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Extrapolating microdomain Ca²⁺ dynamics using BK channels as a Ca²⁺ sensor

SCIENTIFIC REPORTS 2016年第1期6卷 17343-17343页

作者： Hou, Panpan Xiao, Feng Liu, Haowen Ming Yuchi Zhang, Guohui Wu, Ying Wang, Wei Zeng, Wenping Ding, Mingyue Cui, Jianming Wu, Zhengxing Wang, Lu-Yang Ding, Jiuping Huazhong Univ Sci & Technol Minist Educ Coll Life Sci & Technol Key Lab Mol Biophys Wuhan 430074 Hubei Peoples R China Huazhong Univ Sci & Technol Minist Educ Key Lab Image Proc & Intelligent Control Dept Biomed EngnColl Life Sci & Technol Wuhan 430074 Hubei Peoples R China Univ Toronto SickKids Res Inst Program Neurosci & Mental Hlth Toronto ON M5G 1X8 Canada Univ Toronto Dept Physiol Toronto ON M5G 1X8 Canada Washington Univ Dept Biomed Engn Ctr Invest Membrane Excitabil Disorders Cardiac Bioelect & Arrhythmia Ctr St Louis MO 63130 USA Soochow Univ Coll Pharmaceut Sci Dept Pharmacol Suzhou 215123 Peoples R China

Ca2+ ions play crucial roles in mediating physiological and pathophysiological processes, yet Ca2+ dynamics local to the Ca2+ source, either from influx via calcium permeable ion channels on plasmic membrane or release from internal Ca2+ stores, is difficult to delineate. Large-conductance calcium-activated K+ (BK-type) channels, abundantly distribute in excitable cells and often localize to the proximity of voltage-gated Ca2+ channels (VGCCs), spatially enabling the coupling of the intracellular Ca2+ signal to the channel gating to regulate membrane excitability and spike firing patterns. Here we utilized the sensitivity and dynamic range of BK to explore non-uniform Ca2+ local transients in the microdomain of VGCCs. Accordingly, we applied flash photolysis of caged Ca2+ to activate BK channels and determine their intrinsic sensitivity to Ca2+. We found that uncaging Ca2+ activated biphasic BK currents with fast and slow components (time constants being tau(f) approximate to 0.2 ms and tau(s) approximate to 10 ms), which can be accounted for by biphasic Ca2+ transients following light photolysis. We estimated the Ca2+-binding rate constant k(b) (approximate to 1.8 x 10(8) M(-1)s(-1)) for mSlo1 and further developed a model in which BK channels act as a calcium sensor capable of quantitatively predicting local microdomain Ca2+ transients in the vicinity of VGCCs during action potentials.

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The study of NMR relaxation time spectra multi-exponential inversion based on Lloyd-Max optimal quantization

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JOURNAL OF GEOPHYSICS AND ENGINEERING 2015年第1期12卷 144-153页

作者： Li, Xuewei Kong, Li Cheng, Jingjing Wu, Lei Huazhong Univ Sci & Technol Sch Automat Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Minist Educ Key Lab Image Proc & Intelligent Control Wuhan 430074 Peoples R China Beijing Inst Technol Sch Chem Engn & Environm Beijing 100081 Peoples R China

The multi-exponential inversion of a NMR relaxation signal plays a key role in core analysis and logging interpretation in the formation of porous media. To find an efficient metod of inverting high-resolution relaxation time spectra rapidly, this paper studies the effect of inversion which is based on the discretization of the original echo in a time domain by using a simulation model. This paper analyzes the ill-condition of discrete equations on the basis of the NMR inversion model and method, determines the appropriate number of discrete echoes and acquires the optimal distribution of discrete echo points by the Lloyd-Max optimal quantization method, in considering the inverse precision and computational complexity comprehensively. The result shows that this method can effectively improve the efficiency of the relaxation time spectra inversion while guaranteeing inversed accuracy.

