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Assessment of resting-state brain networks in young and older adults by automatic voxel classification with atlas-guided diffuse optical tomography

Assessment of resting-state brain networks in young and olde...

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Clinical and Translational Biophotonics, Translational 2016

作者： Li, Lin Babawale, Olajide Cazzell, Mary Liu, Hanli Department of Bioengineering Joint Graduate Program between University of Texas ArlingtonTX76019 United States University of Texas Southwestern Medical Center University of Texas ArlingtonTX76019 United States Department of Neurology David Geffen School of Medicine University of California at Los Angeles Los AngelesCA90095 United States Cook Children's Medical Center Fort WorthTX76104 United States

We implemented an automatic voxel classification algorithm so that atlas-guided DOT and graph theory analysis can be jointly used to assess hemodynamic resting-state brain networks in young and older adults. © OS... 详细信息

ISBN: (纸本)9781943580101

关键词： Graph theory

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Corrigendum: Rapid and visual Chlamydia trachomatis detection using loop-mediated isothermal amplification and hydroxynaphthol blue

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Letters in applied microbiology 2017年第4期65卷 343页

作者： I Choopara N Arunrut W Kiatpathomchai D Dean N Somboonna Program in Biotechnology Faculty of Science Chulalongkorn University Bangkok Thailand. Bioengineering and Sensing Technology Laboratory National Center for Genetic Engineering and Biotechnology Khlong Nueng Khlong Luang Pathum Thani Thailand. Center for Immunobiology and Vaccine Development UCSF Benioff Children's Hospital Oakland Research Institute Oakland CA USA. Department of Medicine University of California San Francisco CA USA. Joint Graduate Program in Bioengineering University of California Berkeley CA USA. Department of Microbiology Faculty of Science Chulalongkorn University Bangkok Thailand.

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Theoretical design and evaluation of endoluminal ultrasound applicators for thermal therapy of pancreatic cancer under image guidance

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AIP Conference Proceedings 2017年第1期1821卷

作者： Matthew Adams Serena Scott Vasant Salgaonkar Graham Sommer Chris Diederich 1Thermal Therapy Research Group University of California San Francisco 2340 Sutter Street S341 San Francisco CA 94109 USA 2Joint Graduate Program in Bioengineering UC Berkeley and UC San Francisco USA 3Stanford Medical Center 300 Pasteur Drive Stanford CA 94305 USA

An image-guided endoluminal ultrasound applicator has been proposed for palliative and potential curative thermal therapy of pancreatic tumors. By considering a directional transducer array of planar, tubular, or curvilinear transducers, this design offers the potential for fast volumetric therapy and 3D spatial control over the energy deposition profile. Treatment of pancreatic tumor tissue would be performed in a minimally invasive fashion with the applicator positioned in the gastrointestinal (GI) lumen, and sparing of the luminal wall would be achieved with a water-cooled balloon surrounding the transducers. A theoretical evaluation of this design was performed by developing a 3D acoustic and bioheat transfer model, with temperature and thermal dose solutions obtained using a FEM solver (COMSOL Multiphysics). Parametric studies were performed on a generalized anatomical model of the pancreas, tumor, and adjacent luminal wall to determine preferred transducer configurations and frequencies for maximizing lesion volume and penetration while sparing the luminal wall. Patient-specific models of pancreatic tumors were generated from CT studies and used to assess the feasibility of performing thermal ablation or hyperthermia on small (∼2 cm diameter) pancreatic head tumors with an endoluminal applicator positioned within the duodenum. Simulation results indicate lower transducer operating frequencies (1-3 MHz) are necessary to mitigate damage to the luminal wall, and a tradeoff between penetration depth and lesion volume emerges as the degree of focusing increases. For patient-specific ablation modeling of tumors within 30 mm of the luminal wall, approximately 95% of the volume could be ablated within 15 min using a planar or lightly focused transducer configuration without duodenal damage. Over 90% of the volume could be elevated above 40°C at steady state for hyperthermia applications (e.g., radiation sensitization, drug delivery) using a tubular transducer. For tum

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Experimental investigations of an endoluminal ultrasound applicator for MR-guided thermal therapy of pancreatic cancer

