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Bio-Optics: Design and Application, BODA 2013

作者： Yuan, B. Pei, Y. Kandukuri, J. Department of Bioengineering The University of Texas at Arlington Arlington TX 76019 United States Joint Biomedical Engineering Program The University of Texas at Arlington The univ. of Texas Southwestern Med. Center Dallas TX 75390 United States

ISBN: (纸本)9781557529664

An ultrasound-switchable fluorescence (USF) imaging system is developed for deeptissue high-resolution imaging. The system includes acoustic, optical, electronic, mechanical scanning and data acquisition sub-systems. Results show the feasibility of high-resolution fluorescence imaging using this system. Optics in the Life Sciences Congress Technical Digest © 2013 The Optical Society (OSA).

关键词： Ultrasonics

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Towards real-time communication between in vivo neurophysiological data sources and simulator-based brain biomimetic models

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Journal of computational surgery 2014年第12期3卷 1-23页

作者： Giljae Lee Andréa Matsunaga Salvador Dura-Bernal Wenjie Zhang William W Lytton Joseph T Francis José Ab Fortes Department of Electrical and Computer Engineering University of Florida P.O. Box 116200 216 Larsen Hall Gainesville 32611 FL USA. Department of Physiology and Pharmacology State University of New York Downstate Medical Center 450 Clarkson Avenue Brooklyn 11203 NY USA. Department of Physiology and Pharmacology State University of New York Downstate Medical Center 450 Clarkson Avenue Brooklyn 11203 NY USA Department of Neurology State University New York Downstate Medical Center 450 Clarkson Avenue Brooklyn 11203 NY USA Department of Neurology Kings County Hospital 450 Clarkson Avenue Brooklyn 11203 NY USA Joint Program in Biomedical Engineering at Polytechnic Institute of New York University and State University of New York Downstate 450 Clarkson Avenue Brooklyn 11203 NY USA Program in Neural and Behavioral Science at State University of New York Downstate 450 Clarkson Avenue Brooklyn NY 11203 USA The Robert F. Furchgott Center for Neural & Behavioral Science State University of New York Downstate Medical Center 450 Clarkson Avenue Brooklyn NY 11203 USA. Department of Electrical and Computer Engineering University of Florida P.O. Box 116200 216 Larsen Hall Gainesville 32611 FL USA Department of Computer and Information Science and Engineering University of Florida P.O. Box 116120 E301 CSE Building Gainesville 32611 FL USA.

Development of more sophisticated implantable brain-machine interface (BMI) will require both interpretation of the neurophysiological data being measured and subsequent determination of signals to be delivered back to the brain. Computational models are the heart of the machine of BMI and therefore an essential tool in both of these processes. One approach is to utilize brain biomimetic models (BMMs) to develop and instantiate these algorithms. These then must be connected as hybrid systems in order to interface the BMM with data acquisition devices and prosthetic devices. The combined system then provides a test bed for neuroprosthetic rehabilitative solutions and medical devices for the repair and enhancement of damaged brain. We propose here a computer network-based design for this purpose, detailing its internal modules and data flows. We describe a prototype implementation of the design, enabling interaction between the Plexon Multichannel Acquisition Processor (MAP) server, a commercial tool to collect signals from microelectrodes implanted in a live subject and a BMM, a NEURON-based model of sensorimotor cortex capable of controlling a virtual arm. The prototype implementation supports an online mode for real-time simulations, as well as an offline mode for data analysis and simulations without real-time constraints, and provides binning operations to discretize continuous input to the BMM and filtering operations for dealing with noise. Evaluation demonstrated that the implementation successfully delivered monkey spiking activity to the BMM through LAN environments, respecting real-time constraints.

关键词： Biomimetic models Brain-machine interfaces Computational neuroscience Neuroprosthetics

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In vitro cytotoxicity evaluation of four vital pulp therapy materials on l929 fibroblasts

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ISRN dentistry 2014年第1期2014卷 191068页

作者： Aniket S Wadajkar Chul Ahn Kytai T Nguyen Qiang Zhu Takashi Komabayashi Department of Bioengineering University of Texas at Arlington Arlington TX 76019 USA Joint Biomedical Engineering Program University of Texas at Arlington and University of Texas Southwestern Medical Center Dallas TX 75390 USA. Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas TX 75390-9066 USA. Division of Endodontology University of Connecticut Health Center Farmington CT 06030-1715 USA. Department of Endodontics West Virginia University School of Dentistry One Medical Center Drive P.O. Box 9450 Health Science Center North Morgantown WV 26506-9450 USA.