关键词： NMR relaxation time spectra discretization Lloyd-Max optimal quantization

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Fuzzy control for Uncertain Vehicle Active Suspension Systems via Dynamic Sliding-Mode Approach

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IEEE Transactions on Systems, Man, and Cybernetics: Systems 2017年第1期47卷 24-32页

作者： Wen, Shiping Chen, Michael Z. Q. Zeng, Zhigang Yu, Xinghuo Huang, Tingwen School of Automation Huazhong University of Science and Technology Wuhan430074 China Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan430074 China Department of Mechanical Engineering University of Hong Kong Hong Kong Hong Kong Platform Technologies Research Institute RMIT University MelbourneVIC3001 Australia Texas A and M University at Qatar Doha23874 Qatar

This paper investigates the fuzzy control issue for uncertain active suspension systems via dynamic sliding-mode method. The Takagi-Sugeno fuzzy approach is adopted on the background of the varying masses to describe the prescribed nonlinear system in order to achieve the design targets via the method of sector nonlinearity. This paper employs the dynamic sliding-mode scheme to control nonlinear active suspension systems. In the proposed sliding-mode control scheme, the sliding surface function is formed linearly with the system states and control inputs. Then, a fuzzy dynamic term is utilized to construct the sliding-mode feedback controller. In existing results, the sliding mode is achieved and maintained with no consideration of the system perturbations. Thus, sufficient conditions are proposed to make the sliding surface reachable with the existence of the system perturbations to make the augmented system stable. Finally, simulation results are presented to verify the effectiveness of the proposed schemes. © 2013 IEEE.

关键词： Robust control

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Distributed Online Optimization for Charging and Discharging of Plug-in Electric Vehicles

Distributed Online Optimization for Charging and Discharging...

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4th IEEE International Conference on Cyborg and Bionic Systems (CBS)

作者： Xiong, Haiming Chi, Ming Liu, Zhi-Wei Hu, Dandan Zhu, Liang -Liang Jiang, Cheng Gui, Jun -Ping Rao, Yao Huazhong Univ Sci & Technol Sch Artificial Intelligence & Automat Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Key Lab Image Proc & Intelligent Control Minist Educ Wuhan 430074 Peoples R China South Cent Univ National Sch Management Wuhan 430074 Peoples R China Nari Grp Corp State Grid Elect Power Res Inst Nanjing 210000 Peoples R China Wuhan Efficiency Evaluat Co Ltd State Grid Elect Power Res Inst Wuhan Peoples R China

ISBN: (纸本)9781665490283

The increasing number of uncoordinated charging and discharging for plug-in electric vehicles (PEVs) poses new challenges to the operation of the distribution network. We introduce a dynamic price mechanism so that charging at peak load will lead to an increase in cost. Then, a distributed online charging and discharging scheduling scheme for PEVs based on the dynamic price mechanism is proposed, considering the minimization of charging cost and battery degradation cost. Unlike most of the existing studies that require the future information of PEVs to schedule charging, the proposed algorithm can solve the scheduling problem for PEVs by taking advantage of a distributed alternating direction method of multipliers (ADMM). Simulation results demonstrate the effectiveness and correctness of the proposed scheduling scheme.

关键词： Plug-in electric vehicles

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CrossGLG: LLM Guides One-shot Skeleton-based 3D Action Recognition in a Cross-level Manner

arXiv

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arXiv 2024年

作者： Yan, Tingbing Zeng, Wenzheng Xiao, Yang Tong, Xingyu Tan, Bo Fang, Zhiwen Cao, Zhiguo Zhou, Joey Tianyi Key Laboratory of Image Processing and Intelligent Control Ministry of Education School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China School of Biomedical Engineering Southern Medical University Guangzhou510515 China Department of Rehabilitation Medicine Zhujiang Hospital Southern Medical University Guangzhou510280 China Singapore Singapore Singapore Singapore

