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Computed tomography-based delta radiomics of tumor core_edge combination for systemic treatment response evaluation in pancreatic cancer

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Journal of Pancreatology 2024年第3期7卷 181-190页

作者： Xiang Li Na Lu Peijun Hu Yiwen Chen Liying Liu Xinyuan Liu Chengxiang Guo Wenbo Xiao Ke Sun Jingsong Li Xueli Bai Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Key Laboratory of Pancreatic Disease HangzhouChina Research Center for Healthcare Data Science Zhejiang LabHangzhou China Department of Radiology The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhouChina Zhejiang University Cancer Center HangzhouChina

Background:As a systemic disease,pancreatic cancer(PC)can be treated systemically to raise the R0 resection rate and enhance patient *** best ways to assess the treatment response to systemic treatment of patients with PC are still ***:A total of 122 PC patients were enrolled;25 of these patients were used as an independent testing *** to the pathologic response,PC patients were classified into the responder and nonresponder *** whole tumor,core,edge,and peritumoral were segmented from the enhanced computed tomography(CT)***-learning models were created by extracting the variations in radionics features before and after therapy(delta radiomics features).Finally,we compared the performance of models based on radiomics features,changes in tumor markers,and radiologic ***:The model based on the core(area under curve[AUC]=0.864)and edge features(AUC=0.853)showed better performance than that based on the whole tumor(AUC=0.847)or peritumoral area(AUC=0.846).Moreover,the tumor core_edge combination model(AUC=0.899)could better increase confidence in treatment response than using either of them *** accuracies of models based on changes in tumor markers and radiologic evaluation were relatively poorer than of the radiomics ***,Patients predicted to respond to therapy using the radiomics model showed a relatively longer overall survival(43 vs 27 months),although there were no significant differences(P=.063).Conclusions:The tumor core_edge combination delta radiomics model is an effective approach to evaluate pathologic response in PC patients with systemic treatment.

关键词： Computed tomography Delta radiomics Pancreatic cancer Pathologic response Systemic treatment

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Digital personal health libraries: A systematic literature review

arXiv

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arXiv 2020年

作者： Ding, Huitong Zhang, Chi An, Ning Zhang, Lingling Xie, Ning Alterovitz, Gil School of Computer Science and Information Engineering Hefei University of Technology Hefei China Key Laboratory of Knowledge Engineering with Big Data of Ministry of Education Hefei University of Technology Hefei China Department of Computer Science University of California Davis CA United States College of Nursing and Health Sciences University of Massachusetts Boston BostonMA United States Biomedical Cybernetics Laboratory Division of General Internal Medicine and Primary Care Department of Medicine Brigham and Women's Hospital BostonMA United States Department of Medicine Harvard Medical School BostonMA United States

Objective: This paper gives context on recent literature regarding the development of digital personal health libraries (PHL) and provides insights into the potential application of consumer health informatics in diverse clinical specialties. Materials and Methods: A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Here, 2,850 records were retrieved from PubMed and EMBASE in March 2020 using search terms: personal, health, and library. Information related to the health topic, target population, study purpose, library function, data source, data science method, evaluation measure, and status were extracted from each eligible study. In addition, knowledge discovery methods, including co-occurrence analysis and multiple correspondence analysis, were used to explore research trends of PHL. Results: After screening, this systematic review focused on a dozen articles related to PHL. These encompassed health topics such as infectious diseases, congestive heart failure, electronic prescribing. data science methods included relational database, information retrieval technology, ontology construction technology. Evaluation measures were heterogeneous regarding PHL functions and settings. At the time of writing, only one of the PHLs described in these articles is available for the public while the others are either prototypes or in the pilot stage. Discussion: Although PHL researches have used different methods to address problems in diverse health domains, there is a lack of an effective PHL to meet the needs of older adults. Conclusion: The development of PHLs may create an unprecedented opportunity for promoting the health of older consumers by providing diverse health information. Copyright © 2020, The Authors. All rights reserved.