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AIP Conference Proceedings 2017年第1期1821卷

作者： Matthew Adams Vasant Salgaonkar Peter Jones Juan Plata Henry Chen Kim Butts Pauly Graham Sommer Chris Diederich 1Thermal Therapy Research Group University of California San Francisco 2340 Sutter Street S341 San Francisco CA 94109 USA 2Joint Graduate Program in Bioengineering UC Berkeley and UC San Francisco USA 3Radiological Sciences Laboratory Stanford University 1201 Welch Road Palo Alto CA 94304 USA 4Stanford Medical Center 300 Pasteur Drive Stanford CA 94305 USA

An MR-guided endoluminal ultrasound applicator has been proposed for palliative and potential curative thermal therapy of pancreatic tumors. Minimally invasive ablation or hyperthermia treatment of pancreatic tumor tissue would be performed with the applicator positioned in the gastrointestinal (GI) lumen, and sparing of the luminal tissue would be achieved with a water-cooled balloon surrounding the ultrasound transducers. This approach offers the capability of conformal volumetric therapy for fast treatment times, with control over the 3D spatial deposition of energy. Prototype endoluminal ultrasound applicators have been fabricated using 3D printed fixtures that seat two 3.2 or 5.6 MHz planar or curvilinear transducers and contain channels for wiring and water flow. Spiral surface coils have been integrated onto the applicator body to allow for device localization and tracking for therapies performed under MR guidance. Heating experiments with a tissue-mimicking phantom in a 3T MR scanner were performed and demonstrated capability of the prototype to perform volumetric heating through duodenal luminal tissue under real-time PRF-based MR temperature imaging (MRTI). Additional experiments were performed in ex vivo pig carcasses with the applicator inserted into the esophagus and aimed towards liver or soft tissue surrounding the spine under MR guidance. These experiments verified the capacity of heating targets up to 20-25 mm from the GI tract. Active device tracking and automated prescription of imaging and temperature monitoring planes through the applicator were made possible by using Hadamard encoded tracking sequences to obtain the coordinates of the applicator tracking coils. The prototype applicators have been integrated with an MR software suite that performs real-time device tracking and temperature monitoring.

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Towards a Full-Field Strain Sensor for Guiding Hernia Repairs

Towards a Full-Field Strain Sensor for Guiding Hernia Repair...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Amy Liao Hobart W. Harris Michel M. Maharbiz the UC Berkeley/UCSF Joint Bioengineering Program Berkeley CA 94709 USA UCSF Department of Surgery San Francisco CA 77005 USA. the Electrical Engineering Department and Bioengineering Department UC Berkeley Berkeley CA 94720 USA

ISBN: (纸本)9781424492695

Each year, approximately 400,000 ventral hernia repairs are performed in the United States [1], [2]. Large ventral hernias (hernias that occur in the abdominal wall) are typically treated by suturing in a surgical mesh to cover and overlap the hernia defect. However, in 10-20% of patients, the hernia repair fails, resulting in recurrence of the hernia, along with other complications including infection and intestinal obstruction [3], [4]. One potential cause of hernia recurrence is the unequal distribution of stress across the mesh resulting in high stress concentrations at the tissue-mesh interface, particularly at the site of mesh fixation to the abdominal wall muscles[5], [6]. Strain across the mesh can be used as an indicator for how evenly stress is distributed across the surface of the mesh. To this end, we have built a full-field, 3D strain measurement system to enable physicians to actively identify and address areas of high strain during the surgery, thus decreasing the rate of hernia recurrence. The strain sensor uses an optical technique, called the grid method, in conjunction with the defocused particle image velocimetry (DPIV) technique to measure the 3D strain distribution across the mesh. The system can achieve a limit of detection down to 0.4% strain and across a 50 cm range z-axis displacement using a Canon EOS 7D camera with a pinhole aperture mask.