Most existing one-shot skeleton-based action recognition focuses on raw low-level information (e.g., joint location), and may suffer from local information loss and low generalization ability. To alleviate these, we propose to leverage text description generated from large language models (LLM) that contain high-level human knowledge, to guide feature learning, in a global-local-global way. Particularly, during training, we design 2 prompts to gain global and local text descriptions of each action from an LLM. We first utilize the global text description to guide the skeleton encoder focus on informative joints (i.e.,global-tolocal). Then we build non-local interaction between local text and joint features, to form the final global representation (i.e., local-to-global). To mitigate the asymmetry issue between the training and inference phases, we further design a dual-branch architecture that allows the model to perform novel class inference without any text input, also making the additional inference cost neglectable compared with the base skeleton encoder. Extensive experiments on three different benchmarks show that CrossGLG consistently outperforms the existing SOTA methods with large margins, and the inference cost (model size) is only 2.8% than the previous SOTA. CrossGLG can also serve as a plug-and-play module that can substantially enhance the performance of different SOTA skeleton encoders with a neglectable cost during inference. The source code will be released soon. © 2024, CC BY.

关键词： Signal encoding

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Novel low power supply DC-coupled 1.25 Gb/s laser diode driver

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Guti Dianzixue Yanjiu Yu Jinzhan/Research and Progress of Solid State Electronics 2006年第4期26卷 498-503页

作者： Fu, Shengmeng Chen, Zhaoyang Institute for Pattern Recognition and Artificial Intelligence Huazhong University of Science and Technology Wuhan 430074 China Key Laboratory for Image Information Processing and Intelligent Control Huazhong University of Science and Technology Wuhan 430074 China

Since the DC-coupled interface between the driver and the laser diode makes it impossible for the conventional drivers to work with low power supply, an output stage has been proposed. A novel APC can suppress the output average optical power and extinction ratio within ±0.3 dBm and ±0.4 dB(-40°C to 100°C), respectively. The initialization time is not more than 0.6 μs because the fast binary search algorithm is incorporated into the APC. The burst-on delay and burst-off delay are less than 5 ns and meet the requirement of PON system. The chip is fabricated in TSMC 0.8 μm BiCMOS process and occupies an area of 1.56 mm × 1.67 mm with a power consumption of 105 mW.

关键词： Diodes

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E-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER-PM Contact Sites and Accelerate Ca²⁺ Store Replenishment

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SCIENTIFIC REPORTS 2019年第1期9卷 1-1页

作者： Kang, Fei Zhou, Mengxuan Huang, Xiaoshuai Fang, Junchao Wei, Lisi Boulanger, Jerome Liu, Zengzhen Salamero, Jean Liu, Yanmei Chen, Liangyi Peking Univ Inst Mol Med Beijing Key Lab Cardiometab Mol Med State Key Lab Membrane Biol Beijing 100871 Peoples R China Huazhong Univ Sci & Technol Minist Educ China Sch Automat Key Lab Image Proc & Intelligent Control Wuhan 430074 Hubei Peoples R China PSL Res Univ CNRS Inst Curie UMR 144 Paris France PSL Res Univ Inst Curie Cell & Tissue Imaging Facil Paris France

In many non-excitable cells, the depletion of endoplasmic reticulum (ER) Ca2+ stores leads to the dynamic formation of membrane contact sites (MCSs) between the ER and the plasma membrane (PM), which activates the store-operated Ca2+ entry (SOCE) to refill the ER store. Two different Ca(2+)sensitive proteins, STIM1 and extended synaptotagmin-1 (E-syt1), are activated during this process. Due to the lack of live cell super-resolution imaging, how MCSs are dynamically regulated by STIM1 and E-syt1 coordinately during ER Ca2+ store depletion and replenishment remain unknown. With homebuilt super-resolution microscopes that provide superior axial and lateral resolution in live cells, we revealed that extracellular Ca2+ influx via SOCE activated E-syt1s to move towards the PM by similar to 12 nm. Unexpectedly, activated E-syt1s did not constitute the MCSs per se, but re-arranged neighboring ER structures into ring-shaped MCSs (230 similar to 280 nm in diameter) enclosing E-syt1 puncta, which helped to stabilize MCSs and accelerate local ER Ca2+ replenishment. Overall, we have demonstrated different roles of STIM1 and E-syt1 in MCS formation regulation, SOCE activation and ER Ca2+ store replenishment.

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Global Bounded Consensus of General Nonidentical Networks With Distributed Time-Delays

Global Bounded Consensus of General Nonidentical Networks Wi...