The aim of this study was to evaluate cytotoxicity of direct pulp capping materials such as Dycal, Life, ProRoot MTA, and Super-Bond C&B on L929 fibroblasts. Freshly mixed or set materials were prepared and eluted by incubation with cell culture medium for working time period (fresh) or for 6 hours (set). The cells were exposed to media containing elutes for 24 hours, after which the cell survival was evaluated by MTS assays. In freshly mixed materials, average ± standard deviation % cell viabilities were 40.2 ± 14.0%, 43.7 ± 16.0%, 72.9 ± 12.7%, and 66.0 ± 13.6% for Dycal, Life, ProRoot MTA, and Super-Bond C&B, respectively. There was no statistical difference in cell viabilities among material groups, whereas in set materials, the cell viabilities were 48.7 ± 14.8%, 37.2 ± 10.6%, 46.7 ± 15.2%, and 100 ± 21.9% for Dycal, Life, ProRoot MTA, and Super-Bond C&B, respectively. Super-Bond C&B showed more cell viabilities than the other three material groups (P < 0.05). The four vital pulp therapy materials had similar cytotoxicity when the materials were fresh. Super-Bond C&B was less cytotoxic than Dycal, Life, and ProRoot MTA after the materials were set, which suggests the use of SB-C&B in future in vivo clinical investigations.

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31st Annual Meeting and Associated programs of the Society for Immunotherapy of Cancer (SITC 2016): part one: National Harbor, MD, USA. 9-13 November 2016

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J Immunother Cancer 2016年第SUPPL 1期4卷 1-1页

作者： Andreas Lundqvist Vincent van Hoef Xiaonan Zhang Erik Wennerberg Julie Lorent Kristina Witt Laia Masvidal Sanz Shuo Liang Shannon Murray Ola Larsson Rolf Kiessling Yumeng Mao John-William Sidhom Catherine A. Bessell Jonathan Havel Jonathan Schneck Timothy A. Chan Eliot Sachsenmeier David Woods Anders Berglund Rupal Ramakrishnan Andressa Sodre Jeffrey Weber Roberta Zappasodi Yanyun Li Jingjing Qi Philip Wong Cynthia Sirard Michael Postow Walter Newman Henry Koon Vamsidhar Velcheti Margaret K. Callahan Jedd D. Wolchok Taha Merghoub Lawrence G. Lum Minsig Choi Archana Thakur Abhinav Deol Gregory Dyson Anthony Shields Cara Haymaker Marc Uemura Ravi Murthy Marihella James Daqing Wang Julie Brevard Catherine Monaghan Suzanne Swann James Geib Mark Cornfeld Srinivas Chunduru Sudhir Agrawal Cassian Yee Jennifer Wargo Sapna P. Patel Rodabe Amaria Hussein Tawbi Isabella Glitza Scott Woodman Wen-Jen Hwu Michael A. Davies Patrick Hwu Willem W. Overwijk Chantale Bernatchez Adi Diab Erminia Massarelli Neil H. Segal Vincent Ribrag Ignacio Melero Tara C. Gangadhar Walter Urba Dirk Schadendorf Robert L. Ferris Roch Houot Franck Morschhauser Theodore Logan Jason J. Luke William Sharfman Fabrice Barlesi Patrick A. Ott Laura Mansi Shivaani Kummar Gilles Salles Cecilia Carpio Roland Meier Suba Krishnan Dan McDonald Matthew Maurer Xuemin Gu Jaclyn Neely Satyendra Suryawanshi Ronald Levy Nikhil Khushalani Jennifer Wu Jinyu Zhang Fahmin Basher Mark Rubinstein Mark Bucsek Guanxi Qiao Cameron MacDonald Bonnie Hylander Elizabeth Repasky Shilpak Chatterjee Anusara Daenthanasanmak Paramita Chakraborty Kyle Toth Megan Meek Elizabeth Garrett-Mayer Michael Nishimura Chrystal Paulos Craig Beeson Xuezhong Yu Shikhar Mehrotra Fei Zhao Kathy Evans Christine Xiao Alisha Holtzhausen Brent A. Hanks Nicole Scharping Ashley V. Menk Rebecca Moreci Ryan Whetstone Rebekah Dadey Simon Watkins Robert Ferris Greg M. Delgoffe Jonathan Peled Sean Devlin Anna Staffas Melissa Lumish Kori Porosnicu Rodriguez Katya Ahr Miguel Perales Sergio Giralt Ying Taur Eric Pam Karolinska Institutet Stockholm Stockholms Lan Sweden Weill Cornell Medical College New York NY USA Nova Southeastern University Cell Therapy Institute Fort Lauderdale FL USA Johns Hopkins University School of Medicine Baltimore MD USA Immunology Program Johns Hopkins University School of Medicine Columbia MD USA Memorial Sloan Kettering Cancer Center New York NY USA Johns Hopkins Medical Institute Baltimore MD USA University of Rochester Monrovia MD USA NYU Langone Medical Center New York NY USA H. Lee Moffitt Cancer Center Tampa FL USA Ludwig Collaborative Laboratory Memorial Sloan Kettering Cancer Center New York NY USA Immune Monitoring Core Facility Memorial Sloan Kettering Cancer Center New York NY USA Leap Therapeutics Cambridge MA USA Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA Case Western Reserve University Cleveland OH USA Cleveland Clinic Main Campus Cleveland OH USA University of Virginia Cancer Center Charlottesville VA USA Stony Brook University Medical Center Stony Brook NY USA Karmanos Cancer Institute Detroit MI USA University of Texas MD Anderson Cancer Center Houston TX USA Idera Pharmaceuticals Inc. Cambridge MA USA Institut Gustave Roussy Villejuif Ile-de-France France Center for Applied Medical Research (CIMA) University of Navarra Pamplona Navarra Spain University of Pennsylvania Philadelphia PA USA Earle A. Chiles Research Institute Providence Cancer Center Portland OR USA Universitätsklinikum Essen Essen Nordrhein-Westfalen Germany University of Pittsburgh Pittsburgh PA USA CHU Rennes Service Hématologie Clinique and INSERM 0203 Unité d’Investigation Clinique Rennes Bretagne France Centre Hospitalier Régional Universitaire de Lille Lille Nord-Pas-de-Calais France Simon Cancer Center Indiana University Indianapolis IN USA University of Chicago School of Medicine Chicago IL USA Johns Hopkins University School of Medicine Lutherville MD USA Multidisciplinary Oncology and Therapeuti

