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A deep learning system for predicting time to progression of diabetic retinopathy

NATURE MEDICINE 2024年第2期30卷 358-359页

作者： [Anonymous] Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Center for Diabetes Shanghai China MOE Key Laboratory of AI School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Department of Ophthalmology Huadong Sanatorium Wuxi China Department of Ophthalmology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong China Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore Department of Computer Science and Engineering The Hong Kong University of Science and Technology Hong Kong China Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Hong Kong China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Department of Ophthalmology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Medical Records and Statistics Office Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Geriatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Tech

We developed and validated a deep learning system (termed DeepDR Plus) in a diverse, multiethnic, multi-country dataset to predict personalized risk and time to progression of diabetic retinopathy. We show that DeepDR Plus can be integrated into the clinical workflow to promote individualized intervention strategies for the management of diabetic retinopathy.

关键词： Diabetes complications Machine learning Predictive markers

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The Minority Matters: A Diversity-Promoting Collaborative Metric Learning Algorithm

arXiv

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arXiv 2022年

作者： Bao, Shilong Xu, Qianqian Yang, Zhiyong He, Yuan Cao, Xiaochun Huang, Qingming State Key Laboratory of Information Security Institute of Information Engineering CAS China School of Cyber Security University of Chinese Academy of Sciences China Key Lab. of Intelligent Information Processing Institute of Computing Technology CAS China School of Computer Science and Tech. University of Chinese Academy of Sciences China Alibaba Group China School of Cyber Science and Technology Shenzhen Campus Sun Yat-sen University China Key Laboratory of Big Data Mining and Knowledge Management CAS China Peng Cheng Laboratory China

Collaborative Metric Learning (CML) has recently emerged as a popular method in recommendation systems (RS), closing the gap between metric learning and Collaborative Filtering. Following the convention of RS, existing methods exploit unique user representation in their model design. This paper focuses on a challenging scenario where a user has multiple categories of interests. Under this setting, we argue that the unique user representation might induce preference bias, especially when the item category distribution is imbalanced. To address this issue, we propose a novel method called Diversity-Promoting Collaborative Metric Learning (DPCML), with the hope of considering the commonly ignored minority interest of the user. The key idea behind DPCML is to include a multiple set of representations for each user in the system. Based on this embedding paradigm, user preference toward an item is aggregated from different embeddings by taking the minimum item-user distance among the user embedding set. Furthermore, we observe that the diversity of the embeddings for the same user also plays an essential role in the model. To this end, we propose a diversity control regularization term to accommodate the multi-vector representation strategy better. Theoretically, we show that DPCML could generalize well to unseen test data by tackling the challenge of the annoying operation that comes from the minimum value. Experiments over a range of benchmark datasets speak to the efficacy of DPCML. © 2022, CC BY-NC-SA.

关键词： Embeddings

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The minority matters: a diversity-promoting collaborative metric learning algorithm 22

The minority matters: a diversity-promoting collaborative me...

引用

Proceedings of the 36th International Conference on Neural Information Processing Systems

作者： Shilong Bao Qianqian Xu Zhiyong Yang Yuan He Xiaochun Cao Qingming Huang State Key Laboratory of Information Security Institute of Information Engineering CAS and School of Cyber Security University of Chinese Academy of Sciences Key Lab. of Intelligent Information Processing Institute of Computing Technology CAS School of Computer Science and Tech. University of Chinese Academy of Sciences Alibaba Group School of Cyber Science and Technology Shenzhen Campus Sun Yat-sen University Key Lab. of Intelligent Information Processing Institute of Computing Technology CAS and School of Computer Science and Tech. University of Chinese Academy of Sciences and Key Laboratory of Big Data Mining and Knowledge Management CAS and Peng Cheng Laboratory

ISBN: (纸本)9781713871088

Collaborative Metric Learning (CML) has recently emerged as a popular method in recommendation systems (RS), closing the gap between metric learning and Collaborative Filtering. Following the convention of RS, existing methods exploit unique user representation in their model design. This paper focuses on a challenging scenario where a user has multiple categories of interests. Under this setting, we argue that the unique user representation might induce preference bias, especially when the item category distribution is imbalanced. To address this issue, we propose a novel method called Diversity-Promoting Collaborative Metric Learning (DPCML), with the hope of considering the commonly ignored minority interest of the user. The key idea behind DPCML is to include a multiple set of representations for each user in the system. Based on this embedding paradigm, user preference toward an item is aggregated from different embeddings by taking the minimum item-user distance among the user embedding set. Furthermore, we observe that the diversity of the embeddings for the same user also plays an essential role in the model. To this end, we propose a Diversity Control Regularization Scheme (DCRS) to accommodate the multi-vector representation strategy better. Theoretically, we show that DPCML could generalize well to unseen test data by tackling the challenge of the annoying operation that comes from the minimum value. Experiments over a range of benchmark datasets speak to the efficacy of DPCML.

