratory sound labeling software could easily pre-define a label, perform one-click labeling, and overall facilitate the process of accurately labeling. This software helps develop deep learning-based models that require a huge amount of labeled acoustic data. Copyright © 2021, The Authors. All rights reserved.

关键词： Software design

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Relationships between blood leukocyte mitochondrial DNA copy number and inflammatory cytokines in knee osteoarthritis

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2020年第1期21卷 42-52页

作者： Dong ZHAN Aree TANAVALEE Saran TANTAVISUT Srihatach NGARMUKOS Steven WEDWARDS Sittisak HONSAWEK Joint PhD Program in Biomedical Sciences and Biotechnology Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Department of Biochemistry Osteoarthritis and Musculoskeleton Research UnitFaculty of MedicineKing Chulalongkorn Memorial HospitalThai Red Cross SocietyChulalongkorn UniversityBangkok 10330Thailand Department of Orthopaedics Vinai Parkpian Orthopaedic Research CenterFaculty of MedicineKing Chulalongkorn Memorial HospitalThai Red Cross SocietyChulalongkorn UniversityBangkok 10330Thailand Institute of Integrative Biology University of LiverpoolLiverpool L697ZBUK

Osteoarthritis(OA)is a degenerative articular disorder manifested by cartilage destruction,subchondral sclerosis,osteophytes,and synovitis,resulting in chronic joint pain and physical disability in the *** purpose of this study was to investigate mitochondrial DNA copy number(mtDNACN)and inflammatory cytokines in primary knee OA patients and healthy volunteers.A total of 204 knee OA patients and 169 age-matched healthy volunteers were *** relative blood leukocyte mtDNACN was assessed by quantitative real-time polymerase chain reaction(qRT-PCR),and ten inflammatory cytokines in their plasma were detected by multiplex *** leukocyte mtDNACN in the OA group was significantly lower than that in the control *** mtDNACN in the control group was negatively correlated with their age(r=−0.380,P<0.0001),whereas mtDNACN in the OA group was positively correlated with their age(r=0.198,P<0.001).Plasma interleukin-4(IL-4)and IL-6 were significantly higher in the knee OA group than in the control *** plasma IL-6 level was positively correlated with blood leukocyte mtDNACN in the OA group(r=0.547,P=0.0014).IL-5 showed as a major factor(coefficient 0.69)in the second dimension of principle components analysis(PCA)-transformed data and was significantly higher in the OA group(P<0.001)as well as negatively correlated with mtDNACN(r=−0.577,P<0.001).These findings suggest that elevation of plasma IL-4 and IL-6 and a relative reduction in mtDNACN might be effective biomarkers for knee ***-5 is a plausible factor responsible for decreasing blood leukocyte mtDNACN in knee OA patients.

关键词： Inflammatory cytokine Blood leukocyte Knee Mitochondrial DNA copy number Osteoarthritis

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Comparison of endoscopic third ventriculostomy versus cerebrospinal fluid shunt procedures for the treatment of pediatric hydrocephalus in Taiwan

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Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2024年第9期40卷 2883-2891页

作者： Shu-Mei Chen Li-Ying Chen Jiann-Her Lin Nicole Salazar Tu-Hsueh Yeh Wei-Lun Lo Tai-Ngar Lui Yi-Chen Hsieh Li-Nien Chien Department of Neurosurgery Taipei Medical University Hospital Taipei Medical University Taipei Taiwan. Department of Surgery School of Medicine Taipei Medical University Taipei Taiwan. Health Data Analytics and Statistics Center Office of Data Science Taipei Medical University Taipei Taiwan. Julius L. Chambers Biomedical/Biotechnology Institute and Department of Biological & Biomedical Sciences North Carolina Central University Durham NC USA. Department of Neurology Taipei Medical University Hospital Taipei Taipei Medical University Taipei Taiwan. Department of Neurology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Neurosurgery Shuang Ho Hospital Taipei Medical University Taipei Taiwan. The PhD Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University 250 Wu-Hsing Street Taipei Taiwan. ychsieh@tmu.edu.tw. Institute of Health and Welfare Policy College of Medicine National Yang Ming Chiao Tung University No.155 Sec. 2 Linong St. Beitou District Taipei Taiwan. linien.chien@nycu.edu.tw. Graduate Institute of Data Science College of Management Taipei Medical University Taipei Taiwan. linien.chien@nycu.edu.tw.

PURPOSE:Pediatric hydrocephalus is the most common cause of surgically treatable neurological disease in children. Controversies exist whether endoscopic third ventriculostomy (ETV) or cerebrospinal fluid (CSF) shunt placement is the most appropriate treatment for pediatric hydrocephalus. This study aimed to compare the risk of re-operation and death between the two procedures. METHODS:We performed a retrospective population-based cohort study and included patients younger than 20-years-old who underwent CSF shunt or ETV for hydrocephalus from the Taiwan National Health Insurance Research Database. RESULTS:A total of 3,555 pediatric patients from 2004 to 2017 were selected, including 2,340 (65.8%) patients that received CSF shunt placement and 1215 (34.2%) patients that underwent ETV. The incidence of all-cause death was 3.31 per 100 person-year for CSF shunt group and 2.52 per 100 person-year for ETV group, with an adjusted hazard ratio (HR) of 0.79 (95% confidence interval [CI] = 0.66-0.94, p = 0.009). The cumulative incidence competing risk for reoperation was 31.2% for the CSF shunt group and 26.4% for the ETV group, with an adjusted subdistribution HR of 0.82 (95% CI = 0.70-0.96, p = 0.015). Subgroup analysis showed that ETV was beneficial for hydrocephalus coexisting with brain or spinal tumor, central nervous system infection, and intracranial hemorrhage. CONCLUSION:Our data indicates ETV is a better operative procedure for pediatric hydrocephalus when advanced surgical techniques and instruments are available.

关键词： Cerebrospinal shunt Pediatric hydrocephalus Reoperation Third ventriculostomy

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