MicroRNAs(miRNAs)are closely related to numerous complex human diseases,therefore,exploring miRNA-disease associations(MDAs)can help people gain a better understanding of complex disease *** increasing number of compu...
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MicroRNAs(miRNAs)are closely related to numerous complex human diseases,therefore,exploring miRNA-disease associations(MDAs)can help people gain a better understanding of complex disease *** increasing number of computational methods have been developed to predict ***,the sparsity of the MDAs may hinder the performance of many *** addition,many methods fail to capture the nonlinear relationships of miRNA-disease network and inadequately leverage the features of network and neighbor *** this study,we propose a deep matrix factorization model with variational autoencoder(DMFVAE)to predict potential *** first decomposes the original association matrix and the enhanced association matrix,in which the enhanced association matrix is enhanced by self-adjusting the nearest neighbor method,to obtain sparse vectors and dense vectors,***,the variational encoder is employed to obtain the nonlinear latent vectors of miRNA and disease for the sparse vectors,and meanwhile,node2vec is used to obtain the network structure embedding vectors of miRNA and disease for the dense ***,sample features are acquired by combining the latent vectors and network structure embedding vectors,and the final prediction is implemented by convolutional neural network with channel *** evaluate the performance of DMFVAE,we conduct five-fold cross validation on the HMDD v2.0 and HMDD v3.2 datasets and the results show that DMFVAE performs ***,case studies on lung neoplasms,colon neoplasms,and esophageal neoplasms confirm the ability of DMFVAE in identifying potential miRNAs for human diseases.
Currently,most existing inductive relation prediction approaches are based on subgraph structures,with subgraph features extracted using graph neural networks to predict ***,subgraphs may contain disconnected regions,...
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Currently,most existing inductive relation prediction approaches are based on subgraph structures,with subgraph features extracted using graph neural networks to predict ***,subgraphs may contain disconnected regions,which usually represent different semantic *** not all semantic information about the regions is helpful in relation prediction,we propose a relation prediction model based on a disentangled subgraph structure and implement a feature updating approach based on relevant semantic *** indirectly achieve the disentangled subgraph structure from a semantic perspective,the mapping of entity features into different semantic spaces and the aggregation of related semantics on each semantic space are *** disentangled model can focus on features having higher semantic relevance in the prediction,thus addressing a problem with existing approaches,which ignore the semantic differences in different subgraph ***,using a gated recurrent neural network,this model enhances the features of entities by sorting them by distance and extracting the path information in the ***,it is shown that when there are numerous disconnected regions in the subgraph,our model outperforms existing mainstream models in terms of both Area Under the Curve-Precision-Recall(AUC-PR)and Hits@*** prove that semantic differences in the knowledge graph can be effectively distinguished and verify the effectiveness of this method.
Language models have achieved unprecedented success in natural language processing tasks and have recently been adapted for biological sequences. However, GPUs still encounter significant performance bottlenecks when ...
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For more effective image sampling, compressive sensing(CS) imaging methods based on image saliency have been proposed in recent years. Those methods assign higher measurement rates to salient regions,but lower measure...
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For more effective image sampling, compressive sensing(CS) imaging methods based on image saliency have been proposed in recent years. Those methods assign higher measurement rates to salient regions,but lower measurement rate to non-salient regions to improve the performance of CS imaging. However, those methods are block-based, which are difficult to apply to actual CS sampling, as each photodiode should strictly correspond to a block of the scene. In our work, we propose a non-uniform CS imaging method based on image saliency, which assigns higher measurement density to salient regions and lower density to non-salient regions,where measurement density is the number of pixels measured in a unit size. As the dimension of the signal is reduced, the quality of reconstructed image will be improved theoretically, which is confirmed by our experiments. Since the scene is sampled as a whole, our method can be easily applied to actual CS sampling. To verify the feasibility of our approach, we design and implement a hardware sampling system, which can apply our non-uniform sampling method to obtain measurements and reconstruct the images. To our best knowledge, this is the first CS hardware sampling system based on image saliency.
Basecalling is a crucial step in nanopore sequencing as it transforms the raw electrical signal obtained from the nanopore into a readable sequence. The accuracy of basecalling directly affects the quality and reliabi...
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The power spectra estimated from the brain recordings are the mixed representation of aperiodic transient activity and periodic oscillations, i.e., aperiodic component (AC) and periodic component (PC). Quantitative ne...
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Software-Defined Data Center Networks (SDDCNs) utilizes Software Defined Networking (SDN) as a network architecture to achieve highly flexible, programmable, and automated management of Data Center Networks (DCNs). Th...
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As an important branch of the Internet of Things (IoT), vehicular networks play a crucial role in the construction of intelligent transportation systems. However, due to the rapid movement of vehicles and signal obstr...
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Tungsten oxide(WO_(3))-based memristors show promising applications in neuromorphic ***,single-layer WO_(3) memristors suffer from issues such as weak memory performance and nonlinear conductance *** this work,a funct...
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Tungsten oxide(WO_(3))-based memristors show promising applications in neuromorphic ***,single-layer WO_(3) memristors suffer from issues such as weak memory performance and nonlinear conductance *** this work,a functional layer based on the hybrids of WO_(3−x) and TiO_(2) is proposed for constructing flexible memristors featuring outstanding synaptic *** diverse electrical stimulations to the memristor enables a range of synaptic functions,elucidating its conduction mechanism through the conductive filament *** incorporation of TiO_(2) not only enhances the memristor’s memory characteristics but makes its conductance more linear,symmetrical and uniform during the long-term ***,in view of the enhanced device performance by TiO_(2) doping,the potential of this device for simple behavioral simulation and processing of complex computing problems is ***“learning-forgetting-relearning”characteristics and device integrability are visually *** the device to a convolutional neural network,the recognition accuracy of MNIST handwritten digits reaches 98.7%.
Mobile Edge computing(MEC)is a promising *** service migration is a keytechnology in *** order to maintain the continuity of services in a dynamic environment,mobile users need to migrate tasks between multiple serve...
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Mobile Edge computing(MEC)is a promising *** service migration is a keytechnology in *** order to maintain the continuity of services in a dynamic environment,mobile users need to migrate tasks between multiple servers in real *** to the uncertainty of movement,frequent migration will increase delays and costs and non-migration will lead to service ***,it is very challenging to design an optimal migration *** this paper,we investigate the multi-user task migration problem in a dynamic environment and minimizes the average service delay while meeting the migration *** order to optimize the service delay and migration cost,we propose an adaptive weight deep deterministic policy gradient(AWDDPG)*** distributed execution and centralized training are adopted to solve the high-dimensional *** show that the proposed algorithm can greatly reduce the migration cost and service delay compared with the other related algorithms.
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