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11th German Conference on Chemoinformatics (GCC 2015) Abstracts

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JOURNAL OF CHEMINFORMATICS 2016年第SUPPL 1期8卷 1-27页

作者： [Anonymous] GDCh-CIC Division Associated Board Member Beilstein-Institut zur Förderung der Chemischen Wissenschaften Trakehner Str. 7-9 60487 Frankfurt Germany. ufechner@beilstein-institut.de. Division Medicinal Chemistry Amsterdam Institute for Molecules Medicines and Systems (AIMMS) VU University Amsterdam The Netherlands. Centre for Bioinformatics Uni Hamburg Bundesstr. 43 20146 Hamburg Germany. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. stefan.guessregen@***. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. GlaxoSmithKline Stevenage SG1 2NY UK. nicola.j.richmond@***. Discngine Paris 75011 France. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. marwin.segler@wwu.de. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. Bundeskriminalamt Wiesbaden Central Analytics II 65173 Wiesbaden Germany. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. shea@chem.ucsb.edu. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. Chemistry Department Ludwig-Maximilians-Universität München Butenandtstr. 7 81377 Munich Germany. Inorganic Chemistry and Center for Nanointegration University of Duisburg-Essen Essen Germany. CAM-D Technologies Essen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. achim.zielesny@w-hs.de. Leiden University Leiden Netherlands. j.fraaije@chem.leidenuniv.nl. Culgi BV Berlin Germany. Physikalische Chemie III TU Dortmund 44227 Dortmund Germany. stefan.kast@tu-dortmund.de. Centre for Molecular Informatics Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW United Kingdom. kcb27@cam.ac.uk. Centre for Molecular Informatics Department of Chemistry

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Novel Atmospheric plasma enhanced Silk Fibroin nanofiber/Gauze composite wound dressings

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Journal of Fiber Bioengineering and Informatics 2012年第3期5卷 227-242页

作者： Nawalakhe, Rupesh Shi, Quan Vitchuli, Narendiran Bourham, Mohamed A. Zhang, Xiangwu Mccord, Marian G. Fiber and Polymer Science Program Department of Textile Engineering Chemistry and Science North Carolina State University Raleigh NC 27695-8301 United States Department of Nuclear Engineering North Carolina State University Raleigh NC 27695-7909 United States Joint Department of Biomedical Engineering North Carolina State University Raleigh NC 27695-7115 United States University of North Carolina Chapel Hill NC 27599 United States

In this work, Silk Fibroin (SF) nanofibers were electrospun onto plasma-treated 100% cotton gauze bandages to form a novel silk-gauze composite wound dressing. Atmospheric pressure plasma pre- and post- treatments were used to increase the adhesion between the SF nanofibers and cotton substrates. The adhesion of the nanofibers to the substrates was assessed by qualitative and quantitative techniques. Plasma pre-treatment of the substrate with 100% helium and 99% helium/1% oxygen plasmas showed up to a 50% increase in the force required to peel off the nanofiber layer. This force was further increased up to 75% after pre- as well as post-plasma treatment of the composite bandages. Plasma pre-treatment of the gauze fabric prior to nanofiber deposition and post-treatment to the composite bandages significantly reduced degradation of the nanofiber layer during repetitive flexing. Air permeability and moisture vapor transport were significantly reduced due to the presence of a nanofiber layer upon the substrate. The results of surface elemental analysis showed that the adhesion and durability increase are mainly due to the active species generated by plasma on the surface of cotton substrate as well as on the surface of the silk fibroin nanofibers. © 2012 Binary Information Press & Textile Bioengineering and Informatics Society.