关键词： Population statistics

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Toward a comprehensive hypothesis of oxygen-evolution reaction in the presence of iron and gold

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Journal of Energy Chemistry 2024年第2期89卷 172-183,I0005页

作者： Negah Hashemi Jafar Hussain Shah Cejun Hu Subhajit Nandy Pavlo Aleshkevych Sumbal Farid Keun Hwa Chae Wei Xie Taifeng Liu Junhu Wang Mohammad Mahdi Najafpour Department of Chemistry Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Center for Advanced Mössbauer Spectroscopy Mössbauer Effect Data CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Key Lab of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjin 300071China Advanced Analysis Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Institute of Physics Polish Academy of SciencesWarsaw 02-668Poland National and Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials Henan UniversityKaifeng 475004HenanChina Center of Climate Change and Global Warming Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Research Center for Basic Sciences&Modern Technologies(RBST) Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran

This study investigates the effects of Fe on the oxygen-evolution reaction(OER)in the presence of *** distinct areas of OER were identified:the first associated with Fe sites at low overpotential(~330 mV),and the second with Au sites at high overpotential(~870 mV).Various factors such as surface Fe concentration,electrochemical method,scan rate,potential range,concentration,method of adding K_(2)Fe O_(4),nature of Fe,and temperature were varied to observe diverse behaviors during OER for Fe O_(x)H_(y)/*** amounts of Fe ions had a significant impact on OER,reaching a saturation point where the activity did not increase *** electronic interaction between Fe and Au ions was indicated by X-ray photoelectron spectroscopy(XPS)and electron paramagnetic resonance(EPR)*** situ visible spectroscopy confirmed the formation of Fe O_(4)^(2-)during *** situ Mossbauer and surfaceenhanced Raman spectroscopy(SERS)analyses suggest the involvement of Fe-based species as intermediates during the rate-determining step of OER.A lattice OER mechanism based on Fe O_(x)H_(y)was proposed for operation at low *** functional theory(DFT)calculations revealed that Fe oxide,Fe-oxide clusters,and Fe doping on the Au foil exhibited different activities and stabilities during *** study provides insights into the interplay between Fe and Au in OER,advancing the understanding of OER mechanisms and offering implications for the design of efficient electrocatalytic systems.

关键词： DFT calculation Fe/Au electrocatalysis Mechanism Oxygen evolution Water oxidation

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Disentangled Representation Learning with Transmitted Information Bottleneck

arXiv

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arXiv 2023年

作者： Dang, Zhuohang Luo, Minnan Jia, Chengyou Dai, Guang Wang, Jihong Chang, Xiaojun Wang, Jingdong The School of Computer Science and Technology The Ministry of Education Key Laboratory of Intelligent Networks and Network Security The Shaanxi Province Key Laboratory of Big Data Knowledge Engineering Xi'an Jiaotong University Shaanxi Xi’an710049 China The SGIT AI Laboratory Xi’an710048 China The State Grid Shaanxi Electric Power Company Ltd. State Grid Corporation of China Xi’an710048 China The School of Information Science and Technology University of Science and Technology of China Hefei230026 China Abu Dhabi United Arab Emirates Baidu Inc Beijing100085 China

Encoding only the task-related information from the raw data, i.e., disentangled representation learning, can greatly contribute to the robustness and generalizability of models. Although significant advances have been made by regularizing the information in representations with information theory, two major challenges remain: 1) the representation compression inevitably leads to performance drop;2) the disentanglement constraints on representations are in complicated optimization. To these issues, we introduce Bayesian networks with transmitted information to formulate the interaction among input and representations during disentanglement. Building upon this framework, we propose DisTIB (Transmitted Information Bottleneck for Disentangled representation learning), a novel objective that navigates the balance between information compression and preservation. We employ variational inference to derive a tractable estimation for DisTIB. This estimation can be simply optimized via standard gradient descent with a reparameterization trick. Moreover, we theoretically prove that DisTIB can achieve optimal disentanglement, underscoring its superior efficacy. To solidify our claims, we conduct extensive experiments on various downstream tasks to demonstrate the appealing efficacy of DisTIB and validate our theoretical analyses. Copyright © 2023, The Authors. All rights reserved.