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IEEE Annual Conference on Decision and control

作者： Xiuxian Li Housheng Su Chanying Li Zheng Wang Michael Z. Q. Chen Department of Mechanical Engineering The University of Hong Kong Pokfulam Hong Kong School of Automation Image Processing and Intelligent Control Key Laboratory of Education Ministry of China Huazhong University of Science and Technology Wuhan 430074 PR China National Center for Mathematics and Interdisciplinary Sciences Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China

ISBN: (纸本)9781479978878

In this paper, global bounded consensus problem of general nonidentical networks with nonlinear dynamics and distributed time-delays is investigated, in which the distributed time-delays are distinct from each other. The global consensus exists in the sense of boundedness since complete consensus does not often exist in the nonidentical case. With the aid of constructing a Lyapunov-Krasovskii functional and utilizing the technique of integral partitioning, some sufficient delay-dependent conditions are derived to ensure that global bounded consensus is achieved ultimately. Finally, effectiveness of the theoretical result is illustrated by a numerical example.

关键词： Bounded Nonlinear Dynamics numerical example Distribute Automatic incident detection Distinct

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Asynchronous impulsive control for consensus of second-order multi-agent networks

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COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION 2019年 79卷 104892-000页

作者： Liu, Zhi-Wei Hu, Xiong Ge, Ming-Feng Wang, Yan-Wu Huazhong Univ Sci & Technol Sch Artificial Intelligence & Automat Wuhan 430074 Hubei Peoples R China China Univ Geosci Sch Mech Engn & Elect Informat Wuhan 430074 Hubei Peoples R China Huazhong Univ Sci & Technol Minist Educ Key Lab Image Proc & Intelligent Control Wuhan 430074 Hubei Peoples R China

This paper addresses the asynchronous consensus problems of second-order multi-agent networks (MANs) with sampled-data communication, where each agent has its own time clock. An impulsive control is designed to achieve second-order consensus of the considered MANs under such asynchronous setting. By analyzing the presented impulsive control strategy with the discretization method, nonnegative matrix theory and graph theory, some sufficient consensus criteria, on the range of the sampling periods and the control gains of the presented control strategy, are established for multi-agent systems under the asynchronous setting. Finally, a simulation example is presented to show the effectiveness of the proposed control and the correctness of the theoretical analysis. (C) 2019 Elsevier B.V. All rights reserved.

关键词： Impulsive control Asynchronous consensus Second-order dynamics Sampled-data communication

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A polynomial chaos approach to robust H∞ static output-feedback control with bounded truncation error

arXiv

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arXiv 2021年

作者： Wan, Yiming Shen, Dongying E. Lucia, Sergio Findeisen, Rolf Braatz, Richard D. Artificial Intelligence and Automation Huazhong University of Science and Technology Key Laboratory of Image Processing and Intelligent Control Ministry of Education Wuhan430074 China Massachusetts Institute of Technology 77 Massachusetts Avenue CambridgeMA02139 United States TU Dortmund University Dortmund44227 Germany Otto-von-Guericke University Magdeburg Magdeburg39106 Germany

This article considers the H∞ static output-feedback control for linear time-invariant uncertain systems with polynomial dependence on probabilistic time-invariant parametric uncertainties. By applying polynomial chaos theory, the control synthesis problem is solved using a high-dimensional expanded system which characterizes stochastic state uncertainty propagation. A closed-loop polynomial chaos transformation is proposed to derive the closed-loop expanded system. The approach explicitly accounts for the closed-loop dynamics and preserves the L2-induced gain, which results in smaller transformation errors compared to existing polynomial chaos transformations. The effect of using finite-degree polynomial chaos expansions is first captured by a norm-bounded linear differential inclusion, and then addressed by formulating a robust polynomial chaos based control synthesis problem. This proposed approach avoids the use of high-degree polynomial chaos expansions to alleviate the destabilizing effect of truncation errors, which significantly reduces computational complexity. In addition, some analysis is given for the condition under which the robustly stabilized expanded system implies the robust stability of the original system. A numerical example illustrates the effectiveness of the proposed approach. © 2021, CC BY.

关键词： Feedback control

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