关键词：

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Large scale report generation in data consolidation environments of banks

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Huazhong Keji Daxue Xuebao (Ziran Kexue Ban)/Journal of Huazhong University of Science and Technology (Natural Science Edition) 2012年第SUPPL.1期40卷 5-8页

作者： Qin, Xiongpai Zhou, Xiaoyun Wu, Zhongxin Yang, Hongzhi Wang, Wei Ministry of Education Key Lab of Data Engineering and Knowledge Engineering Renmin University of China Beijing 100872 China Information School Renmin University of China Beijing 100872 China Computer Science Department Jiangsu Normal University Xuzhou 221116 Jiangsu China Beijing Nantian Software Co. Ltd. Beijing 100085 China

To generate large number of reports in a limited time window, four techniques were proposed, including ROLAP&SQL, Shared Scanning, Hadoop based Solution, and MOLAP&Cube Sharding, an algorithm that performs in memory aggregation was designed for the second solution. The experiment results show that all techniques except ROLAP&SQL can meet the time window constraint, the Hadoop based solution is a promising technique owe to its highly scalability. Considering maturity of the techniques and their performance, we put MOLAP&Cube Sharding into practice while keeping an eye on Hadoop for future adoption.

关键词： Custom report data consolidation Hadoop Large bank MOLAP ROLAP

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Promoting AI Equity in Science: Generalized Domain Prompt Learning for Accessible VLM Research

arXiv

引用

arXiv 2024年

作者： Cao, Qinglong Chen, Yuntian Lu, Lu Sun, Hao Zeng, Zhenzhong Yang, Xiaokang Zhang, Dongxiao MoE Key Lab of Artificial Intelligence AI Institute Shanghai Jiao Tong University Shanghai200240 China Ningbo Institute of Digital Twin Eastern Institute of Technology Ningbo315200 China Department of Statistics and Data Science Yale University New HavenCT06511 United States School of Environmental Science and Engineering Southern University of Science and Technology Shenzhen China Gaoling School of Artificial Intelligence Renmin University of China Beijing China

Large-scale Vision-Language Models (VLMs) have demonstrated exceptional performance in natural vision tasks, motivating researchers across domains to explore domain-specific VLMs. However, the construction of powerful domain-specific VLMs demands vast amounts of annotated data, substantial electrical energy, and computing resources, primarily accessible to industry, yet hindering VLM research in academia. To address this challenge and foster sustainable and equitable VLM research, we present the Generalized Domain Prompt Learning (GDPL) framework. GDPL facilitates the transfer of VLMs’ robust recognition capabilities from natural vision to specialized domains, without the need for extensive data or resources. By leveraging small-scale domain-specific foundation models and minimal prompt samples, GDPL empowers the language branch with domain knowledge through quaternion networks, uncovering cross-modal relationships between domain-specific vision features and natural vision-based contextual embeddings. Simultaneously, GDPL guides the vision branch into specific domains through hierarchical propagation of generated vision prompt features, grounded in well-matched vision-language relations. Furthermore, to fully harness the domain adaptation potential of VLMs, we introduce a novel low-rank adaptation approach. Extensive experiments across diverse domains like remote sensing, medical imaging, geology, Synthetic Aperture Radar, and fluid dynamics, validate the efficacy of GDPL, demonstrating its ability to achieve state-of-the-art domain recognition performance in a prompt learning paradigm. Our framework paves the way for sustainable and inclusive VLM research, transcending the barriers between academia and industry. Copyright © 2024, The Authors. All rights reserved.