关键词： Adhesion

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What Would You Do? Challenges in Hip Surgery

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Seminars in Arthroplasty JSES 2012年第3期23卷 181-192页

作者： Lombardi, Adolph V. Cameron, Hugh U. Haidukewych, George J. Krackow, Kenneth A. Paprosky, Wayne G. Trousdale, Robert T. Joint Implant Surgeons Inc New Albany OH United States Mount Carmel Health System New Albany OH United States Department of Orthopaedics The Ohio State University Columbus OH United States Department of Biomedical Engineering The Ohio State University Columbus OH United States Department of Surgery University of Toronto Toronto ON Canada Department of Bio-Engineering University of Toronto Toronto ON Canada Orthopedic Trauma and Complex Adult Reconstruction Orlando Regional Medical Center Orlando FL United States Orthopedic Residency Program Orlando Health Orthopedic Faculty Practice Orlando FL United States Department of Orthopaedics State University of New York at Buffalo School of Medicine and Biomedical Sciences Buffalo NY United States Rush University Medical Center Chicago IL United States Department of Orthopedic Surgery Mayo Clinic Rochester MN United States Department of Young Hip Clinic Mayo Clinic Rochester MN United States

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An inexpensive alternative bath system for electrophysiological characterization of isolated cardiac tissue

An inexpensive alternative bath system for electrophysiologi...

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33rd Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBS 2011

作者： Villa, Emanuel White, Alayne Stewart Liao, Jun De Jongh Curry, Amy L. Joint Graduate Program in Biomedical Engineering University of Memphis University of Tennessee Health Science Center Memphis TN 38152 United States Department of Agricultural and Biological Engineering Mississippi State University Mississippi State MS 39762 United States

ISBN: (纸本)9781424441211

A tissue bath system, to be used as an alternative to complex perfusion chambers, was constructed for use in cardiac electrophysiological studies. This system consists of an acrylic chamber to hold circulating physiological medium such as DMEM, suspended in a water bath warmed by a hot plate. Temperature and pH were controlled to mimic physiological conditions. Rat and porcine cardiac tissues, were used to test viability of the conditions presented in the bath system. Using a cardiac mapping system, the tissues were stimulated and responses recorded. From the recordings we were able to calculate conduction velocities and spatial dispersion of activation indices. The results are comparable to previous in-vivo work, which suggests that the tissue bath system design can maintain tissue viability. This tissue bath system is a relatively simple alternative for ex-vivo testing of cardiac tissues. © 2011 IEEE.

关键词： Tissue

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压缩传感可以缩短临床上1H-MRI代谢成像时间

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国际医学放射学杂志 2012年第3期 276-276页

作者： S.Geethanath H.M.Baek S.K.Ganji E.A.Maher R.D.Sims 董龙春 Joint Graduate Program in Biomedical Engineering at UT Arlington and UT Southwestern Medical Center DallasTex

目的回顾性地评价通过压缩传感实现的加速磁共振波谱成像(MRS)数据保存的保真性。材料与方法在数据采集前,这项实验获得了机构审查委员会的认可以及书面同意书,对项目中所获得的MRS数据进行采集和分析。这项研究符合HIPAA。回顾性地对1... 详细信息

目的回顾性地评价通过压缩传感实现的加速磁共振波谱成像(MRS)数据保存的保真性。材料与方法在数据采集前,这项实验获得了机构审查委员会的认可以及书面同意书,对项目中所获得的MRS数据进行采集和分析。这项研究符合HIPAA。回顾性地对10例临床MRS数据集进行压缩

关键词：压缩传感回顾性原始数据加速因子体素 MRI

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An Inexpensive Alternative Bath System for Electrophysiological Characterization of Isolated Cardiac Tissue

An Inexpensive Alternative Bath System for Electrophysiologi...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society

作者： Emanuel Villa Alayne Stewart White Jun Liao Amy L. de Jongh Curry Joint Graduate Program in Biomedical Engineering at The University of Memphis and University of Tennessee Health Science Center Department of Agricultural and Biological Engineering Mississippi State University

ISBN: (纸本)9781424441211

关键词： Isolated tissue Ex-vivo characterization Cardiac mapping

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