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Biomedical Optics, BIOMED 2012

作者： Li, Lin Lin, Zi-Jing Cazzell, Mary Liu, Hanli Department of Bioengineering Joint Graduate Program b/w Univ. of Texas Southwestern Medical University of Texas Arlington TX 76019 United States College of Nursing University of Texas at Arlington Arlington TX 76019 United States

We utilized fNIRS to examine gender differences in brain activation at the prefrontal cortex of forty healthy adults while performing the Balloon Analogue Risk Task (BART). It shows promises of fNIRS to study risk dec... 详细信息

ISBN: (纸本)9781557529428

关键词： Chemical activation

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Ultrasound-switchable fluorescence imaging

Ultrasound-switchable fluorescence imaging

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Bio-Optics: Design and Application, BODA 2013

作者： Yuan, B. Pei, Y. Kandukuri, J. Department of Bioengineering The University of Texas at Arlington Arlington TX 76019 United States Joint Biomedical Engineering Program The University of Texas at Arlington The univ. of Texas Southwestern Med. Center Dallas TX 75390 United States

ISBN: (纸本)9781557529664

An ultrasound-switchable fluorescence (USF) imaging system is developed for deeptissue high-resolution imaging. The system includes acoustic, optical, electronic, mechanical scanning and data acquisition sub-systems. Results show the feasibility of high-resolution fluorescence imaging using this system. Optics in the Life Sciences Congress Technical Digest © 2013 The Optical Society (OSA).

关键词： Ultrasonics

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Development of aliphatic biodegradable photoluminescent polymers (vol 106, pg 10086, 2009)

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009年第28期106卷 11818-11818页

作者： Yang, Jian Zhang, Yi Gautam, Santosh Liu, Li Dey, Jagannath Chen, Wei Mason, Ralph P. Serrano, Carlos A. Schug, Kevin A. Tang, Liping Departments of [a]Bioengineering [d]Physics and [e]Chemistry and Biochemistry University of Texas Arlington TX 76019 [b]Joint Biomedical Engineering Program University of Texas at Arlington and University of Texas Southwestern Medical Center Dallas TX 75390 and [c]Department of Radiology Advanced Radiological Sciences University of Texas Southwestern Medical Center Dallas TX 75390

None of the current biodegradable polymers can function as both implant materials and fluorescent imaging probes. The objective of this study was to develop aliphatic biodegradable photoluminescent polymers (BPLPs) and their associated cross-linked variants (CBPLPs) for biomedical applications. BPLPs are degradable oligomers synthesized from biocompatible monomers including citric acid, aliphatic diols, and various amino acids via a convenient and cost-effective polycondensation reaction. BPLPs can be further cross-linked into elastomeric cross-linked polymers, CBPLPs. We have shown representatively that BPLP-cysteine (BPLP-Cys) and BPLP-serine (BPLP-Ser) offer advantages over the traditional fluorescent organic dyes and quantum dots because of their preliminarily demonstrated cytocompatibility in vitro, minimal chronic inflammatory responses in vivo, controlled degradability and high quantum yields (up to 62.33%), tunable fluorescence emission (up to 725 nm), and photostability. The tensile strength of CBPLP-Cys film ranged from 3.25 ± 0.13 MPa to 6.5 ± 0.8 MPa and the initial Modulus was in a range of 3.34 ± 0.15 MPa to 7.02 ± 1.40 MPa. Elastic CBPLP-Cys could be elongated up to 240 ± 36%. The compressive modulus of BPLP-Cys (0.6) (1:1:0.6 OD:CA:Cys) porous scaffold was 39.60 ± 5.90 KPa confirming the soft nature of the scaffolds. BPLPs also possess great processability for micro/nano-fabrication. We demonstrate the feasibility of using BPLP-Ser nanoparticles ("biodegradable quantum dots") for in vitro cellular labeling and noninvasive in vivo imaging of tissue engineering scaffolds. The development of BPLPs and CBPLPs represents a new direction in developing fluorescent biomaterials and could impact tissue engineering, drug delivery, bioimaging.