关键词： Remote sensing

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Exploring outliers in crowdsourced ranking for QoE

arXiv

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arXiv 2017年

作者： Xu, Qianqian Yan, Ming Huang, Chendi Xiong, Jiechao Huang, Qingming Yao, Yuan Institute of Information Engineering Cas Beijing100093 Department of Computational Mathematics Michigan State University East LansingMI48824 United States BICMR-LMAM-LMEQF-LMP School of Mathematical Sciences Peking University Beijing100871 Tencent Ai Lab Shenzhen518057 University of Chinese Academy of Sciences Beijing100049 China Key Lab of Intell. Info. Process. Inst. of Comput. Tech. Cas Beijing100190 Key Lab of Big Data Mining and Knowledge Management Cas Beijing100190 Department of Mathematics Hong Kong University of Science and Technology 100871 Hong Kong

Outlier detection is a crucial part of robust evaluation for crowd-sourceable assessment of Quality of Experience (QoE) and has attracted much attention in recent years. In this paper, we propose some simple and fast algorithms for outlier detection and robust QoE evaluation based on the nonconvex optimization principle. Several iterative procedures are designed with or without knowing the number of outliers in samples. Theoretical analysis is given to show that such procedures can reach statistically good estimates under mild conditions. Finally, experimental results with simulated and real-world crowdsourcing datasets show that the proposed algorithms could produce similar performance to Huber-LASSO approach in robust ranking, yet with nearly 8 or 90 times speed-up, without or with a prior knowledge on the sparsity size of outliers, respectively. Therefore the proposed methodology provides us a set of helpful tools for robust QoE evaluation with crowdsourcing data. Copyright © 2017, The Authors. All rights reserved.

关键词： Crowdsourcing

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Global Collaboration to Enhance Information Technology & Quantitative Management: Preface for ITQM 2023

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Procedia Computer Science 2023年 221卷 xv-xvii页

作者： Shi, Yong Filip, Florin G. He, Jing Li, Jianping Kou, Gang Tien, James Berg, Daniel Research Centre on Fictitious Economy and Data Science Chinese Academy of Sciences Beijing100190 China Key Lab of Big Data Mining and Knowledge Management Chinese Academy of Sciences Beijing100190 China School of Economics and Management University of Chinese Academy of Sciences Beijing100190 China Romanian Academy Calea Victoriei 125 Sector 1 Bucharest010071 Romania College of Information Science and Technology University of Nebraska at Omaha OmahaNE68182 United States University of Oxford United Kingdom School of Business Chengdu University Sichuan 610106 China College of Engineering University of Miami Coral GablesFL33124 United States

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Identification of Causal Relationship between Amyloid-β Accumulation and Alzheimer’s Disease Progression via Counterfactual Inference

arXiv

引用

arXiv 2023年

作者： Dai, Haixing Hu, Mengxuan Li, Qing Zhang, Lu Zhao, Lin Zhu, Dajiang Diez, Ibai Sepulcre, Jorge Zhang, Fan Gao, Xingyu Liu, Manhua Li, Quanzheng Li, Sheng Liu, Tianming Li, Xiang School of Computing University of Georgia AthensGA United States State Key Lab of Cognitive Neuroscience and Learning Beijing Normal University Beijing100875 China School of Artificial Intelligence Beijing Normal University Beijing100875 China Department of Computer Science and Engineering The University of Texas at Arlington Arlington76019 United States Department of Radiology Massachusetts General Hospital Harvard Medical School Boston02114 United States Department of Radiology Brigham and Women’s Hospital Harvard Medical School Boston02115 United States School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai200240 China The MoE Key Lab of Artificial Intelligence AI Institute Shanghai Jiao Tong University Shanghai200240 China School of Data Science The University of Virginia Charlottesville22903 United States

Alzheimer’s disease (AD) is a neurodegenerative disorder that is beginning with amyloidosis, followed by neuronal loss and deterioration in structure, function, and cognition. The accumulation of amyloid-β in the brain, measured through 18F-florbetapir (AV45) positron emission tomography (PET) imaging, has been widely used for early diagnosis of AD. However, the relationship between amyloid-β accumulation and AD pathophysiology remains unclear, and causal inference approaches are needed to uncover how amyloid-β levels can impact AD development. In this paper, we propose a graph varying coefficient neural network (GVCNet) for estimating the individual treatment effect with continuous treatment levels using a graph convolutional neural network. We highlight the potential of causal inference approaches, including GVCNet, for measuring the regional causal connections between amyloid-β accumulation and AD pathophysiology, which may serve as a robust tool for early diagnosis and tailored care. © 2023, CC BY.