关键词： Information theory

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Zero-knowledge Proof-based Practical Federated Learning on Blockchain

arXiv

引用

arXiv 2023年

作者： Xing, Zhibo Zhang, Zijian Li, Meng Liu, Jiamou Zhu, Liehuang Russello, Giovanni Asghar, Muhammad Rizwan The School of Computer Science The University of Auckland Auckland New Zealand The School of Cyberspace Science and Technology Beijing Institute of Technology Beijing100081 China Southeast Institute of Information Technology Beijing Institute of Technology Fujian351100 China Key Laboratory of Knowledge Engineering with Big Data Hefei University of Technology Ministry of Education School of Computer Science and Information Engineering Hefei University of Technology Anhui Hefei230601 China Anhui Province Key Laboratory of Industry Safety and Emergency Technology Intelligent Interconnected Systems Laboratory of Anhui Province Hefei University of Technology China The Department of Computer Science University of Surrey The School of Computer Science The University of Auckland Auckland New Zealand

Since the concern of privacy leakage extremely discourages user participation in sharing data, federated learning has gradually become a promising technique for both academia and industry for achieving collaborative learning without leaking information about the local data. Unfortunately, most federated learning solutions cannot efficiently verify the execution of each participant's local machine learning model and protect the privacy of user data, simultaneously. In this article, we first propose a Zero-knowledge Proof-based Federated Learning (ZKP-FL) scheme on blockchain. It leverages zero-knowledge proof for both the computation of local data and the aggregation of local model parameters, aiming to verify the computation process without requiring the plaintext of the local data. We further propose a Practical ZKP-FL (PZKP-FL) scheme to support fraction and non-linear operations. Specifically, we explore a Fraction-Integer mapping function, and use Taylor expansion to efficiently handle non-linear operations while maintaining the accuracy of the federated learning model. We also analyze the security of PZKP-FL. Performance analysis demonstrates that the whole running time of the PZKP-FL scheme is approximately less than one minute in parallel execution. Copyright © 2023, The Authors. All rights reserved.

关键词： Blockchain

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Probabilistic Graph Pattern Matching via Tumor knowledge Graph

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ACM Transactions on Probabilistic Machine Learning 1000年

作者： Lei Li Houdie Tu Zhenchao Tao Chenyang Bu Xindong Wu Key Laboratory of Knowledge Engineering with Big Data (the Ministry of Education of China) Hefei University of Technology Hefei 230601 China and School of Computer Science and Information Engineering Hefei University of Technology Hefei 230601 China School of Computer Science and Information Engineering Hefei University of Technology Hefei 230601 China School of Data Science University of Science and Technology of China Hefei 230052 China and West District of the First Affiliated Hospital of University of Science and Technology of China Hefei 230031 China Key Laboratory of Knowledge Engineering with Big Data (the Ministry of Education of China) Hefei University of Technology Hefei 230601 China

Graph Pattern Matching (GPM) entails the identification of subgraphs within a larger graph structure that either precisely mirror or closely parallel a predefined pattern graph. Despite the fact that research on GPM in large-scale graph data has been largely centered on social network analysis or enhancing the precision and efficiency of matching algorithms for expeditious subgraph retrieval, there is a noticeable absence of studies committed to probing GPM in medical domains. To rectify this shortcoming and probe the potential of GPM in clinical contexts, particularly in aiding patients with the selection of optimal tumor treatment plans, this paper introduces the concept of probabilistic graph pattern matching specifically modified for the Tumor knowledge Graph (TKG). We propose a multi-constraint graph pattern matching algorithm, hereinafter designated as TKG-McGPM, customized for the Tumor knowledge Graph. Through experimental verification, we establish that TKG-McGPM can facilitate more efficient and informed decision-making in tumor treatment planning.