关键词： bioimaging elastomers photoluminescence tissue engineering

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Automated voxel classification used with atlas-guided diffuse optical tomography for assessment of functional brain networks in young and older adults

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Neurophotonics 2016年第4期3卷 045002-045002页

作者： Li, Lin Cazzell, Mary Babawale, Olajide Liua, Hanli University of Texas at Arlington Department of Bioengineering Joint Graduate Program between University of Texas ArlingtonTX76019 United States University of California Department of Neurology David Geffen School of Medicine Los AngelesCA90095 United States Cook Children's Medical Center 801 Seventh Avenue Fort WorthTX76104 United States

Atlas-guided diffuse optical tomography (atlas-DOT) is a computational means to image changes in cortical hemodynamic signals during human brain activities. Graph theory analysis (GTA) is a network analysis tool commonly used in functional neuroimaging to study brain networks. Atlas-DOT has not been analyzed with GTA to derive large-scale brain connectivity/networks based on near-infrared spectroscopy (NIRS) measurements. We introduced an automated voxel classification (AVC) method that facilitated the use of GTA with atlas-DOT images by grouping unequal-sized finite element voxels into anatomically meaningful regions of interest within the human brain. The overall approach included volume segmentation, AVC, and cross-correlation. To demonstrate the usefulness of AVC, we applied reproducibility analysis to resting-state functional connectivity measurements conducted from 15 young adults in a two-week period. We also quantified and compared changes in several brain network metrics between young and older adults, which were in agreement with those reported by a previous positron emission tomography study. Overall, this study demonstrated that AVC is a useful means for facilitating integration or combination of atlas-DOT with GTA and thus for quantifying NIRS-based, voxel-wise resting-state functional brain networks. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

关键词： Graph theory

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Near-infrared time-domain ultrasound-switchable fluorescence imaging

Near-infrared time-domain ultrasound-switchable fluorescence...

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Optical Molecular Probes, Imaging and Drug Delivery, OMP 2017

作者： Yu, Shuai Liu, Yuan Kandukuri, Jayanth Yao, Tingfeng Yuan, Baohong Ultrasound and Optical Imaging Laboratory Department of Bioengineering The University of Texas at Arlington ArlingtonTX76019 United States Joint Biomedical Engineering Program The University of Texas at Arlington and The University of Texas Southwestern Medical Center DallasTX75390 United States

High signal-to-noise ratio (SNR) in ultrasound-switchable fluorescence (USF) imaging was achieved via a new contrast agent and a new time-domain system implemented in an inverted fluorescence microscope. © 2017 OSA.

ISBN: (纸本)9781943580255

关键词： Fluorescence imaging

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Perception of 3-D layout in stereo displays

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Information Display 2009年第1期25卷 12-16页

作者： Banks, Martin S. Held, Robert T. Girshick, Ahna R. Science Program School of Optometry University of California at Berkeley Berkeley CA United States Joint Graduate Group in Bioengineering University of California San Francisco CA United States University of California at Berkeley Berkeley CA United States Department of Psychology Center for Neural Science New York University New York NY United States

As stereoscopic displays become more commonplace, it is more important than ever for those displays to create a faithful impression of the 3-D structure of the object or scene being portrayed. This article reviews cur... 详细信息

关键词： Chemicals

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Differences in creep response of GBM cells migrating in confinement

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International Biomechanics 2020年第1期7卷 44-57页

作者： Khan, Ishan Bui, Loan Bachoo, Robert Kim, Young-Tae Chuong, Cheng-Jen University of Texas at Arlington and University of Texas Southwestern Medical Center at Dallas Joint Graduate Program in Biomedical Engineering United States Department of Neurology & Neurotherapeutics University of Texas Southwestern Medical Center at Dallas Dallas TX United States University of Texas at Arlington Department of Bioengineering TX United States

Using a microfluidic platform to apply negative aspiration pressure (–20, –25, –30, –35 and –40 cm H2O), we compared the differences in creep responses of Glioblastoma Multiforme (GBM) cells while migrating in co... 详细信息

Using a microfluidic platform to apply negative aspiration pressure (–20, –25, –30, –35 and –40 cm H₂O), we compared the differences in creep responses of Glioblastoma Multiforme (GBM) cells while migrating in confinement and at a stationary state on a 2D substrate. Cells were either migrating in a channel of 5 x 5 μm cross-section or stationary at the entrance to the channel. In response to aspiration pressure, we found actively migrating GBM cells exhibited a higher stiffness than stationary cells. Additionally, migrating cells absorbed more energy elastically with a relatively small dissipative energy loss. At elevated negative pressure loads up to–30 cm H₂O, we observed a linear increase in elastic deformation and a higher distribution in elastic storage than energy loss, and the response plateaued at further increasing negative pressure loads. To explore the underlying cause, we carried out immuno-cytochemical studies of these cells and found a polarized actin and myosin distribution at the front and posterior ends of the migrating cells, whereas the distribution of the stationary group demonstrated no specific regional differences. These differences in creep response and cytoskeletal protein distribution demonstrate the importance of a migrating cell’s kinematic state to the mechanism of cell migration. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