关键词： Neurodegenerative diseases

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PR-PL: A Novel Transfer Learning Framework with Prototypical Representation based Pairwise Learning for EEG-Based Emotion Recognition

arXiv

引用

arXiv 2022年

作者： Zhou, Rushuang Zhang, Zhiguo Fu, Hong Zhang, Li Li, Linling Huang, Gan Dong, Yining Li, Fali Yang, Xin Jane, Zhen Liang School of Biomedical Engineering Health Science Center Shenzhen University Shenzhen China Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging Shenzhen China School of Computer Science and Technology Harbin Insti- tute of Technology Shenzhen China Marshall Laboratory of Biomedical Engineering Shenzhen China Peng Cheng Laboratory Shenzhen China Department of Mathematics and Information Technology The Education University of Hong Kong Hong Kong School of Data Science City University of Hong Kong Hong Kong The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuroinformation University of Electronic Science and Technology of China China School of Life Science and Technology Center for Information in Medicine University of Electronic Science and Technology of China China

Affective brain-computer interfaces based on electroencephalography (EEG) is an important branch in the field of affective computing. However, individual differences and noisy labels seriously limit the effectiveness and generalizability of EEG-based emotion recognition models. In this paper, we propose a novel transfer learning framework with Prototypical Representation based Pairwise Learning (PR-PL) to learn discriminative and generalized prototypical representations for emotion revealing across individuals and formulate emotion recognition as pairwise learning for alleviating the reliance on precise label information. More specifically, a prototypical learning-based adversarial discriminative domain adaptation method is developed to encode the inherent emotion-related semantic structure of EEG data, while pairwise learning with an adaptive pseudo-labeling method is developed to achieve a reliable and stable model learning with noisy labels. Through domain adaptation, feature representations of source and target domains are aligned on a shared feature space, while the feature separability of both source and target domains is also considered. The characterized prototypical representations are evident with a high feature concentration within one single emotion category and a high feature separability across different emotion categories. Extensive experiments are conducted on two benchmark databases under four cross-validation evaluation protocols (cross-subject cross-session, cross-subject within-session, within-subject cross-session, and within-subject within-session). The experimental results demonstrate the superiority of the proposed PR-PL against the state-of-the-arts under all four evaluation protocols, which shows the effectiveness and generalizability of PR-PL in dealing with the ambiguity of EEG responses in affective studies. The source code is available at https://***/KAZABANA/PR-PL. Copyright © 2022, The Authors. All rights reserved.

关键词： Electrophysiology

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Multi-Channel Masked Autoencoder and Comprehensive Evaluations for Reconstructing 12-Lead ECG from Arbitrary Single-Lead ECG

arXiv

引用

arXiv 2024年

作者： Chen, Jiarong Wu, Wanqing Liu, Tong Hong, Shenda National Institute of Health Data Science Peking University Beijing100191 China School of Biomedical Engineering Sun Yat-sen University Guangdong Shenzhen518107 China Department of Micro/Nano Electronics and MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong University Shanghai200240 China Tianjin Key Laboratory of lonic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin300211 China Institute of Medical Technology Health Science Center of Peking University Beijing100191 China Institute for Artificial Intelligence Peking University Beijing100871 China

Electrocardiogram (ECG) has emerged as a widely accepted diagnostic instrument for cardiovascular diseases (CVD). The standard clinical 12-lead ECG configuration causes considerable inconvenience and discomfort, while wearable devices offers a more practical alternative. To reduce information gap between 12-lead ECG and single-lead ECG, this study proposes a multi-channel masked autoencoder (MCMA) for reconstructing 12-Lead ECG from arbitrary single-lead ECG, and a comprehensive evaluation benchmark, ECGGenEval, encompass the signal-level, feature-level, and diagnostic-level evaluations. MCMA can achieve the state-of-the-art performance. In the signal-level evaluation, the mean square errors of 0.0317 and 0.1034, Pearson correlation coefficients of 0.7885 and 0.7420. In the feature-level evaluation, the average standard deviation of the mean heart rate across the generated 12-lead ECG is 1.0481, the coefficient of variation is 1.58%, and the range is 3.2874. In the diagnostic-level evaluation, the average F1-score with two generated 12-lead ECG from different single-lead ECG are 0.8233 and 0.8410. © 2024, CC BY.

关键词： Mean square error

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