关键词： Graph Pattern Matching Probabilistic Graph Pattern Matching Tumor knowledge Graph Monte Carlo Method

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Distilling the Unknown to Unveil Certainty

arXiv

引用

arXiv 2023年

作者： Zhao, Zhilin Cao, Longbing Zhang, Yixuan Lin, Kun-Yu Zheng, Wei-Shi The Data Science Lab School of Computing Macquarie University SydneyNSW2109 Australia The DataX Research Centre Macquarie University SydneyNSW2109 Australia The China-Austria Belt and Road Joint Laboratory on Artificial Intelligence and Advanced Manufacturing Hangzhou Dianzi University Zhejiang Hangzhou310005 China The School of Computer Science and Engineering Sun Yat-sen University Guangzhou510275 China The School of Computer Science and Engineering Key Laboratory of Machine Intelligence and Advanced Computing Ministry of Education Sun Yat-sen University Guangzhou510275 China

Out-of-distribution (OOD) detection is essential in identifying test samples that deviate from the in-distribution (ID) data upon which a standard network is trained, ensuring network robustness and reliability. This paper introduces OOD knowledge distillation, a pioneering learning framework applicable whether or not training ID data is available, given a standard network. This framework harnesses unknown OOD-sensitive knowledge from the standard network to craft a certain binary classifier adept at distinguishing between ID and OOD samples. To accomplish this, we introduce Confidence Amendment (CA), an innovative methodology that transforms an OOD sample into an ID one while progressively amending prediction confidence derived from the standard network. This approach enables the simultaneous synthesis of both ID and OOD samples, each accompanied by an adjusted prediction confidence, thereby facilitating the training of a binary classifier sensitive to OOD. Theoretical analysis provides bounds on the generalization error of the binary classifier, demonstrating the pivotal role of confidence amendment in enhancing OOD sensitivity. Extensive experiments spanning various datasets and network architectures confirm the efficacy of the proposed method in detecting OOD samples. Copyright © 2023, The Authors. All rights reserved.

关键词： Deep neural networks

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Evaluating the Long-Term Effects of Near-Natural Restoration on Post-Fire Forest Dynamics in a Wildland-Urban Interface Landscape

SSRN

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SSRN 2023年

作者： Xiao, Jiangtao Lin, Yang Zhou, Wangming Qiao, Zeyu Chang, Yu Yu, Xinran Li, Yuanyuan Ren, Ping Fang, Lei Key Lab of Land Resources Evaluation and Monitoring in Southwest China Ministry of Education Sichuan Normal University Chengdu610066 China School of Geography and Resources Sciences Sichuan Normal University Chengdu610066 China CAS Key Laboratory of Forest and Ecology Management Institute of Applied Ecology Chinese Academy of Sciences Shenyang110016 China School of Land and Resources Surveying and Mapping Engineering Shandong Agriculture and Engineering University Jinan250100 China Big Data Research Center for Ecology and Environment Shandong University Qingdao266237 China Environment Research Institute Shandong University Qingdao266237 China

Wildland fire is an important disturbance agent that can drastically alter forest structures and erode forest ecosystem services. Forests in the wildland-urban interface (WUI) are of high value but vulnerable to fires due to abundant fire ignitions and flammable forest fuels. It is critically important to quickly restore the post-fire WUI forest landscape to maintain ecosystem service provision following near-natural restoration strategies. To evaluate the long-term effects of near-natural restoration on the WUI forest landscape, which are largely unclear, we used a wildfire near Shenyang City in northeast China as an example and investigated the post-fire forest dynamics under two different scenarios (i.e., natural succession and near-natural restoration) based on the forest landscape model. The results demonstrated that artificial plantations can significantly accelerate the restoration process in terms of forest biomass, species biodiversity, and age structure. Under the near-natural restoration scenario, the biomass of the burned area can be quickly restored, but biomass under both scenarios tended to equal out at the end of the simulation. At the species level, the biomass of pioneer tree species such as Chinese pine and Black locust decreased under the near-natural restoration scenario, while the biomass of other species started to increase, not only in terms of biomass, but the results also showed that post-fire planting accelerated the restoration of forest biodiversity and increased biodiversity. By 2070, the Shannon‒Wiener index was predicted to be 1.49 under natural succession and remained at 2.02 under near-natural restoration. In terms of age structure, near-natural restoration shortens the evolution time of fire trails to mature forests. In summary, near-natural restoration accelerates forest recovery in post-fire WUI areas. Our results highlighted the impact of near-natural restoration on forest restoration to inform post-fire forest management practi