关键词： actomyosin contraction Cancer cell creep glioblastoma viscoelastic properties

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Biomimetic in silico devices

Biomimetic in silico devices

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International Conference on Computational Methods in Systems Biology, CMSB 2004

作者： Hunt, C. Anthony Ropella, Glen E. P. Roberts, Michael S. Yan, Li Dept. of Biopharmaceutical Sciences Biosystems Group University of California San Francisco CA 94143-0446 United States Department of Medicine University of Queensland Princess Alexandra Hospital Woolloongabba Q 4102 Australia Joint UCSF UC Berkeley Bioengineering Graduate Program

ISBN: (纸本)3540253750

We introduce biomimetic in silico devices, and means for validation along with methods for testing and refining them. The devices are constructed from adaptable software components designed to map logically to biological components at multiple levels of resolution. In this report we focus on the liver;the goal is to validate components that mimic features of the lobule (the hepatic primary functional unit) and dynamic aspects of liver behavior, structure, and function. An assembly of lobule-mimetic devices represents an in silico liver. We validate against outflow profiles for sucrose administered as a bolus to isolated, perfused rat livers. Acceptable in silico profiles are experimentally indistinguishable from those of the in situ referent. This new technology is intended to provide powerful new tools for challenging our understanding of how biological functional units function in vivo. © Springer-Verlag Berlin Heidelberg 2005.

关键词： Biomimetic materials

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CHARACTERIZATION OF POLYMER COATED MAGNETIC NANOPARTICLES FOR TARGETED TREATMENT OF CANCER

CHARACTERIZATION OF POLYMER COATED MAGNETIC NANOPARTICLES FO...

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2007 IEEE Dallas Engineering in Medicine and Biology Workshop: Emerging Technologies for Healthcare and Quality of Life

作者： SIVANIARAVINDAPRIYA NATTAMA MAHAM RAHIMI ANIKET S. WADAJKAR BHANUPRASANTH KOPPOLU JENNIFER HUA FIEMU NWARIAKU KYTAI T. NGUYEN Department of Bioengineering Joint Biomedical Engineering Program of UTA University of Texas Arlington USA Department of Surgery University of Technology USA

The objective of this project is to develop and characterize a targeted drug delivery vehicle capable of the controlled release of chemotherapy to treat malignant tumors. Our construct consists of a magnetic core with a thermosensitive polymer (N-isopropylacrylamide, NIPA) shell. The advantage of this system is that a magnetic field can be used for targeting the construct as well as to induce heat for hyperthermia treatment. Furthermore, the drug can be loaded into the NIPA layer and released when the temperature reaches its lower critical solution temperature (LCST). Drug release studies were used to characterize the thermoresponsive properties of the construct. Cellular uptake and cytotoxicity studies were also performed to determine in vitro behavior. Our NIPA-magnetic nanoparticle presents a unique and effective method of treating many cancers while reducing the deleterious effects associated with traditional drug delivery methods.

关键词： Polymer films Nanoparticles Cancer Temperature Targeted drug delivery Vehicles Malignant tumors Magnetic cores Magnetic fields Heat treatment

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Accessible and accurate cytometry analysis of adherent cells using fluorescence microscopes

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Scientific Reports 2025年第1期15卷 1-9页

作者： Daniel Foyt Yiming Kuang Klaus Yserentant Bo Huang Samma Rehem UCSF-UC Berkeley Joint Graduate Program in Bioengineering University of California San Francisco San Francisco CA 94143 USA Department of Pharmaceutical Chemistry University of California San Francisco San Francisco CA 94143 USA Department of Biochemistry and Biophysics University of California San Francisco San Francisco CA 94143 USA Chan Zuckerberg Biohub San Francisco San Francisco CA 94158 USA Barnard College of Columbia University New York City NY 10027 USA

We have developed a method along with a Python-based analysis tool to capture images and produce flow-cytometry-like data for adherent cell culture utilizing simple accessible microscopes. Leveraging the recently developed generalist algorithms for cell segmentation, our approach efficiently quantifies single-cell fluorescence signals. We demonstrated the utility of this method by screening a set of 88 prime editing conditions using the integration of mNeonGreen211as a reporter.

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