关键词： Towards Full-Field Strain Sensor Guiding Hernia Repairs

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Bioelectronic Interfaces: Inkjet‐Printed Flexible Gold Electrode Arrays for Bioelectronic Interfaces (Adv. Funct. Mater. 7/2016)

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Advanced Functional Materials 2016年第7期26卷

作者： Yasser Khan Felippe J. Pavinatto Monica C. Lin Amy Liao Sarah L. Swisher Kaylee Mann Vivek Subramanian Michel M. Maharbiz Ana C. Arias Department of Electrical Engineering and Computer Sciences University of California Berkeley CA 94720 USA Physics Institute of São Carlos University of São Paulo CEP: 13566‐590 São Carlos SP Brazil Joint Graduate Program in Bioengineering University of California Berkeley CA 94720 USA

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Galvanotactic control of collective cell migration in epithelial monolayers (vol 13, pg 409, 2014)

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NATURE MATERIALS 2014年第5期13卷 530-530页

作者： Cohen, Daniel J. Nelson, W. James Maharbiz, Michel M. Joint Graduate Program in Bioengineering University of California at Berkeley Berkeley California 94720 USA Department of Biology Molelcular Cellular Physiology Stanford University Stanford California 94305 USA Department of Electrical Engineering Computer Science University of California at Berkeley Berkeley California 94720 USA

Many normal and pathological biological processes involve the migration of epithelial cell sheets. This arises from complex emergent behaviour resulting from the interplay between cellular signalling networks and the forces that physically couple the cells. Here, we demonstrate that collective migration of an epithelium can be interactively guided by applying electric fields that bias the underlying signalling networks. We show that complex, spatiotemporal cues are locally interpreted by the epithelium, resulting in rapid, coordinated responses such as a collective U-turn, divergent migration, and unchecked migration against an obstacle. We observed that the degree of external control depends on the size and shape of the cell population, and on the existence of physical coupling between cells. Together, our results offer design and engineering principles for the rational manipulation of the collective behaviour and material properties of a tissue.

关键词： CELL migration EPITHELIUM EPITHELIAL cells CELL populations SPATIOTEMPORAL processes

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Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis (vol 50, pg 1072, 2018)

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NATURE GENETICS 2018年第9期50卷 1343-1343页