关键词： Biomass

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Size-Invariance Matters: Rethinking Metrics and Losses for Imbalanced Multi-object Salient Object Detection

arXiv

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arXiv 2024年

作者： Li, Feiran Xu, Qianqian Bao, Shilong Yang, Zhiyong Cong, Runmin Cao, Xiaochun Huang, Qingming Institute of Information Engineering Chinese Academy of Sciences Beijing China School of Cyber Security University of Chinese Academy of Sciences Beijing China Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing China School of Computer Science and Technology University of Chinese Academy of Sciences Beijing China Institute of Information Science Beijing Jiaotong University Beijing China School of Control Science and Engineering Shandong University Jinan China Key Laboratory of Machine Intelligence and System Control Ministry of Education Jinan China School of Cyber Science and Tech. Sun Yat-Sen University Shenzhen Campus China Key Laboratory of Big Data Mining and Knowledge Management Chinese Academy of Sciences Beijing China

This paper explores the size-invariance of evaluation metrics in Salient Object Detection (SOD), especially when multiple targets of diverse sizes co-exist in the same image. We observe that current metrics are size-sensitive, where larger objects are focused, and smaller ones tend to be ignored. We argue that the evaluation should be size-invariant because bias based on size is unjustified without additional semantic information. In pursuit of this, we propose a generic approach that evaluates each salient object separately and then combines the results, effectively alleviating the imbalance. We further develop an optimization framework tailored to this goal, achieving considerable improvements in detecting objects of different sizes. Theoretically, we provide evidence supporting the validity of our new metrics and present the generalization analysis of SOD. Extensive experiments demonstrate the effectiveness of our method. The code is available at https://***/Ferry-Li/SI-SOD. Copyright © 2024, The Authors. All rights reserved.

关键词： Object detection

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A Survey on Applications of Reinforcement Learning in Spatial Resource Allocation

arXiv

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arXiv 2024年

作者： Zhang, Di Wang, Moyang Mango, Joseph Li, Xiang Xu, Xianrui Key Laboratory of Geographic Information Science Ministry of Education School of Geographic Sciences East China Normal University Shanghai200241 China Department of Transportation and Geotechnical Engineering University of Dar es Salaam Dar es salaam Tanzania United Republic of Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration East China Normal University Shanghai200241 China Key Laboratory of Spatial-Temporal Big Data Analysis and Application of Natural Resources in Megacities Ministry of Natural Resources East China Normal University Shanghai200241 China School of Economics and Management Shanghai University of Sport Shanghai200438 China

The challenge of spatial resource allocation is pervasive across various domains such as transportation, industry, and daily life. As the scale of real-world issues continues to expand and demands for real-time solutions increase, traditional algorithms face significant computational pressures, struggling to achieve optimal efficiency and real-time capabilities. In recent years, with the escalating computational power of computers, the remarkable achievements of reinforcement learning in domains like Go and robotics have demonstrated its robust learning and sequential decision-making capabilities. Given these advancements, there has been a surge in novel methods employing reinforcement learning to tackle spatial resource allocation problems. These methods exhibit advantages such as rapid solution convergence and strong model generalization abilities, offering a new perspective on resolving spatial resource allocation problems. Therefore, this paper aims to summarize and review recent theoretical methods and applied research utilizing reinforcement learning to address spatial resource allocation problems. It provides a summary and comprehensive overview of its fundamental principles, related methodologies, and applied research. Additionally, it highlights several unresolved issues that urgently require attention in this direction for the future. Copyright © 2024, The Authors. All rights reserved.

关键词： Reinforcement learning

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