作者： Waage, Johannes Standl, Marie Curtin, John A. Jessen, Leon E. Thorsen, Jonathan Tian, Chao Schoettler, Nathan Flores, Carlos Abdellaoui, Abdel Ahluwalia, Tarunveer S. Alves, Alexessander C. Amaral, Andre F. S. Anto, Josep M. Arnold, Andreas Barreto-Luis, Amalia Baurecht, Hansjorg van Beijsterveldt, Catharina E. M. Bleecker, Eugene R. Bonas-Guarch, Silvia Boomsma, Dorret I. Brix, Susanne Bunyavanich, Supinda Burchard, Esteban G. Chen, Zhanghua Curjuric, Ivan Custovic, Adnan den Dekker, Herman T. Dharmage, Shyamali C. Dmitrieva, Julia Duijts, Liesbeth Ege, Markus J. Gauderman, W. James Georges, Michel Gieger, Christian Gilliland, Frank Granell, Raquel Gui, Hongsheng Hansen, Torben Heinrich, Joachim Henderson, John Hernandez-Pacheco, Natalia Holt, Patrick Imboden, Medea Jaddoe, Vincent W. V. Jarvelin, Marjo-Riitta Jarvis, Deborah L. Jensen, Kamilla K. Jonsdottir, Ingileif Kabesch, Michael Kaprio, Jaakko Kumar, Ashish Lee, Young-Ae Levin, Albert M. Li, Xingnan Lorenzo-Diaz, Fabian Melen, Erik Mercader, Josep M. Meyers, Deborah A. Myers, Rachel Nicolae, Dan L. Nohr, Ellen A. Palviainen, Teemu Paternoster, Lavinia Pennell, Craig E. Pershagen, Goran Pino-Yanes, Maria Probst-Hensch, Nicole M. Ruschendorf, Franz Simpson, Angela Stefansson, Kari Sunyer, Jordi Sveinbjornsson, Gardar Thiering, Elisabeth Thompson, Philip J. Torrent, Maties Torrents, David Tung, Joyce Y. Wang, Carol A. Weidinger, Stephan Weiss, Scott Willemsen, Gonneke Williams, L. Keoki Ober, Carole Hinds, David A. Ferreira, Manuel A. Bisgaard, Hans Strachan, David P. Bonnelykke, Klaus COPSAC Copenhagen Prospective Studies on Asthma in Childhood Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark Institute of Epidemiology Helmholtz Zentrum München-German Research Center for Environmental Health Neuherberg Germany Division of Infection Immunity and Respiratory Medicine University of Manchester Manchester Academic Health Science Centre Manchester University NHS Foundation Trust Manchester UK 23andMe Inc. Mountain View CA USA Department of Human Genetics University of Chicago Chicago IL USA Research Unit Hospital Universitario N.S. de Candelaria Universidad de La Laguna Tenerife Spain CIBER de Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III Madrid Spain Department of Biological Psychology Netherlands Twin Register VU University Amsterdam The Netherlands Department of Psychiatry Academic Medical Center University of Amsterdam Amsterdam The Netherlands Department of Epidemiology and Biostatistics MRC-PHE Centre for Environment & Health School of Public Health Imperial College London London UK Population Health and Occupational Disease National Heart and Lung Institute Imperial College London London UK ISGlobal Barcelona Spain IMIM (Hospital del Mar Medical Research Institute) Barcelona Spain Universitat Pompeu Fabra (UPF) Barcelona Spain CIBER Epidemiología y Salud Pública (CIBERESP) Barcelona Spain Clinic and Polyclinic of Dermatology University Medicine Greifswald Greifswald Germany Department of Dermatology Venereology and Allergology University-Hospital Schleswig-Hostein Campus Kiel Kiel Germany Divisions of Pharmacogenomics and Genetics Genomics and Precision Medicine Department of Medicine University of Arizona College of Medicine Tucson AZ USA Barcelona Supercomputing Center (BSC) Joint BSC-CRG-IRB Research Program in Computational Biology Barcelona Spain APH Amsterdam Public Health Amsterdam The Netherlands Department of Biotechnology and Biomedicine Technical University of Denma

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understan... 详细信息

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries^1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.

关键词： Allergy Genome-wide association studies

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Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

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Nature communications 2025年第1期16卷 4235-4235页

作者： Cecilia Anza-Ramirez J. Jaime Miranda Benedetta Armocida Jorge César Correia Harriette Gillian Christine Van Spall David Beran Amirali Aali Kalkidan Hassen Abate Semagn Mekonnen Abate Cristiana Abbafati Mohsen Abbasi-Kangevari Zeinab Abbasi-Kangevari Zahra Aryan Sina Azadnajafabad Mohammadreza Azangou-Khyavy Seyyed-Hadi Ghamari Mohammad Keykhaei Javad Khanali Sara Momtazmanesh Fateme Montazeri Shayan Rahmani Mohammad-Mahdi Rashidi Nazila Rezaei Negar Rezaei Sahar Saeedi Moghaddam Hossein Hassanian-Moghaddam Ali-Asghar Kolahi Ali Nikoobar Hedayat Abbastabar Ahmed M. Abdel-Azeem Michael Abdelmasseh Juan Sanabria Sherief Abd-Elsalam Ahmed Abdelwahab Gholamreza Abdoli Mohammad Abdollahi Meriem Abdoun Deldar Morad Abdulah Abu Yousuf Md Abdullah Ame Mehadi Abdurehman Getachew Abebe Aidin Abedi Chirag P. Doshi Vida Abedi Hassan Abidi Richard Gyan Aboagye Hassan Abolhassani Nima Rezaei Lucas Guimarães Abreu Michael R. M. Abrigo Yonas Derso Abtew Hiwa Abubaker Ali Eman Abu-Gharbieh Hiba Jawdat Barqawi Rabih Halwani Maha Mohamed Saber-Ayad Iman M. Talaat Ahmed Abu-Zaid Manfred Mario Kokou Accrombessi Juan Manuel Acuna Denberu Eshetie Adane Tigist Demssew Adane Isaac Yeboah Addo Giovanni Addolorato Oluwafemi Atanda Adeagbo Victor Adekanmbi Miracle Ayomikun Adesina Isaac Iyinoluwa Olufadewa Olatunji O. Adetokunboh Daniel Adedayo Adeyinka Qorinah Estiningtyas Sakilah Adnani Aanuoluwapo Adeyimika Afolabi Olayinka Stephen Ilesanmi Muhammad Sohail Afzal Saira Afzal Gina Agarwal Prerna Agarwal Pradyumna Agasthi Anurag Agrawal Marcela Agudelo-Botero Adolfo Martinez-Valle Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Sohail Ahmad Tauseef Ahmad Ali Ahmadi Siamak Sabour Keivan Ahmadi Sanjay Basu Sepideh Ahmadi Ali Ahmed Shaun Wen Huey Lee Ayman Ahmed Haroon Ahmed Jivan Qasim Ahmed Gahin Abdulraheem Tayib Yahya Yahya Luai A. Ahmed Iffat Elbarazi Syed Mahboob Shah Janardhana P. Aithala Marjan Ajami Budi Aji Hossein Akbarialiabad Yibeltal Akelew Meisam Akhlaghdoust Elham Jamshidi Addis Aklilu Azene Tesfaye Melat Woldemariam Maxwell Ak CRONICAS Center of Excellence in Chronic Diseases Universidad Peruana Cayetano Heredia Lima Peru School of Medicine Universidad Peruana Cayetano Heredia Lima Peru Sydney School of Public Health Faculty of Medicine and Health University of Sydney Sydney NSW Australia Faculty of Epidemiology and Population Health London School of Hygiene & Tropical Medicine London UK Division of Tropical and Humanitarian Medicine University of Geneva Geneva Switzerland Department of Cardiovascular Endocrine-metabolic Diseases and Aging Istituto Superiore di Sanità Rome Italy Division of Endocrinology Diabetology Nutrition and Therapeutic Patient Education Department of Medicine Geneva University Hospitals Geneva Switzerland Department of Medicine and Department of Health Research Evidence and Impact McMaster University Hamilton ON Canada Research Institute of St. Joe’s Hamilton ON Canada Population Health Research Institute Hamilton Canada Geneva University Hospitals Geneva Switzerland Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Nutrition and Dietetics Jimma University Jimma Ethiopia Anesthesiology Department Dilla University Addis Ababa Ethiopia Department of Juridical and Economic Studies La Sapienza University Rome Italy Non-Communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Brigham and Women’s Hospital Harvard University Boston MA USA Students’ Scientific Research Center (SSRC) Tehran University of Medical Sciences Tehran Iran School of Medicine Tehran University of Medical Sciences Tehran Iran School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Institute Tehran University of Medical Sciences Tehran Iran Chapter of Addiction Medicine University of Sydney Sydney NSW Australia Advanced Diagnostic and Intervent

Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into acute or chronic care categories. Data were analysed by age, sex, and socio-demographic index, presenting total numbers and contributions to burden metrics such as Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLD), and Years of Life Lost (YLL). Approximately 68% of DALYs were attributed to chronic care, while 27% were due to acute care. Chronic care needs increased with age, representing 86% of YLDs and 71% of YLLs, and accounting for 93% of YLDs from sequelae. These findings highlight that chronic care needs far exceed acute care needs globally, necessitating health systems to adapt accordingly. © 2025. The Author(s).

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A confocal optical system for detecting high-speed oscillation of a single ultrasound microbubble

A confocal optical system for detecting high-speed oscillati...

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Bio-Optics: Design and Application, BODA 2013

作者： Yuan, Baohon Liu, Yuan Department of Bioengineering The University of Texas Arlington TX 76019 United States Joint Biomedical Engineering Program The University of Texas Arlington TX 75390 United States Joint Biomedical Engineering Program The University of Texas Southwestern Medical Center Dallas TX 75390 United States

ISBN: (纸本)9781557529664

Microbubbles play significant roles in ultrasound imaging. Direct observation and investigation of microbubble oscillations are expensive. We developed a confocal optical system for detecting microbubble oscillations. This system is cost efficient and provides acceptable results. Optics in the Life Sciences Congress Technical Digest © 2013 The Optical Society (OSA).

关键词： Ultrasonic imaging

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